Cyclosporin A_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cyclosporin A perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cyclosporin A_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.228607
MMP1 matrix metallopeptidase 1 0.109075
P4HB prolyl 4-hydroxylase, beta polypeptide 0.107008
STC1 stanniocalcin 1 0.104755
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0893729
VEGFA vascular endothelial growth factor A 0.0853174
B2M beta-2-microglobulin 0.0801338
COL6A3 collagen, type VI, alpha 3 0.0791665
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0742784
EEF2 eukaryotic translation elongation factor 2 0.0741485
ARHGAP21 Rho GTPase activating protein 21 0.0656361
CALR calreticulin 0.0627372
JARID2 jumonji, AT rich interactive domain 2 0.0592257
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.05562
RPS12 ribosomal protein S12 0.0509499
FAM13A family with sequence similarity 13, member A 0.0504959
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0493886
PRRC2C proline-rich coiled-coil 2C 0.0473606
NDRG1 N-myc downstream regulated 1 0.0464896
ANKRD11 ankyrin repeat domain 11 0.0446303
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0428179
RPL23 ribosomal protein L23 0.0427306
MYO10 myosin X 0.0423659
HLA-B major histocompatibility complex, class I, B 0.0421654
TRIO trio Rho guanine nucleotide exchange factor 0.0412652
PTMA prothymosin, alpha 0.040827
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0394716
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0378793
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0374299
SMTN smoothelin 0.0373463
YBX1 Y box binding protein 1 0.0363672
RPS19 ribosomal protein S19 0.0355556
PDIA3 protein disulfide isomerase family A, member 3 0.0354721
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.035211
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0348488
G0S2 G0/G1 switch 2 0.0332626
RPL3 ribosomal protein L3 0.0331261
DUSP10 dual specificity phosphatase 10 0.0325281
PLEC plectin 0.0323503
TNIP1 TNFAIP3 interacting protein 1 0.0321894
SRRM2 serine/arginine repetitive matrix 2 0.0310045
FLNA filamin A, alpha 0.0303016
NFE2L1 nuclear factor, erythroid 2-like 1 0.0302522
FMNL2 formin-like 2 0.0300075
PDIA6 protein disulfide isomerase family A, member 6 0.0298797
SPAG9 sperm associated antigen 9 0.0296963
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0294121
ACTG1 actin gamma 1 0.029012
AMPD3 adenosine monophosphate deaminase 3 0.028983
PICALM phosphatidylinositol binding clathrin assembly protein 0.0289808
HMGB2 high mobility group box 2 0.0289575
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0286822
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0284758
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0283528
NAV2 neuron navigator 2 0.0282612
NGLY1 N-glycanase 1 0.0281342
TPM3 tropomyosin 3 0.0280012
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0274294
RPL37A ribosomal protein L37a 0.0270321
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0268872
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0263624
AFF3 AF4/FMR2 family, member 3 0.0262539
TMED9 transmembrane emp24 protein transport domain containing 9 0.0258373
BCAR1 breast cancer anti-estrogen resistance 1 0.0256925
RPS8 ribosomal protein S8 0.0256055
INHBA inhibin, beta A 0.0253755
ARHGAP22 Rho GTPase activating protein 22 0.024634
NUP58 nucleoporin 58 0.0246054
FNDC3A fibronectin type III domain containing 3A 0.0244828
ADM adrenomedullin 0.0243816
TPM2 tropomyosin 2 (beta) 0.0242675
BHLHE40 basic helix-loop-helix family, member e40 0.0241396
RACK1 receptor for activated C kinase 1 0.0240905
UBA6 ubiquitin-like modifier activating enzyme 6 0.0240483
RPS10 ribosomal protein S10 0.0240314
RPS6 ribosomal protein S6 0.0237715
CTBP2 C-terminal binding protein 2 0.0232651
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.023223
RPS17 ribosomal protein S17 0.0228776
RPL36 ribosomal protein L36 0.0228088
STC2 stanniocalcin 2 0.0225114
APP amyloid beta (A4) precursor protein 0.0222329
RPS3 ribosomal protein S3 0.0221426
HELZ helicase with zinc finger 0.0220118
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0220003
WSB1 WD repeat and SOCS box containing 1 0.0218636
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0217079
ZMIZ1 zinc finger, MIZ-type containing 1 0.0215931
TMSB10 thymosin beta 10 0.0215545
RPL11 ribosomal protein L11 0.021548
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0215002
MMP12 matrix metallopeptidase 12 0.021417
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0213266
RAB8B RAB8B, member RAS oncogene family 0.0212515
MSN moesin 0.0212306
ZNF292 zinc finger protein 292 0.021054
PDE8A phosphodiesterase 8A 0.0204986
COPA coatomer protein complex, subunit alpha 0.0204643
CARS1 cysteinyl-tRNA synthetase 1 0.0203323
KTN1 kinectin 1 (kinesin receptor) 0.0202372

