Cryoglobulinemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A condition characterized by the presence of cryoglobulins in the blood. Cryoglobulins are abnormal proteins that precipitate within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis. --2004 (Experimental Factor Ontology, EFO_0005846)
Similar Terms
Downloads & Tools

Genes

233 genes co-occuring with the disease Cryoglobulinemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
IFNA1 interferon, alpha 1 2.745
IFNA2 interferon, alpha 2 2.692
IFNA17 interferon, alpha 17 2.675
IFNA16 interferon, alpha 16 2.674
IFNA21 interferon, alpha 21 2.674
IFNA8 interferon, alpha 8 2.674
IFNA14 interferon, alpha 14 2.673
IFNA10 interferon, alpha 10 2.673
IFNA7 interferon, alpha 7 2.673
IFNA6 interferon, alpha 6 2.672
IFNA5 interferon, alpha 5 2.671
IFNA13 interferon, alpha 13 2.671
IFNA4 interferon, alpha 4 2.669
TRIM21 tripartite motif containing 21 2.517
SSB Sjogren syndrome antigen B (autoantigen La) 2.489
CD81 CD81 molecule 2.457
PRTN3 proteinase 3 2.444
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 2.43
CD5 CD5 molecule 2.277
IFNL3 interferon, lambda 3 2.254
MYOM2 myomesin 2 2.25
ALB albumin 2.241
CR2 complement component (3d/Epstein Barr virus) receptor 2 2.209
C3 complement component 3 2.199
CD4 CD4 molecule 2.167
CD19 CD19 molecule 2.161
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 2.137
CRP C-reactive protein, pentraxin-related 2.126
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.106
CD27 CD27 molecule 2.102
MPO myeloperoxidase 2.039
DUSP1 dual specificity phosphatase 1 1.995
TNF tumor necrosis factor 1.984
MAG myelin associated glycoprotein 1.975
CD8A CD8a molecule 1.938
MYD88 myeloid differentiation primary response 88 1.936
B2M beta-2-microglobulin 1.875
IFNG interferon, gamma 1.874
IL6 interleukin 6 1.856
PLA2R1 phospholipase A2 receptor 1, 180kDa 1.849
FCRL4 Fc receptor-like 4 1.847
CXCL10 chemokine (C-X-C motif) ligand 10 1.839
RO60 Ro60, Y RNA binding protein 1.838
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.801
BTK Bruton agammaglobulinemia tyrosine kinase 1.8
F2 coagulation factor II (thrombin) 1.78
MME membrane metallo-endopeptidase 1.75
SDC1 syndecan 1 1.747
C4A complement component 4A (Rodgers blood group) 1.728
C1QBP complement component 1, q subcomponent binding protein 1.718
HP haptoglobin 1.713
IL10 interleukin 10 1.71
CFHR5 complement factor H-related 5 1.703
BCR breakpoint cluster region 1.697
BCL2 B-cell CLL/lymphoma 2 1.689
IL1B interleukin 1, beta 1.682
CD38 CD38 molecule 1.68
IL2 interleukin 2 1.68
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 1.634
C4B complement component 4B (Chido blood group) 1.621
CD22 CD22 molecule 1.615
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.608
APOH apolipoprotein H (beta-2-glycoprotein I) 1.604
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.597
TLR9 toll-like receptor 9 1.596
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.587
TLR7 toll-like receptor 7 1.582
AICDA activation-induced cytidine deaminase 1.582
CXCR3 chemokine (C-X-C motif) receptor 3 1.574
CXCL9 chemokine (C-X-C motif) ligand 9 1.569
CFH complement factor H 1.567
CD40LG CD40 ligand 1.564
F3 coagulation factor III (thromboplastin, tissue factor) 1.555
CXCR4 chemokine (C-X-C motif) receptor 4 1.547
IL4 interleukin 4 1.539
ACE angiotensin I converting enzyme 1.537
ENO1 enolase 1, (alpha) 1.533
CFP complement factor properdin 1.53
CD40 CD40 molecule, TNF receptor superfamily member 5 1.523
CXCR5 chemokine (C-X-C motif) receptor 5 1.52
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.514
CXCL13 chemokine (C-X-C motif) ligand 13 1.512
CD79A CD79a molecule, immunoglobulin-associated alpha 1.512
CLDN1 claudin 1 1.51
CNOT11 CCR4-NOT transcription complex, subunit 11 1.51
CFB complement factor B 1.495
FCRL5 Fc receptor-like 5 1.491
TG thyroglobulin 1.488
IL17A interleukin 17A 1.483
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.469
SPATA31A3 SPATA31 subfamily A, member 3 1.469
CD46 CD46 molecule, complement regulatory protein 1.467
C1S complement component 1, s subcomponent 1.457
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.455
IL1A interleukin 1, alpha 1.452
TSLP thymic stromal lymphopoietin 1.45
CLDN7 claudin 7 1.443
FOXP3 forkhead box P3 1.437
BCL6 B-cell CLL/lymphoma 6 1.431
BPIFA2 BPI fold containing family A, member 2 1.431
FN1 fibronectin 1 1.428
CD86 CD86 molecule 1.427
VWF von Willebrand factor 1.427
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.426
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 1.402
EPO erythropoietin 1.401
TLR3 toll-like receptor 3 1.4
APOL1 apolipoprotein L, 1 1.396
IFNB1 interferon, beta 1, fibroblast 1.395
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.383
TGFB1 transforming growth factor, beta 1 1.379
CXCL8 chemokine (C-X-C motif) ligand 8 1.379
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.378
CD79B CD79b molecule, immunoglobulin-associated beta 1.378
CFHR1 complement factor H-related 1 1.365
