Cyclosporin A_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.348931
APOB apolipoprotein B 0.137166
VEGFA vascular endothelial growth factor A 0.133728
FNDC3B fibronectin type III domain containing 3B 0.118634
ERRFI1 ERBB receptor feedback inhibitor 1 0.111112
EEF2 eukaryotic translation elongation factor 2 0.107908
SPTBN1 spectrin, beta, non-erythrocytic 1 0.106624
MYH9 myosin, heavy chain 9, non-muscle 0.0958713
AFDN afadin, adherens junction formation factor 0.0906091
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0851805
FN1 fibronectin 1 0.0814737
C3 complement component 3 0.0755131
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0744799
BHLHE40 basic helix-loop-helix family, member e40 0.0722158
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.066572
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0643408
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0596915
LRMDA leucine rich melanocyte differentiation associated 0.0586072
CFB complement factor B 0.0585113
MACF1 microtubule-actin crosslinking factor 1 0.0579225
RBM39 RNA binding motif protein 39 0.0549764
PLEC plectin 0.0539716
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0517921
RPL3 ribosomal protein L3 0.0504982
SESTD1 SEC14 and spectrin domains 1 0.0491577
DSCAM Down syndrome cell adhesion molecule 0.0490983
NKD1 naked cuticle homolog 1 (Drosophila) 0.0475654
DSPP dentin sialophosphoprotein 0.046745
DDIT4 DNA-damage-inducible transcript 4 0.0465349
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0462993
A2M alpha-2-macroglobulin 0.0457656
SAMD4A sterile alpha motif domain containing 4A 0.0455696
EML4 echinoderm microtubule associated protein like 4 0.0455035
ELL2 elongation factor, RNA polymerase II, 2 0.0434579
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.043394
TRIO trio Rho guanine nucleotide exchange factor 0.0429786
EPAS1 endothelial PAS domain protein 1 0.0429605
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0410161
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0409392
PTPRM protein tyrosine phosphatase, receptor type, M 0.0404609
WAC WW domain containing adaptor with coiled-coil 0.0394759
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0393547
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.039327
TNS1 tensin 1 0.0389967
TF transferrin 0.0387377
PUM2 pumilio RNA-binding family member 2 0.0382995
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0380675
DLC1 DLC1 Rho GTPase activating protein 0.037854
LOC112694756 uncharaterized LOC112694756 0.0371806
PTK2 protein tyrosine kinase 2 0.0371399
FLNB filamin B, beta 0.0361272
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0361034
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0357241
FAT1 FAT atypical cadherin 1 0.0352762
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0350396
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0350198
LCOR ligand dependent nuclear receptor corepressor 0.0345415
SMAD3 SMAD family member 3 0.0329483
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0328739
ICAM1 intercellular adhesion molecule 1 0.0326257
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0325094
IQSEC1 IQ motif and Sec7 domain 1 0.0322892
TRIM26 tripartite motif containing 26 0.0319381
DOCK4 dedicator of cytokinesis 4 0.0316524
WDFY2 WD repeat and FYVE domain containing 2 0.0314526
ABTB3 ankyrin repeat and BTB domain containing 3 0.0305631
EIF4B eukaryotic translation initiation factor 4B 0.0303833
RAD23B RAD23 homolog B (S. cerevisiae) 0.0301846
DOCK5 dedicator of cytokinesis 5 0.0299276
ZMIZ1 zinc finger, MIZ-type containing 1 0.0299062
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0297405
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0297128
HLF hepatic leukemia factor 0.0296731
PTPRF protein tyrosine phosphatase, receptor type, F 0.0296464
MED15 mediator complex subunit 15 0.0292675
QKI QKI, KH domain containing, RNA binding 0.028657
LRRC1 leucine rich repeat containing 1 0.028466
MED13L mediator complex subunit 13-like 0.0284147
TNIP1 TNFAIP3 interacting protein 1 0.0283357
MRTFA myocardin related transcription factor A 0.0282658
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0279945
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0277078
MYO1B myosin IB 0.0271733
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.027124
CAMTA1 calmodulin binding transcription activator 1 0.0271194
MSI2 musashi RNA-binding protein 2 0.0270082
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0267966
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.026614
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0264709
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0264348
PRRC2C proline-rich coiled-coil 2C 0.0263111
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 0.0262751
NONO non-POU domain containing, octamer-binding 0.0259568
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0259265
SEPTIN9 septin 9 0.0257017
