Cysteamine (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

187 genes differentially expressed following the Cysteamine (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.311473
FN1 fibronectin 1 0.146447
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.114807
ENO1 enolase 1, (alpha) 0.110776
ANXA2 annexin A2 0.101652
DSCAM Down syndrome cell adhesion molecule 0.101278
LMO7 LIM domain 7 0.0923274
MMP1 matrix metallopeptidase 1 0.0879316
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0837845
TPM4 tropomyosin 4 0.0792258
LAMC2 laminin, gamma 2 0.0742455
ATXN1 ataxin 1 0.0736848
POTEF POTE ankyrin domain family, member F 0.0708967
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0689923
GDA guanine deaminase 0.0676935
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0670399
TPT1 tumor protein, translationally-controlled 1 0.0628835
NDRG1 N-myc downstream regulated 1 0.0619236
ZC3H11A zinc finger CCCH-type containing 11A 0.0587904
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0584946
HMGA2 high mobility group AT-hook 2 0.0583051
NKD1 naked cuticle homolog 1 (Drosophila) 0.0579606
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0565782
NAV2 neuron navigator 2 0.0538586
DSPP dentin sialophosphoprotein 0.053576
MYO1E myosin IE 0.0533394
PTMA prothymosin, alpha 0.0524193
ASPH aspartate beta-hydroxylase 0.0510368
SLC38A2 solute carrier family 38, member 2 0.0494247
RPS19 ribosomal protein S19 0.0481081
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0478087
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0476936
EZR ezrin 0.0466183
PRKCA protein kinase C, alpha 0.0445945
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0441024
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0437146
CTNND1 catenin (cadherin-associated protein), delta 1 0.0429696
RPS6 ribosomal protein S6 0.0427171
SMYD3 SET and MYND domain containing 3 0.042513
KTN1 kinectin 1 (kinesin receptor) 0.042501
COL5A2 collagen, type V, alpha 2 0.0415219
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0386907
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0383006
SDC4 syndecan 4 0.0379055
SOX5 SRY (sex determining region Y)-box 5 0.0378118
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0372053
RPS12 ribosomal protein S12 0.0363612
ZSWIM6 zinc finger, SWIM-type containing 6 0.03589
NAMPT nicotinamide phosphoribosyltransferase 0.0351966
BPTF bromodomain PHD finger transcription factor 0.0349762
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0345829
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0336642
PDE10A phosphodiesterase 10A 0.0334979
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0330095
TMOD3 tropomodulin 3 (ubiquitous) 0.0328546
JMJD1C jumonji domain containing 1C 0.0311946
RPL12 ribosomal protein L12 0.0311451
BIRC6 baculoviral IAP repeat containing 6 0.031141
TAS2R14 taste receptor, type 2, member 14 0.030817
FTL ferritin, light polypeptide 0.0303407
DIAPH2 diaphanous-related formin 2 0.029773
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0294921
B2M beta-2-microglobulin 0.0293647
RAD51B RAD51 paralog B 0.0275703
RPS8 ribosomal protein S8 0.0271296
AKAP12 A kinase (PRKA) anchor protein 12 0.0261297
MED13L mediator complex subunit 13-like 0.0258717
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0255572
MAML2 mastermind-like 2 (Drosophila) 0.0245467
USP34 ubiquitin specific peptidase 34 0.0238087
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0218028
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0208426
ACTG1 actin gamma 1 0.0181276
AKAP13 A kinase (PRKA) anchor protein 13 0.0173284
TRIO trio Rho guanine nucleotide exchange factor 0.0167232
EFNA5 ephrin-A5 0.012077
NALF1 NALCN channel auxiliary factor 1 0.0114872
MYOF myoferlin 0.0107754
RPL19 ribosomal protein L19 0.0102907
CUX1 cut-like homeobox 1 0.0101513
SEC31A SEC31 homolog A (S. cerevisiae) 0.0100487
GNAS GNAS complex locus 0.00998252
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00825894
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.00550015
EXT1 exostosin glycosyltransferase 1 0.00541723
COL6A3 collagen, type VI, alpha 3 0.00466462
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.00351399
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0029479
MAML3 mastermind-like 3 (Drosophila) 0.00278737
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00274077
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0018331
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 5.8243E-4
FAT1 FAT atypical cadherin 1 1.33599E-4

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.321412
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.190067
