Crizotinib (hydrochloride)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.432667
FN1 fibronectin 1 0.20825
MYH9 myosin, heavy chain 9, non-muscle 0.18209
AKAP12 A kinase (PRKA) anchor protein 12 0.119522
COL6A1 collagen, type VI, alpha 1 0.101487
INHBA inhibin, beta A 0.0843304
COL6A3 collagen, type VI, alpha 3 0.0811844
SOD2 superoxide dismutase 2, mitochondrial 0.0765642
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0590749
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0589257
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0583594
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.055537
FLNA filamin A, alpha 0.0521964
JARID2 jumonji, AT rich interactive domain 2 0.0517608
FMNL2 formin-like 2 0.0498404
NAV2 neuron navigator 2 0.0475406
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0462348
CANX calnexin 0.0449401
STC1 stanniocalcin 1 0.0449383
FAM13A family with sequence similarity 13, member A 0.043656
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0418731
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0377562
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0361907
DST dystonin 0.0361435
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0356369
SPAG9 sperm associated antigen 9 0.0355274
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0331485
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0326312
APLP2 amyloid beta (A4) precursor-like protein 2 0.032165
TRIO trio Rho guanine nucleotide exchange factor 0.031666
APP amyloid beta (A4) precursor protein 0.031455
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0310154
EEF2 eukaryotic translation elongation factor 2 0.0310152
AMPD3 adenosine monophosphate deaminase 3 0.0303429
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0287505
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.028025
ARHGAP21 Rho GTPase activating protein 21 0.0278672
ADM adrenomedullin 0.0272544
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0271379
HIPK2 homeodomain interacting protein kinase 2 0.0267355
TNS1 tensin 1 0.0266796
NFE2L1 nuclear factor, erythroid 2-like 1 0.0266618
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.0265361
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0265317
SUCO SUN domain containing ossification factor 0.0258313
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0257463
ZBTB38 zinc finger and BTB domain containing 38 0.0251384
COPA coatomer protein complex, subunit alpha 0.0249532
PLEC plectin 0.0247798
CLEC11A C-type lectin domain family 11, member A 0.0244686
GOLGA4 golgin A4 0.0242287
DSCAM Down syndrome cell adhesion molecule 0.0238664
SEPTIN9 septin 9 0.0235751
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0235256
CTBP2 C-terminal binding protein 2 0.023497
G0S2 G0/G1 switch 2 0.0234843
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0231595
TNIP1 TNFAIP3 interacting protein 1 0.0227425
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.022736
VEGFA vascular endothelial growth factor A 0.0226743
HSPA8 heat shock 70kDa protein 8 0.022668
STC2 stanniocalcin 2 0.0226625
CORO1C coronin, actin binding protein, 1C 0.0225709
EIF4B eukaryotic translation initiation factor 4B 0.0224689
BHLHE40 basic helix-loop-helix family, member e40 0.0223056
SERINC1 serine incorporator 1 0.0218175
MSN moesin 0.0217594
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0216783
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0216238
CALU calumenin 0.0214509
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0206125
FNIP1 folliculin interacting protein 1 0.0205378
TPM3 tropomyosin 3 0.0204347
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0203578
FGFR1 fibroblast growth factor receptor 1 0.0203319
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0202936
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0201526
HELZ helicase with zinc finger 0.0201253
ACIN1 apoptotic chromatin condensation inducer 1 0.0200497
AHNAK AHNAK nucleoprotein 0.0200471
DSPP dentin sialophosphoprotein 0.0199584
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0198256
HDLBP high density lipoprotein binding protein 0.0197631
MMP12 matrix metallopeptidase 12 0.0193927
MCL1 myeloid cell leukemia 1 0.0192511
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0191911
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0189866
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0188116
HILPDA hypoxia inducible lipid droplet-associated 0.0187912
USP12 ubiquitin specific peptidase 12 0.0182081
RNF145 ring finger protein 145 0.0181936
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.01792
ARHGAP22 Rho GTPase activating protein 22 0.0177964
TMEM165 transmembrane protein 165 0.0177023
MAP2K1 mitogen-activated protein kinase kinase 1 0.0176194
COL6A2 collagen, type VI, alpha 2 0.0176127
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0175338
