Cysteamine (hydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.105691
LAMB3 laminin, beta 3 0.0762196
TPT1 tumor protein, translationally-controlled 1 0.0761905
ACTG1 actin gamma 1 0.068215
EGR1 early growth response 1 0.0596328
MT2A metallothionein 2A 0.0594697
MUC4 mucin 4, cell surface associated 0.0563039
LAMC2 laminin, gamma 2 0.0503435
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0491763
SMAD3 SMAD family member 3 0.0485413
TGM2 transglutaminase 2 0.046678
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.045811
CD44 CD44 molecule (Indian blood group) 0.0453703
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0424911
PCLO piccolo presynaptic cytomatrix protein 0.0407264
RNF213 ring finger protein 213 0.0386171
MAML2 mastermind-like 2 (Drosophila) 0.0375015
RPS12 ribosomal protein S12 0.0372004
SEPTIN9 septin 9 0.0369324
MACF1 microtubule-actin crosslinking factor 1 0.0361273
TJP1 tight junction protein 1 0.0357676
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0353906
RPS13 ribosomal protein S13 0.035142
IFI27 interferon, alpha-inducible protein 27 0.0348293
EGFR epidermal growth factor receptor 0.0335226
BCL2L1 BCL2-like 1 0.0329368
RAD51B RAD51 paralog B 0.0328871
RPL37A ribosomal protein L37a 0.032328
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0322525
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0320164
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0320088
LPP LIM domain containing preferred translocation partner in lipoma 0.0319504
RPL9 ribosomal protein L9 0.0319358
MUC16 mucin 16, cell surface associated 0.0317684
SAMD4A sterile alpha motif domain containing 4A 0.0316502
LAMA4 laminin, alpha 4 0.0309905
HDAC9 histone deacetylase 9 0.0303295
RPS6 ribosomal protein S6 0.0296366
VCL vinculin 0.0295976
BCAR3 breast cancer anti-estrogen resistance 3 0.0294959
VMP1 vacuole membrane protein 1 0.0292776
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.028908
RPS29 ribosomal protein S29 0.0288522
OSMR oncostatin M receptor 0.0284842
POTEF POTE ankyrin domain family, member F 0.0284116
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0281848
NAV2 neuron navigator 2 0.0280639
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0279843
SMYD3 SET and MYND domain containing 3 0.0279128
ZBTB20 zinc finger and BTB domain containing 20 0.0278384
CD59 CD59 molecule, complement regulatory protein 0.027736
INHBA inhibin, beta A 0.0276943
CDCP1 CUB domain containing protein 1 0.027684
RPL37 ribosomal protein L37 0.0275758
AFDN afadin, adherens junction formation factor 0.0275063
G0S2 G0/G1 switch 2 0.0271383
BACE2 beta-site APP-cleaving enzyme 2 0.0270391
IL1RAP interleukin 1 receptor accessory protein 0.0266107
RPL27 ribosomal protein L27 0.0263071
RPS19 ribosomal protein S19 0.0259
TXNIP thioredoxin interacting protein 0.025867
MYO5B myosin VB 0.0257506
MYH9 myosin, heavy chain 9, non-muscle 0.0257112
ANKRD12 ankyrin repeat domain 12 0.0250276
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.02495
RASAL2 RAS protein activator like 2 0.0247939
THSD4 thrombospondin, type I, domain containing 4 0.0247685
SLC35F3 solute carrier family 35, member F3 0.0246761
MELTF melanotransferrin 0.0243125
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0242687
STAT1 signal transducer and activator of transcription 1, 91kDa 0.023899
N4BP2L2 NEDD4 binding protein 2-like 2 0.0234958
ASPH aspartate beta-hydroxylase 0.0232167
PRELID2 PRELI domain containing 2 0.0229982
FHIT fragile histidine triad 0.0228189
RPLP2 ribosomal protein, large, P2 0.0227116
RPS8 ribosomal protein S8 0.0226949
HLA-B major histocompatibility complex, class I, B 0.0224959
C3 complement component 3 0.0224878
SHB Src homology 2 domain containing adaptor protein B 0.0222185
RPL28 ribosomal protein L28 0.0221355
ANO6 anoctamin 6 0.0220277
PLSCR1 phospholipid scramblase 1 0.0216628
PLAT plasminogen activator, tissue 0.0216033
MX1 MX dynamin-like GTPase 1 0.0215655
AREG amphiregulin 0.0215249
ATXN1 ataxin 1 0.0214238
RPL13A ribosomal protein L13a 0.0214218
RUNX1 runt-related transcription factor 1 0.0213029
MPRIP myosin phosphatase Rho interacting protein 0.0210271
DOCK1 dedicator of cytokinesis 1 0.0209811
ETV6 ets variant 6 0.020961
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0208642
RPL23 ribosomal protein L23 0.020598
PPARD peroxisome proliferator-activated receptor delta 0.0203683
ACTN4 actinin, alpha 4 0.0200987
DIAPH1 diaphanous-related formin 1 0.0198969
FLNB filamin B, beta 0.0198959
EXT1 exostosin glycosyltransferase 1 0.0197078
ANXA11 annexin A11 0.0196838

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.168146
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0902265
KRT17 keratin 17, type I -0.0784294
TSC22D2 TSC22 domain family, member 2 -0.0678937