KMT2C lysine (K)-specific methyltransferase 2C -0.128526
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.115089
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.112519
VIM vimentin -0.104774
CDH13 cadherin 13 -0.098657
ELOVL5 ELOVL fatty acid elongase 5 -0.090245
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0899613
PRKD3 protein kinase D3 -0.0842705
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0808981
RIGI RNA sensor RIG-I -0.0779161
AOPEP aminopeptidase O (putative) -0.0738417
BBX bobby sox homolog (Drosophila) -0.0693849
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0682749
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0653611
FNDC3A fibronectin type III domain containing 3A -0.0643838
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0631817
DOCK4 dedicator of cytokinesis 4 -0.0623676
DLG1 discs, large homolog 1 (Drosophila) -0.0623061
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0620109
SRPK2 SRSF protein kinase 2 -0.0607819
EGFR epidermal growth factor receptor -0.0583662
CTIF CBP80/20-dependent translation initiation factor -0.057784
PDLIM5 PDZ and LIM domain 5 -0.0570826
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0561505
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0558699
SAMD4A sterile alpha motif domain containing 4A -0.0542778
THSD4 thrombospondin, type I, domain containing 4 -0.0535177
NAP1L1 nucleosome assembly protein 1-like 1 -0.0528568
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0526584
MARCHF7 membrane associated ring-CH-type finger 7 -0.0496899
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0496149
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0474911
PARD3 par-3 family cell polarity regulator -0.0471101
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0462475
ESYT2 extended synaptotagmin-like protein 2 -0.0451613
KDM2A lysine (K)-specific demethylase 2A -0.0446009
APP amyloid beta (A4) precursor protein -0.0445516
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0442855
GPC6 glypican 6 -0.0435211
PSD3 pleckstrin and Sec7 domain containing 3 -0.0431324
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0406717
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0404016
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0397177
CERS6 ceramide synthase 6 -0.0380881
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0376081
TCF12 transcription factor 12 -0.0359231
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0358728
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.035722
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0355037
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0342919
ATP9B ATPase, class II, type 9B -0.0340863
NBEAL1 neurobeachin-like 1 -0.0331229
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.032692
TMSB10 thymosin beta 10 -0.0296823
GRB10 growth factor receptor-bound protein 10 -0.0296813
WDFY3 WD repeat and FYVE domain containing 3 -0.029664
TXNRD1 thioredoxin reductase 1 -0.0288965
RORA RAR-related orphan receptor A -0.0269999
GMDS GDP-mannose 4,6-dehydratase -0.0264955
ALCAM activated leukocyte cell adhesion molecule -0.0264944
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0246476
DST dystonin -0.0211815
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0209239
ZFAND3 zinc finger, AN1-type domain 3 -0.0197899
COL6A1 collagen, type VI, alpha 1 -0.0185851
WSB1 WD repeat and SOCS box containing 1 -0.0183097
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0182735
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0181828
INHBA inhibin, beta A -0.017211
SMAD3 SMAD family member 3 -0.0163244
PRRC2C proline-rich coiled-coil 2C -0.016309
GPHN gephyrin -0.0159082
RBM25 RNA binding motif protein 25 -0.015275
COL8A1 collagen, type VIII, alpha 1 -0.015163
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0148928
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.014145
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0131095
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0123108
TENM3 teneurin transmembrane protein 3 -0.0120051
SPAG9 sperm associated antigen 9 -0.0112757
VMP1 vacuole membrane protein 1 -0.0105446
CANX calnexin -0.00946336
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.00864348
DOCK5 dedicator of cytokinesis 5 -0.00863902
SLTM SAFB-like, transcription modulator -0.00573979
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.00436321
CD44 CD44 molecule (Indian blood group) -0.00402464
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.00394525
SETD5 SET domain containing 5 -0.00392303
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.00316178
FNDC3B fibronectin type III domain containing 3B -0.00121673
GOLGA4 golgin A4 -2.43585E-4