Cysteamine (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.185095
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.123406
EGFR epidermal growth factor receptor 0.121722
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.113128
LAMB3 laminin, beta 3 0.112542
SACK1A scaffolding CK1 anchoring protein A 0.100262
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0976854
ZSWIM6 zinc finger, SWIM-type containing 6 0.0943563
FLNB filamin B, beta 0.0943115
EFNA5 ephrin-A5 0.09
EXT1 exostosin glycosyltransferase 1 0.0868408
ABTB3 ankyrin repeat and BTB domain containing 3 0.0854184
TGM2 transglutaminase 2 0.0849723
DOCK5 dedicator of cytokinesis 5 0.0784116
PPARD peroxisome proliferator-activated receptor delta 0.0781853
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0779604
HMGA2 high mobility group AT-hook 2 0.0741112
THSD4 thrombospondin, type I, domain containing 4 0.0725686
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0699877
FMNL2 formin-like 2 0.0686307
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0667389
GREB1L growth regulation by estrogen in breast cancer-like 0.0649953
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0627297
CLMP CXADR-like membrane protein 0.0607748
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0605719
MCL1 myeloid cell leukemia 1 0.0591708
RASAL2 RAS protein activator like 2 0.0585577
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0563797
MPRIP myosin phosphatase Rho interacting protein 0.0540948
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0536672
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0524721
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0521667
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0513926
TRRAP transformation/transcription domain-associated protein 0.0510236
GRB10 growth factor receptor-bound protein 10 0.0509396
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0487916
PMM2 phosphomannomutase 2 0.0481297
BMP6 bone morphogenetic protein 6 0.047233
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0460234
MAML2 mastermind-like 2 (Drosophila) 0.0452784
SLC35F3 solute carrier family 35, member F3 0.0450979
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0448853
LPP LIM domain containing preferred translocation partner in lipoma 0.0443491
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0430978
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0429859
PSD3 pleckstrin and Sec7 domain containing 3 0.0426636
NDRG1 N-myc downstream regulated 1 0.0425237
SVIL supervillin 0.0424329
APLP2 amyloid beta (A4) precursor-like protein 2 0.0409195
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0409171
PARD3 par-3 family cell polarity regulator 0.0404091
AKAP13 A kinase (PRKA) anchor protein 13 0.0396856
SMAD3 SMAD family member 3 0.0390292
HDAC9 histone deacetylase 9 0.038208
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0379634
EFNB2 ephrin-B2 0.0366531
ZHX2 zinc fingers and homeoboxes 2 0.0366382
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0358181
TRIO trio Rho guanine nucleotide exchange factor 0.0356054
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0349186
INTS6 integrator complex subunit 6 0.0347216
NRIP1 nuclear receptor interacting protein 1 0.0345623
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0340827
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0337611
PTK2 protein tyrosine kinase 2 0.0333881
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0333712
ZBTB20 zinc finger and BTB domain containing 20 0.0333132
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0325932
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.032593
FER fer (fps/fes related) tyrosine kinase 0.0325238
CD44 CD44 molecule (Indian blood group) 0.0321559
KLK10 kallikrein-related peptidase 10 0.0320534
RUNX1 runt-related transcription factor 1 0.0318764
SKAP2 src kinase associated phosphoprotein 2 0.0317797
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0316399
TM4SF1 transmembrane 4 L six family member 1 0.0311452
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0309598
ASPH aspartate beta-hydroxylase 0.0308986
AHRR aryl-hydrocarbon receptor repressor 0.0307157
LAMC2 laminin, gamma 2 0.0299153
ZCCHC7 zinc finger, CCHC domain containing 7 0.0299053
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0298296
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.029829
F3 coagulation factor III (thromboplastin, tissue factor) 0.0297128
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0296324
TRIP12 thyroid hormone receptor interactor 12 0.0295723
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0292163
DIAPH2 diaphanous-related formin 2 0.0291095
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0290633
HIPK2 homeodomain interacting protein kinase 2 0.0287627
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0285305
TGFA transforming growth factor, alpha 0.0285104
AK1 adenylate kinase 1 0.0284605
MSN moesin 0.0284545
ZFAND3 zinc finger, AN1-type domain 3 0.0282596
