Cysteamine (hydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.142635
COL5A2 collagen, type V, alpha 2 0.141879
GDA guanine deaminase 0.113701
RPS12 ribosomal protein S12 0.105261
MCL1 myeloid cell leukemia 1 0.0924555
RPS3 ribosomal protein S3 0.0804963
TPT1 tumor protein, translationally-controlled 1 0.0795486
RPS8 ribosomal protein S8 0.079072
PDE10A phosphodiesterase 10A 0.0784467
RPL37A ribosomal protein L37a 0.076953
RPL26 ribosomal protein L26 0.0764884
CD109 CD109 molecule 0.0757987
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0742546
RPS2 ribosomal protein S2 0.0694892
PDLIM5 PDZ and LIM domain 5 0.0689863
TGFBI transforming growth factor, beta-induced, 68kDa 0.0625292
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0609103
BASP1 brain abundant, membrane attached signal protein 1 0.060292
RPL37 ribosomal protein L37 0.0597743
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0580546
RPL27 ribosomal protein L27 0.0575748
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0556188
RPS19 ribosomal protein S19 0.0555779
GRAMD1B GRAM domain containing 1B 0.0538922
TM4SF1 transmembrane 4 L six family member 1 0.0534997
KYNU kynureninase 0.0512422
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0504104
RPL12 ribosomal protein L12 0.0483551
RPL11 ribosomal protein L11 0.0481876
HLA-A major histocompatibility complex, class I, A 0.0475301
PYGL phosphorylase, glycogen, liver 0.047226
EEF2 eukaryotic translation elongation factor 2 0.0466031
INHBA inhibin, beta A 0.0463542
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0458876
MT2A metallothionein 2A 0.045578
ZEB2 zinc finger E-box binding homeobox 2 0.04498
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0446058
COL4A5 collagen, type IV, alpha 5 0.0434384
RPS29 ribosomal protein S29 0.0433799
RPS27 ribosomal protein S27 0.0425056
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0420144
NCOR2 nuclear receptor corepressor 2 0.0418351
CTIF CBP80/20-dependent translation initiation factor 0.0417654
FNDC3A fibronectin type III domain containing 3A 0.0417135
RPL36A ribosomal protein L36a 0.0415482
ENO1 enolase 1, (alpha) 0.0408768
TBXT T-box transcription factor T 0.0401749
RPL36 ribosomal protein L36 0.0398685
RPL28 ribosomal protein L28 0.0398197
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0398121
RPS13 ribosomal protein S13 0.0390198
RPLP2 ribosomal protein, large, P2 0.0386743
DGKD diacylglycerol kinase, delta 130kDa 0.0384386
RPL3 ribosomal protein L3 0.0384248
SMOC1 SPARC related modular calcium binding 1 0.0381957
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0380916
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0379079
PM20D1 peptidase M20 domain containing 1 0.0376679
SAMD4A sterile alpha motif domain containing 4A 0.0375073
LAMA5 laminin, alpha 5 0.0374484
CD44 CD44 molecule (Indian blood group) 0.0366259
FTH1 ferritin, heavy polypeptide 1 0.0365246
RPS21 ribosomal protein S21 0.036465
DOCK5 dedicator of cytokinesis 5 0.0364396
SH3KBP1 SH3-domain kinase binding protein 1 0.0361478
NTN4 netrin 4 0.0354622
SFTPA2 surfactant protein A2 0.0350743
SRRM2 serine/arginine repetitive matrix 2 0.0350248
HSPA8 heat shock 70kDa protein 8 0.0347058
HLA-B major histocompatibility complex, class I, B 0.0343466
RPL35 ribosomal protein L35 0.0342905
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0331036
RPL9 ribosomal protein L9 0.0328035
ZNF638 zinc finger protein 638 0.032728
RPL13A ribosomal protein L13a 0.0326739
OASL 2'-5'-oligoadenylate synthetase-like 0.031899
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0318198
COL4A6 collagen, type IV, alpha 6 0.0314724
SVIL supervillin 0.0314394
NPAS2 neuronal PAS domain protein 2 0.0312632
RAD51B RAD51 paralog B 0.0310804
SLK STE20-like kinase 0.030786
B2M beta-2-microglobulin 0.0304441
CEP72 centrosomal protein 72kDa 0.030387
WARS1 tryptophanyl-tRNA synthetase 1 0.0302842
RPL8 ribosomal protein L8 0.0300407
SQSTM1 sequestosome 1 0.0300392
EZR ezrin 0.0295977
RPS27A ribosomal protein S27a 0.029283
CTBP2 C-terminal binding protein 2 0.0287706
RPS14 ribosomal protein S14 0.0286922
MSN moesin 0.0281023
RAB3B RAB3B, member RAS oncogene family 0.0280296
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0280067
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0277816
MGST1 microsomal glutathione S-transferase 1 0.0274519
BMERB1 bMERB domain containing 1 0.0273718
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0273571
YBX3 Y box binding protein 3 0.0272208
MACF1 microtubule-actin crosslinking factor 1 0.0271046

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.135448
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.109769
NAMPT nicotinamide phosphoribosyltransferase -0.0957445
EFNA5 ephrin-A5 -0.0890106
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0828786
