Cryptococcosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii. (Human Disease Ontology, DOID_12053)
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Genes

341 genes co-occuring with the disease Cryptococcosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CD4 CD4 molecule 3.193
PLB1 phospholipase B1 3.016
IFNG interferon, gamma 2.783
ZNF2 zinc finger protein 2 2.647
CLEC7A C-type lectin domain family 7, member A 2.616
CLEC6A C-type lectin domain family 6, member A 2.59
CD8A CD8a molecule 2.537
CARD9 caspase recruitment domain family, member 9 2.47
IL4 interleukin 4 2.447
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.436
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.403
TNF tumor necrosis factor 2.39
UXS1 UDP-glucuronate decarboxylase 1 2.389
IL17A interleukin 17A 2.377
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 2.374
CIR1 corepressor interacting with RBPJ, 1 2.371
CLEC4D C-type lectin domain family 4, member D 2.33
IL10 interleukin 10 2.324
IL13 interleukin 13 2.305
ZHX2 zinc fingers and homeoboxes 2 2.286
IL6 interleukin 6 2.249
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.222
IL5 interleukin 5 2.212
TLR2 toll-like receptor 2 2.159
IL2 interleukin 2 2.128
DMXL1 Dmx-like 1 2.114
IL1B interleukin 1, beta 2.108
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 2.092
CRP C-reactive protein, pentraxin-related 2.088
CGA glycoprotein hormones, alpha polypeptide 2.049
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.018
CLEC4E C-type lectin domain family 4, member E 2.012
ALB albumin 1.999
TLR9 toll-like receptor 9 1.973
CCL2 chemokine (C-C motif) ligand 2 1.972
CCL3 chemokine (C-C motif) ligand 3 1.962
CXCL10 chemokine (C-X-C motif) ligand 10 1.961
STAT1 signal transducer and activator of transcription 1, 91kDa 1.953
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.951
EXOC3 exocyst complex component 3 1.948
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.947
CCR2 chemokine (C-C motif) receptor 2 1.936
TLR4 toll-like receptor 4 1.898
CSF3 colony stimulating factor 3 (granulocyte) 1.889
CHIA chitinase, acidic 1.876
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.874
CHIT1 chitinase 1 (chitotriosidase) 1.874
IL1A interleukin 1, alpha 1.864
MBL2 mannose-binding lectin (protein C) 2, soluble 1.861
IL22 interleukin 22 1.852
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.832
BTK Bruton agammaglobulinemia tyrosine kinase 1.824
MYD88 myeloid differentiation primary response 88 1.814
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.813
ARG1 arginase 1 1.8
IL18 interleukin 18 1.796
GPR4 G protein-coupled receptor 4 1.782
CXCL8 chemokine (C-X-C motif) ligand 8 1.776
SYK spleen tyrosine kinase 1.775
CD209 CD209 molecule 1.759
PTPRC protein tyrosine phosphatase, receptor type, C 1.755
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.749
CD86 CD86 molecule 1.746
SOD1 superoxide dismutase 1, soluble 1.728
IL12RB1 interleukin 12 receptor, beta 1 1.727
MRC1 mannose receptor, C type 1 1.722
CCL4 chemokine (C-C motif) ligand 4 1.696
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.695
CD80 CD80 molecule 1.677
CALML6 calmodulin-like 6 1.673
CALML4 calmodulin-like 4 1.673
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.671
CALML3 calmodulin-like 3 1.67
SGF29 SAGA complex associated factor 29 1.67
CALML5 calmodulin-like 5 1.67
CD40 CD40 molecule, TNF receptor superfamily member 5 1.664
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.66
CCL5 chemokine (C-C motif) ligand 5 1.655
AICDA activation-induced cytidine deaminase 1.654
IL33 interleukin 33 1.65
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.647
SLC39A1 solute carrier family 39 (zinc transporter), member 1 1.646
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 1.636
