Cyclosporin A_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.138914
PDE4B phosphodiesterase 4B, cAMP-specific 0.11706
FLNB filamin B, beta 0.107527
TMSB4X thymosin beta 4, X-linked 0.100025
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0768666
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0761645
HDAC9 histone deacetylase 9 0.0747323
PDE4D phosphodiesterase 4D, cAMP-specific 0.0721936
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0660497
LOC112694756 uncharaterized LOC112694756 0.0613477
RBMS3 RNA binding motif, single stranded interacting protein 3 0.056607
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0562531
ADAM10 ADAM metallopeptidase domain 10 0.0527259
FAT1 FAT atypical cadherin 1 0.0459511
RPL3 ribosomal protein L3 0.0454037
SOX6 SRY (sex determining region Y)-box 6 0.0452435
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.044671
TXNRD1 thioredoxin reductase 1 0.0440364
SLC38A2 solute carrier family 38, member 2 0.0434635
TBC1D22A TBC1 domain family, member 22A 0.0415227
AMOTL2 angiomotin like 2 0.0409646
PRELID2 PRELI domain containing 2 0.0405693
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0404569
CLIP1 CAP-GLY domain containing linker protein 1 0.0383288
CD47 CD47 molecule 0.037772
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0366114
EZR ezrin 0.0364239
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0357982
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0352572
TGFBR3 transforming growth factor, beta receptor III 0.0352337
TTC3 tetratricopeptide repeat domain 3 0.0337057
CPED1 cadherin-like and PC-esterase domain containing 1 0.0335158
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.033434
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0333294
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.033219
ZFAND3 zinc finger, AN1-type domain 3 0.0331618
TMEM65 transmembrane protein 65 0.0329469
PLXNA1 plexin A1 0.0329179
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0329117
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0326344
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0318987
GSE1 Gse1 coiled-coil protein 0.0317901
VCL vinculin 0.0314494
DSCAM Down syndrome cell adhesion molecule 0.031367
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.031348
SRRM2 serine/arginine repetitive matrix 2 0.0312708
SQSTM1 sequestosome 1 0.0310198
DUSP4 dual specificity phosphatase 4 0.0307697
ARID1A AT rich interactive domain 1A (SWI-like) 0.0306449
PGK1 phosphoglycerate kinase 1 0.0305673
APP amyloid beta (A4) precursor protein 0.0304734
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0301831
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0295888
MYOF myoferlin 0.0293826
FAM13A family with sequence similarity 13, member A 0.0292851
EIF4A2 eukaryotic translation initiation factor 4A2 0.0284723
EXT1 exostosin glycosyltransferase 1 0.0283159
LPP LIM domain containing preferred translocation partner in lipoma 0.0281422
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0280917
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0278906
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0277618
ANKRD36 ankyrin repeat domain 36 0.0277165
GLI2 GLI family zinc finger 2 0.0272593
NCEH1 neutral cholesterol ester hydrolase 1 0.0266365
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0264635
SREBF2 sterol regulatory element binding transcription factor 2 0.0260875
NPAS2 neuronal PAS domain protein 2 0.0260151
NBEA neurobeachin 0.0257501
PTPRF protein tyrosine phosphatase, receptor type, F 0.0254851
DLG1 discs, large homolog 1 (Drosophila) 0.0254483
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0254192
COPA coatomer protein complex, subunit alpha 0.025189
NFE2L2 nuclear factor, erythroid 2-like 2 0.0250882
PTPRG protein tyrosine phosphatase, receptor type, G 0.0244926
GOLGA4 golgin A4 0.0242754
ZNF217 zinc finger protein 217 0.0241879
ANKRD17 ankyrin repeat domain 17 0.0240491
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0239507
ZEB1 zinc finger E-box binding homeobox 1 0.0239337
SMYD3 SET and MYND domain containing 3 0.0238152
PICALM phosphatidylinositol binding clathrin assembly protein 0.0233573
MYO5A myosin VA (heavy chain 12, myoxin) 0.0231813
ANKRD11 ankyrin repeat domain 11 0.0230134
CAMTA1 calmodulin binding transcription activator 1 0.0230101
DIDO1 death inducer-obliterator 1 0.0227919
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.022669
SAMD4A sterile alpha motif domain containing 4A 0.0226423
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0226285
HDLBP high density lipoprotein binding protein 0.0225735
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.022363
TTC28 tetratricopeptide repeat domain 28 0.0222534
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0221144
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0220425
FBLN2 fibulin 2 0.0220139
