Cyclosporin A_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.207686
EEF2 eukaryotic translation elongation factor 2 0.136054
EXT1 exostosin glycosyltransferase 1 0.116454
MYH9 myosin, heavy chain 9, non-muscle 0.0870664
RUNX1 runt-related transcription factor 1 0.0802051
TRIO trio Rho guanine nucleotide exchange factor 0.0764711
DST dystonin 0.074521
APP amyloid beta (A4) precursor protein 0.0723943
EFNA5 ephrin-A5 0.069876
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0697472
SAMD4A sterile alpha motif domain containing 4A 0.0690435
FLNA filamin A, alpha 0.0669815
HDAC9 histone deacetylase 9 0.0644495
KDM3A lysine (K)-specific demethylase 3A 0.0642363
ERRFI1 ERBB receptor feedback inhibitor 1 0.0620761
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.061332
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0601658
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0593972
PLEC plectin 0.0592222
SPAG9 sperm associated antigen 9 0.058203
NUP58 nucleoporin 58 0.0581971
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0580011
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0579406
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0563325
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0532235
MACF1 microtubule-actin crosslinking factor 1 0.0519204
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0517533
LOC112694756 uncharaterized LOC112694756 0.0506764
HSPA8 heat shock 70kDa protein 8 0.0483201
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0475523
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.047419
NDRG1 N-myc downstream regulated 1 0.0456217
WDR45B WD repeat domain 45B 0.045159
MCTP1 multiple C2 domains, transmembrane 1 0.0446759
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0438384
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0430979
USP34 ubiquitin specific peptidase 34 0.0422719
PRKCE protein kinase C, epsilon 0.0419299
CD109 CD109 molecule 0.0412766
SRRM2 serine/arginine repetitive matrix 2 0.0410258
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0406882
MYO10 myosin X 0.0404271
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0403765
KMT2C lysine (K)-specific methyltransferase 2C 0.0403716
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0403108
HOOK2 hook microtubule-tethering protein 2 0.0399124
PRRC2A proline-rich coiled-coil 2A 0.0393427
WDR43 WD repeat domain 43 0.0388035
PICALM phosphatidylinositol binding clathrin assembly protein 0.037912
CORO1C coronin, actin binding protein, 1C 0.0372363
PTK2 protein tyrosine kinase 2 0.0368974
EGR1 early growth response 1 0.0364708
ZFAND3 zinc finger, AN1-type domain 3 0.0364073
ATP13A3 ATPase type 13A3 0.0362465
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0356331
WSB1 WD repeat and SOCS box containing 1 0.0356066
ARID1A AT rich interactive domain 1A (SWI-like) 0.0351682
LSAMP limbic system-associated membrane protein 0.0348915
CXCL8 chemokine (C-X-C motif) ligand 8 0.0345711
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.033854
MARCHF4 membrane associated ring-CH-type finger 4 0.0338494
PRRC2B proline-rich coiled-coil 2B 0.0332266
ENKUR enkurin, TRPC channel interacting protein 0.0327772
BIRC6 baculoviral IAP repeat containing 6 0.0323308
CALD1 caldesmon 1 0.0320057
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0318145
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0316994
QKI QKI, KH domain containing, RNA binding 0.0314624
BRD2 bromodomain containing 2 0.0313514
RPL3 ribosomal protein L3 0.0312869
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0310056
EIF4B eukaryotic translation initiation factor 4B 0.0306106
DSCAM Down syndrome cell adhesion molecule 0.0301385
PUM1 pumilio RNA-binding family member 1 0.0299019
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0291252
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.029083
ACTN1 actinin, alpha 1 0.0290267
MARCHF6 membrane associated ring-CH-type finger 6 0.028941
RND3 Rho family GTPase 3 0.0287135
ANXA2 annexin A2 0.0285727
MED13L mediator complex subunit 13-like 0.0283906
ANKRD11 ankyrin repeat domain 11 0.0281475
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0279351
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0278612
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0278099
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0273274
TFRC transferrin receptor 0.0270337
TLE4 transducin-like enhancer of split 4 0.0270063
RAB1A RAB1A, member RAS oncogene family 0.0269165
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0269041
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0265264
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0264657
FUS FUS RNA binding protein 0.0264594
PARD3 par-3 family cell polarity regulator 0.0264161
ABI1 abl-interactor 1 0.0264159
MAP2K1 mitogen-activated protein kinase kinase 1 0.0263896
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0261249