TFPI2 tissue factor pathway inhibitor 2 -0.0755753
TMSB10 thymosin beta 10 -0.0708638
PDE4D phosphodiesterase 4D, cAMP-specific -0.0698577
VCL vinculin -0.0683159
IGFBP3 insulin-like growth factor binding protein 3 -0.0664297
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0571502
NRCAM neuronal cell adhesion molecule -0.0558962
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0520091
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0519753
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0499567
NALF1 NALCN channel auxiliary factor 1 -0.0491476
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0481717
NEK7 NIMA-related kinase 7 -0.0461192
FTL ferritin, light polypeptide -0.0454006
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0420681
FNDC3B fibronectin type III domain containing 3B -0.0409547
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0402712
LDHA lactate dehydrogenase A -0.0395966
TXNRD1 thioredoxin reductase 1 -0.0388676
ASPH aspartate beta-hydroxylase -0.0388328
RGS2 regulator of G-protein signaling 2 -0.0384318
RPS24 ribosomal protein S24 -0.0364445
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0360329
NCOA7 nuclear receptor coactivator 7 -0.0354698
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0345974
ELL2 elongation factor, RNA polymerase II, 2 -0.0340179
MORF4L2 mortality factor 4 like 2 -0.0326558
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0325856
MXI1 MAX interactor 1, dimerization protein -0.031726
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0316467
MFF mitochondrial fission factor -0.0308773
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0296995
RTN4 reticulon 4 -0.0296983
TKT transketolase -0.0294815
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.029184
NUP58 nucleoporin 58 -0.0287379
WDR45B WD repeat domain 45B -0.0285496
CANX calnexin -0.0283045
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0278954
PDIA6 protein disulfide isomerase family A, member 6 -0.027648
VDAC1 voltage-dependent anion channel 1 -0.027544
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0274839
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0273898
TM9SF3 transmembrane 9 superfamily member 3 -0.0273784
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0271789
RBM39 RNA binding motif protein 39 -0.0264544
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0264339
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0261742
DST dystonin -0.0261401
PRKD3 protein kinase D3 -0.0259396
HILPDA hypoxia inducible lipid droplet-associated -0.0258913
PDIA3 protein disulfide isomerase family A, member 3 -0.0253378
RPL4 ribosomal protein L4 -0.0250308
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0247587
WDFY2 WD repeat and FYVE domain containing 2 -0.0246148
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.024243
PDE4B phosphodiesterase 4B, cAMP-specific -0.0241424
OGA O-GlcNAcase -0.0240622
SLC16A6 solute carrier family 16, member 6 -0.0237681
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0237614
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0233406
USP9X ubiquitin specific peptidase 9, X-linked -0.0233388
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0231518
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0230021
SOD2 superoxide dismutase 2, mitochondrial -0.0228952
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0228449
DPYD dihydropyrimidine dehydrogenase -0.022833
SPAG9 sperm associated antigen 9 -0.0226922
KMT2E lysine (K)-specific methyltransferase 2E -0.0224246
BIRC6 baculoviral IAP repeat containing 6 -0.0224039
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0223275
TMEM123 transmembrane protein 123 -0.0223216
RIOK3 RIO kinase 3 -0.0223143
CUL4B cullin 4B -0.0222795
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0218597
KDM3A lysine (K)-specific demethylase 3A -0.0216319
NDRG1 N-myc downstream regulated 1 -0.0216267
MATR3 matrin 3 -0.021597
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0215616
EPHA4 EPH receptor A4 -0.0214822
LMAN1 lectin, mannose-binding, 1 -0.0214253
PHF21A PHD finger protein 21A -0.021417
CHD1L chromodomain helicase DNA binding protein 1-like -0.020756
PCBP3 poly(rC) binding protein 3 -0.0206862
RTN1 reticulon 1 -0.0205876
CDK6 cyclin-dependent kinase 6 -0.0204843
SBF2 SET binding factor 2 -0.0204657
GNAS GNAS complex locus -0.0202243
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.019812
USP3 ubiquitin specific peptidase 3 -0.0197964
PRKN parkin RBR E3 ubiquitin protein ligase -0.0197733
HELZ helicase with zinc finger -0.0196897
MARCHF6 membrane associated ring-CH-type finger 6 -0.0196492
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0196079
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0195776