Crizotinib (hydrochloride)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.239211
MYH9 myosin, heavy chain 9, non-muscle 0.223412
SOD2 superoxide dismutase 2, mitochondrial 0.115778
VEGFA vascular endothelial growth factor A 0.101114
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0791002
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0778858
FLNA filamin A, alpha 0.0771655
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0763218
NAV2 neuron navigator 2 0.0740732
FN1 fibronectin 1 0.0692024
AKAP12 A kinase (PRKA) anchor protein 12 0.0682501
EEF2 eukaryotic translation elongation factor 2 0.0680383
RPS4X ribosomal protein S4, X-linked 0.0629627
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0556086
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0552483
ZMIZ1 zinc finger, MIZ-type containing 1 0.0538802
APLP2 amyloid beta (A4) precursor-like protein 2 0.0537467
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0522518
OGA O-GlcNAcase 0.0494519
MSN moesin 0.0470573
CEP250 centrosomal protein 250kDa 0.0456786
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0453536
FMNL2 formin-like 2 0.0445237
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.042955
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0412608
ADM adrenomedullin 0.0392406
ARRDC3 arrestin domain containing 3 0.0390432
PCBP2 poly(rC) binding protein 2 0.0385645
FLNB filamin B, beta 0.0378808
EEF1G eukaryotic translation elongation factor 1 gamma 0.0367843
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0354073
MYOF myoferlin 0.0351694
UGCG UDP-glucose ceramide glucosyltransferase 0.0347927
MXI1 MAX interactor 1, dimerization protein 0.0344669
SEPTIN9 septin 9 0.0341229
OPTN optineurin 0.0339879
BACE2 beta-site APP-cleaving enzyme 2 0.0331862
TSC22D2 TSC22 domain family, member 2 0.0309754
RB1CC1 RB1-inducible coiled-coil 1 0.0307783
RPL7 ribosomal protein L7 0.0297684
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0282536
TPM3 tropomyosin 3 0.0256869
DSCAM Down syndrome cell adhesion molecule 0.0255664
TNIP1 TNFAIP3 interacting protein 1 0.0254877
INSIG1 insulin induced gene 1 0.0246848
IRS2 insulin receptor substrate 2 0.0246049
SPAG9 sperm associated antigen 9 0.0242302
ESYT2 extended synaptotagmin-like protein 2 0.0241134
GOLGA4 golgin A4 0.0237474
EIF4B eukaryotic translation initiation factor 4B 0.0235512
APP amyloid beta (A4) precursor protein 0.0233128
HELZ helicase with zinc finger 0.0232378
EZR ezrin 0.0230174
CANX calnexin 0.0228632
UBA6 ubiquitin-like modifier activating enzyme 6 0.0227874
PPARD peroxisome proliferator-activated receptor delta 0.0227418
SERINC1 serine incorporator 1 0.0225375
FNIP1 folliculin interacting protein 1 0.022376
RPS12 ribosomal protein S12 0.0223447
ERRFI1 ERBB receptor feedback inhibitor 1 0.0223278
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0221552
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0221477
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.021983
SHB Src homology 2 domain containing adaptor protein B 0.021653
SREBF2 sterol regulatory element binding transcription factor 2 0.021493
FOXO3 forkhead box O3 0.0211972
NAMPT nicotinamide phosphoribosyltransferase 0.0208958
COL6A1 collagen, type VI, alpha 1 0.0205249
BASP1 brain abundant, membrane attached signal protein 1 0.0202299
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0201723
RPS3 ribosomal protein S3 0.020107
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0199148
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.019841
NUP153 nucleoporin 153kDa 0.0198036
CREBRF CREB3 regulatory factor 0.0197568
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0197489
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0196649
NOTCH2 notch 2 0.019647
RAB6A RAB6A, member RAS oncogene family 0.0195548
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0195225
SNX9 sorting nexin 9 0.0194836
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0191895
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.019015
PLIN2 perilipin 2 0.0189789
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0186829
CADM1 cell adhesion molecule 1 0.0185428
RPL3 ribosomal protein L3 0.0184917
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0182933
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0180976
WDFY1 WD repeat and FYVE domain containing 1 0.0180724
MCL1 myeloid cell leukemia 1 0.0179898
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0179572
NUMA1 nuclear mitotic apparatus protein 1 0.0178199
TIMP2 TIMP metallopeptidase inhibitor 2 0.0177913
RPL23 ribosomal protein L23 0.0177696
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0176698
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0175982
KDM3A lysine (K)-specific demethylase 3A 0.0175141
EIF4A1 eukaryotic translation initiation factor 4A1 0.0173361
SFTPA2 surfactant protein A2 0.0172479

decreased expression

Symbol Name Standardized Value
GLIS3 GLIS family zinc finger 3 -0.17124
