Cysteamine (hydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 0.133726
ACTG1 actin gamma 1 0.12391
PLAT plasminogen activator, tissue 0.122656
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.110562
RPS6 ribosomal protein S6 0.0936501
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0779675
TPT1 tumor protein, translationally-controlled 1 0.0679236
TPST1 tyrosylprotein sulfotransferase 1 0.0669212
AKAP12 A kinase (PRKA) anchor protein 12 0.0587504
RPS12 ribosomal protein S12 0.0526072
RPL27 ribosomal protein L27 0.0478615
ANTXR1 anthrax toxin receptor 1 0.0469049
B2M beta-2-microglobulin 0.0462641
BPTF bromodomain PHD finger transcription factor 0.0443943
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0440303
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0423695
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0421187
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0417357
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0411937
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0407204
HSPA8 heat shock 70kDa protein 8 0.0401323
SIK2 salt-inducible kinase 2 0.0393024
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0391008
TRIO trio Rho guanine nucleotide exchange factor 0.0388762
RPS2 ribosomal protein S2 0.038544
EEF2 eukaryotic translation elongation factor 2 0.0384527
RPL37A ribosomal protein L37a 0.0368429
EGR1 early growth response 1 0.0358199
FN1 fibronectin 1 0.0357451
CEMIP cell migration inducing protein, hyaluronan binding 0.035549
HLA-A major histocompatibility complex, class I, A 0.0348658
EIF1 eukaryotic translation initiation factor 1 0.0347005
H1-0 H1.0 linker histone 0.0337636
RPL19 ribosomal protein L19 0.0332839
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0331646
RPL23 ribosomal protein L23 0.0331262
COL6A1 collagen, type VI, alpha 1 0.0323849
SLC38A2 solute carrier family 38, member 2 0.0319572
RNF213 ring finger protein 213 0.0318181
SH3PXD2B SH3 and PX domains 2B 0.0317368
SET SET nuclear proto-oncogene 0.0314446
SRRM2 serine/arginine repetitive matrix 2 0.0313627
RPS8 ribosomal protein S8 0.0313062
VCL vinculin 0.0311421
ANKRD12 ankyrin repeat domain 12 0.0305132
BCAS3 breast carcinoma amplified sequence 3 0.0297051
SMAD3 SMAD family member 3 0.0294245
GAB2 GRB2-associated binding protein 2 0.0291815
NPAS2 neuronal PAS domain protein 2 0.0289762
PCBP3 poly(rC) binding protein 3 0.0286065
PTPRE protein tyrosine phosphatase, receptor type, E 0.0284816
COL4A2 collagen, type IV, alpha 2 0.028412
NCOR2 nuclear receptor corepressor 2 0.0283134
BRD2 bromodomain containing 2 0.0281365
RPL11 ribosomal protein L11 0.0280564
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0278572
ZMIZ1 zinc finger, MIZ-type containing 1 0.0277883
MEF2D myocyte enhancer factor 2D 0.0277769
PSD3 pleckstrin and Sec7 domain containing 3 0.0276347
RPL26 ribosomal protein L26 0.0275486
KLF6 Kruppel-like factor 6 0.0275112
RPL37 ribosomal protein L37 0.0267574
PDE10A phosphodiesterase 10A 0.0264132
KLHL13 kelch-like family member 13 0.0262314
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0261022
RPL36A ribosomal protein L36a 0.0260954
RPL7A ribosomal protein L7a 0.0260741
COL4A1 collagen, type IV, alpha 1 0.0258829
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0257929
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0255981
AMOTL1 angiomotin like 1 0.0252974
PLPP1 phospholipid phosphatase 1 0.0252909
LIMS1 LIM and senescent cell antigen-like domains 1 0.0252852
MT2A metallothionein 2A 0.0251477
RPL12 ribosomal protein L12 0.0250796
FMN1 formin 1 0.0250408
MTREX Mtr4 exosome RNA helicase 0.0250312
COL6A2 collagen, type VI, alpha 2 0.0250256
GPBP1 GC-rich promoter binding protein 1 0.0248746
VMP1 vacuole membrane protein 1 0.0248568
ARHGAP9 Rho GTPase activating protein 9 0.0248473
PTEN phosphatase and tensin homolog 0.0243424
SSH1 slingshot protein phosphatase 1 0.0241548
RPS27A ribosomal protein S27a 0.0236828
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0233564
RPL8 ribosomal protein L8 0.0229725
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0229669
RPL30 ribosomal protein L30 0.022816
NFE2L1 nuclear factor, erythroid 2-like 1 0.0226541
MRTFA myocardin related transcription factor A 0.0224522
NRIP1 nuclear receptor interacting protein 1 0.022425
CTSB cathepsin B 0.0222553
AKAP9 A kinase (PRKA) anchor protein 9 0.0219921
SYTL3 synaptotagmin-like 3 0.0219174
TIMP2 TIMP metallopeptidase inhibitor 2 0.0218635
CD44 CD44 molecule (Indian blood group) 0.0217311
HDAC8 histone deacetylase 8 0.0214927
ACTN1 actinin, alpha 1 0.0213743
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0211425
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0210783

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.502965
IGF2 insulin-like growth factor 2 -0.12757
PTMA prothymosin, alpha -0.0938594
KDM3A lysine (K)-specific demethylase 3A -0.0782882
