Cysteamine (hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.102228
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0983231
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0954724
FN1 fibronectin 1 0.0828529
POTEF POTE ankyrin domain family, member F 0.0769759
FRMD5 FERM domain containing 5 0.0664749
NOTCH2 notch 2 0.0640984
FNDC3B fibronectin type III domain containing 3B 0.0552867
LPP LIM domain containing preferred translocation partner in lipoma 0.0539768
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0537732
HDAC9 histone deacetylase 9 0.0531098
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.052975
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0511875
MSN moesin 0.049494
ANGPTL4 angiopoietin-like 4 0.0487738
FLNA filamin A, alpha 0.0482685
SMAD3 SMAD family member 3 0.0474971
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0462177
CYB5R3 cytochrome b5 reductase 3 0.044188
RPL27 ribosomal protein L27 0.0432534
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0431813
ACTG1 actin gamma 1 0.0429185
RASAL2 RAS protein activator like 2 0.0411287
ACTN4 actinin, alpha 4 0.0411244
WWTR1 WW domain containing transcription regulator 1 0.0407017
AMOTL1 angiomotin like 1 0.0396115
HMGA1 high mobility group AT-hook 1 0.0393217
FAM78B family with sequence similarity 78, member B 0.0387711
ANKRD28 ankyrin repeat domain 28 0.0374248
PTK2 protein tyrosine kinase 2 0.0371735
RUNX1 runt-related transcription factor 1 0.0367091
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0362666
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.035903
SFTPA2 surfactant protein A2 0.0357954
RPS6 ribosomal protein S6 0.0353819
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.03504
LINGO2 leucine rich repeat and Ig domain containing 2 0.0345439
CD59 CD59 molecule, complement regulatory protein 0.0343676
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0342085
RPS3 ribosomal protein S3 0.033889
BPTF bromodomain PHD finger transcription factor 0.0332039
UBASH3B ubiquitin associated and SH3 domain containing B 0.0325879
ATXN1 ataxin 1 0.032537
SOX10 SRY (sex determining region Y)-box 10 0.0322112
ITGB5 integrin, beta 5 0.0318083
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0317484
MELTF melanotransferrin 0.0315891
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0315514
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0313065
LOC112694756 uncharaterized LOC112694756 0.0312209
ACTN1 actinin, alpha 1 0.0307187
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0305122
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0297196
RBM25 RNA binding motif protein 25 0.029612
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.028901
EEF2 eukaryotic translation elongation factor 2 0.0288735
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0285211
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0283597
OPHN1 oligophrenin 1 0.0282134
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0276843
FLNB filamin B, beta 0.0276448
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0270199
SRSF11 serine/arginine-rich splicing factor 11 0.0268573
TM4SF1 transmembrane 4 L six family member 1 0.0267772
IGFBP3 insulin-like growth factor binding protein 3 0.0267242
TRIO trio Rho guanine nucleotide exchange factor 0.0265728
SOX6 SRY (sex determining region Y)-box 6 0.026301
EP300 E1A binding protein p300 0.0262633
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0261912
SLC38A2 solute carrier family 38, member 2 0.0261123
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0260647
NFE2L1 nuclear factor, erythroid 2-like 1 0.0255014
SRRM2 serine/arginine repetitive matrix 2 0.0246295
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0242642
HLA-A major histocompatibility complex, class I, A 0.0241651
ERBIN erbb2 interacting protein 0.0237009
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0235599
SAMD4A sterile alpha motif domain containing 4A 0.0233045
ATXN2 ataxin 2 0.0232308
EXT1 exostosin glycosyltransferase 1 0.023223
MAML2 mastermind-like 2 (Drosophila) 0.0231628
SETD5 SET domain containing 5 0.0231557
HMG20B high mobility group 20B 0.0231262
AKAP13 A kinase (PRKA) anchor protein 13 0.0231243
OSBPL10 oxysterol binding protein-like 10 0.02306
RPS21 ribosomal protein S21 0.0230355
MYH9 myosin, heavy chain 9, non-muscle 0.022702
CDK6 cyclin-dependent kinase 6 0.0226949
MCL1 myeloid cell leukemia 1 0.0226083
MT2A metallothionein 2A 0.0225207
RPL36 ribosomal protein L36 0.0225075
PSD3 pleckstrin and Sec7 domain containing 3 0.0224799
EVI5 ecotropic viral integration site 5 0.0224423
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0222154
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.0221633
RPL23 ribosomal protein L23 0.0221176
SVIL supervillin 0.0220223
ZMIZ2 zinc finger, MIZ-type containing 2 0.021947
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0217111
PXDN peroxidasin 0.0214652

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.21092
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.176024
