Cyclosporin A_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.106175
EEF2 eukaryotic translation elongation factor 2 0.10427
PABPC1 poly(A) binding protein, cytoplasmic 1 0.10315
MYH9 myosin, heavy chain 9, non-muscle 0.0950285
NUP58 nucleoporin 58 0.0894942
PTMA prothymosin, alpha 0.0772269
CEP250 centrosomal protein 250kDa 0.0728733
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0695353
WAC WW domain containing adaptor with coiled-coil 0.0620411
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0602836
YBX3 Y box binding protein 3 0.0568111
RPL23 ribosomal protein L23 0.0545063
ZNF292 zinc finger protein 292 0.0539966
CENPF centromere protein F, 350/400kDa 0.0538924
NAP1L1 nucleosome assembly protein 1-like 1 0.0532209
TRIO trio Rho guanine nucleotide exchange factor 0.0526664
SET SET nuclear proto-oncogene 0.0524154
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0521572
MKI67 marker of proliferation Ki-67 0.0520235
ANLN anillin, actin binding protein 0.0517437
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0515392
PKM pyruvate kinase, muscle 0.0498337
CSNK1A1 casein kinase 1, alpha 1 0.0471232
LOC112694756 uncharaterized LOC112694756 0.0458558
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0451211
CKAP5 cytoskeleton associated protein 5 0.0438299
TPX2 TPX2, microtubule-associated 0.0436448
BHLHE40 basic helix-loop-helix family, member e40 0.0435907
ANKRD11 ankyrin repeat domain 11 0.0435677
YAP1 Yes-associated protein 1 0.0435239
NCAPD2 non-SMC condensin I complex, subunit D2 0.0426495
HJURP Holliday junction recognition protein 0.0425716
NUMA1 nuclear mitotic apparatus protein 1 0.0421459
ECT2 epithelial cell transforming 2 0.0406983
FLNA filamin A, alpha 0.0403143
ANKRD28 ankyrin repeat domain 28 0.0401616
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0399019
DSCAM Down syndrome cell adhesion molecule 0.0390703
MATR3 matrin 3 0.0384422
CKAP2 cytoskeleton associated protein 2 0.0381057
APLP2 amyloid beta (A4) precursor-like protein 2 0.0380496
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0377722
RBM39 RNA binding motif protein 39 0.036615
NAMPT nicotinamide phosphoribosyltransferase 0.0365947
RSRC2 arginine/serine-rich coiled-coil 2 0.0362938
ITCH itchy E3 ubiquitin protein ligase 0.0357352
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0350952
CUL5 cullin 5 0.0349135
HMGB2 high mobility group box 2 0.0344029
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0343748
RACK1 receptor for activated C kinase 1 0.0339833
FUS FUS RNA binding protein 0.0338955
GOLGA2 golgin A2 0.03381
ARRDC3 arrestin domain containing 3 0.0338085
WNK1 WNK lysine deficient protein kinase 1 0.032856
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.032815
SEPTIN2 septin 2 0.0326965
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0326251
COPA coatomer protein complex, subunit alpha 0.0322416
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0318753
NONO non-POU domain containing, octamer-binding 0.0318141
SETD5 SET domain containing 5 0.0317176
ATXN2L ataxin 2-like 0.0316272
MCTP1 multiple C2 domains, transmembrane 1 0.0315035
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0314862
TNIP1 TNFAIP3 interacting protein 1 0.0312079
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.031194
ASXL1 additional sex combs like transcriptional regulator 1 0.0308769
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0307237
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0306098
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0304867
PRPF8 pre-mRNA processing factor 8 0.0304623
MIS18BP1 MIS18 binding protein 1 0.0303164
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0297987
RAD23B RAD23 homolog B (S. cerevisiae) 0.0295121
MYLIP myosin regulatory light chain interacting protein 0.0293376
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0291434
TOP2B topoisomerase (DNA) II beta 180kDa 0.0289456
AFF4 AF4/FMR2 family, member 4 0.0289078
KTN1 kinectin 1 (kinesin receptor) 0.0289052
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0286994
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0284307
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.028384
RAD21 RAD21 homolog (S. pombe) 0.0279396
SRRM2 serine/arginine repetitive matrix 2 0.0276662
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0275262
SNX14 sorting nexin 14 0.0274135
NUP153 nucleoporin 153kDa 0.0271464
XRN2 5'-3' exoribonuclease 2 0.0270369
CALR calreticulin 0.0270113
FXR1 fragile X mental retardation, autosomal homolog 1 0.0268483
FNIP1 folliculin interacting protein 1 0.0266781
MSN moesin 0.0265822
RPL3 ribosomal protein L3 0.0264986
NAV2 neuron navigator 2 0.0264724
TBK1 TANK-binding kinase 1 0.0263743
FEM1C fem-1 homolog c (C. elegans) 0.0262931
GSK3B glycogen synthase kinase 3 beta 0.0262566
TMEM245 transmembrane protein 245 0.0262063
BRD4 bromodomain containing 4 0.025982

