Crizotinib (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0914284
CANX calnexin 0.0871217
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.083005
MYH9 myosin, heavy chain 9, non-muscle 0.0801691
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0665027
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0571079
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0480213
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0474033
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0470448
FLNA filamin A, alpha 0.0449654
KDM3A lysine (K)-specific demethylase 3A 0.0410487
BHLHE40 basic helix-loop-helix family, member e40 0.0395799
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0393321
FNDC3B fibronectin type III domain containing 3B 0.0366918
NEK7 NIMA-related kinase 7 0.0358247
SMAD3 SMAD family member 3 0.0351043
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.034438
APP amyloid beta (A4) precursor protein 0.034415
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0338755
ELL2 elongation factor, RNA polymerase II, 2 0.0334088
RAD21 RAD21 homolog (S. pombe) 0.032568
CXCL8 chemokine (C-X-C motif) ligand 8 0.0307722
APLP2 amyloid beta (A4) precursor-like protein 2 0.0300217
SOD2 superoxide dismutase 2, mitochondrial 0.0300131
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0290355
RNF145 ring finger protein 145 0.0287324
YME1L1 YME1-like 1 ATPase 0.0279943
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0265242
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0264909
SERINC1 serine incorporator 1 0.0264838
WAC WW domain containing adaptor with coiled-coil 0.0264396
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0262463
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0253224
OGA O-GlcNAcase 0.0246783
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0242079
PELO pelota homolog (Drosophila) 0.0241351
ETNK1 ethanolamine kinase 1 0.0240686
MARCHF6 membrane associated ring-CH-type finger 6 0.0237343
AHR aryl hydrocarbon receptor 0.0235003
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0234138
ARRDC3 arrestin domain containing 3 0.0233187
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0233064
ZNF292 zinc finger protein 292 0.0231809
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0227233
RAB8B RAB8B, member RAS oncogene family 0.022404
FAM13A family with sequence similarity 13, member A 0.0223221
YBX3 Y box binding protein 3 0.0218825
TNIP1 TNFAIP3 interacting protein 1 0.0218049
RLF rearranged L-myc fusion 0.0217281
FAT1 FAT atypical cadherin 1 0.0212477
CORO1C coronin, actin binding protein, 1C 0.0210901
RGS2 regulator of G-protein signaling 2 0.0207475
PRRC2C proline-rich coiled-coil 2C 0.0206715
TFG TRK-fused gene 0.0206631
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0206627
NUP58 nucleoporin 58 0.0198547
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0197776
HSPA8 heat shock 70kDa protein 8 0.019767
FXR1 fragile X mental retardation, autosomal homolog 1 0.0196151
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0194738
TMSB4X thymosin beta 4, X-linked 0.0194146
CTNND1 catenin (cadherin-associated protein), delta 1 0.0193688
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0193533
USP3 ubiquitin specific peptidase 3 0.0192555
SEC24C SEC24 family member C 0.0187041
RAD23B RAD23 homolog B (S. cerevisiae) 0.0185842
SMOX spermine oxidase 0.0184966
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0182623
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0182388
CREBRF CREB3 regulatory factor 0.0181488
ARGLU1 arginine and glutamate rich 1 0.0181047
CAB39 calcium binding protein 39 0.0176859
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0175841
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0175763
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0174528
BZW1 basic leucine zipper and W2 domains 1 0.0174222
LCORL ligand dependent nuclear receptor corepressor-like 0.0173879
AFDN afadin, adherens junction formation factor 0.0172593
SHB Src homology 2 domain containing adaptor protein B 0.0172423
HELZ helicase with zinc finger 0.0172019
CDC73 cell division cycle 73 0.0171938
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0171701
USP12 ubiquitin specific peptidase 12 0.0171692
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0171659
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0171552
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0171416
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0171096
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0170908
MATR3 matrin 3 0.0168359
NFE2L1 nuclear factor, erythroid 2-like 1 0.0168211
ANLN anillin, actin binding protein 0.0167767
EPS8 epidermal growth factor receptor pathway substrate 8 0.0167291
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0166964
EIF4A1 eukaryotic translation initiation factor 4A1 0.0165153
XPO1 exportin 1 0.016481
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0164518
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0163426
