Cysteamine (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.137563
POTEF POTE ankyrin domain family, member F 0.097256
MCL1 myeloid cell leukemia 1 0.0785593
JMJD1C jumonji domain containing 1C 0.0743707
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0706778
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0664938
RPS6 ribosomal protein S6 0.0660444
SRRM2 serine/arginine repetitive matrix 2 0.0636778
ACTG1 actin gamma 1 0.0631919
RPL3 ribosomal protein L3 0.0612255
CD68 CD68 molecule 0.0568012
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0558654
APLP2 amyloid beta (A4) precursor-like protein 2 0.0546737
EEF2 eukaryotic translation elongation factor 2 0.0529183
RASA2 RAS p21 protein activator 2 0.0520692
HMGA1 high mobility group AT-hook 1 0.0519682
SGMS2 sphingomyelin synthase 2 0.0500567
NDRG1 N-myc downstream regulated 1 0.0498158
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0485044
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0482308
FLNB filamin B, beta 0.0460053
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0458195
TSC22D2 TSC22 domain family, member 2 0.0457142
FOSL1 FOS-like antigen 1 0.0451802
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0447214
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0428481
BRD2 bromodomain containing 2 0.0409836
KTN1 kinectin 1 (kinesin receptor) 0.0409357
MCTP1 multiple C2 domains, transmembrane 1 0.0406407
RPS2 ribosomal protein S2 0.0405067
CAPRIN2 caprin family member 2 0.0403965
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0394147
UBA6 ubiquitin-like modifier activating enzyme 6 0.0392551
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0390293
BRD4 bromodomain containing 4 0.0379214
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0372391
ZFP36L1 ZFP36 ring finger protein-like 1 0.0356215
SMTN smoothelin 0.0355053
CORO1C coronin, actin binding protein, 1C 0.0342751
MYH9 myosin, heavy chain 9, non-muscle 0.0333956
ADAM9 ADAM metallopeptidase domain 9 0.0327846
EGR1 early growth response 1 0.0326039
NUP58 nucleoporin 58 0.0325416
CREB5 cAMP responsive element binding protein 5 0.0318628
RPS12 ribosomal protein S12 0.0317163
KMT2E lysine (K)-specific methyltransferase 2E 0.0313711
PCBP2 poly(rC) binding protein 2 0.0311781
GLRX glutaredoxin (thioltransferase) 0.031054
RCOR1 REST corepressor 1 0.0306774
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0304145
FHL2 four and a half LIM domains 2 0.0303327
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0298764
EXT1 exostosin glycosyltransferase 1 0.0298329
JUN jun proto-oncogene 0.0296542
AXL AXL receptor tyrosine kinase 0.0288336
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0283538
CCNL1 cyclin L1 0.0283177
EEF1G eukaryotic translation elongation factor 1 gamma 0.0282726
STC1 stanniocalcin 1 0.0280775
RTN4 reticulon 4 0.0277344
TM4SF19 transmembrane 4 L six family member 19 0.0276219
KDM6A lysine (K)-specific demethylase 6A 0.0275889
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0275498
ZEB1 zinc finger E-box binding homeobox 1 0.0274943
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0274826
RPL21 ribosomal protein L21 0.0272159
MAST4 microtubule associated serine/threonine kinase family member 4 0.0272048
PFN1 profilin 1 0.0271479
ZNF292 zinc finger protein 292 0.0270371
FLNA filamin A, alpha 0.0269951
RPL27 ribosomal protein L27 0.0269217
ECPAS Ecm29 proteasome adaptor and scaffold 0.0262505
RPL8 ribosomal protein L8 0.0259462
FAM120A family with sequence similarity 120A 0.0258725
GOLGA4 golgin A4 0.0258238
SEC24A SEC24 family member A 0.0249941
RPL28 ribosomal protein L28 0.0247769
UPP1 uridine phosphorylase 1 0.024703
ZNF638 zinc finger protein 638 0.0240575
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0237554
PICALM phosphatidylinositol binding clathrin assembly protein 0.023656
YBX1 Y box binding protein 1 0.0236537
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0235354
SPRED2 sprouty-related, EVH1 domain containing 2 0.0231888
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0230128
CSNK1A1 casein kinase 1, alpha 1 0.0224993
EFL1 elongation factor like GTPase 1 0.0224793
SET SET nuclear proto-oncogene 0.0224746
AKAP9 A kinase (PRKA) anchor protein 9 0.0223596
ANK2 ankyrin 2, neuronal 0.022254
ANGPTL4 angiopoietin-like 4 0.0220421
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0217646
RPS19 ribosomal protein S19 0.0216564
SCAF11 SR-related CTD-associated factor 11 0.0214911
AKAP12 A kinase (PRKA) anchor protein 12 0.0213188
TIMP1 TIMP metallopeptidase inhibitor 1 0.021243
KDM6B lysine (K)-specific demethylase 6B 0.0211806
SESN2 sestrin 2 0.0211358
PCM1 pericentriolar material 1 0.0210911
UGCG UDP-glucose ceramide glucosyltransferase 0.0210591

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.221586
DLC1 DLC1 Rho GTPase activating protein -0.172487
