Cysteamine (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.385089
FTH1 ferritin, heavy polypeptide 1 0.096442
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0889097
SAMD4A sterile alpha motif domain containing 4A 0.0819746
MT2A metallothionein 2A 0.0815809
TPT1 tumor protein, translationally-controlled 1 0.0787902
MCL1 myeloid cell leukemia 1 0.0620719
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0566797
SMAD3 SMAD family member 3 0.0550013
RPS3 ribosomal protein S3 0.0534648
RPS8 ribosomal protein S8 0.0493189
EXT1 exostosin glycosyltransferase 1 0.0483753
RPLP0 ribosomal protein, large, P0 0.0480208
PTMA prothymosin, alpha 0.0435032
RPL37A ribosomal protein L37a 0.0427746
EGFR epidermal growth factor receptor 0.0423843
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.042376
FTL ferritin, light polypeptide 0.0387972
RPL11 ribosomal protein L11 0.0384709
LOC112694756 uncharaterized LOC112694756 0.0383234
RPL35A ribosomal protein L35a 0.0379767
RPLP1 ribosomal protein, large, P1 0.0373978
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0370701
EGR1 early growth response 1 0.0366064
RPS6 ribosomal protein S6 0.03459
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0334381
SLTM SAFB-like, transcription modulator 0.0330754
EEF2 eukaryotic translation elongation factor 2 0.0317595
BACE2 beta-site APP-cleaving enzyme 2 0.0302613
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0301244
RPL8 ribosomal protein L8 0.0296659
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0294676
DTNA dystrobrevin, alpha 0.0289456
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0285483
RPS12 ribosomal protein S12 0.0284438
GRB10 growth factor receptor-bound protein 10 0.0284274
RPL37 ribosomal protein L37 0.0283981
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0281582
S100P S100 calcium binding protein P 0.0281025
CSNK1E casein kinase 1, epsilon 0.0273697
SQSTM1 sequestosome 1 0.0273633
RPL28 ribosomal protein L28 0.0271742
EIF1 eukaryotic translation initiation factor 1 0.0270636
RPS25 ribosomal protein S25 0.0263225
SDC4 syndecan 4 0.0262436
SEC61G Sec61 gamma subunit 0.0262252
CSTB cystatin B (stefin B) 0.0260455
GRAMD1B GRAM domain containing 1B 0.0259632
CEMIP cell migration inducing protein, hyaluronan binding 0.0253026
INTS6 integrator complex subunit 6 0.0252424
RACK1 receptor for activated C kinase 1 0.0251807
RPS19 ribosomal protein S19 0.0248222
SRRM2 serine/arginine repetitive matrix 2 0.0241032
RPS29 ribosomal protein S29 0.0240284
FAM13A family with sequence similarity 13, member A 0.024016
SLC38A2 solute carrier family 38, member 2 0.0233486
RPL23 ribosomal protein L23 0.0232644
SIK3 SIK family kinase 3 0.0231761
RPL31 ribosomal protein L31 0.0231624
WASF2 WAS protein family, member 2 0.0231146
RPS27 ribosomal protein S27 0.0227645
TMSB10 thymosin beta 10 0.0224937
DUSP5 dual specificity phosphatase 5 0.0223969
DOCK5 dedicator of cytokinesis 5 0.0223258
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0222856
EMP1 epithelial membrane protein 1 0.0222478
RPL30 ribosomal protein L30 0.0220983
EEF1G eukaryotic translation elongation factor 1 gamma 0.0216222
HLA-B major histocompatibility complex, class I, B 0.021566
RPS14 ribosomal protein S14 0.0211765
RPL27 ribosomal protein L27 0.0211235
CREB5 cAMP responsive element binding protein 5 0.0211227
LAMB3 laminin, beta 3 0.0210263
SMYD3 SET and MYND domain containing 3 0.020855
RPL12 ribosomal protein L12 0.0208393
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.02062
RAB7A RAB7A, member RAS oncogene family 0.0205759
RPL36 ribosomal protein L36 0.0204769
HILPDA hypoxia inducible lipid droplet-associated 0.0204739
RPS4X ribosomal protein S4, X-linked 0.0204608
HMGA1 high mobility group AT-hook 1 0.0201194
STC1 stanniocalcin 1 0.019848
DENND4A DENN/MADD domain containing 4A 0.0197275
RPS16 ribosomal protein S16 0.0195243
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0192636
AFF1 AF4/FMR2 family, member 1 0.0191241
RPL19 ribosomal protein L19 0.0190714
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0189755
RPS27A ribosomal protein S27a 0.0186109
HMGA2 high mobility group AT-hook 2 0.0185903
AJAP1 adherens junctions associated protein 1 0.0185488
GUK1 guanylate kinase 1 0.0184389
RPLP2 ribosomal protein, large, P2 0.018408
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0183337
HSPA8 heat shock 70kDa protein 8 0.0182647
ACTG1 actin gamma 1 0.0182511
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0182055
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.018031
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0180105
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0178196

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.245852
TXNRD1 thioredoxin reductase 1 -0.214278
PTPRM protein tyrosine phosphatase, receptor type, M -0.125686
LAMC2 laminin, gamma 2 -0.118456
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.115103
