| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT18 | keratin 18, type I | 0.175049 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.142443 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.127604 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.107184 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0831761 |
| KRT8 | keratin 8, type II | 0.0754377 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0738105 |
| ACTN4 | actinin, alpha 4 | 0.0707641 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0705463 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0666456 |
| DSPP | dentin sialophosphoprotein | 0.0662791 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0661989 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0654027 |
| SNX9 | sorting nexin 9 | 0.0649533 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0612986 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0577015 |
| UBC | ubiquitin C | 0.0532977 |
| H1-0 | H1.0 linker histone | 0.0526445 |
| CANX | calnexin | 0.0516018 |
| TMSB4X | thymosin beta 4, X-linked | 0.0505587 |
| GOLGA4 | golgin A4 | 0.0485243 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0476025 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0469083 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0461848 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0461375 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0454918 |
| MATR3 | matrin 3 | 0.0453841 |
| LDHA | lactate dehydrogenase A | 0.0450021 |
| MKI67 | marker of proliferation Ki-67 | 0.0421345 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0416394 |
| HMGB2 | high mobility group box 2 | 0.0406114 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0404287 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0386822 |
| EPCAM | epithelial cell adhesion molecule | 0.037999 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0376832 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0375798 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0362761 |
| ANXA11 | annexin A11 | 0.0354136 |
| XPO1 | exportin 1 | 0.0348614 |
| KRT19 | keratin 19, type I | 0.0348406 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0343283 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.0329424 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0322656 |
| FLNA | filamin A, alpha | 0.0322624 |
| YME1L1 | YME1-like 1 ATPase | 0.0317949 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0314463 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0312844 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0307494 |
| RPS4X | ribosomal protein S4, X-linked | 0.0299402 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0295537 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0293886 |
| AFDN | afadin, adherens junction formation factor | 0.0285184 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0284298 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0283443 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0280561 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0278986 |
| MKRN1 | makorin ring finger protein 1 | 0.0276896 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0268882 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0263217 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0261966 |
| SERINC3 | serine incorporator 3 | 0.0261825 |
| OGA | O-GlcNAcase | 0.0261395 |
| TPX2 | TPX2, microtubule-associated | 0.0260067 |
| CPLX2 | complexin 2 | 0.0259638 |
| SET | SET nuclear proto-oncogene | 0.0257438 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0251564 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0251184 |
| PRPF6 | pre-mRNA processing factor 6 | 0.0251169 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.0249735 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | 0.0247384 |
| TFG | TRK-fused gene | 0.024716 |
| SERINC1 | serine incorporator 1 | 0.0245118 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0243912 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0243845 |
| TMF1 | TATA element modulatory factor 1 | 0.0242898 |
| TXNRD1 | thioredoxin reductase 1 | 0.0242443 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0242291 |
| IPO7 | importin 7 | 0.0242195 |
| ZNF292 | zinc finger protein 292 | 0.0241621 |
| NCKAP1 | NCK-associated protein 1 | 0.0241504 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0241326 |
| CCDC6 | coiled-coil domain containing 6 | 0.0241269 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0238229 |
| CEP250 | centrosomal protein 250kDa | 0.0238086 |
| CALR | calreticulin | 0.023704 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | 0.0234798 |
| USP3 | ubiquitin specific peptidase 3 | 0.0234499 |
| RPL4 | ribosomal protein L4 | 0.0233876 |
| EHF | ets homologous factor | 0.02305 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | 0.0229995 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0225994 |
| MLEC | malectin | 0.0225191 |
| DIAPH1 | diaphanous-related formin 1 | 0.0225163 |
| APP | amyloid beta (A4) precursor protein | 0.0224425 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0223808 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0218671 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0218176 |
| PNN | pinin, desmosome associated protein | 0.0217224 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0216971 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0216565 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAML2 | mastermind-like 2 (Drosophila) | -0.124218 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.101734 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0818648 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0814319 |
