Cyclosporin A_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.14289
PABPC1 poly(A) binding protein, cytoplasmic 1 0.129944
TPM3 tropomyosin 3 0.093072
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0847252
MYH9 myosin, heavy chain 9, non-muscle 0.0803269
APP amyloid beta (A4) precursor protein 0.0782725
ZFAND3 zinc finger, AN1-type domain 3 0.0763287
WDR43 WD repeat domain 43 0.0722395
MACF1 microtubule-actin crosslinking factor 1 0.0712448
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0699088
ANKRD11 ankyrin repeat domain 11 0.0692115
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0638403
IGF2 insulin-like growth factor 2 0.0624843
COPA coatomer protein complex, subunit alpha 0.0621643
RPL3 ribosomal protein L3 0.0608399
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0570319
WAC WW domain containing adaptor with coiled-coil 0.0539646
RBM39 RNA binding motif protein 39 0.0532437
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0531471
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0531393
ERRFI1 ERBB receptor feedback inhibitor 1 0.0524354
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0509009
CALR calreticulin 0.0504163
ADAM17 ADAM metallopeptidase domain 17 0.0497554
HSPA8 heat shock 70kDa protein 8 0.0486025
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0483874
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0479454
CSNK1A1 casein kinase 1, alpha 1 0.0470739
TRIO trio Rho guanine nucleotide exchange factor 0.0464579
NUP58 nucleoporin 58 0.0463917
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0463445
PDIA3 protein disulfide isomerase family A, member 3 0.0461691
EGR1 early growth response 1 0.0458799
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0457885
FLNA filamin A, alpha 0.0455944
PLEC plectin 0.0451262
BRD2 bromodomain containing 2 0.0445033
MCL1 myeloid cell leukemia 1 0.0439818
PUM1 pumilio RNA-binding family member 1 0.043878
FLNB filamin B, beta 0.0434329
SAMD4A sterile alpha motif domain containing 4A 0.0428917
FMNL2 formin-like 2 0.0425477
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0421144
UBASH3B ubiquitin associated and SH3 domain containing B 0.0409775
PDIA6 protein disulfide isomerase family A, member 6 0.0404386
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0393907
APLP2 amyloid beta (A4) precursor-like protein 2 0.0390241
KTN1 kinectin 1 (kinesin receptor) 0.0389329
BHLHE40 basic helix-loop-helix family, member e40 0.0386906
MSN moesin 0.0383496
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0381732
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0379949
UBAP2L ubiquitin associated protein 2-like 0.0379333
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0376216
CCNL1 cyclin L1 0.0376137
FUS FUS RNA binding protein 0.0372667
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0371205
ACTN1 actinin, alpha 1 0.0367333
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0353856
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0348481
SFTPA2 surfactant protein A2 0.0344839
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.034124
USP36 ubiquitin specific peptidase 36 0.0337519
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0336887
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0336327
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0332004
PRRC2A proline-rich coiled-coil 2A 0.0331987
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0331162
YBX3 Y box binding protein 3 0.0328997
PNN pinin, desmosome associated protein 0.0327297
SRRM2 serine/arginine repetitive matrix 2 0.0324931
ERBIN erbb2 interacting protein 0.0324795
CASC3 cancer susceptibility candidate 3 0.0321906
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0318464
EIF4A1 eukaryotic translation initiation factor 4A1 0.0307445
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0306929
TRA2B transformer 2 beta homolog (Drosophila) 0.0305778
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0304803
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0304747
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0304656
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0303643
EWSR1 EWS RNA-binding protein 1 0.0300019
NUMA1 nuclear mitotic apparatus protein 1 0.0298953
PFDN2 prefoldin subunit 2 0.0295824
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0292497
PTK2 protein tyrosine kinase 2 0.0292313
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0290135
UPP1 uridine phosphorylase 1 0.0288199
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.028773
HYOU1 hypoxia up-regulated 1 0.0287585
KCMF1 potassium channel modulatory factor 1 0.0286786
SRSF5 serine/arginine-rich splicing factor 5 0.0284495
PKM pyruvate kinase, muscle 0.0281093
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0281068
SPAG5 sperm associated antigen 5 0.0277743
MEF2D myocyte enhancer factor 2D 0.0276898
