Cysteamine (hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.0897303
KRT20 keratin 20, type I 0.0849417
LOC102724023 ES1 protein homolog, mitochondrial 0.0831488
MYH14 myosin, heavy chain 14, non-muscle 0.0756883
EXT1 exostosin glycosyltransferase 1 0.0726251
LMO7 LIM domain 7 0.0722343
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0683219
FRY furry homolog (Drosophila) 0.0664726
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0625344
RPS6 ribosomal protein S6 0.0596355
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0536605
TMC5 transmembrane channel-like 5 0.0526095
EGR1 early growth response 1 0.0499139
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0494963
ITPKC inositol-trisphosphate 3-kinase C 0.0451734
PRKN parkin RBR E3 ubiquitin protein ligase 0.0450903
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0427043
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0411688
TRIB1 tribbles pseudokinase 1 0.0409637
PDLIM5 PDZ and LIM domain 5 0.0403276
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0395205
ZSWIM6 zinc finger, SWIM-type containing 6 0.0388876
AFF1 AF4/FMR2 family, member 1 0.0385832
EZR ezrin 0.0384115
TJP1 tight junction protein 1 0.0378714
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0377882
SMAD3 SMAD family member 3 0.0365999
TPT1 tumor protein, translationally-controlled 1 0.0363244
NCEH1 neutral cholesterol ester hydrolase 1 0.0362799
EXPH5 exophilin 5 0.0357511
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.034355
ERRFI1 ERBB receptor feedback inhibitor 1 0.0326976
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0320702
NEBL nebulette 0.0319805
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0315877
FNDC3B fibronectin type III domain containing 3B 0.0314495
ATXN1 ataxin 1 0.0311261
VEGFA vascular endothelial growth factor A 0.0309635
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0289526
SRRM2 serine/arginine repetitive matrix 2 0.0284038
INTS6 integrator complex subunit 6 0.028155
NCOR2 nuclear receptor corepressor 2 0.0280885
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0278639
PGCKA1 PDCD10 and GCKIII kinases associated 1 0.027483
TRAPPC9 trafficking protein particle complex 9 0.0273489
PPARD peroxisome proliferator-activated receptor delta 0.0272135
HKDC1 hexokinase domain containing 1 0.0265293
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.026268
BAIAP2L1 BAI1-associated protein 2-like 1 0.0262221
MCL1 myeloid cell leukemia 1 0.0261421
PDE4D phosphodiesterase 4D, cAMP-specific 0.0258713
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0257428
RNF213 ring finger protein 213 0.025674
GOLGB1 golgin B1 0.0256682
PTPRK protein tyrosine phosphatase, receptor type, K 0.0255226
ACTG1 actin gamma 1 0.0253514
FHL2 four and a half LIM domains 2 0.0253023
FBXO11 F-box protein 11 0.025301
APLP2 amyloid beta (A4) precursor-like protein 2 0.0250679
PELI1 pellino E3 ubiquitin protein ligase 1 0.0249469
N4BP2L2 NEDD4 binding protein 2-like 2 0.0241785
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0239991
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0237696
SIK3 SIK family kinase 3 0.0236288
FOXP1 forkhead box P1 0.022792
MACC1 metastasis associated in colon cancer 1 0.0227195
SGMS2 sphingomyelin synthase 2 0.0224766
TLE4 transducin-like enhancer of split 4 0.0213686
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.021032
GCLC glutamate-cysteine ligase, catalytic subunit 0.0209115
CUX1 cut-like homeobox 1 0.0209028
RPL13A ribosomal protein L13a 0.0206324
OCLN occludin 0.0205604
JMJD1C jumonji domain containing 1C 0.0205016
EPS8 epidermal growth factor receptor pathway substrate 8 0.0204339
CYSTM1 cysteine-rich transmembrane module containing 1 0.020165
EMP1 epithelial membrane protein 1 0.0200143
MARCHF3 membrane associated ring-CH-type finger 3 0.0197761
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0196531
ATF3 activating transcription factor 3 0.0193646
TNS1 tensin 1 0.0193
KLK10 kallikrein-related peptidase 10 0.0192496
RPS12 ribosomal protein S12 0.0191257
LCN2 lipocalin 2 0.0189849
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.018963
JUN jun proto-oncogene 0.0188528
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0186803
RND3 Rho family GTPase 3 0.0182254
LARP1B La ribonucleoprotein domain family, member 1B 0.0178644
LIMCH1 LIM and calponin homology domains 1 0.0178221
POF1B premature ovarian failure, 1B 0.0177171
NTN4 netrin 4 0.0174715
ADIPOR2 adiponectin receptor 2 0.0173948
CLDN4 claudin 4 0.0173556
LIPH lipase, member H 0.017339
B2M beta-2-microglobulin 0.0173212
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0172002
CCNYL1 cyclin Y-like 1 0.0171554
MPHOSPH8 M-phase phosphoprotein 8 0.0169547
SOX4 SRY (sex determining region Y)-box 4 0.016946

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.0940671
LYZ lysozyme -0.0881056
