Cysteamine (hydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.168388
MT1X metallothionein 1X 0.085074
PODXL podocalyxin-like 0.0798122
HLA-B major histocompatibility complex, class I, B 0.0755882
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0708029
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0668571
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0659103
MAP1B microtubule-associated protein 1B 0.0652921
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0623869
DCLK2 doublecortin-like kinase 2 0.0623193
CDH13 cadherin 13 0.0609209
MYADM myeloid-associated differentiation marker 0.0588434
SMC4 structural maintenance of chromosomes 4 0.0583055
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0565356
FLNB filamin B, beta 0.0565158
CD44 CD44 molecule (Indian blood group) 0.056359
TRIO trio Rho guanine nucleotide exchange factor 0.0561345
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0530594
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.0526941
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0526514
EGR1 early growth response 1 0.0516024
NAV1 neuron navigator 1 0.0502672
RTN4 reticulon 4 0.0490615
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0489638
SEPTIN9 septin 9 0.0484157
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0483555
ACTG1 actin gamma 1 0.0482904
CALU calumenin 0.0482505
C1D C1D nuclear receptor corepressor 0.0481484
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0478133
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0477189
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.0473346
COL5A1 collagen, type V, alpha 1 0.0453289
SH3KBP1 SH3-domain kinase binding protein 1 0.0443419
FSTL1 follistatin-like 1 0.044225
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0434604
HDAC9 histone deacetylase 9 0.0432301
LOC102724023 ES1 protein homolog, mitochondrial 0.0422743
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0417877
DOCK5 dedicator of cytokinesis 5 0.0413236
DLG1 discs, large homolog 1 (Drosophila) 0.0412336
BSG basigin (Ok blood group) 0.0411741
FTH1 ferritin, heavy polypeptide 1 0.0411445
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0410109
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0409686
TIMP2 TIMP metallopeptidase inhibitor 2 0.0403231
JMJD1C jumonji domain containing 1C 0.0397503
RABGAP1L RAB GTPase activating protein 1-like 0.0394016
GARS1 glycyl-tRNA synthetase 1 0.0387416
LOC112694756 uncharaterized LOC112694756 0.0379483
RNF213 ring finger protein 213 0.0379181
CAVIN1 caveolae associated protein 1 0.0378828
EGFR epidermal growth factor receptor 0.0377167
RPL28 ribosomal protein L28 0.0363858
SMAD3 SMAD family member 3 0.0359303
PFN1 profilin 1 0.0353425
RSAD2 radical S-adenosyl methionine domain containing 2 0.0352499
LENG8 leukocyte receptor cluster (LRC) member 8 0.0347169
GLIS3 GLIS family zinc finger 3 0.0345316
FLNA filamin A, alpha 0.0345084
SRRM2 serine/arginine repetitive matrix 2 0.0342753
EXT1 exostosin glycosyltransferase 1 0.0342256
ACTN4 actinin, alpha 4 0.0338468
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0338185
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0332307
CCDC88A coiled-coil domain containing 88A 0.0331142
DIAPH3 diaphanous-related formin 3 0.0330367
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0329897
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0325531
IFITM1 interferon induced transmembrane protein 1 0.0323151
PLD3 phospholipase D family, member 3 0.0322802
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0319569
PLXNA2 plexin A2 0.0316398
RBM25 RNA binding motif protein 25 0.0311541
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0311465
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0310169
CD59 CD59 molecule, complement regulatory protein 0.0309202
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0307445
LIMCH1 LIM and calponin homology domains 1 0.0306529
TM4SF1 transmembrane 4 L six family member 1 0.030639
AXL AXL receptor tyrosine kinase 0.0306175
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0303993
KIAA1549L KIAA1549-like 0.0303271
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0301951
EFNA5 ephrin-A5 0.0298744
ANKRD11 ankyrin repeat domain 11 0.0297132
PRRC2C proline-rich coiled-coil 2C 0.0294639
EEF2 eukaryotic translation elongation factor 2 0.0294586
APP amyloid beta (A4) precursor protein 0.0294575
NF1 neurofibromin 1 0.0294488
IFI16 interferon, gamma-inducible protein 16 0.0294057
EZR ezrin 0.0292302
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0292105
S100A4 S100 calcium binding protein A4 0.0291119
H1-10 H1.10 linker histone 0.0287764
BPTF bromodomain PHD finger transcription factor 0.028644
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0286089
EXOC6B exocyst complex component 6B 0.0285299
SPRED2 sprouty-related, EVH1 domain containing 2 0.0283248
RUNX1 runt-related transcription factor 1 0.0281088

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.270472