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.151866
ADGRB3 adhesion G protein-coupled receptor B3 -0.102849
COL1A1 collagen, type I, alpha 1 -0.0988652
NALF1 NALCN channel auxiliary factor 1 -0.0973112
COL1A2 collagen, type I, alpha 2 -0.0933356
FN1 fibronectin 1 -0.0706675
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0654069
VIM vimentin -0.0634122
EMP1 epithelial membrane protein 1 -0.0601064
EXT1 exostosin glycosyltransferase 1 -0.0532706
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0532421
OXR1 oxidation resistance 1 -0.0488578
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0482562
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0450852
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0438496
LOX lysyl oxidase -0.0437377
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0431594
VCL vinculin -0.0410381
FBN1 fibrillin 1 -0.0408234
LOXL2 lysyl oxidase-like 2 -0.0404058
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0398773
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0395717
RAI14 retinoic acid induced 14 -0.0383154
ZEB1 zinc finger E-box binding homeobox 1 -0.0366224
TPT1 tumor protein, translationally-controlled 1 -0.0362836
CAV1 caveolin 1, caveolae protein, 22kDa -0.0349946
CXCL8 chemokine (C-X-C motif) ligand 8 -0.034077
TPM4 tropomyosin 4 -0.0336933
GLIS3 GLIS family zinc finger 3 -0.0324024
COL4A2 collagen, type IV, alpha 2 -0.0319753
IER3 immediate early response 3 -0.0317525
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0311891
AHNAK AHNAK nucleoprotein -0.0304978
COL5A2 collagen, type V, alpha 2 -0.0297605
COL3A1 collagen, type III, alpha 1 -0.0295643
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0288618
TM4SF1 transmembrane 4 L six family member 1 -0.0286501
FRMD4A FERM domain containing 4A -0.0285291
ATP13A3 ATPase type 13A3 -0.0282381
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0278778
CD44 CD44 molecule (Indian blood group) -0.027256
CCND1 cyclin D1 -0.0270787
PRKG1 protein kinase, cGMP-dependent, type I -0.0265418
BZW1 basic leucine zipper and W2 domains 1 -0.0262661
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0257198
MAML2 mastermind-like 2 (Drosophila) -0.0253676
COL4A1 collagen, type IV, alpha 1 -0.0252791
ASPH aspartate beta-hydroxylase -0.0243979
RRBP1 ribosome binding protein 1 -0.0232849
MON2 MON2 homolog (S. cerevisiae) -0.023121
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.022717
PDE4D phosphodiesterase 4D, cAMP-specific -0.0226663
EGFR epidermal growth factor receptor -0.0224493
ARHGAP24 Rho GTPase activating protein 24 -0.0222886
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0221712
OSMR oncostatin M receptor -0.0219756
TTC3 tetratricopeptide repeat domain 3 -0.0219433
BBS9 Bardet-Biedl syndrome 9 -0.0218571
TMEM263 transmembrane protein 263 -0.0216118
SLIT2 slit homolog 2 (Drosophila) -0.0214088
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0213843
CCDC102B coiled-coil domain containing 102B -0.0206051
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0204158
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0203318
DIAPH2 diaphanous-related formin 2 -0.0198942
THBS2 thrombospondin 2 -0.0198861
MAP1B microtubule-associated protein 1B -0.0195396
ARF4 ADP-ribosylation factor 4 -0.019522
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0194426
RPS24 ribosomal protein S24 -0.0191644
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0191233
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0190452
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0187187
GCC2 GRIP and coiled-coil domain containing 2 -0.0186344
RPL27A ribosomal protein L27a -0.0184457
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0181955
SRGN serglycin -0.0181669
SUCO SUN domain containing ossification factor -0.0179389
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.017731
LMAN1 lectin, mannose-binding, 1 -0.0177293
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0177096
EBF1 early B-cell factor 1 -0.0176973
MBD5 methyl-CpG binding domain protein 5 -0.0175908
RTN4 reticulon 4 -0.0174306
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.017419
NSD3 nuclear receptor binding SET domain protein 3 -0.0173771
CDK6 cyclin-dependent kinase 6 -0.0173411
GREM1 gremlin 1, DAN family BMP antagonist -0.0171849
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0171204
CALD1 caldesmon 1 -0.0170405
PRRC1 proline-rich coiled-coil 1 -0.0169181
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0166996
GLG1 golgi glycoprotein 1 -0.0165734
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0163851
FBXL17 F-box and leucine-rich repeat protein 17 -0.0163723
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0163454
ATM ATM serine/threonine kinase -0.0163323
COL8A1 collagen, type VIII, alpha 1 -0.016297
BLZF1 basic leucine zipper nuclear factor 1 -0.0162599
CHSY1 chondroitin sulfate synthase 1 -0.0162555