Cyclosporin A_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0891119
LAMB3 laminin, beta 3 0.0813877
EZR ezrin 0.0646517
MACF1 microtubule-actin crosslinking factor 1 0.062879
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0597508
MYH9 myosin, heavy chain 9, non-muscle 0.059595
TRIO trio Rho guanine nucleotide exchange factor 0.0578307
NAV2 neuron navigator 2 0.05594
KRT17 keratin 17, type I 0.0527541
KRT18 keratin 18, type I 0.0521502
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0503167
FAM3C family with sequence similarity 3, member C 0.0480022
DSCAM Down syndrome cell adhesion molecule 0.0474205
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0450849
RUNX1 runt-related transcription factor 1 0.0437353
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0420236
SMAD3 SMAD family member 3 0.0413525
ANLN anillin, actin binding protein 0.0404777
KRT8 keratin 8, type II 0.0401967
VEGFA vascular endothelial growth factor A 0.0394179
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0390835
ARRDC3 arrestin domain containing 3 0.0389435
TGM2 transglutaminase 2 0.0377803
ANXA2 annexin A2 0.0376911
BHLHE40 basic helix-loop-helix family, member e40 0.0371089
MBNL2 muscleblind-like splicing regulator 2 0.0370334
AFDN afadin, adherens junction formation factor 0.0369755
MKI67 marker of proliferation Ki-67 0.0368736
CANX calnexin 0.0368724
ERRFI1 ERBB receptor feedback inhibitor 1 0.0364575
FNDC3B fibronectin type III domain containing 3B 0.0360651
OGA O-GlcNAcase 0.0348305
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0346633
EEF2 eukaryotic translation elongation factor 2 0.034359
TNIP1 TNFAIP3 interacting protein 1 0.0338597
ARHGAP29 Rho GTPase activating protein 29 0.0337152
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0331689
TSC22D2 TSC22 domain family, member 2 0.0330577
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0311128
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.030955
WWC1 WW and C2 domain containing 1 0.0309437
LAMC2 laminin, gamma 2 0.0305318
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0303553
MED15 mediator complex subunit 15 0.0301899
PLEC plectin 0.0298535
XPO1 exportin 1 0.029423
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0290373
EPS8 epidermal growth factor receptor pathway substrate 8 0.028464
MYOF myoferlin 0.0281207
FLNB filamin B, beta 0.0277809
ECT2 epithelial cell transforming 2 0.0275958
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0273157
UBE2H ubiquitin-conjugating enzyme E2H 0.0268996
NCEH1 neutral cholesterol ester hydrolase 1 0.0260677
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0256247
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0256134
FOSL1 FOS-like antigen 1 0.0254588
DIAPH3 diaphanous-related formin 3 0.0253768
OSBPL3 oxysterol binding protein-like 3 0.0252985
APP amyloid beta (A4) precursor protein 0.0249289
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0248976
NUMA1 nuclear mitotic apparatus protein 1 0.0246469
NRIP1 nuclear receptor interacting protein 1 0.0242054
DLG1 discs, large homolog 1 (Drosophila) 0.0240582
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0239577
CALR calreticulin 0.0239574
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.023957
GOLGA4 golgin A4 0.0237259
UGCG UDP-glucose ceramide glucosyltransferase 0.0235769
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0235115
BCAR3 breast cancer anti-estrogen resistance 3 0.023506
CTNND1 catenin (cadherin-associated protein), delta 1 0.0234672
LOC112694756 uncharaterized LOC112694756 0.0233783
SPTBN1 spectrin, beta, non-erythrocytic 1 0.022854
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0228155
CKAP5 cytoskeleton associated protein 5 0.0224173
UBA6 ubiquitin-like modifier activating enzyme 6 0.0224093
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0222133
SHROOM3 shroom family member 3 0.0218682
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0218678
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0218353
MYO6 myosin VI 0.021711
HMGB2 high mobility group box 2 0.0217092
APLP2 amyloid beta (A4) precursor-like protein 2 0.0214754
IL1RAP interleukin 1 receptor accessory protein 0.0214276
DSPP dentin sialophosphoprotein 0.0212768
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0212109
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0212071
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0210136
EHF ets homologous factor 0.0207569
FGD4 FYVE, RhoGEF and PH domain containing 4 0.020656
ATP13A3 ATPase type 13A3 0.0206229
SLTM SAFB-like, transcription modulator 0.0204334
JMJD1C jumonji domain containing 1C 0.0204128
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0201964
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0200863
