Cyclosporin A_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.111072
MYH9 myosin, heavy chain 9, non-muscle 0.0965828
EEF2 eukaryotic translation elongation factor 2 0.0928556
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0875934
KRT18 keratin 18, type I 0.081731
NKD1 naked cuticle homolog 1 (Drosophila) 0.0805
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0765295
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0749044
NAV2 neuron navigator 2 0.0728856
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0697043
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0689804
KRT8 keratin 8, type II 0.0685411
MACF1 microtubule-actin crosslinking factor 1 0.0657653
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.061858
ITGA6 integrin, alpha 6 0.0613433
EZR ezrin 0.0568505
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0562471
ANXA2 annexin A2 0.0530935
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0522637
ESYT2 extended synaptotagmin-like protein 2 0.0506061
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0499658
EFNB2 ephrin-B2 0.0465867
ITPRID2 ITPR interacting domain containing 2 0.0464999
NONO non-POU domain containing, octamer-binding 0.0455509
HDAC4 histone deacetylase 4 0.0427205
FLNB filamin B, beta 0.0419044
LMO7 LIM domain 7 0.041675
FLNA filamin A, alpha 0.040946
ANLN anillin, actin binding protein 0.0403799
DST dystonin 0.0400377
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0395786
PDGFA platelet-derived growth factor alpha polypeptide 0.0394147
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0393891
RPL3 ribosomal protein L3 0.0388902
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0386029
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0377175
USP9X ubiquitin specific peptidase 9, X-linked 0.0375953
AKAP12 A kinase (PRKA) anchor protein 12 0.037331
ASPH aspartate beta-hydroxylase 0.0367938
ERRFI1 ERBB receptor feedback inhibitor 1 0.0362192
CDH13 cadherin 13 0.0350717
SEPTIN9 septin 9 0.0350118
ACTN1 actinin, alpha 1 0.0348858
MED13 mediator complex subunit 13 0.0347932
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.034664
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0343405
BHLHE40 basic helix-loop-helix family, member e40 0.0342453
SPATA13 spermatogenesis associated 13 0.033969
HSPA8 heat shock 70kDa protein 8 0.0337023
MSN moesin 0.0323055
DSPP dentin sialophosphoprotein 0.0322911
CSNK1A1 casein kinase 1, alpha 1 0.0320424
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0317689
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0313072
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0303071
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0299747
ATXN1 ataxin 1 0.0296268
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0290543
BIRC6 baculoviral IAP repeat containing 6 0.0287799
UBA6 ubiquitin-like modifier activating enzyme 6 0.0285606
BCL2L1 BCL2-like 1 0.0284835
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0279068
ETNK1 ethanolamine kinase 1 0.0276176
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0275313
NUMA1 nuclear mitotic apparatus protein 1 0.0270564
EGR1 early growth response 1 0.0270454
TRIO trio Rho guanine nucleotide exchange factor 0.0269951
VMP1 vacuole membrane protein 1 0.0267799
HELZ helicase with zinc finger 0.0267194
EIF4B eukaryotic translation initiation factor 4B 0.026247
COPA coatomer protein complex, subunit alpha 0.0257453
FNIP1 folliculin interacting protein 1 0.025633
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0253672
KIZ kizuna centrosomal protein 0.025172
JAG1 jagged 1 0.0251628
NUP58 nucleoporin 58 0.0249896
TBC1D22A TBC1 domain family, member 22A 0.0249359
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0249147
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0249131
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0248382
MAML2 mastermind-like 2 (Drosophila) 0.0247284
SMAD3 SMAD family member 3 0.0245135
TPM3 tropomyosin 3 0.0243902
AFDN afadin, adherens junction formation factor 0.024224
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0242068
WNK1 WNK lysine deficient protein kinase 1 0.0242015
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.024144
SET SET nuclear proto-oncogene 0.0237522
SEC31A SEC31 homolog A (S. cerevisiae) 0.0237381
PRPF8 pre-mRNA processing factor 8 0.023683
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0234346
SETD5 SET domain containing 5 0.0232845
ANO1 anoctamin 1, calcium activated chloride channel 0.0231513
RAD23B RAD23 homolog B (S. cerevisiae) 0.0230224
USP34 ubiquitin specific peptidase 34 0.0229788