FRMD4A FERM domain containing 4A -0.145797
BICC1 BicC family RNA binding protein 1 -0.123743
EXT1 exostosin glycosyltransferase 1 -0.11836
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113856
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.102872
VCL vinculin -0.101227
HLA-B major histocompatibility complex, class I, B -0.101157
IER3 immediate early response 3 -0.0718006
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0706238
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0646674
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0607288
VCAN versican -0.0591828
CD44 CD44 molecule (Indian blood group) -0.0587775
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0554932
ZBTB20 zinc finger and BTB domain containing 20 -0.0546629
THBS1 thrombospondin 1 -0.054002
EGR1 early growth response 1 -0.0533902
ZMYND8 zinc finger, MYND-type containing 8 -0.0520206
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0516283
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0511977
KYNU kynureninase -0.0499956
DIAPH2 diaphanous-related formin 2 -0.0493678
RIGI RNA sensor RIG-I -0.0487563
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0477949
IFI16 interferon, gamma-inducible protein 16 -0.0465312
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0464405
NABP1 nucleic acid binding protein 1 -0.0459584
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0455625
TMSB10 thymosin beta 10 -0.0454559
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0453273
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0447945
IGFBP3 insulin-like growth factor binding protein 3 -0.044333
PALLD palladin, cytoskeletal associated protein -0.0442173
HMGA2 high mobility group AT-hook 2 -0.0441028
PTPRK protein tyrosine phosphatase, receptor type, K -0.0417653
VMP1 vacuole membrane protein 1 -0.040752
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.040029
RNF213 ring finger protein 213 -0.0397685
SMYD3 SET and MYND domain containing 3 -0.0389912
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0386532
EHBP1 EH domain binding protein 1 -0.0383963
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0381548
GPC6 glypican 6 -0.0375049
DST dystonin -0.0374784
MAML2 mastermind-like 2 (Drosophila) -0.0366663
NAV1 neuron navigator 1 -0.03647
NCOA7 nuclear receptor coactivator 7 -0.0361744
SLC38A1 solute carrier family 38, member 1 -0.0343733
TNS3 tensin 3 -0.0342715
TPM1 tropomyosin 1 (alpha) -0.0337874
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0337164
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0336175
ACTG1 actin gamma 1 -0.0333885
FBXL7 F-box and leucine-rich repeat protein 7 -0.0332445
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0332358
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0331589
CTSD cathepsin D -0.0331428
OSMR oncostatin M receptor -0.0331121
SOX5 SRY (sex determining region Y)-box 5 -0.0330487
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0328308
COL1A1 collagen, type I, alpha 1 -0.0324592
LPP LIM domain containing preferred translocation partner in lipoma -0.0324115
LOX lysyl oxidase -0.0322559
PMP22 peripheral myelin protein 22 -0.0322128
SMAD3 SMAD family member 3 -0.0319992
IFI6 interferon, alpha-inducible protein 6 -0.0318411
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0318179
PDE10A phosphodiesterase 10A -0.0309644
SLC38A2 solute carrier family 38, member 2 -0.0301805
FTL ferritin, light polypeptide -0.0300922
RAD51B RAD51 paralog B -0.0300625
TGFBI transforming growth factor, beta-induced, 68kDa -0.0298113
BPTF bromodomain PHD finger transcription factor -0.0297185
HDAC8 histone deacetylase 8 -0.0296752
AHNAK AHNAK nucleoprotein -0.0296276
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0295865
PLSCR1 phospholipid scramblase 1 -0.028927
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0288139
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0275804
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.027185
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0270936
CALD1 caldesmon 1 -0.0268037
SFRP1 secreted frizzled-related protein 1 -0.026768
TENM2 teneurin transmembrane protein 2 -0.0265133
XAF1 XIAP associated factor 1 -0.0263918
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0262704
ADAM12 ADAM metallopeptidase domain 12 -0.02615
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0257374
METTL15 methyltransferase like 15 -0.0256051
PRKN parkin RBR E3 ubiquitin protein ligase -0.0255897
FOXP1 forkhead box P1 -0.0255881
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.0254631
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0253885
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0252043
ASPH aspartate beta-hydroxylase -0.0251848
SAMD3 sterile alpha motif domain containing 3 -0.0248458
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0243006
DPYD dihydropyrimidine dehydrogenase -0.0241738
TRIM55 tripartite motif containing 55 -0.0241057