| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cyclosporin A perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cyclosporin A_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.130314 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.110175 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0995189 |
| TXNRD1 | thioredoxin reductase 1 | 0.0923366 |
| JMJD1C | jumonji domain containing 1C | 0.0852895 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0805981 |
| LAMB3 | laminin, beta 3 | 0.0804697 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0755735 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0729356 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0728049 |
| NAV3 | neuron navigator 3 | 0.0717029 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0682186 |
| HDAC9 | histone deacetylase 9 | 0.0655254 |
| STC1 | stanniocalcin 1 | 0.0642015 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.062517 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0617068 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0600299 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0567539 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0553721 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0539217 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0538334 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0530996 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.052251 |
| ACTG1 | actin gamma 1 | 0.0517991 |
| OGA | O-GlcNAcase | 0.0496447 |
| RPLP0 | ribosomal protein, large, P0 | 0.0490292 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0477666 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0472155 |
| NAV2 | neuron navigator 2 | 0.0466081 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0448883 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0447614 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0435127 |
| CALU | calumenin | 0.0433405 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0430669 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0429737 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0424648 |
| MCL1 | myeloid cell leukemia 1 | 0.041353 |
| RASA2 | RAS p21 protein activator 2 | 0.0412029 |
| ACTN1 | actinin, alpha 1 | 0.0411096 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0408001 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0404736 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0399787 |
| UPP1 | uridine phosphorylase 1 | 0.0391287 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0378595 |
| DGKI | diacylglycerol kinase, iota | 0.0378119 |
| CAPRIN2 | caprin family member 2 | 0.0377525 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0371779 |
| ANXA5 | annexin A5 | 0.0367399 |
| ANXA2 | annexin A2 | 0.0363363 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0360635 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.035764 |
| NUP58 | nucleoporin 58 | 0.0356194 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0351781 |
| SMTN | smoothelin | 0.0349485 |
| ERBIN | erbb2 interacting protein | 0.034797 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0346773 |
| TMEM156 | transmembrane protein 156 | 0.0343307 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0341784 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0341515 |
| SGMS2 | sphingomyelin synthase 2 | 0.0341126 |
| SFTPA2 | surfactant protein A2 | 0.0340017 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0337404 |
| APP | amyloid beta (A4) precursor protein | 0.0336346 |
| PTK2 | protein tyrosine kinase 2 | 0.0334654 |
| WDR26 | WD repeat domain 26 | 0.0331886 |
| SEC24D | SEC24 family member D | 0.0330446 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 0.0330385 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0330066 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0329972 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0326548 |
| SETX | senataxin | 0.0321986 |
| RUNX1 | runt-related transcription factor 1 | 0.0321363 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0320412 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0319934 |
| KLC1 | kinesin light chain 1 | 0.0318995 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0315596 |
| ABI1 | abl-interactor 1 | 0.0314452 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.030414 |
| MKI67 | marker of proliferation Ki-67 | 0.0303973 |
| CORO1C | coronin, actin binding protein, 1C | 0.0303767 |
| FNIP1 | folliculin interacting protein 1 | 0.0301918 |
| ADTRP | androgen-dependent TFPI-regulating protein | 0.0301902 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0301411 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0301241 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0301053 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0296612 |
| CLTC | clathrin, heavy chain (Hc) | 0.0295187 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0294532 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0292028 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0291175 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0290315 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.029006 |
| PGK1 | phosphoglycerate kinase 1 | 0.0288433 |
| FLNA | filamin A, alpha | 0.0288339 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0285757 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0285361 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0284132 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.028355 |