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.14844
ZNF438 zinc finger protein 438 -0.0887122
MTAP methylthioadenosine phosphorylase -0.0618846
STAT1 signal transducer and activator of transcription 1, 91kDa -0.059299
RPS24 ribosomal protein S24 -0.0579578
PTMA prothymosin, alpha -0.0577921
RAD21 RAD21 homolog (S. pombe) -0.0527005
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0510524
RPL4 ribosomal protein L4 -0.0500932
HMGA2 high mobility group AT-hook 2 -0.0485824
IFI16 interferon, gamma-inducible protein 16 -0.0483516
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0475247
LPP LIM domain containing preferred translocation partner in lipoma -0.0466119
ANTXR2 anthrax toxin receptor 2 -0.0444396
RPLP1 ribosomal protein, large, P1 -0.044287
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0436407
PCNX4 pecanex 4 -0.0413531
NAP1L1 nucleosome assembly protein 1-like 1 -0.0408339
AHNAK AHNAK nucleoprotein -0.0404229
FRMD4A FERM domain containing 4A -0.0402253
RSL1D1 ribosomal L1 domain containing 1 -0.0399037
RPL35A ribosomal protein L35a -0.0398261
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0384175
TTR transthyretin -0.0382447
NAV3 neuron navigator 3 -0.0377205
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0372548
KDM3A lysine (K)-specific demethylase 3A -0.0355673
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0352582
TPT1 tumor protein, translationally-controlled 1 -0.0351496
LAMB3 laminin, beta 3 -0.0346836
MATR3 matrin 3 -0.0346308
CANX calnexin -0.0344179
SENP5 SUMO1/sentrin specific peptidase 5 -0.0342242
CALD1 caldesmon 1 -0.0328536
TAS2R14 taste receptor, type 2, member 14 -0.0325957
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.032352
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0320924
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0320772
ZBTB20 zinc finger and BTB domain containing 20 -0.0317537
RIGI RNA sensor RIG-I -0.0314815
TMSB10 thymosin beta 10 -0.0312615
ARF1 ADP-ribosylation factor 1 -0.0307955
RPL31 ribosomal protein L31 -0.0304663
BZW1 basic leucine zipper and W2 domains 1 -0.0299904
PGK1 phosphoglycerate kinase 1 -0.029564
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.02924
SP100 SP100 nuclear antigen -0.0291616
RRBP1 ribosome binding protein 1 -0.0291402
RPS27A ribosomal protein S27a -0.029057
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0281278
CDK6 cyclin-dependent kinase 6 -0.0277463
RPL30 ribosomal protein L30 -0.0275562
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0268495
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.026834
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0261833
GPATCH8 G patch domain containing 8 -0.0260694
RPL7 ribosomal protein L7 -0.0260519
SBF2 SET binding factor 2 -0.0260091
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -0.0259974
RPL6 ribosomal protein L6 -0.0259867
CDK12 cyclin-dependent kinase 12 -0.0259161
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0259123
SCLT1 sodium channel and clathrin linker 1 -0.0250318
PTK2 protein tyrosine kinase 2 -0.0249521
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0246066
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0244516
UBE3C ubiquitin protein ligase E3C -0.0243958
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0242398
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0240119
STK4 serine/threonine kinase 4 -0.0237836
MAP4 microtubule-associated protein 4 -0.0236081
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0235291
TPM4 tropomyosin 4 -0.0234943
HDAC9 histone deacetylase 9 -0.0234879
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.023478
RPL34 ribosomal protein L34 -0.0234767
BMAL2 basic helix-loop-helix ARNT like 2 -0.0232664
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0231463
RPL32 ribosomal protein L32 -0.0228469
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0228307
STAU1 staufen double-stranded RNA binding protein 1 -0.0226417
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0224669
LARP4B La ribonucleoprotein domain family, member 4B -0.0220621
CCDC47 coiled-coil domain containing 47 -0.0215078
EIF1 eukaryotic translation initiation factor 1 -0.0214115
NABP1 nucleic acid binding protein 1 -0.0214026
HMGB2 high mobility group box 2 -0.0210919
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0210914
WNT2B wingless-type MMTV integration site family, member 2B -0.0210805
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0210431
MON2 MON2 homolog (S. cerevisiae) -0.0209299
GNAS GNAS complex locus -0.0208597
MARCHF6 membrane associated ring-CH-type finger 6 -0.0206247
TEX10 testis expressed 10 -0.0206001
ARHGAP22 Rho GTPase activating protein 22 -0.0204044
KPNB1 karyopherin (importin) beta 1 -0.0203266
MKI67 marker of proliferation Ki-67 -0.0202274
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.020142