| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cyclosporin A perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cyclosporin A_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.22789 |
| EGR1 | early growth response 1 | 0.175981 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.164884 |
| COPA | coatomer protein complex, subunit alpha | 0.10841 |
| PLEC | plectin | 0.0756827 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0682541 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0616036 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.05744 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0572298 |
| KRT18 | keratin 18, type I | 0.0567435 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0518754 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0498267 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0496227 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0447751 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0444521 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0437684 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0410153 |
| CEP250 | centrosomal protein 250kDa | 0.0409929 |
| FLNA | filamin A, alpha | 0.040651 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0397933 |
| IGF2 | insulin-like growth factor 2 | 0.0395508 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0395137 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0392419 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0371143 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0365167 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0359338 |
| TPM3 | tropomyosin 3 | 0.0357592 |
| RPL3 | ribosomal protein L3 | 0.0357231 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0356907 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0345312 |
| NUP58 | nucleoporin 58 | 0.0342687 |
| H1-0 | H1.0 linker histone | 0.034048 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0339511 |
| RAB7A | RAB7A, member RAS oncogene family | 0.03296 |
| ACTN1 | actinin, alpha 1 | 0.03269 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0325199 |
| MORF4L2 | mortality factor 4 like 2 | 0.0320316 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0315482 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0308269 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0304974 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0304752 |
| NONO | non-POU domain containing, octamer-binding | 0.0298076 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0296836 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0295287 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0295038 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0294039 |
| MSN | moesin | 0.0278379 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0275426 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0274712 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0272856 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0271765 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0270928 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0269931 |
| PER1 | period circadian clock 1 | 0.0269805 |
| MLEC | malectin | 0.026963 |
| FUS | FUS RNA binding protein | 0.0268582 |
| SEPTIN2 | septin 2 | 0.0268398 |
| CANX | calnexin | 0.026753 |
| USP36 | ubiquitin specific peptidase 36 | 0.0266063 |
| ATXN2 | ataxin 2 | 0.0261116 |
| MINK1 | misshapen-like kinase 1 | 0.0259621 |
| YBX1 | Y box binding protein 1 | 0.0254883 |
| CALR | calreticulin | 0.0254767 |
| HELZ | helicase with zinc finger | 0.0253105 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0252873 |
| RBMX | RNA binding motif protein, X-linked | 0.025276 |
| HYOU1 | hypoxia up-regulated 1 | 0.0251857 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0251777 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0250572 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | 0.024921 |
| TMEM39A | transmembrane protein 39A | 0.0248388 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.024623 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0244496 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0241311 |
| ARFGAP1 | ADP-ribosylation factor GTPase activating protein 1 | 0.024 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0239831 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.023929 |
| TFG | TRK-fused gene | 0.0238974 |
| MKI67 | marker of proliferation Ki-67 | 0.0238194 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0237695 |
| RLIM | ring finger protein, LIM domain interacting | 0.0237482 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0234482 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0232996 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0232405 |
| DAND5 | DAN domain family member 5, BMP antagonist | 0.0232023 |
| BRD2 | bromodomain containing 2 | 0.0231579 |
| CCDC200 | coiled-coil domain containing 200 | 0.0229783 |
| ANXA2 | annexin A2 | 0.022971 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0229686 |
| RACK1 | receptor for activated C kinase 1 | 0.0228339 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0228241 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0227062 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0226976 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0226562 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0226385 |
| WASF2 | WAS protein family, member 2 | 0.0225171 |
| MEF2D | myocyte enhancer factor 2D | 0.0224157 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0223973 |
| SMAD3 | SMAD family member 3 | 0.0223858 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0220075 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.24515 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.201698 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.103399 |
| GRAMD1B | GRAM domain containing 1B | -0.100525 |
| TMSB10 | thymosin beta 10 | -0.0950117 |
| UBC | ubiquitin C | -0.0816085 |
| VIM | vimentin | -0.0708743 |
| YBX3 | Y box binding protein 3 | -0.0694832 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0680053 |
| RPS27A | ribosomal protein S27a | -0.0661673 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0655469 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.064831 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0640761 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0592634 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0568267 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0537523 |
| OSMR | oncostatin M receptor | -0.0532025 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0488763 |
| AHNAK | AHNAK nucleoprotein | -0.0487015 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0483 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0475802 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0473026 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.046462 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0445638 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0433702 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0407225 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0403501 |
| CDK17 | cyclin-dependent kinase 17 | -0.0403224 |
| ENO1 | enolase 1, (alpha) | -0.0396676 |
| RTN4 | reticulon 4 | -0.0394997 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0391174 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0382732 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0361833 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0357469 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0353878 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0348366 |
| TXNRD1 | thioredoxin reductase 1 | -0.0344765 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0331646 |
| RPS2 | ribosomal protein S2 | -0.0328356 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0328029 |
| DEK | DEK proto-oncogene | -0.0325267 |
| CCND1 | cyclin D1 | -0.0322972 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0321112 |
| PTMA | prothymosin, alpha | -0.0320986 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0320821 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0320639 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0320268 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0319823 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0316764 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0315248 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0313567 |
| HLA-B | major histocompatibility complex, class I, B | -0.0310294 |
| RPL26 | ribosomal protein L26 | -0.0308959 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0308764 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0306928 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0305824 |
| RPS15 | ribosomal protein S15 | -0.0303506 |
| RPS29 | ribosomal protein S29 | -0.0295852 |
| CENPF | centromere protein F, 350/400kDa | -0.0294782 |
| RPLP1 | ribosomal protein, large, P1 | -0.0294067 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0293781 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0293483 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0293189 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0291896 |
| IER3 | immediate early response 3 | -0.0290979 |
| CCND2 | cyclin D2 | -0.0288015 |
| RPS24 | ribosomal protein S24 | -0.0285947 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0282544 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0281885 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0277103 |
| RPS21 | ribosomal protein S21 | -0.0274423 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0272126 |
| TUBA1B | tubulin, alpha 1b | -0.0270541 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0270118 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0267441 |
| PCBP2 | poly(rC) binding protein 2 | -0.0267036 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0266968 |
| PDE10A | phosphodiesterase 10A | -0.0266208 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0264398 |
| ATP11A | ATPase, class VI, type 11A | -0.0262005 |
| RPL9 | ribosomal protein L9 | -0.0260243 |
| CAVIN1 | caveolae associated protein 1 | -0.0259249 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0258601 |
| RRM2 | ribonucleotide reductase M2 | -0.0254391 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0253446 |
| EXOC4 | exocyst complex component 4 | -0.0253398 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0252919 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0252441 |
| RPLP2 | ribosomal protein, large, P2 | -0.0250472 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0246696 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0246441 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0246145 |
| SSH2 | slingshot protein phosphatase 2 | -0.0244742 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0244652 |
| ZNF638 | zinc finger protein 638 | -0.0243868 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0243431 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0242612 |
| WDR70 | WD repeat domain 70 | -0.0242239 |
| EFNA5 | ephrin-A5 | -0.023376 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0231164 |
