Cyclosporin A_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.171613
EEF2 eukaryotic translation elongation factor 2 0.146677
EGR1 early growth response 1 0.142645
PABPC1 poly(A) binding protein, cytoplasmic 1 0.111475
ANXA1 annexin A1 0.110903
ACTG1 actin gamma 1 0.0965355
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0890151
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0780008
ANXA2 annexin A2 0.0748871
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0649887
EZR ezrin 0.0628058
RPL3 ribosomal protein L3 0.0586316
RPS3 ribosomal protein S3 0.0583844
AREG amphiregulin 0.058235
RPS6 ribosomal protein S6 0.0577422
RPS8 ribosomal protein S8 0.0571882
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.05645
LAMB3 laminin, beta 3 0.0544142
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0526909
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0510477
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0506836
HSPA8 heat shock 70kDa protein 8 0.0498897
LDHA lactate dehydrogenase A 0.0498531
DSPP dentin sialophosphoprotein 0.0488926
RPS12 ribosomal protein S12 0.0471891
CD9 CD9 molecule 0.0464991
MPRIP myosin phosphatase Rho interacting protein 0.0458676
TMSB10 thymosin beta 10 0.0449273
LAMA4 laminin, alpha 4 0.0447465
MYH9 myosin, heavy chain 9, non-muscle 0.0442885
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0440431
RACK1 receptor for activated C kinase 1 0.0437539
LOC102724023 ES1 protein homolog, mitochondrial 0.0432885
ZFP36L1 ZFP36 ring finger protein-like 1 0.0424605
EMP1 epithelial membrane protein 1 0.0417737
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0407595
RCOR1 REST corepressor 1 0.0404187
HILPDA hypoxia inducible lipid droplet-associated 0.0401077
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0396002
KRT18 keratin 18, type I 0.0394556
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0386931
MYO5B myosin VB 0.0384744
RPL23 ribosomal protein L23 0.0376442
NDRG1 N-myc downstream regulated 1 0.0373754
RPS19 ribosomal protein S19 0.0370032
EPHA2 EPH receptor A2 0.036852
RPLP0 ribosomal protein, large, P0 0.0362037
LOC112694756 uncharaterized LOC112694756 0.0353502
RPS17 ribosomal protein S17 0.0336214
RPL37A ribosomal protein L37a 0.0326473
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0323676
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0323119
SET SET nuclear proto-oncogene 0.032221
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0319531
RPL31 ribosomal protein L31 0.0319392
RPS27A ribosomal protein S27a 0.0318927
FOS FBJ murine osteosarcoma viral oncogene homolog 0.031463
RPS13 ribosomal protein S13 0.0314327
SRRM2 serine/arginine repetitive matrix 2 0.0312916
DDIT4 DNA-damage-inducible transcript 4 0.0312914
SREBF2 sterol regulatory element binding transcription factor 2 0.030927
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0306261
RPL35A ribosomal protein L35a 0.0303513
SNX9 sorting nexin 9 0.0296813
PDIA3 protein disulfide isomerase family A, member 3 0.0291949
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0290172
SQSTM1 sequestosome 1 0.0289168
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0288741
YBX1 Y box binding protein 1 0.0284801
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0282541
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0280201
MKI67 marker of proliferation Ki-67 0.0276902
PKM pyruvate kinase, muscle 0.0276723
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0275773
BRD2 bromodomain containing 2 0.027315
PUM1 pumilio RNA-binding family member 1 0.0270842
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0268835
CSNK1A1 casein kinase 1, alpha 1 0.0268159
EEF1G eukaryotic translation elongation factor 1 gamma 0.0267582
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0267219
IGFBP3 insulin-like growth factor binding protein 3 0.0266973
OXSR1 oxidative stress responsive 1 0.0264959
RPS10 ribosomal protein S10 0.0264384
RPS25 ribosomal protein S25 0.0263188
S100A6 S100 calcium binding protein A6 0.0260423
EIF1 eukaryotic translation initiation factor 1 0.0256837
RPL8 ribosomal protein L8 0.0256448
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.025624
RPL11 ribosomal protein L11 0.0256104
PARD3 par-3 family cell polarity regulator 0.0255426
BAMBI BMP and activin membrane-bound inhibitor 0.0254097
FAT1 FAT atypical cadherin 1 0.0253254
RPL19 ribosomal protein L19 0.0252946
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0251336
PTPRF protein tyrosine phosphatase, receptor type, F 0.0251204
RPL7 ribosomal protein L7 0.0249567
RPL26 ribosomal protein L26 0.0247679
MYH14 myosin, heavy chain 14, non-muscle 0.0247332
RPL7A ribosomal protein L7a 0.0246775
S100A10 S100 calcium binding protein A10 0.0246757

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0776537
RNF43 ring finger protein 43 -0.0357146
CD36 CD36 molecule (thrombospondin receptor) -0.0348828
