Cyclosporin A_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.214996
TRIO trio Rho guanine nucleotide exchange factor 0.186863
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.173038
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.168214
BHLHE40 basic helix-loop-helix family, member e40 0.124086
NDRG1 N-myc downstream regulated 1 0.119026
MYH9 myosin, heavy chain 9, non-muscle 0.094638
VEGFA vascular endothelial growth factor A 0.0854459
TNIP1 TNFAIP3 interacting protein 1 0.0845603
NAV2 neuron navigator 2 0.0697913
FLNB filamin B, beta 0.0647817
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0634582
SLC39A11 solute carrier family 39, member 11 0.0629709
B2M beta-2-microglobulin 0.0628291
CDH13 cadherin 13 0.0599803
FLNA filamin A, alpha 0.0562767
NCOR2 nuclear receptor corepressor 2 0.055068
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0548535
ZFP36L1 ZFP36 ring finger protein-like 1 0.054472
PLEC plectin 0.0543383
ANKRD11 ankyrin repeat domain 11 0.0517978
SQSTM1 sequestosome 1 0.048998
EEF2 eukaryotic translation elongation factor 2 0.0489861
ZMIZ1 zinc finger, MIZ-type containing 1 0.0461201
IGFBP3 insulin-like growth factor binding protein 3 0.0455943
SEPTIN9 septin 9 0.0453771
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0447542
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0445985
CALR calreticulin 0.0430198
LMNA lamin A/C 0.0428479
HDAC9 histone deacetylase 9 0.0401774
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0401213
LENG8 leukocyte receptor cluster (LRC) member 8 0.0389623
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0381287
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0380221
SFTPA2 surfactant protein A2 0.0372967
C1D C1D nuclear receptor corepressor 0.0360691
CSTB cystatin B (stefin B) 0.0360023
AUTS2 autism susceptibility candidate 2 0.035995
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0358065
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0356945
LOXL2 lysyl oxidase-like 2 0.0356881
FOSL1 FOS-like antigen 1 0.0338986
MSI2 musashi RNA-binding protein 2 0.0337848
GOLGA4 golgin A4 0.0336852
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0328631
MSN moesin 0.0323988
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0323217
S100A10 S100 calcium binding protein A10 0.0321238
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0319132
CCL5 chemokine (C-C motif) ligand 5 0.0316259
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0316004
HELZ helicase with zinc finger 0.0307714
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0300058
FMNL2 formin-like 2 0.0296713
MACF1 microtubule-actin crosslinking factor 1 0.0289885
DBN1 drebrin 1 0.0288201
WDFY1 WD repeat and FYVE domain containing 1 0.0288091
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0287853
L1CAM L1 cell adhesion molecule 0.0285113
COPA coatomer protein complex, subunit alpha 0.0282057
FAM107B family with sequence similarity 107, member B 0.0281356
DDIT4 DNA-damage-inducible transcript 4 0.0280907
MED15 mediator complex subunit 15 0.0278321
WTAP Wilms tumor 1 associated protein 0.0277871
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0276855
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0275369
AHNAK2 AHNAK nucleoprotein 2 0.0274681
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0273095
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0271992
MINK1 misshapen-like kinase 1 0.0271035
TRAM2 translocation associated membrane protein 2 0.0268796
RND3 Rho family GTPase 3 0.0261575
GOLGA2 golgin A2 0.0258713
CD109 CD109 molecule 0.0258155
DPYSL2 dihydropyrimidinase-like 2 0.0255105
CLIP2 CAP-GLY domain containing linker protein 2 0.025121
WSB1 WD repeat and SOCS box containing 1 0.0247835
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0245113
COL5A1 collagen, type V, alpha 1 0.0243845
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0242969
INSIG1 insulin induced gene 1 0.0241956
BACE2 beta-site APP-cleaving enzyme 2 0.0239848
BCAR1 breast cancer anti-estrogen resistance 1 0.0238969
NUMA1 nuclear mitotic apparatus protein 1 0.0238604
MIDEAS mitotic deacetylase associated SANT domain protein 0.0237397
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.023668
SH3BP2 SH3-domain binding protein 2 0.0235714
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0235695
ARRDC3 arrestin domain containing 3 0.0233147
CTBP2 C-terminal binding protein 2 0.0230922
COL18A1 collagen, type XVIII, alpha 1 0.0230507
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0225316
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0225047
SETD5 SET domain containing 5 0.0223921
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0221527
GRB10 growth factor receptor-bound protein 10 0.0221112
ANXA6 annexin A6 0.0220911
SEPTIN2 septin 2 0.0220147
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0219652

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.196162
LOX lysyl oxidase -0.150618
COL3A1 collagen, type III, alpha 1 -0.149752
UBC ubiquitin C -0.143253
