Cysteamine (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.176522
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0943202
RPS19 ribosomal protein S19 0.0673201
ACTG1 actin gamma 1 0.0655972
EPAS1 endothelial PAS domain protein 1 0.0649424
POTEF POTE ankyrin domain family, member F 0.0648774
RPS6 ribosomal protein S6 0.0590877
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0529944
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.052919
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0517488
ZSWIM6 zinc finger, SWIM-type containing 6 0.0504225
FTL ferritin, light polypeptide 0.0481133
PDLIM5 PDZ and LIM domain 5 0.0476004
DOCK5 dedicator of cytokinesis 5 0.0467599
HMGA2 high mobility group AT-hook 2 0.0453632
ALCAM activated leukocyte cell adhesion molecule 0.045216
MT1X metallothionein 1X 0.0444034
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0415001
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0404459
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0400266
ARHGAP26 Rho GTPase activating protein 26 0.0388128
EGFR epidermal growth factor receptor 0.0384468
PFN1 profilin 1 0.0374979
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0363899
TGM2 transglutaminase 2 0.0358462
SLC35F3 solute carrier family 35, member F3 0.0356718
RHCG Rh family, C glycoprotein 0.034364
MCL1 myeloid cell leukemia 1 0.0336914
RPS8 ribosomal protein S8 0.0333249
RPL37A ribosomal protein L37a 0.033096
INTS6 integrator complex subunit 6 0.0323902
RPLP1 ribosomal protein, large, P1 0.0315381
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.031454
RPS3 ribosomal protein S3 0.0313741
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0311591
RPL28 ribosomal protein L28 0.0310352
MSN moesin 0.030956
DUSP5 dual specificity phosphatase 5 0.0309111
LIMCH1 LIM and calponin homology domains 1 0.0308262
STC1 stanniocalcin 1 0.0307026
EGR1 early growth response 1 0.0306957
VCL vinculin 0.03008
EXT1 exostosin glycosyltransferase 1 0.0292396
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0286949
VMP1 vacuole membrane protein 1 0.0285984
RPS29 ribosomal protein S29 0.0265553
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0257453
PCBP2 poly(rC) binding protein 2 0.0254288
AXL AXL receptor tyrosine kinase 0.0251446
BPTF bromodomain PHD finger transcription factor 0.0250141
RPL21 ribosomal protein L21 0.0248222
AADAC arylacetamide deacetylase 0.0247596
RPL36 ribosomal protein L36 0.0246272
SHB Src homology 2 domain containing adaptor protein B 0.0244922
SAMD4A sterile alpha motif domain containing 4A 0.0243003
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0240473
RPLP2 ribosomal protein, large, P2 0.0239569
BMP6 bone morphogenetic protein 6 0.0238484
NTN4 netrin 4 0.0234828
AKAP13 A kinase (PRKA) anchor protein 13 0.0234141
UBASH3B ubiquitin associated and SH3 domain containing B 0.0233475
SMAD3 SMAD family member 3 0.0222083
RPS13 ribosomal protein S13 0.0218135
RPL12 ribosomal protein L12 0.0216246
RPS12 ribosomal protein S12 0.0213463
RPL23 ribosomal protein L23 0.0208058
RPL27 ribosomal protein L27 0.0207769
RPS17 ribosomal protein S17 0.0207344
PABPC1 poly(A) binding protein, cytoplasmic 1 0.020552
RPL9 ribosomal protein L9 0.0201472
BRD2 bromodomain containing 2 0.0201318
LAMA5 laminin, alpha 5 0.0201073
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0200783
CCDC88A coiled-coil domain containing 88A 0.0200762
EIF1 eukaryotic translation initiation factor 1 0.0198633
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0196265
WWOX WW domain containing oxidoreductase 0.0195965
KYNU kynureninase 0.0194426
RPS16 ribosomal protein S16 0.0194142
RPL19 ribosomal protein L19 0.019394
GRAMD1B GRAM domain containing 1B 0.0193417
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0191546
MCTP1 multiple C2 domains, transmembrane 1 0.0190952
USP47 ubiquitin specific peptidase 47 0.018917
RPL7 ribosomal protein L7 0.0187889
SP100 SP100 nuclear antigen 0.0184343
RASAL2 RAS protein activator like 2 0.0182903
MEMO1 mediator of cell motility 1 0.0182724
RPS11 ribosomal protein S11 0.0182296
RPL7A ribosomal protein L7a 0.0178375
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.0177722
CDKL5 cyclin-dependent kinase-like 5 0.0176596
CCNL1 cyclin L1 0.0176224
RPL35A ribosomal protein L35a 0.0175921
SLC38A2 solute carrier family 38, member 2 0.0175096
NRIP1 nuclear receptor interacting protein 1 0.0173002
EEF1G eukaryotic translation elongation factor 1 gamma 0.0171707
MAML3 mastermind-like 3 (Drosophila) 0.0171158
EFNA5 ephrin-A5 0.0170207
RPL37 ribosomal protein L37 0.0169528

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.129498
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.100066
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0984803
IGFBP3 insulin-like growth factor binding protein 3 -0.0916702