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0676559
VIM vimentin -0.0655152
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0614997
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0598434
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0563136
NPEPPS aminopeptidase puromycin sensitive -0.052188
FAM13A family with sequence similarity 13, member A -0.051428
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0492068
WDR45B WD repeat domain 45B -0.0479576
NALF1 NALCN channel auxiliary factor 1 -0.0473719
CANX calnexin -0.045491
NDRG1 N-myc downstream regulated 1 -0.0448663
COL3A1 collagen, type III, alpha 1 -0.0446858
HELZ helicase with zinc finger -0.0427006
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0425437
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0417396
NAMPT nicotinamide phosphoribosyltransferase -0.0403387
MSI2 musashi RNA-binding protein 2 -0.0392627
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0387046
LSAMP limbic system-associated membrane protein -0.0371687
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0370136
GLG1 golgi glycoprotein 1 -0.0364434
DTNA dystrobrevin, alpha -0.0363021
PTK2 protein tyrosine kinase 2 -0.0362084
TMSB10 thymosin beta 10 -0.0356079
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0355504
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.034421
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.034367
PKM pyruvate kinase, muscle -0.0342078
PUM2 pumilio RNA-binding family member 2 -0.0335953
CCND1 cyclin D1 -0.0331786
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0331039
USP3 ubiquitin specific peptidase 3 -0.0329712
SCG2 secretogranin II -0.0328857
ZNF804A zinc finger protein 804A -0.0327519
PLCB4 phospholipase C, beta 4 -0.0324343
UNC5C unc-5 homolog C (C. elegans) -0.0323097
LCORL ligand dependent nuclear receptor corepressor-like -0.0323065
CDC27 cell division cycle 27 -0.031926
HILPDA hypoxia inducible lipid droplet-associated -0.0315616
MXI1 MAX interactor 1, dimerization protein -0.0311236
MBNL2 muscleblind-like splicing regulator 2 -0.0307927
ERRFI1 ERBB receptor feedback inhibitor 1 -0.03055
DACH2 dachshund family transcription factor 2 -0.030377
WSB1 WD repeat and SOCS box containing 1 -0.0295845
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0294534
NREP neuronal regeneration related protein -0.0293056
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0292752
AHNAK AHNAK nucleoprotein -0.0291896
GATAD2B GATA zinc finger domain containing 2B -0.0290892
TMEM131 transmembrane protein 131 -0.0288655
NCAM2 neural cell adhesion molecule 2 -0.0288384
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0286851
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0286708
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0283162
SPAG9 sperm associated antigen 9 -0.0281453
RBM39 RNA binding motif protein 39 -0.0281083
TRIB2 tribbles pseudokinase 2 -0.0270985
TAS2R14 taste receptor, type 2, member 14 -0.0269423
HMGB2 high mobility group box 2 -0.026751
TMEM123 transmembrane protein 123 -0.0266742
KCNIP4 Kv channel interacting protein 4 -0.0266362
RYBP RING1 and YY1 binding protein -0.026437
NPR2 natriuretic peptide receptor 2 -0.0262533
EXT1 exostosin glycosyltransferase 1 -0.0262167
ZNF207 zinc finger protein 207 -0.0261507
FNDC3B fibronectin type III domain containing 3B -0.0260111
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0259397
ZMYM2 zinc finger, MYM-type 2 -0.0258933
AOPEP aminopeptidase O (putative) -0.0256557
PRKCA protein kinase C, alpha -0.0256478
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.025626
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -0.0255856
GRB2 growth factor receptor-bound protein 2 -0.0255239
KMT2E lysine (K)-specific methyltransferase 2E -0.0254297
ZNF292 zinc finger protein 292 -0.0253748
CUX1 cut-like homeobox 1 -0.025109
CADM2 cell adhesion molecule 2 -0.0249311
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0248796
KLHL24 kelch-like family member 24 -0.0248748
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.024802
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0247946
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0246165
IGFBP3 insulin-like growth factor binding protein 3 -0.0244177
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0242491
SETD5 SET domain containing 5 -0.0241617
CLINT1 clathrin interactor 1 -0.0241558
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0240773
CDH13 cadherin 13 -0.0240754
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0239255
ZC3H15 zinc finger CCCH-type containing 15 -0.0238618
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0238251
MATR3 matrin 3 -0.0238033
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0237684
CCDC47 coiled-coil domain containing 47 -0.0230639
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0230193