Cyclophosphamide Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom. (Chemical Entities of Biological Interest Ontology, CHEBI_4027)
External Link http://ctdbase.org/detail.go?type=chem&acc=D003520
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Genes

175 genes/proteins interacting with the chemical Cyclophosphamide from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADM adrenomedullin
AFP alpha-fetoprotein
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAD aminolevulinate dehydratase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLVRB biliverdin reductase B
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCIN calicin
CCL2 chemokine (C-C motif) ligand 2
CFI complement factor I
CHRM5 cholinergic receptor, muscarinic 5
CLDN4 claudin 4
COCH cochlin
CREB1 cAMP responsive element binding protein 1
CREM cAMP responsive element modulator
CRH corticotropin releasing hormone
CRHR2 corticotropin releasing hormone receptor 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSD cathepsin D
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ELOVL2 ELOVL fatty acid elongase 2
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F2RL2 coagulation factor II (thrombin) receptor-like 2
F2RL3 coagulation factor II (thrombin) receptor-like 3
FAS Fas cell surface death receptor
FKBP1B FK506 binding protein 1B, 12.6 kDa
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FSHB follicle stimulating hormone, beta polypeptide
GAL galanin/GMAP prepropeptide
GALC galactosylceramidase
GAP43 growth associated protein 43
GAS2 growth arrest-specific 2
GLS glutaminase
GPX4 glutathione peroxidase 4
GSR glutathione reductase
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GUSB glucuronidase, beta
HCRT hypocretin (orexin) neuropeptide precursor
HMOX1 heme oxygenase 1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HOXA1 homeobox A1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
ICA1 islet cell autoantigen 1, 69kDa
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL15 interleukin 15
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL23A interleukin 23, alpha subunit p19
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
KDM1A lysine (K)-specific demethylase 1A
KDR kinase insert domain receptor
KLF5 Kruppel-like factor 5 (intestinal)
LDHB lactate dehydrogenase B
LHB luteinizing hormone beta polypeptide
LMNB1 lamin B1
MAGED1 melanoma antigen family D1
MAGED4B melanoma antigen family D4B
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MGMT O-6-methylguanine-DNA methyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MPC2 mitochondrial pyruvate carrier 2
MPO myeloperoxidase
MXI1 MAX interactor 1, dimerization protein
MYH10 myosin, heavy chain 10, non-muscle
NFE2L2 nuclear factor, erythroid 2-like 2
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NID1 nidogen 1
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPN3 opsin 3
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
POMC proopiomelanocortin
PON1 paraoxonase 1
POR P450 (cytochrome) oxidoreductase
PRSS3 protease, serine, 3
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REG3G regenerating islet-derived 3 gamma
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REV1 REV1, polymerase (DNA directed)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTEL1 regulator of telomere elongation helicase 1
S100P S100 calcium binding protein P
SALL1 spalt-like transcription factor 1
SGCE sarcoglycan, epsilon
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SOAT1 sterol O-acyltransferase 1
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TJP1 tight junction protein 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNF tumor necrosis factor
TNNI3 troponin I type 3 (cardiac)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TXNRD1 thioredoxin reductase 1
TYMP thymidine phosphorylase
UPK2 uroplakin 2
UPK3A uroplakin 3A
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
ZIC1 Zic family member 1