Cysteamine (hydrochloride)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.194227
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.109564
NALF1 NALCN channel auxiliary factor 1 0.107877
HLA-B major histocompatibility complex, class I, B 0.1037
MT2A metallothionein 2A 0.101878
IGFBP3 insulin-like growth factor binding protein 3 0.0895983
TGFBI transforming growth factor, beta-induced, 68kDa 0.0768132
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.073976
B2M beta-2-microglobulin 0.0680979
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0579478
HLA-A major histocompatibility complex, class I, A 0.055571
VIM vimentin 0.0456541
FN1 fibronectin 1 0.0432466
CD44 CD44 molecule (Indian blood group) 0.0420075
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0386949
PRSS23 protease, serine, 23 0.0361907
EGR1 early growth response 1 0.0358936
SDC4 syndecan 4 0.0347215
TIMP3 TIMP metallopeptidase inhibitor 3 0.0337726
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0332739
RPS8 ribosomal protein S8 0.0318127
TPT1 tumor protein, translationally-controlled 1 0.0305087
GRB10 growth factor receptor-bound protein 10 0.0304028
NAV1 neuron navigator 1 0.0301762
SFTPA2 surfactant protein A2 0.0296376
CALD1 caldesmon 1 0.0284455
AKAP12 A kinase (PRKA) anchor protein 12 0.0283248
ENO2 enolase 2 (gamma, neuronal) 0.0268652
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.026698
RPL37A ribosomal protein L37a 0.0242013
CLMP CXADR-like membrane protein 0.0241271
COL6A2 collagen, type VI, alpha 2 0.0238416
MT1X metallothionein 1X 0.0236465
RPL37 ribosomal protein L37 0.0232204
TIMP1 TIMP metallopeptidase inhibitor 1 0.0222575
IGFBP5 insulin-like growth factor binding protein 5 0.0220625
MYLK myosin light chain kinase 0.0215217
RPS6 ribosomal protein S6 0.0214242
ACTG1 actin gamma 1 0.0213724
TTC17 tetratricopeptide repeat domain 17 0.0211458
VCL vinculin 0.0202955
GANAB glucosidase, alpha; neutral AB 0.0202797
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0202407
CD59 CD59 molecule, complement regulatory protein 0.019968
NPAS2 neuronal PAS domain protein 2 0.0196938
RPS3 ribosomal protein S3 0.0195709
RPS12 ribosomal protein S12 0.0194406
HLA-C major histocompatibility complex, class I, C 0.0192673
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0191464
RPL9 ribosomal protein L9 0.0190292
VEGFC vascular endothelial growth factor C 0.0189324
OSMR oncostatin M receptor 0.0182527
HIPK2 homeodomain interacting protein kinase 2 0.0178221
SLC38A2 solute carrier family 38, member 2 0.0177052
COL5A1 collagen, type V, alpha 1 0.0176497
PLEC plectin 0.0176173
CSNK1A1 casein kinase 1, alpha 1 0.0172258
RPS13 ribosomal protein S13 0.016833
RPL28 ribosomal protein L28 0.0167533
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0166453
COL6A1 collagen, type VI, alpha 1 0.0166033
VEGFA vascular endothelial growth factor A 0.016444
PSD3 pleckstrin and Sec7 domain containing 3 0.0163991
DOCK5 dedicator of cytokinesis 5 0.016344
ECE1 endothelin converting enzyme 1 0.0163264
C1S complement component 1, s subcomponent 0.0161371
CTSB cathepsin B 0.0161217
RPL11 ribosomal protein L11 0.0160875
ENO1 enolase 1, (alpha) 0.0160463
RPLP0 ribosomal protein, large, P0 0.0158236
RPL8 ribosomal protein L8 0.0158231
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0157742
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0156806
FGF13 fibroblast growth factor 13 0.0155695
C3 complement component 3 0.0155618
RPLP2 ribosomal protein, large, P2 0.0155251
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0155133
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0152192
LENG8 leukocyte receptor cluster (LRC) member 8 0.015198
HMGA1 high mobility group AT-hook 1 0.0151264
AGRN agrin 0.0151163
KYNU kynureninase 0.015043
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0149981
ITGB5 integrin, beta 5 0.0149754
RPL23 ribosomal protein L23 0.014971
OASL 2'-5'-oligoadenylate synthetase-like 0.0149654
EXT1 exostosin glycosyltransferase 1 0.0149218
DSTN destrin (actin depolymerizing factor) 0.0148746
KDM4B lysine (K)-specific demethylase 4B 0.0148139
POTEF POTE ankyrin domain family, member F 0.0146897
JUN jun proto-oncogene 0.0146761
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0143471
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0142953
AJAP1 adherens junctions associated protein 1 0.0142691
PFN1 profilin 1 0.0141301
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.014005
TAPBP TAP binding protein (tapasin) 0.0139774
WARS1 tryptophanyl-tRNA synthetase 1 0.0139619
EGFR epidermal growth factor receptor 0.0138651
MRC2 mannose receptor, C type 2 0.0137966

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.13576
FTL ferritin, light polypeptide -0.077164
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.072155
