| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cyclosporin A perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cyclosporin A_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.142393 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.119277 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0798545 |
| ANXA1 | annexin A1 | 0.0681439 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0660319 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0609609 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0534714 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0491846 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0473249 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0440209 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0410093 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0409854 |
| RPL3 | ribosomal protein L3 | 0.0396357 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0395618 |
| TXNRD1 | thioredoxin reductase 1 | 0.0391953 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0386451 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0380758 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0376951 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0376559 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0354543 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0354191 |
| TPM3 | tropomyosin 3 | 0.0352259 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0352061 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.034836 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0347696 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0340816 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0333692 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0333513 |
| VMP1 | vacuole membrane protein 1 | 0.0331759 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0329052 |
| CPOX | coproporphyrinogen oxidase | 0.0319594 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0319075 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0311454 |
| PLEC | plectin | 0.0306968 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0305426 |
| NONO | non-POU domain containing, octamer-binding | 0.0302462 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0292652 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.028674 |
| RRM2 | ribonucleotide reductase M2 | 0.0282695 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.027475 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0272608 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0272178 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0268964 |
| MED13L | mediator complex subunit 13-like | 0.0265642 |
| ATP11A | ATPase, class VI, type 11A | 0.0262286 |
| YEATS2 | YEATS domain containing 2 | 0.0258655 |
| FUS | FUS RNA binding protein | 0.0254901 |
| EGR1 | early growth response 1 | 0.025484 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.02502 |
| CEP250 | centrosomal protein 250kDa | 0.0249959 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0245819 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0241909 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0240861 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0240322 |
| PNN | pinin, desmosome associated protein | 0.0239261 |
| NUP58 | nucleoporin 58 | 0.0237505 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0236204 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0230414 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0229384 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0227623 |
| KLC1 | kinesin light chain 1 | 0.0224228 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0223619 |
| ARRDC3 | arrestin domain containing 3 | 0.0222614 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0219776 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0219328 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0219297 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0219081 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.021883 |
| YBX1 | Y box binding protein 1 | 0.0217469 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0217256 |
| PREPL | prolyl endopeptidase-like | 0.0214997 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0214808 |
| CDK19 | cyclin-dependent kinase 19 | 0.0213925 |
| SESN2 | sestrin 2 | 0.0212925 |
| KLHL24 | kelch-like family member 24 | 0.0212708 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0212359 |
| SETD5 | SET domain containing 5 | 0.0208967 |
| PCM1 | pericentriolar material 1 | 0.0208837 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0208758 |
| H1-0 | H1.0 linker histone | 0.0208449 |
| CEP192 | centrosomal protein 192kDa | 0.0207699 |
| CLDND1 | claudin domain containing 1 | 0.0206841 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0205776 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.020517 |
| LEMD3 | LEM domain containing 3 | 0.0204309 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0201481 |
| DCTN1 | dynactin 1 | 0.0200917 |
| TMEM41B | transmembrane protein 41B | 0.019837 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0197467 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0194436 |
| TBK1 | TANK-binding kinase 1 | 0.0193757 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0192437 |
| HELZ | helicase with zinc finger | 0.0191968 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.0191746 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0190626 |
| DBN1 | drebrin 1 | 0.0190458 |
| TFG | TRK-fused gene | 0.0189767 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0189643 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0189557 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0189243 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.194626 |
| NLGN1 | neuroligin 1 | -0.141853 |
| TMSB10 | thymosin beta 10 | -0.12621 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.113444 |
| PCDH7 | protocadherin 7 | -0.0878709 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0855759 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0743669 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0739217 |
| ZNF804A | zinc finger protein 804A | -0.0718708 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0712323 |
| VIM | vimentin | -0.0602463 |
| HMGA2 | high mobility group AT-hook 2 | -0.0547645 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0504631 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0496818 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0486117 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0446617 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.043704 |
| AHNAK | AHNAK nucleoprotein | -0.0434353 |
| CCND1 | cyclin D1 | -0.0424717 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0417416 |
| CDK6 | cyclin-dependent kinase 6 | -0.0415085 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0403703 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0402601 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0393805 |
| RPL35A | ribosomal protein L35a | -0.0385502 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0383716 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0372967 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0368975 |
| RPS6 | ribosomal protein S6 | -0.0361846 |
| DST | dystonin | -0.0350488 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0342007 |
| FTL | ferritin, light polypeptide | -0.0341231 |
| NABP1 | nucleic acid binding protein 1 | -0.0332606 |
| HMGA1 | high mobility group AT-hook 1 | -0.03286 |
| CLDN1 | claudin 1 | -0.0310236 |
| MYPN | myopalladin | -0.0302664 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0300778 |
| RPLP1 | ribosomal protein, large, P1 | -0.0298668 |
| CMIP | c-Maf inducing protein | -0.0297808 |
| RASAL2 | RAS protein activator like 2 | -0.0291719 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0283791 |
| EDN1 | endothelin 1 | -0.0281168 |
| CEP112 | centrosomal protein 112kDa | -0.0274093 |
| CCDC88A | coiled-coil domain containing 88A | -0.0273629 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0271186 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.026857 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0264648 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.025942 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0257229 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0256387 |
| SYT1 | synaptotagmin I | -0.0252995 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.025083 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0247474 |
| ZNF638 | zinc finger protein 638 | -0.0246595 |
| CENPF | centromere protein F, 350/400kDa | -0.0243582 |
| RPS24 | ribosomal protein S24 | -0.0242354 |
| ACTG1 | actin gamma 1 | -0.0239587 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0238972 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0233155 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0232297 |
| RPS27A | ribosomal protein S27a | -0.0231676 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0230646 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0226972 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0226345 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0225286 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0222629 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0222391 |
| TBCA | tubulin folding cofactor A | -0.022065 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0220173 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0220003 |
| RPS16 | ribosomal protein S16 | -0.0219308 |
| PDGFC | platelet derived growth factor C | -0.0216128 |
| EDARADD | EDAR-associated death domain | -0.0214934 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0210781 |
| NEGR1 | neuronal growth regulator 1 | -0.021078 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0210383 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0207816 |
| RANBP17 | RAN binding protein 17 | -0.0204569 |
| EFNA5 | ephrin-A5 | -0.0203961 |
| MMP12 | matrix metallopeptidase 12 | -0.0203218 |
| CENPE | centromere protein E, 312kDa | -0.0201889 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0200539 |
| ERBIN | erbb2 interacting protein | -0.019828 |
| ECT2 | epithelial cell transforming 2 | -0.0197735 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0195799 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0194902 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0194829 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.019394 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0193926 |
| LMO7 | LIM domain 7 | -0.0193802 |
| GNAS | GNAS complex locus | -0.0193302 |
| LDHB | lactate dehydrogenase B | -0.0192744 |
| SETX | senataxin | -0.0192109 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0191849 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0191384 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0191211 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0191161 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.019103 |
| RPL28 | ribosomal protein L28 | -0.0190319 |
| RPL4 | ribosomal protein L4 | -0.0189015 |