DSCAM Down syndrome cell adhesion molecule 0.0229752
AKAP13 A kinase (PRKA) anchor protein 13 0.0226477
KMT2C lysine (K)-specific methyltransferase 2C 0.0225931
RICTOR RPTOR independent companion of MTOR, complex 2 0.0225265
KMT2D lysine (K)-specific methyltransferase 2D 0.0224501

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152831
TMSB10 thymosin beta 10 -0.147767
RPL35A ribosomal protein L35a -0.139264
RPS6 ribosomal protein S6 -0.135897
TPT1 tumor protein, translationally-controlled 1 -0.12514
RPLP1 ribosomal protein, large, P1 -0.108404
RPS19 ribosomal protein S19 -0.0897112
RPLP2 ribosomal protein, large, P2 -0.0887378
PTMA prothymosin, alpha -0.0853042
RPS24 ribosomal protein S24 -0.0835141
MT2A metallothionein 2A -0.0755573
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0726143
RPL26 ribosomal protein L26 -0.0697012
RPL23 ribosomal protein L23 -0.0691558
RPL12 ribosomal protein L12 -0.0677691
RPS13 ribosomal protein S13 -0.0651609
RPS3 ribosomal protein S3 -0.0634797
RPS8 ribosomal protein S8 -0.0630378
RPL31 ribosomal protein L31 -0.0617288
RPL37A ribosomal protein L37a -0.0583141
RPL19 ribosomal protein L19 -0.056223
RPS23 ribosomal protein S23 -0.0535995
RPL32 ribosomal protein L32 -0.0530859
RPL9 ribosomal protein L9 -0.0518088
VIM vimentin -0.0516886
RPS27A ribosomal protein S27a -0.0516503
RPL5 ribosomal protein L5 -0.0494201
RPL11 ribosomal protein L11 -0.0489623
RPL34 ribosomal protein L34 -0.0472912
RPS25 ribosomal protein S25 -0.0471181
RPS21 ribosomal protein S21 -0.0469268
RPL36 ribosomal protein L36 -0.0462637
RPS29 ribosomal protein S29 -0.0460296
RPL36A ribosomal protein L36a -0.0454959
FTL ferritin, light polypeptide -0.0450119
RPL37 ribosomal protein L37 -0.042782
RPS12 ribosomal protein S12 -0.042225
RPS16 ribosomal protein S16 -0.0417129
RPL28 ribosomal protein L28 -0.0412307
RPS14 ribosomal protein S14 -0.0407503
RPL27A ribosomal protein L27a -0.0397594
RPS11 ribosomal protein S11 -0.0396476
RPL7A ribosomal protein L7a -0.0388114
RPL38 ribosomal protein L38 -0.037726
RPL13A ribosomal protein L13a -0.0375083
RPS4X ribosomal protein S4, X-linked -0.0367618
RPS20 ribosomal protein S20 -0.0358534
RPS5 ribosomal protein S5 -0.0355821
RPS15 ribosomal protein S15 -0.0351397
RPL35 ribosomal protein L35 -0.0350545
HMGB1 high mobility group box 1 -0.0342793
RPL7 ribosomal protein L7 -0.0302297
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0301265
RPL8 ribosomal protein L8 -0.0297644
RPS17 ribosomal protein S17 -0.0296685
RPL18 ribosomal protein L18 -0.0295091
MYL12B myosin, light chain 12B, regulatory -0.0282362
HMGA1 high mobility group AT-hook 1 -0.0278479
RPL27 ribosomal protein L27 -0.0266665
SOX4 SRY (sex determining region Y)-box 4 -0.0259271
EIF1 eukaryotic translation initiation factor 1 -0.0255622
DEK DEK proto-oncogene -0.0251257
EIF5B eukaryotic translation initiation factor 5B -0.0250712
RPL10A ribosomal protein L10a -0.0246659
IER3 immediate early response 3 -0.0246592
H3-3B H3.3 histone B -0.0242865
TUBA1B tubulin, alpha 1b -0.0241946
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0240447
NAP1L1 nucleosome assembly protein 1-like 1 -0.0235643
UBB ubiquitin B -0.0228954
S100A6 S100 calcium binding protein A6 -0.0227687
SMC4 structural maintenance of chromosomes 4 -0.0224655
GNAS GNAS complex locus -0.0223724
RPL30 ribosomal protein L30 -0.0223152
CCND1 cyclin D1 -0.0220932
RPS27 ribosomal protein S27 -0.0216585
RPL39 ribosomal protein L39 -0.0215322
PDE4D phosphodiesterase 4D, cAMP-specific -0.0215075
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0215051
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0210345
RPLP0 ribosomal protein, large, P0 -0.0210149
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0209769
ATP5F1E ATP synthase F1 subunit epsilon -0.0207049
ACTG1 actin gamma 1 -0.0204459
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0201652
SEC61G Sec61 gamma subunit -0.0197858
NACA nascent polypeptide-associated complex alpha subunit -0.0196149
ENO1 enolase 1, (alpha) -0.0195164
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0192729
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0192166
PFN1 profilin 1 -0.0190354
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0188585
RPS10 ribosomal protein S10 -0.0187081
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.018646
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0177167
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.017556
RPL4 ribosomal protein L4 -0.0174711
RBM25 RNA binding motif protein 25 -0.0172036
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0171884
RPL21 ribosomal protein L21 -0.0171588