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0218768
TMF1 TATA element modulatory factor 1 0.0218495
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0217522
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.021516
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0215067
TCF12 transcription factor 12 0.0213699

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0799513
RPS6 ribosomal protein S6 -0.0722363
PTMA prothymosin, alpha -0.0547183
RPLP1 ribosomal protein, large, P1 -0.0487281
RPL35A ribosomal protein L35a -0.048514
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0480126
RPS19 ribosomal protein S19 -0.0459874
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0447692
RPL34 ribosomal protein L34 -0.0441348
RPS8 ribosomal protein S8 -0.0401867
RPL12 ribosomal protein L12 -0.0382286
RPL23 ribosomal protein L23 -0.0334037
RPS23 ribosomal protein S23 -0.0321375
TPT1 tumor protein, translationally-controlled 1 -0.0317871
RPLP2 ribosomal protein, large, P2 -0.0316102
PFN1 profilin 1 -0.030011
FTL ferritin, light polypeptide -0.0289671
RBM25 RNA binding motif protein 25 -0.0288585
RPL36 ribosomal protein L36 -0.0279713
S100A6 S100 calcium binding protein A6 -0.0272051
RPL28 ribosomal protein L28 -0.0270846
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0255514
RPL19 ribosomal protein L19 -0.0251655
NAMPT nicotinamide phosphoribosyltransferase -0.0250497
RPL32 ribosomal protein L32 -0.024875
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0247359
RPL37A ribosomal protein L37a -0.0247122
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.023664
TMSB10 thymosin beta 10 -0.0235993
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0233805
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0233249
RPS16 ribosomal protein S16 -0.0224753
RPS3 ribosomal protein S3 -0.0219125
RPS14 ribosomal protein S14 -0.0217685
RPS27A ribosomal protein S27a -0.0216255
RPL26 ribosomal protein L26 -0.0211099
DSTN destrin (actin depolymerizing factor) -0.0209223
RPL5 ribosomal protein L5 -0.0208208
FAM162A family with sequence similarity 162, member A -0.020806
HMGA1 high mobility group AT-hook 1 -0.0207068
HMGB1 high mobility group box 1 -0.0204522
USP3 ubiquitin specific peptidase 3 -0.0204067
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0197168
RPL13A ribosomal protein L13a -0.0195155
RPL9 ribosomal protein L9 -0.0192331
RHOA ras homolog family member A -0.0190546
TPR translocated promoter region, nuclear basket protein -0.0187911
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0186867
GNAS GNAS complex locus -0.0182214
SMC4 structural maintenance of chromosomes 4 -0.0177908
RPS21 ribosomal protein S21 -0.0177459
RPL31 ribosomal protein L31 -0.0174856
RPL35 ribosomal protein L35 -0.0173395
RPS17 ribosomal protein S17 -0.0172587
CCNL1 cyclin L1 -0.0170303
RPS5 ribosomal protein S5 -0.0169139
RPS20 ribosomal protein S20 -0.0168427
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.016685
IFI6 interferon, alpha-inducible protein 6 -0.016621
RPL18 ribosomal protein L18 -0.0165286
RPS13 ribosomal protein S13 -0.0164037
RPL38 ribosomal protein L38 -0.0163404
RPL8 ribosomal protein L8 -0.0161361
RPL21 ribosomal protein L21 -0.0161192
SMC3 structural maintenance of chromosomes 3 -0.0161102
RPL37 ribosomal protein L37 -0.0159841
LDHB lactate dehydrogenase B -0.0159272
RPS12 ribosomal protein S12 -0.0157707
WSB1 WD repeat and SOCS box containing 1 -0.0155659
S100A10 S100 calcium binding protein A10 -0.0155153
SSBP2 single-stranded DNA binding protein 2 -0.0155078
ACTG1 actin gamma 1 -0.0154355
RPS11 ribosomal protein S11 -0.0154106
RPL27A ribosomal protein L27a -0.0151875
RPS24 ribosomal protein S24 -0.0151434
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.015009
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.014999
BTG3 BTG family, member 3 -0.0149922
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0149388
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0148479
IFITM3 interferon induced transmembrane protein 3 -0.014829
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0146052
RPS25 ribosomal protein S25 -0.0145102
RPS2 ribosomal protein S2 -0.0144549
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0143843
SEPTIN7 septin 7 -0.0143576
MIS18BP1 MIS18 binding protein 1 -0.0143189
KMT2E lysine (K)-specific methyltransferase 2E -0.0142896
PHIP pleckstrin homology domain interacting protein -0.0142556
RAP1B RAP1B, member of RAS oncogene family -0.0141926
PIAS1 protein inhibitor of activated STAT, 1 -0.0140221
RPL30 ribosomal protein L30 -0.0136168
S100A9 S100 calcium binding protein A9 -0.0135113
VIM vimentin -0.0134493
RBBP6 retinoblastoma binding protein 6 -0.0133636
POTEF POTE ankyrin domain family, member F -0.0133107
RNF145 ring finger protein 145 -0.0131981
CDC73 cell division cycle 73 -0.0131904
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0131715
RPL27 ribosomal protein L27 -0.0129344