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 1.36
IL18 interleukin 18 1.357
ACTA1 actin, alpha 1, skeletal muscle 1.35
SPN sialophorin 1.35
STAT4 signal transducer and activator of transcription 4 1.346
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.341
AFP alpha-fetoprotein 1.338
CXCL11 chemokine (C-X-C motif) ligand 11 1.33
IL5 interleukin 5 1.322
WDR11 WD repeat domain 11 1.319
CD68 CD68 molecule 1.309
PTPRC protein tyrosine phosphatase, receptor type, C 1.309
CFHR3 complement factor H-related 3 1.302
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 1.291
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.291
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.282
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.274
CLEC18A C-type lectin domain family 18, member A 1.271
MBL2 mannose-binding lectin (protein C) 2, soluble 1.271
MALT1 MALT1 paracaspase 1.27
INS insulin 1.267
OCLN occludin 1.263
CD80 CD80 molecule 1.263
SCARB1 scavenger receptor class B, member 1 1.255
THBD thrombomodulin 1.253
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.252
IL7 interleukin 7 1.25
PAX5 paired box 5 1.249
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.248
FAS Fas cell surface death receptor 1.248
REN renin 1.24
C1R complement component 1, r subcomponent 1.239
NCAM1 neural cell adhesion molecule 1 1.239
C5AR1 complement component 5a receptor 1 1.233
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.233
TLR4 toll-like receptor 4 1.233
CKMT1B creatine kinase, mitochondrial 1B 1.232
CKB creatine kinase, brain 1.229
TBX21 T-box 21 1.229
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.228
CKM creatine kinase, muscle 1.227
TPO thyroid peroxidase 1.223
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.223
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.216
CD69 CD69 molecule 1.212
CD59 CD59 molecule, complement regulatory protein 1.212
TLR2 toll-like receptor 2 1.207
NOTCH4 notch 4 1.199
CARD11 caspase recruitment domain family, member 11 1.194
NLRP3 NLR family, pyrin domain containing 3 1.191
CD52 CD52 molecule 1.191
CFI complement factor I 1.19
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 1.186
FCRLA Fc receptor-like A 1.183
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.181
DUSP5 dual specificity phosphatase 5 1.177
IL15 interleukin 15 1.175
CTTNBP2 cortactin binding protein 2 1.167
DGKE diacylglycerol kinase, epsilon 64kDa 1.166
IRAK1 interleukin-1 receptor-associated kinase 1 1.163
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.163
IGLL5 immunoglobulin lambda-like polypeptide 5 1.163
THSD7A thrombospondin, type I, domain containing 7A 1.16
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.154
MX1 MX dynamin-like GTPase 1 1.153
CSF3 colony stimulating factor 3 (granulocyte) 1.15
IRF5 interferon regulatory factor 5 1.141
CFHR2 complement factor H-related 2 1.14
OR5H15 olfactory receptor, family 5, subfamily H, member 15 1.137
SPTAN1 spectrin, alpha, non-erythrocytic 1 1.132
DNAL1 dynein, axonemal, light chain 1 1.127
MASP2 mannan-binding lectin serine peptidase 2 1.127
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.126
CCL2 chemokine (C-C motif) ligand 2 1.119
CCND1 cyclin D1 1.111
FCRL3 Fc receptor-like 3 1.1
JAK2 Janus kinase 2 1.099
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.098
IL22 interleukin 22 1.095
IFIH1 interferon induced with helicase C domain 1 1.095
IFNL1 interferon, lambda 1 1.083
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.08
CA6 carbonic anhydrase VI 1.079
TP53 tumor protein p53 1.077
THPO thrombopoietin 1.076
FCAR Fc fragment of IgA receptor 1.075
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 1.071
C5 complement component 5 1.067
CD28 CD28 molecule 1.065
TLR8 toll-like receptor 8 1.059
ERVW-1 endogenous retrovirus group W, member 1 1.059
CST3 cystatin C 1.058
STAT1 signal transducer and activator of transcription 1, 91kDa 1.049
FASLG Fas ligand (TNF superfamily, member 6) 1.048
SIGLEC6 sialic acid binding Ig-like lectin 6 1.047
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.047
CDR2 cerebellar degeneration-related protein 2, 62kDa 1.042
HAMP hepcidin antimicrobial peptide 1.038
CD72 CD72 molecule 1.034
UROD uroporphyrinogen decarboxylase 1.034
IL13 interleukin 13 1.033
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 1.032
IL7R interleukin 7 receptor 1.029
CD2 CD2 molecule 1.024
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 1.023
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.02
OR2G3 olfactory receptor, family 2, subfamily G, member 3 1.019
CD7 CD7 molecule 1.018
ICOS inducible T-cell co-stimulator 1.018
PTH parathyroid hormone 1.015
SOX5 SRY (sex determining region Y)-box 5 1.014
PLG plasminogen 1.012
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.009
AGRN agrin 1.006
CCL5 chemokine (C-C motif) ligand 5 1.005
APLP1 amyloid beta (A4) precursor-like protein 1 1.005
NPPB natriuretic peptide B 1.005
MAVS mitochondrial antiviral signaling protein 1.002