| INTS6 | integrator complex subunit 6 | -0.0755164 |
| RPL35A | ribosomal protein L35a | -0.07331 |
| EHBP1 | EH domain binding protein 1 | -0.0706737 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0689703 |
| EGR1 | early growth response 1 | -0.0658678 |
| FTL | ferritin, light polypeptide | -0.0648614 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0645805 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0608484 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0588727 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0579398 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0568363 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0549464 |
| TMSB10 | thymosin beta 10 | -0.0546312 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0538334 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0521952 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0519364 |
| CADPS | Ca++-dependent secretion activator | -0.0515604 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0511314 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0504343 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0472309 |
| NDRG1 | N-myc downstream regulated 1 | -0.0466332 |
| RAD51B | RAD51 paralog B | -0.0462827 |
| NFIA | nuclear factor I/A | -0.0452172 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0450701 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0444205 |
| RPL37A | ribosomal protein L37a | -0.0444158 |
| FRMD5 | FERM domain containing 5 | -0.0439871 |
| EXOC4 | exocyst complex component 4 | -0.0438163 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0429822 |
| CDK13 | cyclin-dependent kinase 13 | -0.0416805 |
| VCL | vinculin | -0.0416678 |
| NABP1 | nucleic acid binding protein 1 | -0.0391811 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0387147 |
| UBAP2 | ubiquitin associated protein 2 | -0.0378311 |
| RUNX1 | runt-related transcription factor 1 | -0.0372084 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0370342 |
| HM13 | histocompatibility (minor) 13 | -0.0366901 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0358075 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0350938 |
| RIGI | RNA sensor RIG-I | -0.0349316 |
| NEBL | nebulette | -0.0348407 |
| DENND1A | DENN/MADD domain containing 1A | -0.0348219 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0346172 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0345267 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0344853 |
| RPLP2 | ribosomal protein, large, P2 | -0.0343476 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0342043 |
| IER3 | immediate early response 3 | -0.0334264 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0333717 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0331847 |
| MX2 | MX dynamin-like GTPase 2 | -0.0328595 |
| HDAC4 | histone deacetylase 4 | -0.0327491 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0326419 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0317325 |
| PKP4 | plakophilin 4 | -0.0316693 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0313358 |
| DIAPH2 | diaphanous-related formin 2 | -0.0298696 |
| GNAS | GNAS complex locus | -0.0298506 |
| RCOR1 | REST corepressor 1 | -0.0298189 |
| EGFR | epidermal growth factor receptor | -0.0295099 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0294753 |
| USP34 | ubiquitin specific peptidase 34 | -0.0293123 |
| ASPH | aspartate beta-hydroxylase | -0.029274 |
| SMYD3 | SET and MYND domain containing 3 | -0.0291434 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0291216 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0291078 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0289122 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.028359 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0282472 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0282331 |
| RPL31 | ribosomal protein L31 | -0.0281336 |
| RPL9 | ribosomal protein L9 | -0.0279176 |
| GPHN | gephyrin | -0.0278092 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0277259 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0276678 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0276638 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0276288 |
| HLA-B | major histocompatibility complex, class I, B | -0.0273876 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0272253 |
| RPL28 | ribosomal protein L28 | -0.0271344 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0271003 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0268741 |
| RNF43 | ring finger protein 43 | -0.0268355 |
| FAM107B | family with sequence similarity 107, member B | -0.0264169 |
| PHF14 | PHD finger protein 14 | -0.0263783 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0263269 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0262468 |
| RPS21 | ribosomal protein S21 | -0.0260619 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0258028 |
| RPL34 | ribosomal protein L34 | -0.0257929 |
| SP100 | SP100 nuclear antigen | -0.0256267 |
| HMGA2 | high mobility group AT-hook 2 | -0.0255403 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0254769 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0252602 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0252297 |
| RPS29 | ribosomal protein S29 | -0.0248997 |