ANXA2 annexin A2 -0.0585701
TMSB10 thymosin beta 10 -0.0579938
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0568374
ANLN anillin, actin binding protein -0.054117
CANX calnexin -0.0501771
TMEM123 transmembrane protein 123 -0.0489451
KDM3A lysine (K)-specific demethylase 3A -0.0480628
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0473852
RLF rearranged L-myc fusion -0.0440941
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0440422
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0440202
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0424859
DDIT4 DNA-damage-inducible transcript 4 -0.040482
CALR calreticulin -0.03987
OGA O-GlcNAcase -0.0391102
LOC102724023 ES1 protein homolog, mitochondrial -0.0378199
SPAG9 sperm associated antigen 9 -0.0377136
IGFBP3 insulin-like growth factor binding protein 3 -0.0375618
TMSB4X thymosin beta 4, X-linked -0.0364955
ECT2 epithelial cell transforming 2 -0.0362036
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0362029
RAD21 RAD21 homolog (S. pombe) -0.0352924
NPEPPS aminopeptidase puromycin sensitive -0.0347634
ZNF207 zinc finger protein 207 -0.032975
USP3 ubiquitin specific peptidase 3 -0.0328996
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0327508
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0319009
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0302758
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0294653
BHLHE40 basic helix-loop-helix family, member e40 -0.0294097
CAV1 caveolin 1, caveolae protein, 22kDa -0.02894
LDHA lactate dehydrogenase A -0.0283261
UGCG UDP-glucose ceramide glucosyltransferase -0.0282096
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0279379
RBM39 RNA binding motif protein 39 -0.027544
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0265113
MARCHF6 membrane associated ring-CH-type finger 6 -0.0262303
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0259833
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0256932
WSB1 WD repeat and SOCS box containing 1 -0.025261
HMGB2 high mobility group box 2 -0.0251517
CD2AP CD2-associated protein -0.0246637
WDR45B WD repeat domain 45B -0.0242124
XPO1 exportin 1 -0.0240723
RAB1A RAB1A, member RAS oncogene family -0.0240088
CENPF centromere protein F, 350/400kDa -0.0236898
WAC WW domain containing adaptor with coiled-coil -0.0236637
RAB6A RAB6A, member RAS oncogene family -0.0234447
ARF1 ADP-ribosylation factor 1 -0.0226009
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0225133
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0224795
RIOK3 RIO kinase 3 -0.0222669
HBP1 HMG-box transcription factor 1 -0.0222036
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0221184
SMC4 structural maintenance of chromosomes 4 -0.0220545
C15ORF48 chromosome 15 open reading frame 48 -0.0220168
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.021932
ATF3 activating transcription factor 3 -0.0218376
KMT2E lysine (K)-specific methyltransferase 2E -0.0216463
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0214973
PARD3 par-3 family cell polarity regulator -0.0211567
MATR3 matrin 3 -0.0211082
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0210273
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0208305
MYO6 myosin VI -0.0206457
NAMPT nicotinamide phosphoribosyltransferase -0.0204636
GNAS GNAS complex locus -0.0204455
TLK2 tousled-like kinase 2 -0.0203353
OSBPL3 oxysterol binding protein-like 3 -0.0203227
CKAP5 cytoskeleton associated protein 5 -0.0201739
COPA coatomer protein complex, subunit alpha -0.0198166
TOP1 topoisomerase (DNA) I -0.019802
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0196531
ANXA1 annexin A1 -0.0194663
LRRC1 leucine rich repeat containing 1 -0.0194607
PIAS1 protein inhibitor of activated STAT, 1 -0.0192793
DLG1 discs, large homolog 1 (Drosophila) -0.019046
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0189359
BIRC3 baculoviral IAP repeat containing 3 -0.0188795
SETD5 SET domain containing 5 -0.0188152
HLA-E major histocompatibility complex, class I, E -0.0187393
S100A6 S100 calcium binding protein A6 -0.0186611
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0184683
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0183787
RAB2A RAB2A, member RAS oncogene family -0.0183603
MORF4L2 mortality factor 4 like 2 -0.0183166
ATP11B ATPase, class VI, type 11B -0.0180586
RYBP RING1 and YY1 binding protein -0.0180358
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0178887
UBE2B ubiquitin-conjugating enzyme E2B -0.0178373
AHNAK AHNAK nucleoprotein -0.0177993
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0177921
STAG2 stromal antigen 2 -0.0177712
ANKRD10 ankyrin repeat domain 10 -0.0177124
PDS5B PDS5 cohesin associated factor B -0.0177041
KLHL24 kelch-like family member 24 -0.0176516