Cyclosporin A_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.269533
EEF2 eukaryotic translation elongation factor 2 0.12278
IGFBP3 insulin-like growth factor binding protein 3 0.117169
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.113321
TRIO trio Rho guanine nucleotide exchange factor 0.0871832
LIMCH1 LIM and calponin homology domains 1 0.0694666
FLNB filamin B, beta 0.0638138
MCL1 myeloid cell leukemia 1 0.0628795
CANX calnexin 0.0626187
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0625511
COPA coatomer protein complex, subunit alpha 0.0614949
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0585775
NPAS2 neuronal PAS domain protein 2 0.0570246
ELL2 elongation factor, RNA polymerase II, 2 0.054572
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0528105
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0510517
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0504919
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0487394
ZEB2 zinc finger E-box binding homeobox 2 0.0485688
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0482655
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0472674
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0465632
CD109 CD109 molecule 0.0462851
DNER delta/notch-like EGF repeat containing 0.0462245
FLNA filamin A, alpha 0.0459357
FNDC3B fibronectin type III domain containing 3B 0.0457213
FNDC3A fibronectin type III domain containing 3A 0.0450859
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0438171
SPAG9 sperm associated antigen 9 0.0437699
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0433632
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0432206
SAMD4A sterile alpha motif domain containing 4A 0.0430286
BIRC6 baculoviral IAP repeat containing 6 0.0424811
ITPRID2 ITPR interacting domain containing 2 0.0422952
EFNA5 ephrin-A5 0.0419492
SOD2 superoxide dismutase 2, mitochondrial 0.0415557
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.040216
DDIT4 DNA-damage-inducible transcript 4 0.038336
TNIP1 TNFAIP3 interacting protein 1 0.0383107
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0379586
LOC112694756 uncharaterized LOC112694756 0.037398
SMOC1 SPARC related modular calcium binding 1 0.0372646
PDIA3 protein disulfide isomerase family A, member 3 0.0368414
ERRFI1 ERBB receptor feedback inhibitor 1 0.036545
OGA O-GlcNAcase 0.0361343
STC1 stanniocalcin 1 0.0356644
EGR1 early growth response 1 0.035408
BHLHE40 basic helix-loop-helix family, member e40 0.0354066
CSNK1A1 casein kinase 1, alpha 1 0.0352963
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0352035
CTBP2 C-terminal binding protein 2 0.0347626
NDRG1 N-myc downstream regulated 1 0.0346275
MYOF myoferlin 0.034493
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0341471
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0340847
GRB10 growth factor receptor-bound protein 10 0.0340157
LAMA1 laminin, alpha 1 0.0338747
FAM13A family with sequence similarity 13, member A 0.0331794
KYNU kynureninase 0.0328497
PTEN phosphatase and tensin homolog 0.0328237
AKAP13 A kinase (PRKA) anchor protein 13 0.0325192
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0321742
CTIF CBP80/20-dependent translation initiation factor 0.0320505
NCOR2 nuclear receptor corepressor 2 0.0319219
NONO non-POU domain containing, octamer-binding 0.0318774
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0318143
ESYT2 extended synaptotagmin-like protein 2 0.0316792
DOCK4 dedicator of cytokinesis 4 0.031588
PYGL phosphorylase, glycogen, liver 0.0312162
NUP58 nucleoporin 58 0.0310444
KMT2C lysine (K)-specific methyltransferase 2C 0.0308366
CCL5 chemokine (C-C motif) ligand 5 0.0305172
UBAP2L ubiquitin associated protein 2-like 0.0300235
PDIA6 protein disulfide isomerase family A, member 6 0.0297109
INHBA inhibin, beta A 0.0296805
USP9X ubiquitin specific peptidase 9, X-linked 0.0296753
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0295046
PDGFA platelet-derived growth factor alpha polypeptide 0.0289402
HELZ helicase with zinc finger 0.0288389
EZR ezrin 0.0287699
HDAC4 histone deacetylase 4 0.0285495
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0284934
IL1RAP interleukin 1 receptor accessory protein 0.0283425
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.028198
MSN moesin 0.0281789
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0281155
ANXA1 annexin A1 0.0280443
PM20D1 peptidase M20 domain containing 1 0.0279776
ARRDC3 arrestin domain containing 3 0.0277311
TGFBI transforming growth factor, beta-induced, 68kDa 0.0273604
PGK1 phosphoglycerate kinase 1 0.0272886
RPL3 ribosomal protein L3 0.027098
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0270908
NBAS neuroblastoma amplified sequence 0.0261335
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0260947