NAMPT nicotinamide phosphoribosyltransferase -0.0704057
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0680277
CANX calnexin -0.0639667
NDRG1 N-myc downstream regulated 1 -0.0625294
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0484743
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.048221
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0393893
PKM pyruvate kinase, muscle -0.0371462
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0359491
AVL9 AVL9 homolog (S. cerevisiase) -0.035051
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0332652
FNDC3B fibronectin type III domain containing 3B -0.0329712
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0320918
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0309924
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0283393
TMSB10 thymosin beta 10 -0.0277668
RTN4 reticulon 4 -0.0274596
SBF2 SET binding factor 2 -0.0274013
ATP13A3 ATPase type 13A3 -0.0272756
COPB1 coatomer protein complex, subunit beta 1 -0.0272152
CENPF centromere protein F, 350/400kDa -0.026784
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0263503
LCORL ligand dependent nuclear receptor corepressor-like -0.026333
TXNIP thioredoxin interacting protein -0.0261038
LMAN1 lectin, mannose-binding, 1 -0.0258698
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0257678
ANLN anillin, actin binding protein -0.0257627
NIPBL Nipped-B homolog (Drosophila) -0.0257261
GLG1 golgi glycoprotein 1 -0.0256435
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0256379
CLTC clathrin, heavy chain (Hc) -0.0250925
TXNRD1 thioredoxin reductase 1 -0.0245132
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0244283
LRRC49 leucine rich repeat containing 49 -0.0242727
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0242703
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0241936
RBM39 RNA binding motif protein 39 -0.0240024
NF1 neurofibromin 1 -0.0237595
KMT2E lysine (K)-specific methyltransferase 2E -0.0237595
KDM3A lysine (K)-specific demethylase 3A -0.0236762
AHNAK AHNAK nucleoprotein -0.0235059
RRBP1 ribosome binding protein 1 -0.0233403
MXI1 MAX interactor 1, dimerization protein -0.0228346
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0227577
FAM13A family with sequence similarity 13, member A -0.0226449
ZBTB20 zinc finger and BTB domain containing 20 -0.0225561
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0225129
TRA2A transformer 2 alpha homolog (Drosophila) -0.0223267
HELZ helicase with zinc finger -0.0221808
PTMA prothymosin, alpha -0.0220214
MORF4L2 mortality factor 4 like 2 -0.0217173
LDHA lactate dehydrogenase A -0.0214547
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0214088
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0214035
SEPTIN7 septin 7 -0.0212722
ADAM17 ADAM metallopeptidase domain 17 -0.020956
RARS1 arginyl-tRNA synthetase 1 -0.020866
PHF21A PHD finger protein 21A -0.0207508
COG5 component of oligomeric golgi complex 5 -0.0207164
MARCHF6 membrane associated ring-CH-type finger 6 -0.0203765
SEC24D SEC24 family member D -0.020282
RNF216 ring finger protein 216 -0.0202808
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0201625
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0200667
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0200552
BRWD3 bromodomain and WD repeat domain containing 3 -0.0200136
NAV2 neuron navigator 2 -0.0200057
GOLGB1 golgin B1 -0.0199608
ELL2 elongation factor, RNA polymerase II, 2 -0.0197804
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.019304
INSIG2 insulin induced gene 2 -0.0192349
PRELID2 PRELI domain containing 2 -0.0192044
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0191239
MSN moesin -0.019123
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0191117
STC1 stanniocalcin 1 -0.0191062
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0190572
ZNF451 zinc finger protein 451 -0.0190512
TNIP1 TNFAIP3 interacting protein 1 -0.0190417
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0189891
SUCO SUN domain containing ossification factor -0.0189624
STK17A serine/threonine kinase 17a -0.0189617
ZNF395 zinc finger protein 395 -0.018597
MKI67 marker of proliferation Ki-67 -0.0185087
CHD1 chromodomain helicase DNA binding protein 1 -0.0184743
ZNF292 zinc finger protein 292 -0.0184379
AFF4 AF4/FMR2 family, member 4 -0.0184373
SEC24A SEC24 family member A -0.0182813
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0182476
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0182213
CLINT1 clathrin interactor 1 -0.0181456
XPO1 exportin 1 -0.0181426
RLF rearranged L-myc fusion -0.0181302
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0181086
POM121C POM121 transmembrane nucleoporin C -0.0179489
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.017948
MATR3 matrin 3 -0.0176057