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0172068
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0170107
DUSP10 dual specificity phosphatase 10 0.0169629

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.437035
TMSB10 thymosin beta 10 -0.114886
NALF1 NALCN channel auxiliary factor 1 -0.10739
COL1A1 collagen, type I, alpha 1 -0.0985186
FTL ferritin, light polypeptide -0.0882559
MT2A metallothionein 2A -0.0792526
HLA-B major histocompatibility complex, class I, B -0.078292
ACTG1 actin gamma 1 -0.078194
CD44 CD44 molecule (Indian blood group) -0.068889
RPLP1 ribosomal protein, large, P1 -0.0607614
RPL35A ribosomal protein L35a -0.0594029
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0588031
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0548544
TPT1 tumor protein, translationally-controlled 1 -0.0521508
CALD1 caldesmon 1 -0.0513479
EXT1 exostosin glycosyltransferase 1 -0.0490906
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0482248
PDE4D phosphodiesterase 4D, cAMP-specific -0.0481925
ADGRB3 adhesion G protein-coupled receptor B3 -0.0479625
B2M beta-2-microglobulin -0.0467228
PRKG1 protein kinase, cGMP-dependent, type I -0.0445514
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0423908
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0422143
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0415041
RPS6 ribosomal protein S6 -0.0413386
POTEF POTE ankyrin domain family, member F -0.0410014
LOC112694756 uncharaterized LOC112694756 -0.0407913
RPL34 ribosomal protein L34 -0.0406272
RPS19 ribosomal protein S19 -0.0379802
EIF1 eukaryotic translation initiation factor 1 -0.0370778
EGR1 early growth response 1 -0.0370561
COL1A2 collagen, type I, alpha 2 -0.03646
OSMR oncostatin M receptor -0.0347673
RPLP2 ribosomal protein, large, P2 -0.0331689
RPL37A ribosomal protein L37a -0.0331584
PFN1 profilin 1 -0.0310866
MBD5 methyl-CpG binding domain protein 5 -0.0306369
EGFR epidermal growth factor receptor -0.0304408
MAML2 mastermind-like 2 (Drosophila) -0.0300966
RPL32 ribosomal protein L32 -0.0297353
RPS24 ribosomal protein S24 -0.0295975
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0294473
LOX lysyl oxidase -0.0294356
RPS13 ribosomal protein S13 -0.0290832
RPL28 ribosomal protein L28 -0.0285637
IER3 immediate early response 3 -0.0285205
RPS8 ribosomal protein S8 -0.0282174
CAV1 caveolin 1, caveolae protein, 22kDa -0.0278248
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0273872
ZBTB20 zinc finger and BTB domain containing 20 -0.0270667
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0268431
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0266033
RTN4 reticulon 4 -0.0257946
RPL5 ribosomal protein L5 -0.0254361
RPL23 ribosomal protein L23 -0.0251822
TXNIP thioredoxin interacting protein -0.024799
S100A9 S100 calcium binding protein A9 -0.0245062
RPS29 ribosomal protein S29 -0.0241394
BPTF bromodomain PHD finger transcription factor -0.0240062
VMP1 vacuole membrane protein 1 -0.0238108
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0237898
ANKRD28 ankyrin repeat domain 28 -0.0237608
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0234458
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0233682
RPL12 ribosomal protein L12 -0.0233434
IFITM3 interferon induced transmembrane protein 3 -0.0232646
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.022749
RPL35 ribosomal protein L35 -0.022632
ANXA2 annexin A2 -0.022571
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0217991
RPS20 ribosomal protein S20 -0.0217114
RPL9 ribosomal protein L9 -0.0216391
RPS16 ribosomal protein S16 -0.021555
TGFBI transforming growth factor, beta-induced, 68kDa -0.0214946
RPS25 ribosomal protein S25 -0.0214883
CCDC102B coiled-coil domain containing 102B -0.0213254
RPL11 ribosomal protein L11 -0.0209639
RPL8 ribosomal protein L8 -0.020932
FOXP1 forkhead box P1 -0.0209161
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0206153
RPS15 ribosomal protein S15 -0.0204574
RPS21 ribosomal protein S21 -0.0202968
VCL vinculin -0.0199996
RPL38 ribosomal protein L38 -0.0196881
RPL30 ribosomal protein L30 -0.0196319
H3-3B H3.3 histone B -0.0194694
NABP1 nucleic acid binding protein 1 -0.0194552
RPL27 ribosomal protein L27 -0.0192875
FBN1 fibrillin 1 -0.0192316
PRRX1 paired related homeobox 1 -0.0192045
SASH1 SAM and SH3 domain containing 1 -0.0191785
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0191317
GREM1 gremlin 1, DAN family BMP antagonist -0.0190043
CYB5R3 cytochrome b5 reductase 3 -0.0188672
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0187299
COL5A3 collagen, type V, alpha 3 -0.0186038
VDAC1 voltage-dependent anion channel 1 -0.0185641
RPL26 ribosomal protein L26 -0.0184756
DPYD dihydropyrimidine dehydrogenase -0.018368
BCAS3 breast carcinoma amplified sequence 3 -0.0179903