| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11626560 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Crizotinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL14A1 | collagen, type XIV, alpha 1 | 6.53 |
| PIP | prolactin-induced protein | 2.58 |
| TP53 | tumor protein p53 | 2.19 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 2.16 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 1.99 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 1.71 |
| NUTF2 | nuclear transport factor 2 | 1.43 |
| CHURC1 | churchill domain containing 1 | 1.35 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 1.32 |
| NDUFS8 | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) | 1.3 |
| MT1L | metallothionein 1L (gene/pseudogene) | 1.27 |
| TPM4 | tropomyosin 4 | 1.24 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 1.21 |
| PER2 | period circadian clock 2 | 1.2 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 1.15 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | 1.15 |
| HPCAL4 | hippocalcin like 4 | 1.15 |
| FAM136A | family with sequence similarity 136, member A | 1.14 |
| PDCD6 | programmed cell death 6 | 1.14 |
| SEMG2 | semenogelin II | 1.11 |
| COX5B | cytochrome c oxidase subunit Vb | 1.1 |
| RNASE4 | ribonuclease, RNase A family, 4 | 1.06 |
| CHP1 | calcineurin-like EF-hand protein 1 | 1.06 |
| RABIF | RAB interacting factor | 1.05 |
| LYPLA2 | lysophospholipase II | 0.99 |
| VSNL1 | visinin-like 1 | 0.98 |
| TPM3 | tropomyosin 3 | 0.98 |
| ACY1 | aminoacylase 1 | 0.97 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.96 |
| PDCD7 | programmed cell death 7 | 0.96 |
| RNF13 | ring finger protein 13 | 0.94 |
| S100A14 | S100 calcium binding protein A14 | 0.93 |
| MT1E | metallothionein 1E | 0.91 |
| SOD1 | superoxide dismutase 1, soluble | 0.91 |
| FASTK | Fas-activated serine/threonine kinase | 0.9 |
| PXN | paxillin | 0.89 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.88 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | 0.87 |
| PHPT1 | phosphohistidine phosphatase 1 | 0.87 |
| DDT | D-dopachrome tautomerase | 0.87 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.87 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.85 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.85 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.85 |
| NDUFS6 | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) | 0.84 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.83 |
| DDTL | D-dopachrome tautomerase-like | 0.83 |
| PGLS | 6-phosphogluconolactonase | 0.82 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 0.82 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 0.82 |
| RBL2 | retinoblastoma-like 2 | 0.81 |
| CCND1 | cyclin D1 | 0.81 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.81 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | 0.8 |
| PLK2 | polo-like kinase 2 | 0.79 |
| DAP | death-associated protein | 0.79 |
| PPP1R2B | PPP1R2 family member B | 0.78 |
| ZPR1 | ZPR1 zinc finger | 0.77 |
| TFG | TRK-fused gene | 0.76 |
| RINL | Ras and Rab interactor-like | 0.76 |
| GDF15 | growth differentiation factor 15 | 0.76 |
| MT1X | metallothionein 1X | 0.76 |
| RNF14 | ring finger protein 14 | 0.76 |
| CCS | copper chaperone for superoxide dismutase | 0.75 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | 0.75 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.75 |
| TXN | thioredoxin | 0.75 |
| TXN2 | thioredoxin 2 | 0.74 |
| ZNF536 | zinc finger protein 536 | 0.74 |
| MED4 | mediator complex subunit 4 | 0.73 |
| LZIC | leucine zipper and CTNNBIP1 domain containing | 0.73 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.72 |
| MYO3A | myosin IIIA | 0.72 |
| STMN1 | stathmin 1 | 0.71 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.71 |
| ATXN1L | ataxin 1-like | 0.7 |
| PSAP | prosaposin | 0.7 |
| TPM2 | tropomyosin 2 (beta) | 0.7 |
| ELP5 | elongator acetyltransferase complex subunit 5 | 0.7 |
| NAXE | NAD(P)HX epimerase | 0.7 |
| MED8 | mediator complex subunit 8 | 0.69 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.69 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.69 |
| ISCA2 | iron-sulfur cluster assembly 2 | 0.69 |
| SYTL1 | synaptotagmin-like 1 | 0.69 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | 0.68 |
| RNF220 | ring finger protein 220 | 0.67 |
| CEPT1 | choline/ethanolamine phosphotransferase 1 | 0.67 |
| BANF1 | barrier to autointegration factor 1 | 0.67 |
| MT2A | metallothionein 2A | 0.66 |
| OSTF1 | osteoclast stimulating factor 1 | 0.66 |
| JUN | jun proto-oncogene | 0.66 |
| DNLZ | DNL-type zinc finger | 0.65 |
| HEBP2 | heme binding protein 2 | 0.65 |
| TANK | TRAF family member-associated NFKB activator | 0.65 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.65 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | 0.64 |
| TDG | thymine-DNA glycosylase | 0.64 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.64 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF317 | zinc finger protein 317 | -2.18 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -1.73 |