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0259602
CUL4B cullin 4B 0.0255273
PTPRF protein tyrosine phosphatase, receptor type, F 0.0248576
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.024738
PSD3 pleckstrin and Sec7 domain containing 3 0.0247177

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.144448
TPT1 tumor protein, translationally-controlled 1 -0.107323
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.104342
RPS6 ribosomal protein S6 -0.102184
PTMA prothymosin, alpha -0.101001
RPLP1 ribosomal protein, large, P1 -0.0903497
RPS24 ribosomal protein S24 -0.0783088
RPL37A ribosomal protein L37a -0.0737627
RPS8 ribosomal protein S8 -0.0680088
TMSB10 thymosin beta 10 -0.0668567
RPL31 ribosomal protein L31 -0.0648321
RPL26 ribosomal protein L26 -0.0635997
RPL35A ribosomal protein L35a -0.0612158
TXNRD1 thioredoxin reductase 1 -0.0604288
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0603935
FTL ferritin, light polypeptide -0.0594731
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0586904
NALF1 NALCN channel auxiliary factor 1 -0.0579334
RPL12 ribosomal protein L12 -0.0572053
RPL19 ribosomal protein L19 -0.0560878
RPS19 ribosomal protein S19 -0.053442
RPS12 ribosomal protein S12 -0.0523117
RPS2 ribosomal protein S2 -0.051662
RPLP2 ribosomal protein, large, P2 -0.0511625
RPL9 ribosomal protein L9 -0.0508644
RPS23 ribosomal protein S23 -0.0491549
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0488872
RPS29 ribosomal protein S29 -0.048074
VIM vimentin -0.0446612
RPS27A ribosomal protein S27a -0.0442877
ASPH aspartate beta-hydroxylase -0.0437973
RPL38 ribosomal protein L38 -0.0432298
RPL34 ribosomal protein L34 -0.0431413
RPL23 ribosomal protein L23 -0.0409294
RPL36A ribosomal protein L36a -0.0401119
RPL37 ribosomal protein L37 -0.0399337
RPS3 ribosomal protein S3 -0.0395188
RPS16 ribosomal protein S16 -0.0369432
NAP1L1 nucleosome assembly protein 1-like 1 -0.036915
RPS13 ribosomal protein S13 -0.0366015
RPS25 ribosomal protein S25 -0.036506
GRAMD1B GRAM domain containing 1B -0.0349324
RPL7A ribosomal protein L7a -0.0346297
RPS17 ribosomal protein S17 -0.0345504
RPL36 ribosomal protein L36 -0.0340498
SMYD3 SET and MYND domain containing 3 -0.0338743
PRKN parkin RBR E3 ubiquitin protein ligase -0.0335665
RPS21 ribosomal protein S21 -0.0326774
CTSL cathepsin L -0.0314199
SRGN serglycin -0.0313145
RPS14 ribosomal protein S14 -0.0310392
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0308161
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0305664
RPL13A ribosomal protein L13a -0.0303319
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0300532
RPL11 ribosomal protein L11 -0.0299591
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0292784
RPL27 ribosomal protein L27 -0.0282676
TFPI2 tissue factor pathway inhibitor 2 -0.0271271
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0269489
RPL5 ribosomal protein L5 -0.0267701
RPL35 ribosomal protein L35 -0.0267367
PTGR1 prostaglandin reductase 1 -0.0265026
COL5A2 collagen, type V, alpha 2 -0.0259455
CADM2 cell adhesion molecule 2 -0.0258264
RPL32 ribosomal protein L32 -0.0257619
RPS27 ribosomal protein S27 -0.0252187
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0250812
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0250473
PRDX1 peroxiredoxin 1 -0.0249815
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0246968
RPL28 ribosomal protein L28 -0.0246883
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0246615
CENPF centromere protein F, 350/400kDa -0.0244904
RPS5 ribosomal protein S5 -0.0243378
EIF5B eukaryotic translation initiation factor 5B -0.0241922
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.02414
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0241075
RPL4 ribosomal protein L4 -0.0238632
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0237983
RPS20 ribosomal protein S20 -0.0237508
RPL7 ribosomal protein L7 -0.0235884
RGS2 regulator of G-protein signaling 2 -0.0228686
RPS15 ribosomal protein S15 -0.0223435
RPS11 ribosomal protein S11 -0.0221893
ACTG1 actin gamma 1 -0.0217455
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0217433
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0216205
VCL vinculin -0.020555
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.020495
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0204638
MT2A metallothionein 2A -0.0204208
ANTXR1 anthrax toxin receptor 1 -0.0203369
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0203307
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0203136
TNPO1 transportin 1 -0.0202549
LSAMP limbic system-associated membrane protein -0.0193839
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0193751
HLA-B major histocompatibility complex, class I, B -0.0188531
PTPRM protein tyrosine phosphatase, receptor type, M -0.0183357