Cyclosporin A_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.139507
FN1 fibronectin 1 0.0902859
PGK1 phosphoglycerate kinase 1 0.0851662
VEGFA vascular endothelial growth factor A 0.0790635
ZNF292 zinc finger protein 292 0.0755677
GOLGA4 golgin A4 0.0747143
MT2A metallothionein 2A 0.0626419
NAV2 neuron navigator 2 0.06182
FLNB filamin B, beta 0.0594912
FNDC3B fibronectin type III domain containing 3B 0.0594332
CD109 CD109 molecule 0.0591902
NDRG1 N-myc downstream regulated 1 0.0575185
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.057363
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0566522
CENPF centromere protein F, 350/400kDa 0.0562673
UBA6 ubiquitin-like modifier activating enzyme 6 0.0559688
KLF7 Kruppel-like factor 7 (ubiquitous) 0.054911
DSCAM Down syndrome cell adhesion molecule 0.0533376
NAMPT nicotinamide phosphoribosyltransferase 0.0532606
MKI67 marker of proliferation Ki-67 0.052005
XPO1 exportin 1 0.051735
TFG TRK-fused gene 0.0516576
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0516543
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0510698
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0502291
STC1 stanniocalcin 1 0.0495111
KMT2E lysine (K)-specific methyltransferase 2E 0.0480537
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0475562
ATP13A3 ATPase type 13A3 0.0460565
ADAM17 ADAM metallopeptidase domain 17 0.0459259
SETD5 SET domain containing 5 0.0454858
RAD21 RAD21 homolog (S. pombe) 0.0452197
MSN moesin 0.044208
PLEC plectin 0.0437574
GARS1 glycyl-tRNA synthetase 1 0.0426545
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0422651
SEPTIN7 septin 7 0.0404999
TNIP1 TNFAIP3 interacting protein 1 0.0402467
WAC WW domain containing adaptor with coiled-coil 0.0390211
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0386077
RBM39 RNA binding motif protein 39 0.0383952
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0383675
OGA O-GlcNAcase 0.0383272
ACTN4 actinin, alpha 4 0.0381618
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0377958
EEF2 eukaryotic translation elongation factor 2 0.0369267
CALD1 caldesmon 1 0.0369206
RAD23B RAD23 homolog B (S. cerevisiae) 0.0366978
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0366438
HMGB2 high mobility group box 2 0.0365718
YEATS2 YEATS domain containing 2 0.03655
BRWD3 bromodomain and WD repeat domain containing 3 0.0365383
ANKRD11 ankyrin repeat domain 11 0.0360208
NONO non-POU domain containing, octamer-binding 0.0358174
RNF145 ring finger protein 145 0.035619
INSIG2 insulin induced gene 2 0.0351788
SNAP25 synaptosomal-associated protein, 25kDa 0.0350885
TRIO trio Rho guanine nucleotide exchange factor 0.0350746
ITCH itchy E3 ubiquitin protein ligase 0.0346688
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0346298
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0343253
BHLHE40 basic helix-loop-helix family, member e40 0.0333077
CD44 CD44 molecule (Indian blood group) 0.0331521
NUP58 nucleoporin 58 0.0326325
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0325818
RB1CC1 RB1-inducible coiled-coil 1 0.0324305
FMNL2 formin-like 2 0.0316934
SMC4 structural maintenance of chromosomes 4 0.0314405
FLNA filamin A, alpha 0.0310114
DIAPH3 diaphanous-related formin 3 0.0305711
SOD2 superoxide dismutase 2, mitochondrial 0.0302514
MCTP2 multiple C2 domains, transmembrane 2 0.0301312
WSB1 WD repeat and SOCS box containing 1 0.0300598
USP9X ubiquitin specific peptidase 9, X-linked 0.0300329
LCORL ligand dependent nuclear receptor corepressor-like 0.0297925
COPA coatomer protein complex, subunit alpha 0.0296342
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0293662
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0293619
MMP12 matrix metallopeptidase 12 0.0290203
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.028649
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0284074
DOCK5 dedicator of cytokinesis 5 0.0282032
DDR2 discoidin domain receptor tyrosine kinase 2 0.0281438
VIM vimentin 0.0280427
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0280271
NCKAP1 NCK-associated protein 1 0.027689
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0276593
ECT2 epithelial cell transforming 2 0.0276332
AFAP1 actin filament associated protein 1 0.0275844
NGLY1 N-glycanase 1 0.027529
NUMA1 nuclear mitotic apparatus protein 1 0.0275107
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0273874
RRBP1 ribosome binding protein 1 0.0272134
NKTR natural killer cell triggering receptor 0.0271892
TPX2 TPX2, microtubule-associated 0.0271839
RTN4 reticulon 4 0.0270277
FOXJ3 forkhead box J3 0.0268782
YBX1 Y box binding protein 1 0.026867
BIRC6 baculoviral IAP repeat containing 6 0.0267818
PRRC2C proline-rich coiled-coil 2C 0.0266397

decreased expression

Symbol Name Standardized Value
HLA-B major histocompatibility complex, class I, B -0.182671
COL1A2 collagen, type I, alpha 2 -0.156691