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0274909
YBX1 Y box binding protein 1 0.0274826
PRRC2C proline-rich coiled-coil 2C 0.0270717
RPS12 ribosomal protein S12 0.0270104

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.20224
MT2A metallothionein 2A -0.177275
FTL ferritin, light polypeptide -0.160434
TMSB10 thymosin beta 10 -0.154412
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.121141
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116314
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0980142
PDE4D phosphodiesterase 4D, cAMP-specific -0.0922741
VIM vimentin -0.0854373
TFPI2 tissue factor pathway inhibitor 2 -0.0775891
RPLP1 ribosomal protein, large, P1 -0.0724295
IER3 immediate early response 3 -0.0719393
GRAMD1B GRAM domain containing 1B -0.0662956
S100A6 S100 calcium binding protein A6 -0.0632519
RPL19 ribosomal protein L19 -0.0599696
PM20D1 peptidase M20 domain containing 1 -0.0534401
FTH1 ferritin, heavy polypeptide 1 -0.0502393
TPT1 tumor protein, translationally-controlled 1 -0.0453614
C15ORF48 chromosome 15 open reading frame 48 -0.0414356
THSD4 thrombospondin, type I, domain containing 4 -0.0406193
RPS21 ribosomal protein S21 -0.0391744
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0378704
TXNRD1 thioredoxin reductase 1 -0.036341
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0351821
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0344536
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0329447
RPS20 ribosomal protein S20 -0.0326936
CAVIN1 caveolae associated protein 1 -0.0305562
BICC1 BicC family RNA binding protein 1 -0.0302751
RPL35A ribosomal protein L35a -0.0293536
MYL12B myosin, light chain 12B, regulatory -0.0289834
EFNA5 ephrin-A5 -0.0278563
HMGB1 high mobility group box 1 -0.0264168
RPS16 ribosomal protein S16 -0.0263879
RPS24 ribosomal protein S24 -0.0261918
NNMT nicotinamide N-methyltransferase -0.0261912
BIRC3 baculoviral IAP repeat containing 3 -0.0260786
RPS19 ribosomal protein S19 -0.0255242
BASP1 brain abundant, membrane attached signal protein 1 -0.0238274
GNAS GNAS complex locus -0.0235627
AHNAK AHNAK nucleoprotein -0.0231716
RPL4 ribosomal protein L4 -0.0229749
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0228307
RPL34 ribosomal protein L34 -0.0227692
MAML3 mastermind-like 3 (Drosophila) -0.0227124
HMGA1 high mobility group AT-hook 1 -0.022076
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.021927
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0218822
NRG1 neuregulin 1 -0.0213384
RPS5 ribosomal protein S5 -0.0210235
PRDX1 peroxiredoxin 1 -0.0203189
RPS6 ribosomal protein S6 -0.0201413
S100A11 S100 calcium binding protein A11 -0.0196529
UBB ubiquitin B -0.0194115
KYNU kynureninase -0.0189017
TUBA1B tubulin, alpha 1b -0.018617
GLIS3 GLIS family zinc finger 3 -0.0184012
RPS15 ribosomal protein S15 -0.0181297
RPS25 ribosomal protein S25 -0.0180069
OSMR oncostatin M receptor -0.0179923
ZBTB20 zinc finger and BTB domain containing 20 -0.0178837
SRGN serglycin -0.0178088
ATP5F1E ATP synthase F1 subunit epsilon -0.0177623
RPL12 ribosomal protein L12 -0.0176235
IFITM3 interferon induced transmembrane protein 3 -0.0176153
SERF2 small EDRK-rich factor 2 -0.0174708
RPL28 ribosomal protein L28 -0.0174693
S100A10 S100 calcium binding protein A10 -0.0172641
NCOA7 nuclear receptor coactivator 7 -0.0172361
RPS2 ribosomal protein S2 -0.0168823
RPL23 ribosomal protein L23 -0.0168427
DEK DEK proto-oncogene -0.0165491
RPL32 ribosomal protein L32 -0.0164765
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0162866
AK1 adenylate kinase 1 -0.0161967
RPL26 ribosomal protein L26 -0.0161324
RSPO3 R-spondin 3 -0.0160441
WWOX WW domain containing oxidoreductase -0.0158525
LDHA lactate dehydrogenase A -0.0156541
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0156121
ENO1 enolase 1, (alpha) -0.0155689
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0154571
RPL8 ribosomal protein L8 -0.0153133
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0151041
PARK7 parkinson protein 7 -0.0150888
RPL36AL ribosomal protein L36a-like -0.0149958
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.01493
ROMO1 reactive oxygen species modulator 1 -0.0147258
RPS27A ribosomal protein S27a -0.0146199
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0144443
SPIDR scaffolding protein involved in DNA repair -0.0144311
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0141858
ASTN2 astrotactin 2 -0.0140961
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0140429
SOX4 SRY (sex determining region Y)-box 4 -0.0139552
IGFBP4 insulin-like growth factor binding protein 4 -0.0139041
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0138942
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0138313
RPLP0 ribosomal protein, large, P0 -0.0137841
GCLM glutamate-cysteine ligase, modifier subunit -0.0137663