FTL ferritin, light polypeptide -0.0704469
TXNRD1 thioredoxin reductase 1 -0.0685509
RAD21 RAD21 homolog (S. pombe) -0.0569137
SLC45A4 solute carrier family 45, member 4 -0.0557201
LDHA lactate dehydrogenase A -0.0504563
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0460865
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0458824
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0441275
GARS1 glycyl-tRNA synthetase 1 -0.043947
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0426533
KMT2C lysine (K)-specific methyltransferase 2C -0.039475
MKI67 marker of proliferation Ki-67 -0.0390154
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0389903
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0383403
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0372754
NF1 neurofibromin 1 -0.0368259
USP3 ubiquitin specific peptidase 3 -0.0365297
KDM3A lysine (K)-specific demethylase 3A -0.0362431
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0361346
PTK2 protein tyrosine kinase 2 -0.0359557
BIRC6 baculoviral IAP repeat containing 6 -0.0359468
CENPF centromere protein F, 350/400kDa -0.0346175
GOLGA4 golgin A4 -0.0342169
COG5 component of oligomeric golgi complex 5 -0.0341383
PTMA prothymosin, alpha -0.0340745
WWC1 WW and C2 domain containing 1 -0.032455
ANLN anillin, actin binding protein -0.0319937
RPL19 ribosomal protein L19 -0.0319206
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0318756
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0317512
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0316273
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0315159
RPS24 ribosomal protein S24 -0.0313533
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0313192
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0309868
OGA O-GlcNAcase -0.0304564
ZMYM2 zinc finger, MYM-type 2 -0.0301262
NBEAL1 neurobeachin-like 1 -0.0301225
EPCAM epithelial cell adhesion molecule -0.0300972
TMEM123 transmembrane protein 123 -0.028884
ABLIM1 actin binding LIM protein 1 -0.0288248
CLTC clathrin, heavy chain (Hc) -0.0288112
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.028608
TFRC transferrin receptor -0.0279201
SQSTM1 sequestosome 1 -0.0273901
CD164 CD164 molecule, sialomucin -0.0269529
NIPBL Nipped-B homolog (Drosophila) -0.0265184
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0264327
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0263055
PTBP3 polypyrimidine tract binding protein 3 -0.0261023
RPLP0 ribosomal protein, large, P0 -0.0261013
RPL12 ribosomal protein L12 -0.0256804
PUM2 pumilio RNA-binding family member 2 -0.0256391
CKAP2 cytoskeleton associated protein 2 -0.0256331
MARCHF6 membrane associated ring-CH-type finger 6 -0.0256301
YBX1 Y box binding protein 1 -0.0252033
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0251893
XPO1 exportin 1 -0.0250563
PYGB phosphorylase, glycogen; brain -0.0248001
HMGA1 high mobility group AT-hook 1 -0.0245687
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.024451
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0240445
PGK1 phosphoglycerate kinase 1 -0.0240229
PRRC2C proline-rich coiled-coil 2C -0.0235652
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0234858
PERP PERP, TP53 apoptosis effector -0.0232585
UBE2K ubiquitin-conjugating enzyme E2K -0.0231055
RPL18 ribosomal protein L18 -0.0229728
MMP7 matrix metallopeptidase 7 -0.0226087
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0225524
TPI1 triosephosphate isomerase 1 -0.0225231
TM9SF3 transmembrane 9 superfamily member 3 -0.0222809
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0222772
SMC4 structural maintenance of chromosomes 4 -0.0219805
S100A10 S100 calcium binding protein A10 -0.0219767
NUSAP1 nucleolar and spindle associated protein 1 -0.0219319
PICALM phosphatidylinositol binding clathrin assembly protein -0.0219153
TPX2 TPX2, microtubule-associated -0.0211623
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0211521
CALR calreticulin -0.0210161
RPS21 ribosomal protein S21 -0.0209734
FAM135A family with sequence similarity 135, member A -0.0208272
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0208001
KRT8 keratin 8, type II -0.0206354
KIAA0232 KIAA0232 -0.0204569
LNX2 ligand of numb-protein X 2 -0.0204091
NAP1L1 nucleosome assembly protein 1-like 1 -0.0203872
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0203206
RBM39 RNA binding motif protein 39 -0.0202847
PNISR PNN-interacting serine/arginine-rich protein -0.0201382
CKAP5 cytoskeleton associated protein 5 -0.0201226
DLG1 discs, large homolog 1 (Drosophila) -0.0201173
NCOR1 nuclear receptor corepressor 1 -0.0200934
NFIA nuclear factor I/A -0.0200934
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0200208
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0199418
RAB10 RAB10, member RAS oncogene family -0.0198586
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0198353