CXCR3 chemokine (C-X-C motif) receptor 3 1.632
MOGS mannosyl-oligosaccharide glucosidase 1.628
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.626
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.623
CD40LG CD40 ligand 1.611
SELL selectin L 1.608
C3 complement component 3 1.605
MSMO1 methylsterol monooxygenase 1 1.605
CD19 CD19 molecule 1.594
IFNA1 interferon, alpha 1 1.581
C5AR1 complement component 5a receptor 1 1.573
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 1.556
PRF1 perforin 1 (pore forming protein) 1.553
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.551
GNLY granulysin 1.546
IFNB1 interferon, beta 1, fibroblast 1.541
UGDH UDP-glucose 6-dehydrogenase 1.54
IL1R1 interleukin 1 receptor, type I 1.538
LTF lactotransferrin 1.538
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 1.536
IL17RA interleukin 17 receptor A 1.526
SCARF1 scavenger receptor class F, member 1 1.526
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.524
IL17F interleukin 17F 1.524
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.52
IL7 interleukin 7 1.518
CD101 CD101 molecule 1.517
CXCL9 chemokine (C-X-C motif) ligand 9 1.506
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.501
PNKD paroxysmal nonkinesigenic dyskinesia 1.498
FKBP1A FK506 binding protein 1A, 12kDa 1.493
UGCG UDP-glucose ceramide glucosyltransferase 1.488
NELFCD negative elongation factor complex member C/D 1.487
IRF4 interferon regulatory factor 4 1.485
EMB embigin 1.485
GPHA2 glycoprotein hormone alpha 2 1.481
MPO myeloperoxidase 1.479
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 1.476
ZNF569 zinc finger protein 569 1.476
STAT5B signal transducer and activator of transcription 5B 1.471
SFTPD surfactant protein D 1.468
MARCO macrophage receptor with collagenous structure 1.465
TLR3 toll-like receptor 3 1.465
TM2D2 TM2 domain containing 2 1.464
NOS2 nitric oxide synthase 2, inducible 1.462
STAT5A signal transducer and activator of transcription 5A 1.457
GLRX3 glutaredoxin 3 1.455
RABAC1 Rab acceptor 1 (prenylated) 1.452
CCL7 chemokine (C-C motif) ligand 7 1.447
TGFB1 transforming growth factor, beta 1 1.438
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 1.43
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 1.429
LGALS3 lectin, galactoside-binding, soluble, 3 1.428
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 1.424
DHODH dihydroorotate dehydrogenase (quinone) 1.421
CCR7 chemokine (C-C motif) receptor 7 1.417
RAG1 recombination activating gene 1 1.417
FOXP3 forkhead box P3 1.413
XCR1 chemokine (C motif) receptor 1 1.412
CD52 CD52 molecule 1.404
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 1.4
PTX3 pentraxin 3, long 1.398
BCL10 B-cell CLL/lymphoma 10 1.397
CD44 CD44 molecule (Indian blood group) 1.396
VCX variable charge, X-linked 1.395
CD28 CD28 molecule 1.389
NFYC nuclear transcription factor Y, gamma 1.388
IFNGR1 interferon gamma receptor 1 1.384
TLR1 toll-like receptor 1 1.381
GATA2 GATA binding protein 2 1.38
HSPA4 heat shock 70kDa protein 4 1.375
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.371
CDR2 cerebellar degeneration-related protein 2, 62kDa 1.369
IL4R interleukin 4 receptor 1.368
CCL11 chemokine (C-C motif) ligand 11 1.366
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 1.363
TBX21 T-box 21 1.356
CX3CR1 chemokine (C-X3-C motif) receptor 1 1.356
HTN3 histatin 3 1.354
CD27 CD27 molecule 1.352
ADA adenosine deaminase 1.351
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.342
CXCL13 chemokine (C-X-C motif) ligand 13 1.338
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 1.328
SLC30A1 solute carrier family 30 (zinc transporter), member 1 1.327
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.32
TPSAB1 tryptase alpha/beta 1 1.32
