| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.0879867 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0580401 |
| VGF | VGF nerve growth factor inducible | 0.0556996 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0467835 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0461885 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0383112 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.031486 |
| CHGB | chromogranin B | 0.0308567 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0285595 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.027525 |
| FAT1 | FAT atypical cadherin 1 | 0.0274552 |
| RPL4 | ribosomal protein L4 | 0.0269292 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0262948 |
| IRS2 | insulin receptor substrate 2 | 0.0240878 |
| RPL7 | ribosomal protein L7 | 0.0231072 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0229782 |
| MATR3 | matrin 3 | 0.022118 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.021813 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0215228 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0209166 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0199536 |
| SET | SET nuclear proto-oncogene | 0.0194114 |
| YY1AP1 | YY1 associated protein 1 | 0.0190178 |
| INCENP | inner centromere protein antigens 135/155kDa | 0.0175509 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0173891 |
| SPAG5 | sperm associated antigen 5 | 0.0170923 |
| RPL13A | ribosomal protein L13a | 0.0167533 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0161521 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0158792 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0156167 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0153077 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0152928 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0150931 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0149727 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0149361 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0146336 |
| CPE | carboxypeptidase E | 0.0145887 |
| KIF1A | kinesin family member 1A | 0.014236 |
| NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) | 0.0142201 |
| SYT13 | synaptotagmin XIII | 0.0140633 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0140222 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0139834 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0139099 |
| FLNA | filamin A, alpha | 0.0138867 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0138289 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0138145 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0134746 |
| SIK3 | SIK family kinase 3 | 0.0134435 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0133795 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0133694 |
| RPS4X | ribosomal protein S4, X-linked | 0.0131331 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0130968 |
| RPS3 | ribosomal protein S3 | 0.0130959 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0129743 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0129365 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0129278 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.01247 |
| ACTN4 | actinin, alpha 4 | 0.0123672 |
| AHR | aryl hydrocarbon receptor | 0.0121531 |
| HSPA8 | heat shock 70kDa protein 8 | 0.01211 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0119086 |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.0118381 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0118245 |
| PRPF6 | pre-mRNA processing factor 6 | 0.0117917 |
| KIF22 | kinesin family member 22 | 0.0115365 |
| CPLX2 | complexin 2 | 0.0115357 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0113949 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0112731 |
| PNN | pinin, desmosome associated protein | 0.0112595 |
| TPM3 | tropomyosin 3 | 0.0111748 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0110797 |
| HMGB2 | high mobility group box 2 | 0.0109921 |
| POU2F1 | POU class 2 homeobox 1 | 0.0107766 |
| RPL3 | ribosomal protein L3 | 0.0107335 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0107261 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0106824 |
| DIAPH1 | diaphanous-related formin 1 | 0.0106149 |
| HYOU1 | hypoxia up-regulated 1 | 0.0105523 |
| GANAB | glucosidase, alpha; neutral AB | 0.0104979 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0104629 |
| CORO1C | coronin, actin binding protein, 1C | 0.0104512 |
| PER1 | period circadian clock 1 | 0.0104382 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0103435 |
| CDC20 | cell division cycle 20 | 0.0102979 |
| SIK2 | salt-inducible kinase 2 | 0.0102277 |
| CCNY | cyclin Y | 0.0102117 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0102044 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0101997 |
| PHF3 | PHD finger protein 3 | 0.0101824 |
| ATP5F1A | ATP synthase F1 subunit alpha | 0.010121 |
| HDAC5 | histone deacetylase 5 | 0.0100837 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0100549 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.010023 |
| LMNB1 | lamin B1 | 0.0100226 |
| CEP250 | centrosomal protein 250kDa | 0.00987858 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.00984397 |
| GNL1 | guanine nucleotide binding protein-like 1 | 0.00980787 |
| RBM19 | RNA binding motif protein 19 | 0.00980082 |
| MSN | moesin | 0.00969702 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.00956809 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.122021 |
