| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.318077 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.178157 |
| FN1 | fibronectin 1 | 0.138952 |
| FLNA | filamin A, alpha | 0.13595 |
| CANX | calnexin | 0.10014 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0918174 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0900423 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0739864 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0730895 |
| PGK1 | phosphoglycerate kinase 1 | 0.0714897 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.071292 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0677013 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0630519 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0601435 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0541496 |
| FMNL2 | formin-like 2 | 0.0505789 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0495293 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0493958 |
| SFTPA2 | surfactant protein A2 | 0.0487536 |
| RPS4X | ribosomal protein S4, X-linked | 0.0465128 |
| SEPTIN9 | septin 9 | 0.0432828 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0429614 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0427406 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0420081 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0419485 |
| RPS3 | ribosomal protein S3 | 0.0418318 |
| PLEC | plectin | 0.0416516 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0414168 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0402326 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0400131 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0394764 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0393914 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0393316 |
| NLGN1 | neuroligin 1 | 0.0390895 |
| KAZN | kazrin, periplakin interacting protein | 0.0385565 |
| CEP250 | centrosomal protein 250kDa | 0.0382619 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0372634 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0370608 |
| TNNC1 | troponin C type 1 (slow) | 0.034312 |
| CTTN | cortactin | 0.033616 |
| MSI2 | musashi RNA-binding protein 2 | 0.031919 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0319145 |
| SERINC1 | serine incorporator 1 | 0.0311686 |
| RPL4 | ribosomal protein L4 | 0.0310395 |
| MCL1 | myeloid cell leukemia 1 | 0.031021 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0307996 |
| RPL14 | ribosomal protein L14 | 0.0305973 |
| HLA-E | major histocompatibility complex, class I, E | 0.030579 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0302531 |
| STK10 | serine/threonine kinase 10 | 0.0295916 |
| TCF20 | transcription factor 20 (AR1) | 0.0290394 |
| AATF | apoptosis antagonizing transcription factor | 0.0289266 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0284989 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | 0.0283677 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0282696 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0281001 |
| PRELID2 | PRELI domain containing 2 | 0.0278699 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0276997 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0274889 |
| CCDC47 | coiled-coil domain containing 47 | 0.0274783 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0271553 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0271323 |
| ALMS1 | Alstrom syndrome protein 1 | 0.0269352 |
| LSAMP | limbic system-associated membrane protein | 0.0268695 |
| RPL13A | ribosomal protein L13a | 0.0263759 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0262035 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0256068 |
| MSN | moesin | 0.0253367 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0251215 |
| ACLY | ATP citrate lyase | 0.0251104 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0247277 |
| RPL7 | ribosomal protein L7 | 0.0239482 |
| DST | dystonin | 0.0239318 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0238632 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0238577 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0237004 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0236094 |
| FAM219A | family with sequence similarity 219, member A | 0.0234809 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0233994 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.023165 |
| ACTN4 | actinin, alpha 4 | 0.0231177 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0230753 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0227105 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.022697 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0225952 |
| HDLBP | high density lipoprotein binding protein | 0.022394 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0223302 |
| ADAR | adenosine deaminase, RNA-specific | 0.0222866 |
| SUCO | SUN domain containing ossification factor | 0.0222009 |
| CALR | calreticulin | 0.0221428 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0219645 |
| PMEL | premelanosome protein | 0.0214938 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0213636 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0213598 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0213193 |
| YME1L1 | YME1-like 1 ATPase | 0.0212793 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0210781 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0207179 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0207133 |