CSNK1A1 casein kinase 1, alpha 1 0.0256487
PTBP3 polypyrimidine tract binding protein 3 0.0252397
TGFBI transforming growth factor, beta-induced, 68kDa 0.0251903
NIPBL Nipped-B homolog (Drosophila) 0.0248376
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0246683

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.267144
AKAP12 A kinase (PRKA) anchor protein 12 -0.200696
IGF2 insulin-like growth factor 2 -0.150338
MT2A metallothionein 2A -0.103364
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0970144
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0964803
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.092865
IGFBP1 insulin-like growth factor binding protein 1 -0.0739321
TMSB10 thymosin beta 10 -0.0622267
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0621406
RPS6 ribosomal protein S6 -0.0580256
GPC6 glypican 6 -0.0560716
CP ceruloplasmin (ferroxidase) -0.0512973
AHSG alpha-2-HS-glycoprotein -0.0511433
RPS24 ribosomal protein S24 -0.0493495
HMGA1 high mobility group AT-hook 1 -0.0448066
RPLP1 ribosomal protein, large, P1 -0.044089
FTL ferritin, light polypeptide -0.0411856
RPS19 ribosomal protein S19 -0.0406738
TPT1 tumor protein, translationally-controlled 1 -0.0401179
ENO1 enolase 1, (alpha) -0.0399363
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0387792
PLIN2 perilipin 2 -0.0367067
RPL35A ribosomal protein L35a -0.0355238
RPS8 ribosomal protein S8 -0.0345165
RPLP2 ribosomal protein, large, P2 -0.0320369
ZBTB20 zinc finger and BTB domain containing 20 -0.0312985
RPL31 ribosomal protein L31 -0.0307492
APOA2 apolipoprotein A-II -0.0289991
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0289743
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.028094
GMDS GDP-mannose 4,6-dehydratase -0.0275237
RPL37A ribosomal protein L37a -0.0271887
GCLC glutamate-cysteine ligase, catalytic subunit -0.026813
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0263674
RPL34 ribosomal protein L34 -0.025196
INTS6 integrator complex subunit 6 -0.0242249
ASPH aspartate beta-hydroxylase -0.0240654
TPM4 tropomyosin 4 -0.0240196
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0238236
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0235767
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0234596
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0234025
RPS16 ribosomal protein S16 -0.0219887
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0217777
RPS29 ribosomal protein S29 -0.0215788
GPC3 glypican 3 -0.0215137
RPS14 ribosomal protein S14 -0.02106
FOXP1 forkhead box P1 -0.0210092
IFITM1 interferon induced transmembrane protein 1 -0.0205285
ACTG1 actin gamma 1 -0.0204406
RPL36 ribosomal protein L36 -0.0202663
RPL12 ribosomal protein L12 -0.0201374
DSTN destrin (actin depolymerizing factor) -0.0198479
RPS5 ribosomal protein S5 -0.0196913
GOLGB1 golgin B1 -0.0192914
PDLIM5 PDZ and LIM domain 5 -0.019254
RPL9 ribosomal protein L9 -0.019014
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0188901
RPS25 ribosomal protein S25 -0.0188893
ENKUR enkurin, TRPC channel interacting protein -0.018424
AMBP alpha-1-microglobulin/bikunin precursor -0.0184093
MAP1B microtubule-associated protein 1B -0.0184007
RPS20 ribosomal protein S20 -0.0183256
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0182118
RPS15 ribosomal protein S15 -0.0181424
ATP10A ATPase, class V, type 10A -0.0180131
GCC2 GRIP and coiled-coil domain containing 2 -0.0179109
BTG1 B-cell translocation gene 1, anti-proliferative -0.0178078
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0176039
EHBP1 EH domain binding protein 1 -0.0175879
RPL5 ribosomal protein L5 -0.0174544
NPR2 natriuretic peptide receptor 2 -0.0172442
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0171074
BPTF bromodomain PHD finger transcription factor -0.0170933
RPL38 ribosomal protein L38 -0.0169524
ISG15 ISG15 ubiquitin-like modifier -0.0169032
AHNAK AHNAK nucleoprotein -0.0168931
RPL10A ribosomal protein L10a -0.0168816
RPS13 ribosomal protein S13 -0.0166894
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0166465
RPL19 ribosomal protein L19 -0.0165884
RPL28 ribosomal protein L28 -0.016445
POTEF POTE ankyrin domain family, member F -0.0164087
TMEM123 transmembrane protein 123 -0.0163485
MCL1 myeloid cell leukemia 1 -0.0163361
IFI6 interferon, alpha-inducible protein 6 -0.0162233
S100A9 S100 calcium binding protein A9 -0.0162012
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0161902
RNF213 ring finger protein 213 -0.0160801
SLC38A1 solute carrier family 38, member 1 -0.0159666
ARHGAP18 Rho GTPase activating protein 18 -0.0157984
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.0157139
UGDH UDP-glucose 6-dehydrogenase -0.0156697
UBC ubiquitin C -0.0156541
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.015597
RBBP6 retinoblastoma binding protein 6 -0.0155812
SPDYA speedy/RINGO cell cycle regulator family member A -0.0154737
GK glycerol kinase -0.0154715
NPAS2 neuronal PAS domain protein 2 -0.0152799