LSAMP limbic system-associated membrane protein -0.126106
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0962122
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0759882
CANX calnexin -0.0704077
FMN1 formin 1 -0.0696481
SLC39A11 solute carrier family 39, member 11 -0.0656787
NAMPT nicotinamide phosphoribosyltransferase -0.0655081
LAMP2 lysosomal-associated membrane protein 2 -0.0632493
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0588989
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0586751
SQSTM1 sequestosome 1 -0.050344
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.050339
PMEL premelanosome protein -0.0501186
VIM vimentin -0.0493458
MSI2 musashi RNA-binding protein 2 -0.0477387
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0471852
PTMA prothymosin, alpha -0.0414034
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0390704
TENM1 teneurin transmembrane protein 1 -0.038126
PTPRM protein tyrosine phosphatase, receptor type, M -0.0366585
RPL4 ribosomal protein L4 -0.0364792
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.03609
TFRC transferrin receptor -0.0357597
ANLN anillin, actin binding protein -0.0355207
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0354312
PGK1 phosphoglycerate kinase 1 -0.0351699
SPAG9 sperm associated antigen 9 -0.0330889
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0324668
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0319744
TNNC1 troponin C type 1 (slow) -0.031797
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.031241
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0311757
KDM3A lysine (K)-specific demethylase 3A -0.0309503
CADM1 cell adhesion molecule 1 -0.0308674
CLTC clathrin, heavy chain (Hc) -0.0305618
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0305264
MMP12 matrix metallopeptidase 12 -0.0294806
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0291422
TFPI2 tissue factor pathway inhibitor 2 -0.0285291
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0282193
CCND1 cyclin D1 -0.0280062
BBX bobby sox homolog (Drosophila) -0.0278586
MARCHF1 membrane associated ring-CH-type finger 1 -0.0277776
GARS1 glycyl-tRNA synthetase 1 -0.0277602
PRAME preferentially expressed antigen in melanoma -0.0274266
ZNF292 zinc finger protein 292 -0.0273887
IGF1R insulin-like growth factor 1 receptor -0.0267395
RYBP RING1 and YY1 binding protein -0.0262328
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.02609
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0259612
DIAPH2 diaphanous-related formin 2 -0.0254062
CCDC47 coiled-coil domain containing 47 -0.0252355
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0249067
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0246587
CA8 carbonic anhydrase VIII -0.0246289
FRMD4A FERM domain containing 4A -0.0244233
TXNRD1 thioredoxin reductase 1 -0.024115
ARMC9 armadillo repeat containing 9 -0.0241039
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0240421
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0238967
NBPF8 neuroblastoma breakpoint family, member 8 -0.0237729
CENPF centromere protein F, 350/400kDa -0.0234157
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0232797
MAP4 microtubule-associated protein 4 -0.0232636
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.023192
SOD2 superoxide dismutase 2, mitochondrial -0.0231624
ELL2 elongation factor, RNA polymerase II, 2 -0.0229302
BRWD3 bromodomain and WD repeat domain containing 3 -0.022831
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0226659
MATR3 matrin 3 -0.0226468
ICAM1 intercellular adhesion molecule 1 -0.0225392
RPS24 ribosomal protein S24 -0.0224823
MORF4L2 mortality factor 4 like 2 -0.0223595
SENP5 SUMO1/sentrin specific peptidase 5 -0.0222558
KAZN kazrin, periplakin interacting protein -0.0218312
NAP1L1 nucleosome assembly protein 1-like 1 -0.021539
ARHGAP5 Rho GTPase activating protein 5 -0.0215246
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0213222
LCORL ligand dependent nuclear receptor corepressor-like -0.0212236
CFAP20DC CFAP20 domain containing -0.0210099
TAS2R14 taste receptor, type 2, member 14 -0.0209078
AFF3 AF4/FMR2 family, member 3 -0.0208139
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0207086
TASOR2 transcription activation suppressor family member 2 -0.0204994
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0204767
IFIH1 interferon induced with helicase C domain 1 -0.0201902
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0201899
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0201229
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0201144
KIF4A kinesin family member 4A -0.0198696
HLA-E major histocompatibility complex, class I, E -0.019826
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0196203
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0195189
LARS1 leucyl-tRNA synthetase 1 -0.019508
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0192664
CLINT1 clathrin interactor 1 -0.0192324
ENTHD1 ENTH domain containing 1 -0.0191272
TKT transketolase -0.0191081