decreased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0857752
HMGA2 high mobility group AT-hook 2 -0.0711353
TPT1 tumor protein, translationally-controlled 1 -0.069788
AHNAK AHNAK nucleoprotein -0.055615
ZBTB20 zinc finger and BTB domain containing 20 -0.0525697
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0501029
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0496843
RIGI RNA sensor RIG-I -0.0437352
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0429551
DST dystonin -0.0426309
SVIL supervillin -0.0404866
TMSB10 thymosin beta 10 -0.0400211
VIM vimentin -0.0398446
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0390133
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0381923
EFNA5 ephrin-A5 -0.0366347
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0365047
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0364155
ATM ATM serine/threonine kinase -0.0344002
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0341765
RIN2 Ras and Rab interactor 2 -0.034172
PRR16 proline rich 16 -0.0318447
NALCN sodium leak channel, non selective -0.0317102
OSMR oncostatin M receptor -0.0307785
SH3KBP1 SH3-domain kinase binding protein 1 -0.0306356
LDHA lactate dehydrogenase A -0.0304218
GNAS GNAS complex locus -0.0303844
DPYD dihydropyrimidine dehydrogenase -0.0293485
CAVIN1 caveolae associated protein 1 -0.0292885
RAI14 retinoic acid induced 14 -0.0291046
RPLP1 ribosomal protein, large, P1 -0.0290466
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0288845
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0288177
PCED1B PC-esterase domain containing 1B -0.0287759
PRSS23 protease, serine, 23 -0.0285249
NT5E 5'-nucleotidase, ecto (CD73) -0.0280151
SCAPER S-phase cyclin A-associated protein in the ER -0.0280077
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0279426
BICD1 bicaudal D homolog 1 (Drosophila) -0.0278144
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0276115
FMN1 formin 1 -0.0275136
SETX senataxin -0.0272901
GPC6 glypican 6 -0.0271826
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.027015
ANGPTL4 angiopoietin-like 4 -0.0269318
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0261453
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0257723
CD44 CD44 molecule (Indian blood group) -0.0257196
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0255153
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0252485
SLC38A2 solute carrier family 38, member 2 -0.0252417
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0249972
AKAP12 A kinase (PRKA) anchor protein 12 -0.0247085
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0241907
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0239981
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0238043
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0237935
ZC3H12C zinc finger CCCH-type containing 12C -0.0235872
MBD5 methyl-CpG binding domain protein 5 -0.0235308
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0235271
RNF213 ring finger protein 213 -0.0235133
IER3 immediate early response 3 -0.0229509
ZBTB38 zinc finger and BTB domain containing 38 -0.0229215
THSD4 thrombospondin, type I, domain containing 4 -0.0228512
COL5A1 collagen, type V, alpha 1 -0.0227509
EGFR epidermal growth factor receptor -0.0224342
BPTF bromodomain PHD finger transcription factor -0.0222715
FER fer (fps/fes related) tyrosine kinase -0.0221674
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0220666
CCND1 cyclin D1 -0.022002
GCC2 GRIP and coiled-coil domain containing 2 -0.0218673
FNDC3B fibronectin type III domain containing 3B -0.0217269
RAD51B RAD51 paralog B -0.0215818
CCNH cyclin H -0.0215616
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0215011
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.021309
GPC5 glypican 5 -0.0212123
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0208882
RASAL2 RAS protein activator like 2 -0.0208205
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0207546
MAML3 mastermind-like 3 (Drosophila) -0.0206915
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0206564
NPAS2 neuronal PAS domain protein 2 -0.0204041
TAOK3 TAO kinase 3 -0.0202877
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0201531
ZFHX3 zinc finger homeobox 3 -0.0201274
SLC35F3 solute carrier family 35, member F3 -0.019951
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0199355
OASL 2'-5'-oligoadenylate synthetase-like -0.0199278
DNAAF9 dynein axonemal assembly factor 9 -0.0199043
SATB2 SATB homeobox 2 -0.0198606
STAU2 staufen double-stranded RNA binding protein 2 -0.01983
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0192613
SUMF1 sulfatase modifying factor 1 -0.0191482
EXOC4 exocyst complex component 4 -0.0191095
UBB ubiquitin B -0.0186879
BCAS3 breast carcinoma amplified sequence 3 -0.0186645
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0186473
RAB31 RAB31, member RAS oncogene family -0.0185521
THBS1 thrombospondin 1 -0.0185139