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.169103
FBN1 fibrillin 1 -0.142355
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.133652
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.114106
PTMA prothymosin, alpha -0.100522
AKAP12 A kinase (PRKA) anchor protein 12 -0.0979369
FNDC3B fibronectin type III domain containing 3B -0.0902612
PKM pyruvate kinase, muscle -0.0874797
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0768315
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.07478
COL5A2 collagen, type V, alpha 2 -0.0696395
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0680836
NDRG1 N-myc downstream regulated 1 -0.0650051
TMSB10 thymosin beta 10 -0.0643945
FTL ferritin, light polypeptide -0.0595873
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.058804
UBC ubiquitin C -0.0583217
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0568795
SQSTM1 sequestosome 1 -0.0548728
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.054824
SOD2 superoxide dismutase 2, mitochondrial -0.0541314
IGFBP3 insulin-like growth factor binding protein 3 -0.0535831
TNIP1 TNFAIP3 interacting protein 1 -0.0528638
COL3A1 collagen, type III, alpha 1 -0.0492736
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0452288
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0448431
DTNA dystrobrevin, alpha -0.04475
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0442528
AUTS2 autism susceptibility candidate 2 -0.0435178
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0433572
CCND1 cyclin D1 -0.0432755
S100A10 S100 calcium binding protein A10 -0.042897
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0426025
COL1A2 collagen, type I, alpha 2 -0.041782
MXI1 MAX interactor 1, dimerization protein -0.0398361
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0395914
GPC6 glypican 6 -0.0393595
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0393453
PGK1 phosphoglycerate kinase 1 -0.0390889
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0390834
CYLD cylindromatosis (turban tumor syndrome) -0.037952
SDK1 sidekick cell adhesion molecule 1 -0.0378395
ATP13A3 ATPase type 13A3 -0.037503
LDHA lactate dehydrogenase A -0.0369958
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0368951
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0366899
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0365517
UBQLN1 ubiquilin 1 -0.0364323
KDM3A lysine (K)-specific demethylase 3A -0.0353885
NAMPT nicotinamide phosphoribosyltransferase -0.0353747
MACF1 microtubule-actin crosslinking factor 1 -0.0348137
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0342661
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0330666
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0329162
KIAA1217 KIAA1217 -0.0324473
SBF2 SET binding factor 2 -0.0316974
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0310699
ANKRD10 ankyrin repeat domain 10 -0.030797
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0307956
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0301787
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0301426
RPS24 ribosomal protein S24 -0.030074
RPL31 ribosomal protein L31 -0.0300252
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0298299
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0292646
IL32 interleukin 32 -0.02924
NT5C2 5'-nucleotidase, cytosolic II -0.0290556
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0284833
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0283179
KIFAP3 kinesin-associated protein 3 -0.0282407
ADAR adenosine deaminase, RNA-specific -0.0276994
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0274018
E2F7 E2F transcription factor 7 -0.0273973
ZNF207 zinc finger protein 207 -0.0272201
ULK1 unc-51 like autophagy activating kinase 1 -0.0271896
CFLAR CASP8 and FADD-like apoptosis regulator -0.0268936
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.0268335
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0268314
GLS2 glutaminase 2 (liver, mitochondrial) -0.0266319
CLTC clathrin, heavy chain (Hc) -0.0264319
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -0.0262216
RPL35A ribosomal protein L35a -0.0261514
USP12 ubiquitin specific peptidase 12 -0.025932
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.025834
CANX calnexin -0.0252141
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0249516
FBXL7 F-box and leucine-rich repeat protein 7 -0.0249047
LRRC49 leucine rich repeat containing 49 -0.0248658
POTEF POTE ankyrin domain family, member F -0.024851
WTAP Wilms tumor 1 associated protein -0.0246462
AFF4 AF4/FMR2 family, member 4 -0.0245965
RAI14 retinoic acid induced 14 -0.0245641
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0245455
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.024121
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0240169
ADAM9 ADAM metallopeptidase domain 9 -0.0239313
AHNAK AHNAK nucleoprotein -0.0239229
ESYT2 extended synaptotagmin-like protein 2 -0.0235829
MMP12 matrix metallopeptidase 12 -0.0234361