| CLIC4 | chloride intracellular channel 4 | 0.0205708 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.18478 |
| POTEF | POTE ankyrin domain family, member F | -0.0964109 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.095703 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0662677 |
| MT2A | metallothionein 2A | -0.0641868 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0615025 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0539157 |
| FRMD5 | FERM domain containing 5 | -0.0487706 |
| CCND1 | cyclin D1 | -0.0475144 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0436935 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0427918 |
| NDRG1 | N-myc downstream regulated 1 | -0.0414991 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0401595 |
| TMSB10 | thymosin beta 10 | -0.0393318 |
| FTL | ferritin, light polypeptide | -0.0374498 |
| HMGA1 | high mobility group AT-hook 1 | -0.0353037 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0345505 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0343619 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0331852 |
| ACTG1 | actin gamma 1 | -0.0319809 |
| RNF145 | ring finger protein 145 | -0.0295188 |
| CCNL1 | cyclin L1 | -0.0293933 |
| SEPTIN7 | septin 7 | -0.0292135 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0286014 |
| RPLP1 | ribosomal protein, large, P1 | -0.0283595 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.027572 |
| RPL35A | ribosomal protein L35a | -0.0271885 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0269242 |
| BPTF | bromodomain PHD finger transcription factor | -0.0268694 |
| JMJD1C | jumonji domain containing 1C | -0.0261498 |
| QKI | QKI, KH domain containing, RNA binding | -0.0256821 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0254396 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0249845 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0245663 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0245321 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0244338 |
| TAGLN2 | transgelin 2 | -0.024239 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0242176 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0239449 |
| S100A9 | S100 calcium binding protein A9 | -0.0236269 |
| PFN1 | profilin 1 | -0.0235004 |
| PKM | pyruvate kinase, muscle | -0.0233001 |
| TENM1 | teneurin transmembrane protein 1 | -0.0232653 |
| PDCD10 | programmed cell death 10 | -0.022861 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0226711 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0223561 |
| RBM39 | RNA binding motif protein 39 | -0.0214607 |
| RPL36 | ribosomal protein L36 | -0.0214028 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0212524 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0212036 |
| SEC24A | SEC24 family member A | -0.0210799 |
| RHEB | Ras homolog enriched in brain | -0.0208754 |
| CBX3 | chromobox homolog 3 | -0.020707 |
| S100A10 | S100 calcium binding protein A10 | -0.0205908 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0204486 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0203785 |
| RPL28 | ribosomal protein L28 | -0.0199071 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0199016 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0196222 |
| EGR1 | early growth response 1 | -0.0195399 |
| SOX10 | SRY (sex determining region Y)-box 10 | -0.0193768 |
| CFAP20DC | CFAP20 domain containing | -0.0193712 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0191249 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0190529 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0188679 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0187527 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0187449 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0185252 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0183734 |
| CDK6 | cyclin-dependent kinase 6 | -0.0183416 |
| PHF21A | PHD finger protein 21A | -0.0181277 |
| RPLP2 | ribosomal protein, large, P2 | -0.0180498 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.0179439 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0179355 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0179222 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0179199 |
| NOP58 | NOP58 ribonucleoprotein | -0.0179187 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0179159 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0177814 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0176341 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0176193 |
| SHISA5 | shisa family member 5 | -0.0176163 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.017614 |
| NEK1 | NIMA-related kinase 1 | -0.0175476 |
| RPS6 | ribosomal protein S6 | -0.0174308 |
| SRPK2 | SRSF protein kinase 2 | -0.0173124 |
| TOB2 | transducer of ERBB2, 2 | -0.0171698 |
| ZNF207 | zinc finger protein 207 | -0.0170822 |
| IER3 | immediate early response 3 | -0.0168403 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0168135 |
| LINC02798 | long intergenic non-protein coding RNA 2798 | -0.016611 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0165714 |
| PHF14 | PHD finger protein 14 | -0.0165202 |
| RPL34 | ribosomal protein L34 | -0.016498 |
| RPS14 | ribosomal protein S14 | -0.0164903 |
| FBXO32 | F-box protein 32 | -0.0161507 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0160401 |
| SBF2 | SET binding factor 2 | -0.0159938 |
| ZNF292 | zinc finger protein 292 | -0.0159914 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0159693 |