ZC3H11A zinc finger CCCH-type containing 11A 0.016188
SINHCAF SIN3-HDAC complex associated factor 0.0161094
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.016072

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.259551
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.214167
HMGA2 high mobility group AT-hook 2 -0.14619
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.12736
TMSB10 thymosin beta 10 -0.0996745
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0995122
FTL ferritin, light polypeptide -0.0866559
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0864476
GLIS3 GLIS family zinc finger 3 -0.0809044
PTMA prothymosin, alpha -0.0757707
NDRG1 N-myc downstream regulated 1 -0.0735179
SQSTM1 sequestosome 1 -0.0728512
FN1 fibronectin 1 -0.0692697
HLA-B major histocompatibility complex, class I, B -0.0686112
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0670109
IFI27 interferon, alpha-inducible protein 27 -0.0668518
ENO2 enolase 2 (gamma, neuronal) -0.0653542
SYT1 synaptotagmin I -0.0631004
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0588671
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.057417
POTEF POTE ankyrin domain family, member F -0.0573929
MRPS6 mitochondrial ribosomal protein S6 -0.0572301
ACTG1 actin gamma 1 -0.0547696
EFNA5 ephrin-A5 -0.0539369
RPS6 ribosomal protein S6 -0.0522068
INTS6 integrator complex subunit 6 -0.0517473
RPL35A ribosomal protein L35a -0.0514495
ITGA1 integrin, alpha 1 -0.0509242
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0499719
RAI14 retinoic acid induced 14 -0.0477756
S100A6 S100 calcium binding protein A6 -0.046599
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0456657
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0449592
ZBTB20 zinc finger and BTB domain containing 20 -0.044916
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0442617
ASPH aspartate beta-hydroxylase -0.0430925
MBD5 methyl-CpG binding domain protein 5 -0.0430734
PDE4D phosphodiesterase 4D, cAMP-specific -0.0408289
IGFBP3 insulin-like growth factor binding protein 3 -0.040799
TPT1 tumor protein, translationally-controlled 1 -0.0397237
STC2 stanniocalcin 2 -0.0392282
B2M beta-2-microglobulin -0.0387186
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0385143
RPL31 ribosomal protein L31 -0.037792
TAS2R14 taste receptor, type 2, member 14 -0.037295
GPC6 glypican 6 -0.0360941
EGR1 early growth response 1 -0.0359985
SPDYA speedy/RINGO cell cycle regulator family member A -0.0359715
AEBP2 AE binding protein 2 -0.0352572
EXT1 exostosin glycosyltransferase 1 -0.0348852
BPTF bromodomain PHD finger transcription factor -0.0343666
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0339624
LOC102724023 ES1 protein homolog, mitochondrial -0.0339472
ENO1 enolase 1, (alpha) -0.033702
RPL37A ribosomal protein L37a -0.0328385
RPL37 ribosomal protein L37 -0.0322154
HMGA1 high mobility group AT-hook 1 -0.0321169
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0319978
SLC38A2 solute carrier family 38, member 2 -0.0318446
LIMCH1 LIM and calponin homology domains 1 -0.0317163
TNS3 tensin 3 -0.0306886
RPS25 ribosomal protein S25 -0.0303475
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0299374
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0299255
TMEM165 transmembrane protein 165 -0.0298353
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0294243
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0293383
DPYD dihydropyrimidine dehydrogenase -0.0288814
RPL9 ribosomal protein L9 -0.0286141
LRRC23 leucine rich repeat containing 23 -0.0285903
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.02776
ATN1 atrophin 1 -0.0267485
CUX1 cut-like homeobox 1 -0.0267435
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0266759
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0265088
ETV1 ets variant 1 -0.0262199
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0261987
CTSD cathepsin D -0.0260212
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0257578
USP34 ubiquitin specific peptidase 34 -0.0257497
RPS8 ribosomal protein S8 -0.0252824
PKM pyruvate kinase, muscle -0.0252268
ANKRD12 ankyrin repeat domain 12 -0.0249157
TBC1D22A TBC1 domain family, member 22A -0.0246784
SLC35F3 solute carrier family 35, member F3 -0.0245572
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.024297
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0242583
AKAP12 A kinase (PRKA) anchor protein 12 -0.0242135
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0241852
NKTR natural killer cell triggering receptor -0.0235587
CDK13 cyclin-dependent kinase 13 -0.0234692
PLIN2 perilipin 2 -0.023425
RPL34 ribosomal protein L34 -0.0231256
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0230461
SOX5 SRY (sex determining region Y)-box 5 -0.022874
UBXN4 UBX domain protein 4 -0.0227071
DNAH5 dynein, axonemal, heavy chain 5 -0.0224881
S100A10 S100 calcium binding protein A10 -0.0224495
RPL28 ribosomal protein L28 -0.0222638
RPL38 ribosomal protein L38 -0.0220934