Crizotinib Gene Set

Dataset LINCS KinomeScan Kinase Inhibitor Targets
Category physical interactions
Type small molecule
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Genes

97 kinases inhibited by the Crizotinib small molecule from the KinomeScan Kinase Inhibitor Targets dataset.

Symbol Name Standardized Value
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 1.36211
MAPK7 mitogen-activated protein kinase 7 1.36211
SLK STE20-like kinase 1.36211
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.36211
CDK11B cyclin-dependent kinase 11B 1.36211
LCK LCK proto-oncogene, Src family tyrosine kinase 1.35325
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.35325
MAP3K3 mitogen-activated protein kinase kinase kinase 3 1.35325
BMPR1B bone morphogenetic protein receptor, type IB 1.35325
INSR insulin receptor 1.35325
EPHB1 EPH receptor B1 1.35325
EPHB6 EPH receptor B6 1.35325
CSF1R colony stimulating factor 1 receptor 1.35325
EPHA8 EPH receptor A8 1.35325
EPHA7 EPH receptor A7 1.34449
MUSK muscle, skeletal, receptor tyrosine kinase 1.34449
AURKB aurora kinase B 1.34449
LTK leukocyte receptor tyrosine kinase 1.34449
MST1R macrophage stimulating 1 receptor 1.34449
INSRR insulin receptor-related receptor 1.34449
DDR1 discoidin domain receptor tyrosine kinase 1 1.33582
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 1.33582
BMP2K BMP2 inducible kinase 1.32726
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.31878
ACVR1 activin A receptor, type I 1.31878
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 1.31878
EPHA6 EPH receptor A6 1.3104
NUAK1 NUAK family, SNF1-like kinase, 1 1.3104
TAOK2 TAO kinase 2 1.29393
IGF1R insulin-like growth factor 1 receptor 1.29393
EPHA1 EPH receptor A1 1.29393
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 1.29393
IRAK3 interleukin-1 receptor-associated kinase 3 1.28583
ULK1 unc-51 like autophagy activating kinase 1 1.28583
TEK TEK tyrosine kinase, endothelial 1.28583
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 1.27782
PTK2B protein tyrosine kinase 2 beta 1.27782
TAOK1 TAO kinase 1 1.26991
DCLK2 doublecortin-like kinase 2 1.26991
CDK7 cyclin-dependent kinase 7 1.26991
BLK BLK proto-oncogene, Src family tyrosine kinase 1.26991
TAOK3 TAO kinase 3 1.25436
EPHA2 EPH receptor A2 1.24671
DMPK dystrophia myotonica-protein kinase 1.23916
EPHA5 EPH receptor A5 1.22432
DCLK1 doublecortin-like kinase 1 1.20983
FER fer (fps/fes related) tyrosine kinase 1.20983
MERTK MER proto-oncogene, tyrosine kinase 1.20271
TNNI3K TNNI3 interacting kinase 1.18186
FES FES proto-oncogene, tyrosine kinase 1.16177
LIMK1 LIM domain kinase 1 1.16177
TNK2 tyrosine kinase, non-receptor, 2 1.15523
AURKA aurora kinase A 1.12988
STK35 serine/threonine kinase 35 1.12988
TESK1 testis-specific kinase 1 1.11767
AURKC aurora kinase C 1.11767
RIOK1 RIO kinase 1 1.11767
ADCK4 aarF domain containing kinase 4 1.11767
RIOK3 RIO kinase 3 1.11767
SBK3 SH3 domain binding kinase family, member 3 1.11767
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 1.09415
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 1.08283
TGFBR1 transforming growth factor, beta receptor 1 1.08283
ANKK1 ankyrin repeat and kinase domain containing 1 1.0718
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.06105
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 1.06105
LIMK2 LIM domain kinase 2 1.05057
TYRO3 TYRO3 protein tyrosine kinase 1.05057
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 1.05057
ULK2 unc-51 like autophagy activating kinase 2 1.04543
EPHB4 EPH receptor B4 1.04035
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.03041
AXL AXL receptor tyrosine kinase 1.01596
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 1.01127
NUAK2 NUAK family, SNF1-like kinase, 2 1.00664
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.993117
TXK TXK tyrosine kinase 0.988726
SBK1 SH3 domain binding kinase 1 0.984392
EPHA4 EPH receptor A4 0.984392
MET MET proto-oncogene, receptor tyrosine kinase 0.975893
NEK9 NIMA-related kinase 9 0.975893
NEK7 NIMA-related kinase 7 0.955601
FGR FGR proto-oncogene, Src family tyrosine kinase 0.9517
TNK1 tyrosine kinase, non-receptor, 1 0.940302
MARK3 MAP/microtubule affinity-regulating kinase 3 0.936602
FLT3 fms-related tyrosine kinase 3 0.915387
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.908676
RIPK4 receptor-interacting serine-threonine kinase 4 0.902136
ALK anaplastic lymphoma receptor tyrosine kinase 0.889549
TBK1 TANK-binding kinase 1 0.886502
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.883492
ULK3 unc-51 like kinase 3 0.883492
ACVR1B activin A receptor, type IB 0.877587
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 0.860727
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.850157
SYK spleen tyrosine kinase 0.850157
FYN FYN proto-oncogene, Src family tyrosine kinase 0.850157