| PRXL2C | peroxiredoxin like 2C | -1.28 |
| HIST3H2A | histone cluster 3, H2a | -1.25 |
| SP140 | SP140 nuclear body protein | -1.07 |
| CDC6 | cell division cycle 6 | -1.01 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.97 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.93 |
| AEN | apoptosis enhancing nuclease | -0.92 |
| HSPA8 | heat shock 70kDa protein 8 | -0.89 |
| AREG | amphiregulin | -0.88 |
| COL2A1 | collagen, type II, alpha 1 | -0.86 |
| EXO1 | exonuclease 1 | -0.85 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.84 |
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | -0.84 |
| FICD | FIC domain containing | -0.81 |
| CCPG1 | cell cycle progression 1 | -0.8 |
| ZNF675 | zinc finger protein 675 | -0.8 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.79 |
| EGFL7 | EGF-like-domain, multiple 7 | -0.79 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.79 |
| AP1S1 | adaptor-related protein complex 1, sigma 1 subunit | -0.78 |
| PHF13 | PHD finger protein 13 | -0.75 |
| RBL1 | retinoblastoma-like 1 | -0.74 |
| CD151 | CD151 molecule (Raph blood group) | -0.74 |
| RPS27A | ribosomal protein S27a | -0.73 |
| PTTG1 | pituitary tumor-transforming 1 | -0.73 |
| TYRO3 | TYRO3 protein tyrosine kinase | -0.72 |
| CLSPN | claspin | -0.72 |
| EREG | epiregulin | -0.72 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | -0.72 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.72 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -0.7 |
| WDR76 | WD repeat domain 76 | -0.7 |
| MACROD1 | MACRO domain containing 1 | -0.69 |
| RAD51 | RAD51 recombinase | -0.69 |
| PCLAF | PCNA clamp associated factor | -0.69 |
| CCNB2 | cyclin B2 | -0.67 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.67 |
| RUNDC1 | RUN domain containing 1 | -0.66 |
| STC2 | stanniocalcin 2 | -0.65 |
| ORC6 | origin recognition complex, subunit 6 | -0.64 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.64 |
| RRM2 | ribonucleotide reductase M2 | -0.64 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.63 |
| COL1A1 | collagen, type I, alpha 1 | -0.63 |
| KLHL18 | kelch-like family member 18 | -0.63 |
| CCNE2 | cyclin E2 | -0.63 |
| JOSD1 | Josephin domain containing 1 | -0.62 |
| SDC1 | syndecan 1 | -0.61 |
| ZNF367 | zinc finger protein 367 | -0.61 |
| FOXM1 | forkhead box M1 | -0.61 |
| TK1 | thymidine kinase 1, soluble | -0.61 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.6 |
| S100A11 | S100 calcium binding protein A11 | -0.6 |
| STIL | SCL/TAL1 interrupting locus | -0.59 |
| DIXDC1 | DIX domain containing 1 | -0.59 |
| CENPM | centromere protein M | -0.59 |
| HELLS | helicase, lymphoid-specific | -0.58 |
| NFIA | nuclear factor I/A | -0.58 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.57 |
| FANCE | Fanconi anemia, complementation group E | -0.57 |
| USP37 | ubiquitin specific peptidase 37 | -0.57 |
| MCM8 | minichromosome maintenance complex component 8 | -0.57 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | -0.57 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | -0.57 |
| CHRNA5 | cholinergic receptor, nicotinic, alpha 5 (neuronal) | -0.57 |
| PLK1 | polo-like kinase 1 | -0.57 |
| UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | -0.57 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.56 |
| UBL5 | ubiquitin-like 5 | -0.56 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.56 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | -0.55 |
| ADM | adrenomedullin | -0.55 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.55 |
| MND1 | meiotic nuclear divisions 1 homolog (S. cerevisiae) | -0.55 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | -0.55 |
| MTMR4 | myotubularin related protein 4 | -0.54 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.54 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.54 |
| RGS3 | regulator of G-protein signaling 3 | -0.54 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | -0.53 |
| GMPR | guanosine monophosphate reductase | -0.53 |
| CDC25B | cell division cycle 25B | -0.53 |
| MCM10 | minichromosome maintenance complex component 10 | -0.53 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -0.53 |
| LYSMD1 | LysM, putative peptidoglycan-binding, domain containing 1 | -0.53 |
| JPH1 | junctophilin 1 | -0.53 |
| CCNA2 | cyclin A2 | -0.53 |
| DIAPH3 | diaphanous-related formin 3 | -0.52 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | -0.52 |
| KIF2C | kinesin family member 2C | -0.52 |
| NADK | NAD kinase | -0.51 |
| RCE1 | Ras converting CAAX endopeptidase 1 | -0.51 |
| SDC4 | syndecan 4 | -0.51 |
| MTFR2 | mitochondrial fission regulator 2 | -0.51 |
| NET1 | neuroepithelial cell transforming 1 | -0.51 |
| APEX2 | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 | -0.51 |
| FBXO5 | F-box protein 5 | -0.51 |
| ANKRD54 | ankyrin repeat domain 54 | -0.5 |