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.142222
VIM vimentin -0.141402
AHNAK AHNAK nucleoprotein -0.118505
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108063
COL1A2 collagen, type I, alpha 2 -0.0800868
FBN1 fibrillin 1 -0.0793839
COL5A2 collagen, type V, alpha 2 -0.0696383
GLIS3 GLIS family zinc finger 3 -0.0691563
MAP1B microtubule-associated protein 1B -0.0488597
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0485111
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0466606
RAI14 retinoic acid induced 14 -0.0465607
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0465134
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0453185
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.042367
SLC38A1 solute carrier family 38, member 1 -0.0419519
ZBTB20 zinc finger and BTB domain containing 20 -0.0390585
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0390572
LDHA lactate dehydrogenase A -0.0375465
MEIS2 Meis homeobox 2 -0.0372117
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0363575
MX2 MX dynamin-like GTPase 2 -0.0357944
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0350624
THBS2 thrombospondin 2 -0.0341479
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0340852
SAMD9 sterile alpha motif domain containing 9 -0.034028
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0339815
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0324004
VCL vinculin -0.0312278
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0308632
CDK6 cyclin-dependent kinase 6 -0.0308548
SMC4 structural maintenance of chromosomes 4 -0.0298838
NAP1L1 nucleosome assembly protein 1-like 1 -0.0291653
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0290086
VMP1 vacuole membrane protein 1 -0.0286851
NPR2 natriuretic peptide receptor 2 -0.0282612
ENO1 enolase 1, (alpha) -0.0280851
IFI16 interferon, gamma-inducible protein 16 -0.0275351
RTN4 reticulon 4 -0.0274931
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0262854
RPS27A ribosomal protein S27a -0.0262583
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0261984
RIGI RNA sensor RIG-I -0.0252996
PDE4D phosphodiesterase 4D, cAMP-specific -0.024337
EHBP1 EH domain binding protein 1 -0.024108
TXNIP thioredoxin interacting protein -0.0236623
GLG1 golgi glycoprotein 1 -0.0233859
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0231849
RBM25 RNA binding motif protein 25 -0.0231312
MBNL1 muscleblind-like splicing regulator 1 -0.0225755
CD44 CD44 molecule (Indian blood group) -0.0224493
TM9SF3 transmembrane 9 superfamily member 3 -0.0220288
ARB2A ARB2 cotranscriptional regulator A -0.0217619
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0216762
SAMD9L sterile alpha motif domain containing 9-like -0.0215842
NSD3 nuclear receptor binding SET domain protein 3 -0.0215197
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0214622
WWTR1 WW domain containing transcription regulator 1 -0.0212439
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0209913
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0209828
EXT1 exostosin glycosyltransferase 1 -0.0209828
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.020853
IFITM1 interferon induced transmembrane protein 1 -0.02082
SP100 SP100 nuclear antigen -0.0206212
DIAPH3 diaphanous-related formin 3 -0.0205541
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0200354
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0198692
MBD5 methyl-CpG binding domain protein 5 -0.0198618
HLA-E major histocompatibility complex, class I, E -0.0198291
DPYSL3 dihydropyrimidinase-like 3 -0.0197432
OSMR oncostatin M receptor -0.0194112
SPDYA speedy/RINGO cell cycle regulator family member A -0.0193283
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0192544
SMYD3 SET and MYND domain containing 3 -0.0190317
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0189432
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0189088
SCLT1 sodium channel and clathrin linker 1 -0.0188259
KIFAP3 kinesin-associated protein 3 -0.0187759
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0187081
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0187016
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0186648
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0184311
POTEF POTE ankyrin domain family, member F -0.0182964
PLSCR1 phospholipid scramblase 1 -0.0181159
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0178557
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0175493
CENPF centromere protein F, 350/400kDa -0.0174629
MT2A metallothionein 2A -0.0173771
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0172336
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0171264
PRELID2 PRELI domain containing 2 -0.016974
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0169225
RSRC1 arginine/serine-rich coiled-coil 1 -0.0168706
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -0.0168644
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0167281
RRM2 ribonucleotide reductase M2 -0.0166885