SAMD4A sterile alpha motif domain containing 4A 0.0278395
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0275836
TXNIP thioredoxin interacting protein 0.0272027
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0271239
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0271093

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.0668481
FTH1 ferritin, heavy polypeptide 1 -0.0610521
MUC17 mucin 17, cell surface associated -0.0579532
TMSB10 thymosin beta 10 -0.0496857
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0484399
PTPRR protein tyrosine phosphatase, receptor type, R -0.0477782
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0466068
VIM vimentin -0.0448644
LMTK2 lemur tyrosine kinase 2 -0.0447038
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0432907
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0396589
VCL vinculin -0.0394751
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0388959
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0380618
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0371267
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0357226
PTMA prothymosin, alpha -0.0327342
ITGA6 integrin, alpha 6 -0.0319317
EMP1 epithelial membrane protein 1 -0.0314023
NEK7 NIMA-related kinase 7 -0.0313789
FOSL1 FOS-like antigen 1 -0.0313295
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0303425
RTN4 reticulon 4 -0.0302379
CDH17 cadherin 17, LI cadherin (liver-intestine) -0.0298366
RAD21 RAD21 homolog (S. pombe) -0.0296889
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0293947
DSG2 desmoglein 2 -0.0288082
PLAUR plasminogen activator, urokinase receptor -0.0285857
LMO7 LIM domain 7 -0.0277502
ITGB4 integrin, beta 4 -0.0271609
ADAM9 ADAM metallopeptidase domain 9 -0.0268104
LDHA lactate dehydrogenase A -0.026032
S100A4 S100 calcium binding protein A4 -0.025945
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0258253
MYO6 myosin VI -0.0251496
NCOA3 nuclear receptor coactivator 3 -0.0250288
EPCAM epithelial cell adhesion molecule -0.0250079
S100A10 S100 calcium binding protein A10 -0.0246596
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0243624
OGA O-GlcNAcase -0.0233546
RBM39 RNA binding motif protein 39 -0.0231137
LOC112694756 uncharaterized LOC112694756 -0.0230804
TMEM41B transmembrane protein 41B -0.0228196
ANLN anillin, actin binding protein -0.0227312
TUFT1 tuftelin 1 -0.0226336
KCMF1 potassium channel modulatory factor 1 -0.0223819
EIF1 eukaryotic translation initiation factor 1 -0.0218637
PERP PERP, TP53 apoptosis effector -0.0217719
AKAP12 A kinase (PRKA) anchor protein 12 -0.0214817
CD2AP CD2-associated protein -0.0208418
ADAM17 ADAM metallopeptidase domain 17 -0.0206103
ARHGAP42 Rho GTPase activating protein 42 -0.0203371
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0202674
MYOF myoferlin -0.0200884
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0196494
ZNF292 zinc finger protein 292 -0.0195864
PON2 paraoxonase 2 -0.019516
CDC42SE2 CDC42 small effector 2 -0.0194646
GARS1 glycyl-tRNA synthetase 1 -0.0193818
VCAN versican -0.019167
CCNL1 cyclin L1 -0.0186667
FOXO3 forkhead box O3 -0.0183383
DSTN destrin (actin depolymerizing factor) -0.0182618
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0179509
MKI67 marker of proliferation Ki-67 -0.0178903
RBM25 RNA binding motif protein 25 -0.0177891
TOP1 topoisomerase (DNA) I -0.0173321
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0170594
RHEB Ras homolog enriched in brain -0.0169031
ARHGAP29 Rho GTPase activating protein 29 -0.0168969
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0168029
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.016797
CD164 CD164 molecule, sialomucin -0.0167734
BHLHE40 basic helix-loop-helix family, member e40 -0.0166202
NAMPT nicotinamide phosphoribosyltransferase -0.0164973
UBC ubiquitin C -0.0155288
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0154792
ANKRD10 ankyrin repeat domain 10 -0.0154768
MATR3 matrin 3 -0.0154332
RSRC2 arginine/serine-rich coiled-coil 2 -0.0154294
AHNAK AHNAK nucleoprotein -0.0154233
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0154189
PNISR PNN-interacting serine/arginine-rich protein -0.0149593
LYZ lysozyme -0.0149157
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.014649
OSBPL3 oxysterol binding protein-like 3 -0.0143904
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0143144
COL17A1 collagen, type XVII, alpha 1 -0.0142303
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.014083
TPM4 tropomyosin 4 -0.0139898
OPTN optineurin -0.0139729
S100A6 S100 calcium binding protein A6 -0.0138281
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0134679
NACA nascent polypeptide-associated complex alpha subunit -0.0133962
KRT18 keratin 18, type I -0.0133818
KMT2E lysine (K)-specific methyltransferase 2E -0.0133368
STAG2 stromal antigen 2 -0.0132911
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0131471
PDIA3 protein disulfide isomerase family A, member 3 -0.0130539
APAF1 apoptotic peptidase activating factor 1 -0.0130096