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0261171
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0260223
RAB8B RAB8B, member RAS oncogene family 0.0259443

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.203048
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.154599
TMSB10 thymosin beta 10 -0.103043
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.100789
RPS6 ribosomal protein S6 -0.0977463
FTL ferritin, light polypeptide -0.0908884
AKAP12 A kinase (PRKA) anchor protein 12 -0.0833641
ALCAM activated leukocyte cell adhesion molecule -0.0667007
HMGA1 high mobility group AT-hook 1 -0.0588618
MT2A metallothionein 2A -0.0496195
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0468252
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0462061
VCL vinculin -0.0461873
PTMA prothymosin, alpha -0.044023
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0437953
AHNAK AHNAK nucleoprotein -0.0401848
RPS19 ribosomal protein S19 -0.0387725
NLGN1 neuroligin 1 -0.0378649
GPC6 glypican 6 -0.0377225
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0376804
RPLP1 ribosomal protein, large, P1 -0.036943
PDE4D phosphodiesterase 4D, cAMP-specific -0.0360552
POTEF POTE ankyrin domain family, member F -0.0346596
MAP1B microtubule-associated protein 1B -0.0339284
TPM4 tropomyosin 4 -0.0336202
CENPF centromere protein F, 350/400kDa -0.0335542
NALF1 NALCN channel auxiliary factor 1 -0.0331175
RPL35A ribosomal protein L35a -0.0317493
PFN1 profilin 1 -0.0304524
LDHA lactate dehydrogenase A -0.0296428
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0294875
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0286268
DEK DEK proto-oncogene -0.0272231
RPS24 ribosomal protein S24 -0.0271232
IFI16 interferon, gamma-inducible protein 16 -0.0271074
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0270614
RPL23 ribosomal protein L23 -0.0270396
RIGI RNA sensor RIG-I -0.0264436
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0262758
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0260678
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0258619
RPS25 ribosomal protein S25 -0.0251556
HMGB1 high mobility group box 1 -0.0246881
RPS21 ribosomal protein S21 -0.0241921
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0239208
RTN4 reticulon 4 -0.0237013
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0235082
ENO1 enolase 1, (alpha) -0.0229819
RPLP2 ribosomal protein, large, P2 -0.0228312
RPL21 ribosomal protein L21 -0.0218314
RPL19 ribosomal protein L19 -0.0208772
PCBP2 poly(rC) binding protein 2 -0.0207086
RPL27A ribosomal protein L27a -0.0204341
RPL12 ribosomal protein L12 -0.0204258
TPT1 tumor protein, translationally-controlled 1 -0.0203166
GNAS GNAS complex locus -0.0203158
SMC4 structural maintenance of chromosomes 4 -0.0199977
RPS23 ribosomal protein S23 -0.0197785
TUBA1B tubulin, alpha 1b -0.0197565
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0196829
PTCHD4 patched domain containing 4 -0.0196105
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0192049
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0190482
TPI1 triosephosphate isomerase 1 -0.0188642
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0188633
MBD5 methyl-CpG binding domain protein 5 -0.0185866
DPYD dihydropyrimidine dehydrogenase -0.0184035
RPS8 ribosomal protein S8 -0.0182851
LDHB lactate dehydrogenase B -0.0181125
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0177625
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0177514
MYL12B myosin, light chain 12B, regulatory -0.0176243
FOXP1 forkhead box P1 -0.0169615
PTBP3 polypyrimidine tract binding protein 3 -0.0169207
RPL32 ribosomal protein L32 -0.0168875
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0168624
CAV1 caveolin 1, caveolae protein, 22kDa -0.0168593
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0168199
KISS1 KiSS-1 metastasis-suppressor -0.0165293
ATP5F1B ATP synthase F1 subunit beta -0.0164098
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0160221
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.015789
RPS5 ribosomal protein S5 -0.0156453
TUBA1C tubulin, alpha 1c -0.0155959
RPS14 ribosomal protein S14 -0.0155201
BSG basigin (Ok blood group) -0.015363
RPL27 ribosomal protein L27 -0.0152028
RPS16 ribosomal protein S16 -0.0151186
RIMS2 regulating synaptic membrane exocytosis 2 -0.015082
RAI14 retinoic acid induced 14 -0.0148401
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0146764
BNC2 basonuclin 2 -0.0146357
BDNF brain-derived neurotrophic factor -0.0145892
DSTN destrin (actin depolymerizing factor) -0.014578
BLZF1 basic leucine zipper nuclear factor 1 -0.0145644
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0145257
RPL36 ribosomal protein L36 -0.0144264
RPL35 ribosomal protein L35 -0.0144019
PMP22 peripheral myelin protein 22 -0.0143288
ARF4 ADP-ribosylation factor 4 -0.0142512