EGFR epidermal growth factor receptor -0.0337623
PDE4B phosphodiesterase 4B, cAMP-specific -0.0312901
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0312187
TOP1 topoisomerase (DNA) I -0.0300503
NT5DC3 5'-nucleotidase domain containing 3 -0.0215781
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0205979
EVA1C eva-1 homolog C (C. elegans) -0.0201179
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0185878
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0184244
PDE4D phosphodiesterase 4D, cAMP-specific -0.0183375
NAMPT nicotinamide phosphoribosyltransferase -0.0177919
COG5 component of oligomeric golgi complex 5 -0.0174281
YAP1 Yes-associated protein 1 -0.0173953
EXOC6B exocyst complex component 6B -0.0169645
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0168349
FHL2 four and a half LIM domains 2 -0.0168315
TXNRD1 thioredoxin reductase 1 -0.0168012
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0157504
FAM3C family with sequence similarity 3, member C -0.0155327
ATXN1 ataxin 1 -0.0152169
AVL9 AVL9 homolog (S. cerevisiase) -0.0151767
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0148783
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0146563
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0143357
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0138838
USP6NL USP6 N-terminal like -0.0137133
MON2 MON2 homolog (S. cerevisiae) -0.0131404
SEC24D SEC24 family member D -0.012906
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0126444
MTAP methylthioadenosine phosphorylase -0.012572
KIAA0040 KIAA0040 -0.0125686
SCLT1 sodium channel and clathrin linker 1 -0.0125336
VCL vinculin -0.0122138
RTN4 reticulon 4 -0.0119835
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0111317
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0109872
SAMD5 sterile alpha motif domain containing 5 -0.0108406
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0106523
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0105028
BTBD9 BTB (POZ) domain containing 9 -0.0104907
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0104051
ZMYM2 zinc finger, MYM-type 2 -0.0103429
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0102649
SDC4 syndecan 4 -0.0102334
STRN3 striatin, calmodulin binding protein 3 -0.01015
BMAL2 basic helix-loop-helix ARNT like 2 -0.0101154
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0100723
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.00992703
THSD4 thrombospondin, type I, domain containing 4 -0.00966218
ARL15 ADP-ribosylation factor-like 15 -0.00966008
KITLG KIT ligand -0.00961926
RPS24 ribosomal protein S24 -0.00959451
SMC5 structural maintenance of chromosomes 5 -0.00954972
UTRN utrophin -0.00954078
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.00951909
PTBP2 polypyrimidine tract binding protein 2 -0.00949019
TGIF1 TGFB-induced factor homeobox 1 -0.00946198
TENM3 teneurin transmembrane protein 3 -0.00943278
ZNF431 zinc finger protein 431 -0.00929417
CEP95 centrosomal protein 95kDa -0.00892491
KDM3A lysine (K)-specific demethylase 3A -0.00888553
JMJD1C jumonji domain containing 1C -0.00885802
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.00878456
TET3 tet methylcytosine dioxygenase 3 -0.00877687
TMEM62 transmembrane protein 62 -0.00877329
NT5E 5'-nucleotidase, ecto (CD73) -0.00865753
FRMD5 FERM domain containing 5 -0.00863728
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.00859187
FER fer (fps/fes related) tyrosine kinase -0.00848575
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.00839284
ZFR zinc finger RNA binding protein -0.0082879
NKTR natural killer cell triggering receptor -0.00828358
DUSP4 dual specificity phosphatase 4 -0.00820385
KLHL28 kelch-like family member 28 -0.00816901
KIFAP3 kinesin-associated protein 3 -0.00808198
CFAP73 cilia and flagella associated protein 73 -0.00807575
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.00807452
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.00801948
TMEM263 transmembrane protein 263 -0.00798358
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.00794122
MSI2 musashi RNA-binding protein 2 -0.00792281
ETV5 ets variant 5 -0.00790141
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -0.00785886
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.00780911
PNISR PNN-interacting serine/arginine-rich protein -0.00779978
TGFB2 transforming growth factor, beta 2 -0.0077734
CUL1 cullin 1 -0.00776782
SGO2 shugoshin 2 -0.0077246
FLOT1 flotillin 1 -0.00771435
H1-4 H1.4 linker histone, cluster member -0.00770431
GCC2 GRIP and coiled-coil domain containing 2 -0.0076965
WDPCP WD repeat containing planar cell polarity effector -0.00766635
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.00762585
FBXL17 F-box and leucine-rich repeat protein 17 -0.00761492
PRDM1 PR domain containing 1, with ZNF domain -0.00760209
FBXO34 F-box protein 34 -0.00757985
ATF6 activating transcription factor 6 -0.00753628