CD68 CD68 molecule 1.316
NLRP3 NLR family, pyrin domain containing 3 1.315
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.312
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.307
TLR7 toll-like receptor 7 1.305
AIRE autoimmune regulator 1.305
IK IK cytokine, down-regulator of HLA II 1.305
TSG101 tumor susceptibility 101 1.304
CD69 CD69 molecule 1.301
IL15 interleukin 15 1.295
IL23A interleukin 23, alpha subunit p19 1.288
CSF1 colony stimulating factor 1 (macrophage) 1.287
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.286
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 1.284
DNAH8 dynein, axonemal, heavy chain 8 1.284
PXDNL peroxidasin-like 1.279
PXDN peroxidasin 1.278
FIBCD1 fibrinogen C domain containing 1 1.276
ERVW-1 endogenous retrovirus group W, member 1 1.273
MALT1 MALT1 paracaspase 1.273
ZNF3 zinc finger protein 3 1.272
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.272
CD207 CD207 molecule, langerin 1.271
CLEC1A C-type lectin domain family 1, member A 1.269
CDA cytidine deaminase 1.262
CXCL2 chemokine (C-X-C motif) ligand 2 1.258
GATA3 GATA binding protein 3 1.256
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 1.255
IL9 interleukin 9 1.251
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.25
CD38 CD38 molecule 1.248
SAV1 salvador family WW domain containing protein 1 1.241
SIDT1 SID1 transmembrane family, member 1 1.238
ALG3 ALG3, alpha-1,3- mannosyltransferase 1.231
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.23
JAK1 Janus kinase 1 1.227
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.224
SQLE squalene epoxidase 1.223
TLR6 toll-like receptor 6 1.223
ISYNA1 inositol-3-phosphate synthase 1 1.221
LGALS7B lectin, galactoside-binding, soluble, 7B 1.22
LGALS7 lectin, galactoside-binding, soluble, 7 1.22
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.22
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.22
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.219
CCL20 chemokine (C-C motif) ligand 20 1.218
FASLG Fas ligand (TNF superfamily, member 6) 1.213
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.209
CHMP6 charged multivesicular body protein 6 1.208
ERV3-1 endogenous retrovirus group 3, member 1 1.207
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.206
NCAM1 neural cell adhesion molecule 1 1.205
BATF3 basic leucine zipper transcription factor, ATF-like 3 1.205
SPI1 Spi-1 proto-oncogene 1.205
ICAM1 intercellular adhesion molecule 1 1.204
POMC proopiomelanocortin 1.203
LAMP1 lysosomal-associated membrane protein 1 1.201
CD276 CD276 molecule 1.198
PRTN3 proteinase 3 1.195
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 1.189
CD200R1 CD200 receptor 1 1.184
IFNA2 interferon, alpha 2 1.182
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.182
CD163 CD163 molecule 1.182
TBRG4 transforming growth factor beta regulator 4 1.179
RETNLB resistin like beta 1.177
STK24 serine/threonine kinase 24 1.175
SPO11 SPO11 meiotic protein covalently bound to DSB 1.169
S1PR3 sphingosine-1-phosphate receptor 3 1.157
ACE angiotensin I converting enzyme 1.155
PXYLP1 2-phosphoxylose phosphatase 1 1.151
MPPE1 metallophosphoesterase 1 1.15
GPR174 G protein-coupled receptor 174 1.149
ZNF140 zinc finger protein 140 1.148
KLHL41 kelch-like family member 41 1.145
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 1.142
ACSS2 acyl-CoA synthetase short-chain family member 2 1.141
IGF2R insulin-like growth factor 2 receptor 1.14
CCDC117 coiled-coil domain containing 117 1.138
CAMP cathelicidin antimicrobial peptide 1.138
S1PR1 sphingosine-1-phosphate receptor 1 1.136
VSIG4 V-set and immunoglobulin domain containing 4 1.13
ARG2 arginase 2 1.127
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.126
CD5 CD5 molecule 1.125