ZFAND3 zinc finger, AN1-type domain 3 0.0200674
NDRG1 N-myc downstream regulated 1 0.0200217
IL6ST interleukin 6 signal transducer 0.0199913
FRMD6 FERM domain containing 6 0.0199596

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.206395
RPL35A ribosomal protein L35a -0.120096
PTMA prothymosin, alpha -0.0926745
RPS6 ribosomal protein S6 -0.0887256
TMSB10 thymosin beta 10 -0.0674781
RPS8 ribosomal protein S8 -0.0665602
ACTG1 actin gamma 1 -0.065792
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0643995
RPL31 ribosomal protein L31 -0.0643491
RPS29 ribosomal protein S29 -0.0617281
FTL ferritin, light polypeptide -0.0612458
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0577618
RPL37A ribosomal protein L37a -0.056302
RPS13 ribosomal protein S13 -0.056123
RPL23 ribosomal protein L23 -0.0559995
RPLP1 ribosomal protein, large, P1 -0.0553154
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0536881
INTS6 integrator complex subunit 6 -0.0528054
HMGA1 high mobility group AT-hook 1 -0.0499704
HLA-B major histocompatibility complex, class I, B -0.0498729
RPS19 ribosomal protein S19 -0.0491501
RPS27A ribosomal protein S27a -0.0490709
IFI27 interferon, alpha-inducible protein 27 -0.046421
RPS23 ribosomal protein S23 -0.0454539
RPS25 ribosomal protein S25 -0.0446335
RPS3 ribosomal protein S3 -0.0438939
RPS24 ribosomal protein S24 -0.0428379
RPL37 ribosomal protein L37 -0.0423502
RPL34 ribosomal protein L34 -0.0414239
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0401634
RPL19 ribosomal protein L19 -0.0396389
RPL28 ribosomal protein L28 -0.0378319
RPL12 ribosomal protein L12 -0.0375987
RPL36A ribosomal protein L36a -0.0374782
RNF213 ring finger protein 213 -0.0368399
RPS21 ribosomal protein S21 -0.0361463
RPLP2 ribosomal protein, large, P2 -0.0358405
SOX4 SRY (sex determining region Y)-box 4 -0.0343342
RPS14 ribosomal protein S14 -0.0335421
IFIH1 interferon induced with helicase C domain 1 -0.0334285
WFDC2 WAP four-disulfide core domain 2 -0.0333694
RPL38 ribosomal protein L38 -0.0329686
SQSTM1 sequestosome 1 -0.0329509
RPS15 ribosomal protein S15 -0.032849
RPL36 ribosomal protein L36 -0.0328474
RPL9 ribosomal protein L9 -0.032344
TPM4 tropomyosin 4 -0.0321086
RPS16 ribosomal protein S16 -0.0319111
IFITM3 interferon induced transmembrane protein 3 -0.0318624
RPS17 ribosomal protein S17 -0.0314184
ZBTB20 zinc finger and BTB domain containing 20 -0.0311836
RPL7A ribosomal protein L7a -0.0311443
IFITM1 interferon induced transmembrane protein 1 -0.0306102
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.030357
SP100 SP100 nuclear antigen -0.0302836
RPS12 ribosomal protein S12 -0.0294119
RPL26 ribosomal protein L26 -0.029003
HLA-E major histocompatibility complex, class I, E -0.0287591
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0287116
FN1 fibronectin 1 -0.0284413
HLA-A major histocompatibility complex, class I, A -0.0283745
SYT14 synaptotagmin XIV -0.0281096
LOC102724023 ES1 protein homolog, mitochondrial -0.0276265
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0276195
MX2 MX dynamin-like GTPase 2 -0.0275296
EIF1 eukaryotic translation initiation factor 1 -0.0274982
LMO7 LIM domain 7 -0.0268461
RPL11 ribosomal protein L11 -0.0267979
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0265331
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.026473
RPS11 ribosomal protein S11 -0.026435
RPL10A ribosomal protein L10a -0.0262951
RIGI RNA sensor RIG-I -0.0257742
RPL15 ribosomal protein L15 -0.0250632
RPS27 ribosomal protein S27 -0.0250361
RPL27 ribosomal protein L27 -0.0249685
HLA-C major histocompatibility complex, class I, C -0.0242633
RPS20 ribosomal protein S20 -0.024101
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0239191
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0239149
RPS10 ribosomal protein S10 -0.0232785
RPS5 ribosomal protein S5 -0.0231523
IFI6 interferon, alpha-inducible protein 6 -0.0231236
RPL5 ribosomal protein L5 -0.0231111
GNAS GNAS complex locus -0.0229042
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0227242
RPL13A ribosomal protein L13a -0.0221724
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0220306
S100A6 S100 calcium binding protein A6 -0.0216436
IGFBP3 insulin-like growth factor binding protein 3 -0.0216146
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0214323
SULF2 sulfatase 2 -0.0211633
CCND1 cyclin D1 -0.0210347
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0205341
RPL32 ribosomal protein L32 -0.0203556
LRRC23 leucine rich repeat containing 23 -0.0203481
MX1 MX dynamin-like GTPase 1 -0.0202934
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0201693
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0200115
RPL8 ribosomal protein L8 -0.0199795