| SDCBP | syndecan binding protein (syntenin) | 0.0281661 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0279026 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DLC1 | DLC1 Rho GTPase activating protein | -0.133553 |
| MT2A | metallothionein 2A | -0.102411 |
| TTR | transthyretin | -0.0896988 |
| CALD1 | caldesmon 1 | -0.0700007 |
| PTMA | prothymosin, alpha | -0.0681333 |
| NABP1 | nucleic acid binding protein 1 | -0.0680031 |
| FTL | ferritin, light polypeptide | -0.0675219 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0673513 |
| TMSB10 | thymosin beta 10 | -0.066828 |
| RPL35A | ribosomal protein L35a | -0.0629536 |
| FRMD6 | FERM domain containing 6 | -0.0607746 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0524005 |
| ZNF438 | zinc finger protein 438 | -0.0502299 |
| RPL8 | ribosomal protein L8 | -0.0468616 |
| RPS6 | ribosomal protein S6 | -0.0461788 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.045121 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0447113 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.044431 |
| HMGA2 | high mobility group AT-hook 2 | -0.0443151 |
| BNC2 | basonuclin 2 | -0.0437837 |
| DIAPH3 | diaphanous-related formin 3 | -0.0424308 |
| RPS3 | ribosomal protein S3 | -0.0385932 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0368892 |
| RPL36 | ribosomal protein L36 | -0.0359608 |
| RPLP1 | ribosomal protein, large, P1 | -0.0348159 |
| RPS19 | ribosomal protein S19 | -0.0338732 |
| RPL12 | ribosomal protein L12 | -0.0328869 |
| RPS8 | ribosomal protein S8 | -0.0324461 |
| HMGA1 | high mobility group AT-hook 1 | -0.0322191 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0320224 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0313408 |
| RPL34 | ribosomal protein L34 | -0.0304562 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0294878 |
| RPL28 | ribosomal protein L28 | -0.029482 |
| RPS23 | ribosomal protein S23 | -0.029141 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0287874 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0287289 |
| RPL13A | ribosomal protein L13a | -0.0284035 |
| RAD51B | RAD51 paralog B | -0.0275921 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0267094 |
| GNAS | GNAS complex locus | -0.0263827 |
| RAB3IP | RAB3A interacting protein | -0.0259737 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0257083 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0256315 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0256282 |
| RPL32 | ribosomal protein L32 | -0.0248252 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0243317 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0235127 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.023498 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0234299 |
| S100A9 | S100 calcium binding protein A9 | -0.0233857 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0233782 |
| CDK6 | cyclin-dependent kinase 6 | -0.0228858 |
| RPS29 | ribosomal protein S29 | -0.0222337 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0219755 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.021704 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0215586 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0215273 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0212983 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.021158 |
| RPL31 | ribosomal protein L31 | -0.0211397 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0206533 |
| CNTLN | centlein, centrosomal protein | -0.0204262 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0203682 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.0203198 |
| VWA8 | von Willebrand factor A domain containing 8 | -0.0201669 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0199428 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0198144 |
| NPR2 | natriuretic peptide receptor 2 | -0.0197543 |
| RPL19 | ribosomal protein L19 | -0.0194464 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0193994 |
| FRMD4A | FERM domain containing 4A | -0.0192484 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0189066 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | -0.0185231 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0184131 |
| CSPP1 | centrosome and spindle pole associated protein 1 | -0.018344 |
| MTAP | methylthioadenosine phosphorylase | -0.0182932 |
| RPL23 | ribosomal protein L23 | -0.018248 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0180861 |
| RPS11 | ribosomal protein S11 | -0.0180194 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0179257 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0178628 |
| MX1 | MX dynamin-like GTPase 1 | -0.0177034 |
| CCDC138 | coiled-coil domain containing 138 | -0.0176762 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0176362 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0176352 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0176242 |
| RPS25 | ribosomal protein S25 | -0.017624 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0172635 |
| RPS2 | ribosomal protein S2 | -0.0172353 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -0.0172315 |
| RPL35 | ribosomal protein L35 | -0.0171781 |
| RPL26 | ribosomal protein L26 | -0.0170411 |
| FAM13A | family with sequence similarity 13, member A | -0.0170076 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.016965 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0169642 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0167185 |
| EFNB2 | ephrin-B2 | -0.0162488 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.016194 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0161144 |