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.142233
TIMP3 TIMP metallopeptidase inhibitor 3 -0.138691
COL1A1 collagen, type I, alpha 1 -0.137148
B2M beta-2-microglobulin -0.112342
IFI6 interferon, alpha-inducible protein 6 -0.0841305
FTL ferritin, light polypeptide -0.0790599
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0782922
EGR1 early growth response 1 -0.0756152
IER3 immediate early response 3 -0.0687476
HLA-A major histocompatibility complex, class I, A -0.067664
EXT1 exostosin glycosyltransferase 1 -0.0661474
PSD3 pleckstrin and Sec7 domain containing 3 -0.0651101
COL6A1 collagen, type VI, alpha 1 -0.0635965
TPT1 tumor protein, translationally-controlled 1 -0.0620153
CDH13 cadherin 13 -0.05899
IGFBP3 insulin-like growth factor binding protein 3 -0.0576263
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0573276
LOC102724023 ES1 protein homolog, mitochondrial -0.0559803
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.054918
SP100 SP100 nuclear antigen -0.0537195
TGFBI transforming growth factor, beta-induced, 68kDa -0.0502939
TMEM178B transmembrane protein 178B -0.050078
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0483366
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0461702
HLA-C major histocompatibility complex, class I, C -0.0461609
IFIH1 interferon induced with helicase C domain 1 -0.0457256
PTPRG protein tyrosine phosphatase, receptor type, G -0.0453937
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0421739
HLA-E major histocompatibility complex, class I, E -0.0410889
ZBTB20 zinc finger and BTB domain containing 20 -0.0405635
NAV1 neuron navigator 1 -0.0405201
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0403345
IL1B interleukin 1, beta -0.0389021
LOXL2 lysyl oxidase-like 2 -0.0387248
GLIS3 GLIS family zinc finger 3 -0.0379249
IFITM3 interferon induced transmembrane protein 3 -0.0377657
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0373247
TPM4 tropomyosin 4 -0.0372449
COL6A2 collagen, type VI, alpha 2 -0.0372164
IGFBP5 insulin-like growth factor binding protein 5 -0.0370371
FRMD4A FERM domain containing 4A -0.0369921
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0369268
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.03569
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0348401
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0346266
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0323196
MAML3 mastermind-like 3 (Drosophila) -0.0319535
RPL31 ribosomal protein L31 -0.0316475
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0313138
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0310421
COL5A3 collagen, type V, alpha 3 -0.0305327
ZBTB38 zinc finger and BTB domain containing 38 -0.0302015
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0296722
TFPI2 tissue factor pathway inhibitor 2 -0.0295239
VCL vinculin -0.0294357
ZHX2 zinc fingers and homeoboxes 2 -0.0292854
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0291174
SHISA5 shisa family member 5 -0.0290025
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0285673
TNS3 tensin 3 -0.0285403
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.028435
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0283653
EGFR epidermal growth factor receptor -0.0280299
CADM1 cell adhesion molecule 1 -0.0279297
SQSTM1 sequestosome 1 -0.0277791
MCL1 myeloid cell leukemia 1 -0.0277196
FHIT fragile histidine triad -0.0276349
SLIT2 slit homolog 2 (Drosophila) -0.0274006
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0268872
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0265649
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0262593
NREP neuronal regeneration related protein -0.0260059
TMSB10 thymosin beta 10 -0.0259224
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0257624
LRRC23 leucine rich repeat containing 23 -0.02574
NCOA7 nuclear receptor coactivator 7 -0.0249563
RPL35A ribosomal protein L35a -0.0249545
ACTG1 actin gamma 1 -0.0248114
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0244572
ARL4C ADP-ribosylation factor-like 4C -0.024178
IFI16 interferon, gamma-inducible protein 16 -0.0238669
POTEF POTE ankyrin domain family, member F -0.0238622
HDAC9 histone deacetylase 9 -0.0234396
CCND1 cyclin D1 -0.0234289
EML5 echinoderm microtubule associated protein like 5 -0.0232756
FAM20C family with sequence similarity 20, member C -0.0228774
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0227432
SDK1 sidekick cell adhesion molecule 1 -0.0223969
TNNC1 troponin C type 1 (slow) -0.0223224
PMP22 peripheral myelin protein 22 -0.0220143
RAI14 retinoic acid induced 14 -0.0218592
RPS24 ribosomal protein S24 -0.0216793
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0214392
PXDN peroxidasin -0.0213833
RIGI RNA sensor RIG-I -0.0212855
ARF4 ADP-ribosylation factor 4 -0.0212134
EXOC4 exocyst complex component 4 -0.0211894
AGO3 argonaute RISC catalytic component 3 -0.0211861