| GPC6 | glypican 6 | -0.0940985 |
| NRG1 | neuregulin 1 | -0.0888055 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0720751 |
| NDRG1 | N-myc downstream regulated 1 | -0.0569189 |
| STC1 | stanniocalcin 1 | -0.0554731 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.055421 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0524519 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0522627 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.051632 |
| CALCA | calcitonin-related polypeptide alpha | -0.0504045 |
| TENM1 | teneurin transmembrane protein 1 | -0.0490614 |
| GPC5 | glypican 5 | -0.0481093 |
| NCKAP5 | NCK-associated protein 5 | -0.0479145 |
| SYT1 | synaptotagmin I | -0.0470794 |
| SMYD3 | SET and MYND domain containing 3 | -0.045954 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0443712 |
| EGR1 | early growth response 1 | -0.0440807 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.043331 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0424364 |
| ENO1 | enolase 1, (alpha) | -0.0419243 |
| SNTG1 | syntrophin, gamma 1 | -0.0407459 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0404152 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0401699 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0380118 |
| DGKB | diacylglycerol kinase, beta 90kDa | -0.0372508 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0357968 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.035715 |
| ACTG1 | actin gamma 1 | -0.0334922 |
| KIF26B | kinesin family member 26B | -0.0332341 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0317883 |
| ESRRG | estrogen-related receptor gamma | -0.0314662 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0312851 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0309986 |
| PEX5L | peroxisomal biogenesis factor 5-like | -0.0309159 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0302345 |
| DTNA | dystrobrevin, alpha | -0.0300988 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0294365 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0287482 |
| EFNA5 | ephrin-A5 | -0.0284089 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0276221 |
| PTCHD4 | patched domain containing 4 | -0.0275415 |
| RORA | RAR-related orphan receptor A | -0.0274863 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0267049 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0265567 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0256256 |
| STXBP5L | syntaxin binding protein 5-like | -0.0254224 |
| NBEA | neurobeachin | -0.0254194 |
| FGF14 | fibroblast growth factor 14 | -0.0250001 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0243862 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.024144 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0235837 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0232035 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0229373 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0228909 |
| EPHA6 | EPH receptor A6 | -0.0224558 |
| RNF213 | ring finger protein 213 | -0.0224453 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0220404 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0218666 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0214962 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0213697 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0209907 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0209657 |
| CNTNAP2 | contactin associated protein-like 2 | -0.0209297 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0208216 |
| FAM13A | family with sequence similarity 13, member A | -0.0207806 |
| RAD51B | RAD51 paralog B | -0.0205904 |
| POTEF | POTE ankyrin domain family, member F | -0.0201465 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0200598 |
| KIAA0825 | KIAA0825 | -0.0200116 |
| RIGI | RNA sensor RIG-I | -0.0199149 |
| LSAMP | limbic system-associated membrane protein | -0.019766 |
| SCFD2 | sec1 family domain containing 2 | -0.0196801 |
| NF1 | neurofibromin 1 | -0.0196045 |
| EXOC4 | exocyst complex component 4 | -0.0195302 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0192803 |
| NAV2 | neuron navigator 2 | -0.0190828 |
| NELL1 | NEL-like 1 (chicken) | -0.0190022 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0189156 |
| PCDH9 | protocadherin 9 | -0.0186866 |
| CHGA | chromogranin A | -0.0185971 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.018511 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0183619 |
| ZNF804A | zinc finger protein 804A | -0.0183245 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0182856 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0182766 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0180371 |
| SCG2 | secretogranin II | -0.0179453 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.017944 |
| NRXN1 | neurexin 1 | -0.0178732 |
| WDR45B | WD repeat domain 45B | -0.0178124 |
| FTL | ferritin, light polypeptide | -0.0177301 |
| GPHN | gephyrin | -0.0176588 |
| KCNH7 | potassium channel, voltage gated eag related subfamily H, member 7 | -0.0175492 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0175317 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.017374 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0172669 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.017222 |
| TXNRD1 | thioredoxin reductase 1 | -0.016844 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0165612 |
