Crizotinib (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0528784
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0443677
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0390072
FLNA filamin A, alpha 0.0338372
EEF2 eukaryotic translation elongation factor 2 0.0280762
MYH9 myosin, heavy chain 9, non-muscle 0.0274192
SRRM2 serine/arginine repetitive matrix 2 0.0269436
CANX calnexin 0.0267723
KDM3A lysine (K)-specific demethylase 3A 0.0265057
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0228836
LAMB3 laminin, beta 3 0.0217023
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0216076
APLP2 amyloid beta (A4) precursor-like protein 2 0.0216018
KDM6A lysine (K)-specific demethylase 6A 0.0201871
BHLHE40 basic helix-loop-helix family, member e40 0.0189037
YTHDC1 YTH domain containing 1 0.017517
EIF4B eukaryotic translation initiation factor 4B 0.0171362
ARGLU1 arginine and glutamate rich 1 0.0168673
RPL3 ribosomal protein L3 0.0166839
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0161402
KDM5C lysine (K)-specific demethylase 5C 0.0161179
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0155179
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.014962
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0149417
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.014928
TMF1 TATA element modulatory factor 1 0.0149011
KMT2C lysine (K)-specific methyltransferase 2C 0.0148689
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0147736
CRY1 cryptochrome circadian clock 1 0.0144686
MCL1 myeloid cell leukemia 1 0.0144047
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0141672
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.013871
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0133616
RBM33 RNA binding motif protein 33 0.0133462
CEP250 centrosomal protein 250kDa 0.0132944
BRD2 bromodomain containing 2 0.0132245
SAMD4A sterile alpha motif domain containing 4A 0.0131996
TSC22D2 TSC22 domain family, member 2 0.0131605
CASC3 cancer susceptibility candidate 3 0.0129557
EXT1 exostosin glycosyltransferase 1 0.0127913
EEF1G eukaryotic translation elongation factor 1 gamma 0.0127588
DSCAM Down syndrome cell adhesion molecule 0.0127547
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0126486
RPL4 ribosomal protein L4 0.0123911
NUP58 nucleoporin 58 0.0123059
FNBP4 formin binding protein 4 0.0122918
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0122054
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.012185
YME1L1 YME1-like 1 ATPase 0.0121714
KIF1B kinesin family member 1B 0.0121571
JMJD1C jumonji domain containing 1C 0.0120668
DIAPH1 diaphanous-related formin 1 0.0120662
ADAM9 ADAM metallopeptidase domain 9 0.0119898
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0118678
RPS4X ribosomal protein S4, X-linked 0.0118606
DENND5A DENN/MADD domain containing 5A 0.011841
KAT6A K(lysine) acetyltransferase 6A 0.0118405
RIOK3 RIO kinase 3 0.01169
KMT2E lysine (K)-specific methyltransferase 2E 0.0116894
CPNE1 copine I 0.0116893
OGA O-GlcNAcase 0.0116842
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0116316
HDAC9 histone deacetylase 9 0.0115301
RLF rearranged L-myc fusion 0.0114483
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.0114225
AARS1 alanyl-tRNA synthetase 1 0.0113789
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0112083
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0111697
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.011138
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.011081
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0109254
FOXO3 forkhead box O3 0.0107365
RSRC2 arginine/serine-rich coiled-coil 2 0.0106647
RPL14 ribosomal protein L14 0.0106542
CREB5 cAMP responsive element binding protein 5 0.0106345
PICALM phosphatidylinositol binding clathrin assembly protein 0.0105467
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0105465
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0105164
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0103389
SUCO SUN domain containing ossification factor 0.0103139
RBM39 RNA binding motif protein 39 0.0102284
ACIN1 apoptotic chromatin condensation inducer 1 0.0101534
CD274 CD274 molecule 0.0100716
CALR calreticulin 0.0100597
FXR1 fragile X mental retardation, autosomal homolog 1 0.0100451
SPAG9 sperm associated antigen 9 0.00990028
CORO1C coronin, actin binding protein, 1C 0.00979653
RAD23B RAD23 homolog B (S. cerevisiae) 0.00969319
CCDC50 coiled-coil domain containing 50 0.00968166
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.00962949
PTPRJ protein tyrosine phosphatase, receptor type, J 0.00960895
RPL13A ribosomal protein L13a 0.00954208
USP9X ubiquitin specific peptidase 9, X-linked 0.00948503
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.00934595
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00925512