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0855921
ANXA2 annexin A2 -0.0780585
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0775604
NAMPT nicotinamide phosphoribosyltransferase -0.0685097
AHNAK AHNAK nucleoprotein -0.0671249
RRBP1 ribosome binding protein 1 -0.064238
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0595092
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0593843
SPAG9 sperm associated antigen 9 -0.057409
USP3 ubiquitin specific peptidase 3 -0.0543319
KDM3A lysine (K)-specific demethylase 3A -0.0535239
TXNRD1 thioredoxin reductase 1 -0.0531843
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0501974
PGK1 phosphoglycerate kinase 1 -0.0486412
AKR1C2 aldo-keto reductase family 1, member C2 -0.0486097
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0458475
CA12 carbonic anhydrase XII -0.0454015
CANX calnexin -0.0450078
RAI14 retinoic acid induced 14 -0.0446333
NDRG1 N-myc downstream regulated 1 -0.0440224
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0435972
RBM39 RNA binding motif protein 39 -0.0423292
CEP95 centrosomal protein 95kDa -0.041952
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0412273
OGA O-GlcNAcase -0.0408479
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0407156
SOD2 superoxide dismutase 2, mitochondrial -0.0399692
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0397915
OSMR oncostatin M receptor -0.0393281
IGF1R insulin-like growth factor 1 receptor -0.039122
PDE10A phosphodiesterase 10A -0.0381175
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0373503
BHLHE40 basic helix-loop-helix family, member e40 -0.0361011
AHNAK2 AHNAK nucleoprotein 2 -0.0358014
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0357893
SBF2 SET binding factor 2 -0.0356804
TMSB4X thymosin beta 4, X-linked -0.0355607
BIRC6 baculoviral IAP repeat containing 6 -0.0339693
RPL4 ribosomal protein L4 -0.0339144
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0338842
KCTD9 potassium channel tetramerization domain containing 9 -0.0337614
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0332626
NGLY1 N-glycanase 1 -0.0326301
NCOA7 nuclear receptor coactivator 7 -0.0316537
S100A6 S100 calcium binding protein A6 -0.031589
DENND4C DENN/MADD domain containing 4C -0.0315449
AGFG1 ArfGAP with FG repeats 1 -0.0314225
KDM7A lysine (K)-specific demethylase 7A -0.0310938
HDLBP high density lipoprotein binding protein -0.0306686
NAP1L1 nucleosome assembly protein 1-like 1 -0.0305584
RAD21 RAD21 homolog (S. pombe) -0.0304152
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0301509
BZW1 basic leucine zipper and W2 domains 1 -0.0301104
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0299815
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0299579
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0298305
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.029671
SLC38A1 solute carrier family 38, member 1 -0.0295526
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0286795
HELZ helicase with zinc finger -0.0286322
AOPEP aminopeptidase O (putative) -0.0284194
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0283417
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0279933
FAM107B family with sequence similarity 107, member B -0.0279657
RNF213 ring finger protein 213 -0.0276644
JMJD1C jumonji domain containing 1C -0.027515
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0272938
TNS3 tensin 3 -0.0265543
USP9X ubiquitin specific peptidase 9, X-linked -0.0263721
TNIP1 TNFAIP3 interacting protein 1 -0.0261646
MARCHF6 membrane associated ring-CH-type finger 6 -0.0259175
VEZT vezatin, adherens junctions transmembrane protein -0.0258197
UBC ubiquitin C -0.0257711
ZFAND3 zinc finger, AN1-type domain 3 -0.0257157
GRB10 growth factor receptor-bound protein 10 -0.0255393
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0254617
APP amyloid beta (A4) precursor protein -0.0251069
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0250201
RAB1A RAB1A, member RAS oncogene family -0.025005
RAP1B RAP1B, member of RAS oncogene family -0.0242783
LAMB3 laminin, beta 3 -0.0240766
MACF1 microtubule-actin crosslinking factor 1 -0.0239059
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0235046
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0233773
ZNF292 zinc finger protein 292 -0.023308
DENND4A DENN/MADD domain containing 4A -0.0233046
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0230568
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0227333
CLTC clathrin, heavy chain (Hc) -0.0225617
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0225348
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0221364
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0220901
GARS1 glycyl-tRNA synthetase 1 -0.021991
MATR3 matrin 3 -0.0218651
FBXL2 F-box and leucine-rich repeat protein 2 -0.0217922
UBQLN1 ubiquilin 1 -0.0217825