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0945741
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0833046
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0657712
NAMPT nicotinamide phosphoribosyltransferase -0.063851
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0630589
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0623629
AHNAK AHNAK nucleoprotein -0.0572399
OSMR oncostatin M receptor -0.05634
LMO7 LIM domain 7 -0.0561497
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0541576
LAMA4 laminin, alpha 4 -0.053473
GCLC glutamate-cysteine ligase, catalytic subunit -0.0522326
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0518291
VCL vinculin -0.0505715
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0505709
PKM pyruvate kinase, muscle -0.0500516
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0488406
TBC1D22A TBC1 domain family, member 22A -0.0445696
RBM39 RNA binding motif protein 39 -0.0415105
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0414654
LRP1B low density lipoprotein receptor-related protein 1B -0.0413238
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0408947
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0396763
IGFBP5 insulin-like growth factor binding protein 5 -0.0394981
ZC3H11A zinc finger CCCH-type containing 11A -0.0393823
KRT18 keratin 18, type I -0.0383399
PATJ PATJ crumbs cell polarity complex component -0.03612
GPC6 glypican 6 -0.0349092
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0335661
AKR1C1 aldo-keto reductase family 1, member C1 -0.0332554
PDLIM5 PDZ and LIM domain 5 -0.0331432
BRWD3 bromodomain and WD repeat domain containing 3 -0.0326877
CAV1 caveolin 1, caveolae protein, 22kDa -0.0326692
MKI67 marker of proliferation Ki-67 -0.0326411
DSPP dentin sialophosphoprotein -0.0323025
SCEL sciellin -0.0322922
TAS2R14 taste receptor, type 2, member 14 -0.0319141
PDE4D phosphodiesterase 4D, cAMP-specific -0.0318551
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.031812
CANX calnexin -0.0316836
PTPRD protein tyrosine phosphatase, receptor type, D -0.0315643
RIMS2 regulating synaptic membrane exocytosis 2 -0.0314456
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0311264
IGFBP3 insulin-like growth factor binding protein 3 -0.0310235
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0307109
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0304902
PGK1 phosphoglycerate kinase 1 -0.0302653
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.029462
PDIA3 protein disulfide isomerase family A, member 3 -0.0293077
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.02904
FRMD4B FERM domain containing 4B -0.0287472
FNDC3B fibronectin type III domain containing 3B -0.028471
ZMYND8 zinc finger, MYND-type containing 8 -0.028241
BBX bobby sox homolog (Drosophila) -0.0277439
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0274793
SEPTIN10 septin 10 -0.0273744
AHR aryl hydrocarbon receptor -0.0272983
CLTC clathrin, heavy chain (Hc) -0.0271363
GSK3B glycogen synthase kinase 3 beta -0.0267193
KRT8 keratin 8, type II -0.026587
BZW1 basic leucine zipper and W2 domains 1 -0.026415
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.026125
BIRC6 baculoviral IAP repeat containing 6 -0.0251008
ANKRD11 ankyrin repeat domain 11 -0.0248386
MAP7 microtubule-associated protein 7 -0.0248107
AFF4 AF4/FMR2 family, member 4 -0.024702
KDM3A lysine (K)-specific demethylase 3A -0.0240817
AHNAK2 AHNAK nucleoprotein 2 -0.0240191
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0239813
SUMF1 sulfatase modifying factor 1 -0.0237802
TM9SF3 transmembrane 9 superfamily member 3 -0.0237477
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0237439
MATR3 matrin 3 -0.0231454
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.022624
ARHGAP32 Rho GTPase activating protein 32 -0.0225894
ATAD2B ATPase family, AAA domain containing 2B -0.0221433
THSD4 thrombospondin, type I, domain containing 4 -0.0219113
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0217926
TRIP12 thyroid hormone receptor interactor 12 -0.0216834
EHBP1 EH domain binding protein 1 -0.0216085
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0215951
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0214779
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0210494
ZMYM2 zinc finger, MYM-type 2 -0.0208499
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0208231
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0203541
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0202487
USP34 ubiquitin specific peptidase 34 -0.0202163
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.020137
PRKCA protein kinase C, alpha -0.0199026
NIPBL Nipped-B homolog (Drosophila) -0.0198047
FAAH2 fatty acid amide hydrolase 2 -0.0197895
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0197102
AGR2 anterior gradient 2 -0.019518
RIN2 Ras and Rab interactor 2 -0.0194934