HSPA8 heat shock 70kDa protein 8 0.0092497
MTMR3 myotubularin related protein 3 0.00921075
SPAG5 sperm associated antigen 5 0.00917542
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.00899119
RPS18 ribosomal protein S18 0.00896988

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.140856
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107412
ACTG1 actin gamma 1 -0.0692862
ZNF438 zinc finger protein 438 -0.063973
RPS6 ribosomal protein S6 -0.0595688
IFI16 interferon, gamma-inducible protein 16 -0.0588042
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.057204
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0549972
RPL35A ribosomal protein L35a -0.0547112
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0545187
DLC1 DLC1 Rho GTPase activating protein -0.0538517
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0503792
TPT1 tumor protein, translationally-controlled 1 -0.047216
RPLP0 ribosomal protein, large, P0 -0.0470132
RPS8 ribosomal protein S8 -0.0454876
RPS21 ribosomal protein S21 -0.0450535
POTEF POTE ankyrin domain family, member F -0.0443361
RPL8 ribosomal protein L8 -0.0412232
RPLP1 ribosomal protein, large, P1 -0.0409827
HMGA2 high mobility group AT-hook 2 -0.0399984
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0376497
ARHGAP22 Rho GTPase activating protein 22 -0.0373798
NAV3 neuron navigator 3 -0.0373578
RPL12 ribosomal protein L12 -0.036206
HMGA1 high mobility group AT-hook 1 -0.0353407
ANTXR2 anthrax toxin receptor 2 -0.0346566
RAD51B RAD51 paralog B -0.034046
RPLP2 ribosomal protein, large, P2 -0.0333346
RPS24 ribosomal protein S24 -0.0330152
ENO1 enolase 1, (alpha) -0.0325821
RPS19 ribosomal protein S19 -0.0323381
RPL9 ribosomal protein L9 -0.0323005
PFN1 profilin 1 -0.0319912
RPL30 ribosomal protein L30 -0.0311298
TMSB10 thymosin beta 10 -0.0307299
FHIT fragile histidine triad -0.0305638
BNC2 basonuclin 2 -0.0302028
SLC38A2 solute carrier family 38, member 2 -0.0297115
SMYD3 SET and MYND domain containing 3 -0.0293434
FTL ferritin, light polypeptide -0.0291117
AHNAK AHNAK nucleoprotein -0.028777
RPL34 ribosomal protein L34 -0.0286769
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0279249
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0274168
MTAP methylthioadenosine phosphorylase -0.0272585
RPS15 ribosomal protein S15 -0.027123
STC1 stanniocalcin 1 -0.0269667
RPS13 ribosomal protein S13 -0.026832
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0266015
RPL23 ribosomal protein L23 -0.0263982
TM4SF1 transmembrane 4 L six family member 1 -0.0263282
ZBTB20 zinc finger and BTB domain containing 20 -0.0263272
FRMD4A FERM domain containing 4A -0.0262409
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0259805
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0258674
PBX3 pre-B-cell leukemia homeobox 3 -0.0253785
TCF12 transcription factor 12 -0.0252392
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0252386
S100A9 S100 calcium binding protein A9 -0.0247153
GPHN gephyrin -0.0241261
RPS27A ribosomal protein S27a -0.0238046
FLNB filamin B, beta -0.0238034
RPL26 ribosomal protein L26 -0.02318
KPNB1 karyopherin (importin) beta 1 -0.0229046
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0227293
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0225559
FAF1 Fas (TNFRSF6) associated factor 1 -0.0224339
RPL5 ribosomal protein L5 -0.0222418
ASPH aspartate beta-hydroxylase -0.0220311
PDIA3 protein disulfide isomerase family A, member 3 -0.0219069
RPS29 ribosomal protein S29 -0.0215881
RPL32 ribosomal protein L32 -0.0214634
RPL35 ribosomal protein L35 -0.0214038
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0209336
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0205071
MT1X metallothionein 1X -0.0203103
RIGI RNA sensor RIG-I -0.0202258
EXOC4 exocyst complex component 4 -0.0202148
RPS5 ribosomal protein S5 -0.0201274
UPP1 uridine phosphorylase 1 -0.0196209
RPL7A ribosomal protein L7a -0.0193686
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0191939
GNAS GNAS complex locus -0.0191666
TBC1D5 TBC1 domain family, member 5 -0.0190866
RPL31 ribosomal protein L31 -0.0190497
RPL28 ribosomal protein L28 -0.0189808
ANKRD17 ankyrin repeat domain 17 -0.018908
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0188382
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.018824
SPIDR scaffolding protein involved in DNA repair -0.0188106
RPS16 ribosomal protein S16 -0.0184581
C2CD2 C2 calcium-dependent domain containing 2 -0.0183913
PTMA prothymosin, alpha -0.0183462
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0182305
PARD3 par-3 family cell polarity regulator -0.0180775
CENPF centromere protein F, 350/400kDa -0.018032
DEK DEK proto-oncogene -0.0178937
SP100 SP100 nuclear antigen -0.0178288
DIAPH3 diaphanous-related formin 3 -0.0177974
RPS23 ribosomal protein S23 -0.0173291