NEFL neurofilament, light polypeptide 1.123
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.121
CCR1 chemokine (C-C motif) receptor 1 1.12
GABARAPL1 GABA(A) receptor-associated protein like 1 1.119
CDC42 cell division cycle 42 1.118
CORO7-PAM16 CORO7-PAM16 readthrough 1.116
DOCK8 dedicator of cytokinesis 8 1.116
NOD2 nucleotide-binding oligomerization domain containing 2 1.109
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 1.109
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.107
ICAM3 intercellular adhesion molecule 3 1.103
RGS21 regulator of G-protein signaling 21 1.103
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.103
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.102
IFNA4 interferon, alpha 4 1.1
INS insulin 1.099
AOC3 amine oxidase, copper containing 3 1.092
ACD adrenocortical dysplasia homolog (mouse) 1.089
ACE2 angiotensin I converting enzyme 2 1.088
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.087
EFS embryonal Fyn-associated substrate 1.087
NCR3 natural cytotoxicity triggering receptor 3 1.086
DCLK3 doublecortin-like kinase 3 1.085
SLC30A10 solute carrier family 30, member 10 1.083
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.081
ITK IL2-inducible T-cell kinase 1.08
ADCY10 adenylate cyclase 10 (soluble) 1.079
IL17RB interleukin 17 receptor B 1.078
JAK2 Janus kinase 2 1.078
IRF1 interferon regulatory factor 1 1.076
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 1.075
RNMT RNA (guanine-7-) methyltransferase 1.072
SCARB2 scavenger receptor class B, member 2 1.071
SPN sialophorin 1.07
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) 1.069
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 1.069
ACSS1 acyl-CoA synthetase short-chain family member 1 1.066
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 1.066
TBL1X transducin (beta)-like 1X-linked 1.064
XPO1 exportin 1 1.064
IL3 interleukin 3 1.058
CD36 CD36 molecule (thrombospondin receptor) 1.058
TADA1 transcriptional adaptor 1 1.058
IL17RC interleukin 17 receptor C 1.058
RGS8 regulator of G-protein signaling 8 1.057
TP53RK TP53 regulating kinase 1.055
OCSTAMP osteoclast stimulatory transmembrane protein 1.055
PAK1IP1 PAK1 interacting protein 1 1.054
IFIH1 interferon induced with helicase C domain 1 1.05
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.049
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 1.048
NFYB nuclear transcription factor Y, beta 1.047
IFNA10 interferon, alpha 10 1.047
CD274 CD274 molecule 1.047
RGS11 regulator of G-protein signaling 11 1.046
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.046
KAT2A K(lysine) acetyltransferase 2A 1.045
ZNF341 zinc finger protein 341 1.045
NCR1 natural cytotoxicity triggering receptor 1 1.043
SCARB1 scavenger receptor class B, member 1 1.042
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 1.038
TYMS thymidylate synthetase 1.035
RGS13 regulator of G-protein signaling 13 1.034
CCL24 chemokine (C-C motif) ligand 24 1.032
CXCR4 chemokine (C-X-C motif) receptor 4 1.031
RGS20 regulator of G-protein signaling 20 1.03
PLG plasminogen 1.028
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.027
H1-8 H1.8 linker histone 1.024
TSLP thymic stromal lymphopoietin 1.022
RGS12 regulator of G-protein signaling 12 1.02
CTSB cathepsin B 1.02
ANXA2 annexin A2 1.02
JAK3 Janus kinase 3 1.017
MT1E metallothionein 1E 1.016
IL7R interleukin 7 receptor 1.016
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 1.01
TXN thioredoxin 1.008
CD83 CD83 molecule 1.004
CCL17 chemokine (C-C motif) ligand 17 1.004
IFNA17 interferon, alpha 17 1.003
ALG12 ALG12, alpha-1,6-mannosyltransferase 1.002
IFNA16 interferon, alpha 16 1.001
IFNA21 interferon, alpha 21 1.0
IFNA14 interferon, alpha 14 1.0
IFNA7 interferon, alpha 7 1.0