| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cysteamine (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cysteamine (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.18009 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.106858 |
| TXNRD1 | thioredoxin reductase 1 | 0.101305 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0903607 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0902606 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.072356 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0699298 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0676751 |
| GRAMD1B | GRAM domain containing 1B | 0.0662258 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0644871 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0632245 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0628522 |
| JMJD1C | jumonji domain containing 1C | 0.0625626 |
| TPM3 | tropomyosin 3 | 0.062384 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.062015 |
| RTN4 | reticulon 4 | 0.0615024 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0602098 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0580829 |
| COPA | coatomer protein complex, subunit alpha | 0.056974 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0538905 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0532336 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0486343 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0477081 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0465729 |
| EXT1 | exostosin glycosyltransferase 1 | 0.046493 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0442674 |
| BRD2 | bromodomain containing 2 | 0.0436311 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0433351 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0430496 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0429207 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0425599 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0424954 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0423222 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0421692 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0421397 |
| RUNX1 | runt-related transcription factor 1 | 0.0416228 |
| GPHN | gephyrin | 0.0413817 |
| ERBIN | erbb2 interacting protein | 0.041312 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0404723 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.040408 |
| TLN1 | talin 1 | 0.040307 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0400014 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0391688 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0385985 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0385175 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0382506 |
| SMAD3 | SMAD family member 3 | 0.0380218 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0378615 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0371649 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0370069 |
| VMP1 | vacuole membrane protein 1 | 0.0362062 |
| DST | dystonin | 0.0357633 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0356979 |
| GOLGB1 | golgin B1 | 0.0356425 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.035373 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0350442 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0350095 |
| POTEF | POTE ankyrin domain family, member F | 0.0349988 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0349915 |
| NOTCH2 | notch 2 | 0.0349701 |
| ANO6 | anoctamin 6 | 0.0348997 |
| TMEM41B | transmembrane protein 41B | 0.0347225 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0346558 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0342019 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0341506 |
| SPAG9 | sperm associated antigen 9 | 0.0336599 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0335531 |
| MSN | moesin | 0.0335061 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0333088 |
| WDR43 | WD repeat domain 43 | 0.0328593 |
| IPO7 | importin 7 | 0.0328205 |
| CDYL | chromodomain protein, Y-like | 0.0321401 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0316137 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0315521 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0309927 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0307699 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0307534 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.030739 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.030488 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0304514 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0302863 |
| ANXA5 | annexin A5 | 0.03022 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0301556 |
| ADIPOR2 | adiponectin receptor 2 | 0.0298354 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0295507 |
| RPL3 | ribosomal protein L3 | 0.0293557 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0292639 |
| PTEN | phosphatase and tensin homolog | 0.0292251 |
| COG5 | component of oligomeric golgi complex 5 | 0.0291574 |
| BRD4 | bromodomain containing 4 | 0.0286555 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0285895 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0285195 |
| INTS1 | integrator complex subunit 1 | 0.0283045 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0282189 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0282146 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0279861 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0279853 |
| SRP54 | signal recognition particle 54kDa | 0.0279742 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0278559 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.027853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.182859 |
| TMSB10 | thymosin beta 10 | -0.150123 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0957845 |
| PTMA | prothymosin, alpha | -0.0780712 |
| RAD51B | RAD51 paralog B | -0.0748154 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0707006 |
| RYR3 | ryanodine receptor 3 | -0.068862 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0657225 |
| PDE10A | phosphodiesterase 10A | -0.0643542 |
| YBX3 | Y box binding protein 3 | -0.0640959 |
| TPI1 | triosephosphate isomerase 1 | -0.0598342 |
| RPS21 | ribosomal protein S21 | -0.0589926 |
| PRELID2 | PRELI domain containing 2 | -0.0551606 |
| MT2A | metallothionein 2A | -0.0551188 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0541567 |
| HMGA2 | high mobility group AT-hook 2 | -0.0511459 |
| EXOC4 | exocyst complex component 4 | -0.0493133 |
| NCOA7 | nuclear receptor coactivator 7 | -0.048332 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.048106 |
| RPS29 | ribosomal protein S29 | -0.0466863 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0463807 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0454223 |
| RPLP1 | ribosomal protein, large, P1 | -0.0428483 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.042092 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0417872 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0410619 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0406764 |
| RPL26 | ribosomal protein L26 | -0.0401831 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0401206 |
| RPL35A | ribosomal protein L35a | -0.0400659 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0400496 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0395216 |
| SMYD3 | SET and MYND domain containing 3 | -0.0391208 |
| RPS24 | ribosomal protein S24 | -0.0379719 |
| FMN1 | formin 1 | -0.0372071 |
| RPLP2 | ribosomal protein, large, P2 | -0.0366423 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0360951 |
| RBM39 | RNA binding motif protein 39 | -0.0355692 |
| RNF213 | ring finger protein 213 | -0.0354795 |
| WWOX | WW domain containing oxidoreductase | -0.0352413 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0346942 |
| RPS3 | ribosomal protein S3 | -0.0345057 |
| PHF21A | PHD finger protein 21A | -0.0340823 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0338567 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0338162 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0337099 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.0334411 |
| RPL36 | ribosomal protein L36 | -0.0325693 |
| OSMR | oncostatin M receptor | -0.0321918 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0318409 |
| CCDC91 | coiled-coil domain containing 91 | -0.0313862 |
| RPS27A | ribosomal protein S27a | -0.0313003 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0312358 |
| ATXN1 | ataxin 1 | -0.0308762 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0306208 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0305191 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0304559 |
| RPL23 | ribosomal protein L23 | -0.029823 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0295123 |
| DENND5B | DENN/MADD domain containing 5B | -0.0291764 |
| RPS19 | ribosomal protein S19 | -0.0291208 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0287995 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.02848 |
| RPS15 | ribosomal protein S15 | -0.0284557 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0277937 |
| RPL38 | ribosomal protein L38 | -0.0272509 |
| ENOSF1 | enolase superfamily member 1 | -0.0272106 |
| EHBP1 | EH domain binding protein 1 | -0.0267313 |
| AFF3 | AF4/FMR2 family, member 3 | -0.026593 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0261925 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0258972 |
| RPL12 | ribosomal protein L12 | -0.0255466 |
| RPL19 | ribosomal protein L19 | -0.0251499 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0247953 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0246808 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0246268 |
| HLA-C | major histocompatibility complex, class I, C | -0.0245405 |
| RPS27 | ribosomal protein S27 | -0.0245363 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0244536 |
| RPL31 | ribosomal protein L31 | -0.0243805 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0241395 |
| AHNAK | AHNAK nucleoprotein | -0.0241154 |
| NLGN1 | neuroligin 1 | -0.0239989 |
| AEBP2 | AE binding protein 2 | -0.0239609 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0239514 |
| CAVIN1 | caveolae associated protein 1 | -0.0237443 |
| IGF2 | insulin-like growth factor 2 | -0.0236317 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0236168 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.023614 |
| RPL5 | ribosomal protein L5 | -0.0233555 |
| CALR | calreticulin | -0.0233357 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0233162 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0232397 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0232061 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0232055 |
| GNAS | GNAS complex locus | -0.0229607 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0229389 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0228662 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0223224 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0222487 |
