Cysteamine (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.292739
PDE4D phosphodiesterase 4D, cAMP-specific 0.125134
EEF2 eukaryotic translation elongation factor 2 0.0980281
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0821776
AHNAK AHNAK nucleoprotein 0.0808846
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.079015
ACTG1 actin gamma 1 0.0780285
VCL vinculin 0.0746545
LOC112694756 uncharaterized LOC112694756 0.0655062
EGFR epidermal growth factor receptor 0.0644262
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.063361
PFN1 profilin 1 0.0629046
PYGB phosphorylase, glycogen; brain 0.0587431
GLI3 GLI family zinc finger 3 0.0577566
DUSP4 dual specificity phosphatase 4 0.0538035
LOXL3 lysyl oxidase-like 3 0.0525756
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0485417
TJP1 tight junction protein 1 0.0480888
GLI2 GLI family zinc finger 2 0.0479395
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0465449
MYO5C myosin VC 0.046102
PDGFC platelet derived growth factor C 0.045892
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0457312
TM4SF1 transmembrane 4 L six family member 1 0.0444575
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.043285
RPL27 ribosomal protein L27 0.0425109
SOX6 SRY (sex determining region Y)-box 6 0.0420667
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0415314
FBLN2 fibulin 2 0.0393873
ENO1 enolase 1, (alpha) 0.0377722
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0374945
TGFBR3 transforming growth factor, beta receptor III 0.036944
ATP9B ATPase, class II, type 9B 0.0364484
GCLM glutamate-cysteine ligase, modifier subunit 0.0359591
RPL3 ribosomal protein L3 0.035805
RAB27B RAB27B, member RAS oncogene family 0.0357629
SOX9 SRY (sex determining region Y)-box 9 0.0356182
PRELID2 PRELI domain containing 2 0.0355195
MT2A metallothionein 2A 0.0352686
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0351866
S100A4 S100 calcium binding protein A4 0.0350334
ZNF608 zinc finger protein 608 0.0348452
RPL13A ribosomal protein L13a 0.0345999
HSPB1 heat shock 27kDa protein 1 0.0343558
PRPF38B pre-mRNA processing factor 38B 0.0340779
POTEF POTE ankyrin domain family, member F 0.0335118
FLNB filamin B, beta 0.0329908
EZR ezrin 0.0328552
IFI16 interferon, gamma-inducible protein 16 0.0325619
RPS4X ribosomal protein S4, X-linked 0.0318937
SRRM2 serine/arginine repetitive matrix 2 0.0317816
GSE1 Gse1 coiled-coil protein 0.0315564
KLF2 Kruppel-like factor 2 0.031361
TACC2 transforming, acidic coiled-coil containing protein 2 0.0313263
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0308511
ARL4C ADP-ribosylation factor-like 4C 0.030779
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0306117
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0305183
RPL28 ribosomal protein L28 0.0304083
TSC22D1 TSC22 domain family, member 1 0.029658
RPL11 ribosomal protein L11 0.0295063
TBC1D5 TBC1 domain family, member 5 0.0292004
LPP LIM domain containing preferred translocation partner in lipoma 0.0290241
PRDX2 peroxiredoxin 2 0.0287565
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.028698
PKM pyruvate kinase, muscle 0.0285592
SLC38A2 solute carrier family 38, member 2 0.0285013
GANAB glucosidase, alpha; neutral AB 0.0275398
ENO2 enolase 2 (gamma, neuronal) 0.0271468
NCOR2 nuclear receptor corepressor 2 0.0267087
HEG1 heart development protein with EGF-like domains 1 0.0266989
MACROD2 MACRO domain containing 2 0.0264095
ZMYND8 zinc finger, MYND-type containing 8 0.0263374
ARHGAP25 Rho GTPase activating protein 25 0.0259876
ACTN1 actinin, alpha 1 0.0259278
USP47 ubiquitin specific peptidase 47 0.0250556
IRS1 insulin receptor substrate 1 0.024992
AHCYL2 adenosylhomocysteinase-like 2 0.0249571
SPRY4 sprouty homolog 4 (Drosophila) 0.0242024
EEF1G eukaryotic translation elongation factor 1 gamma 0.0238145
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0237882
PRRC2A proline-rich coiled-coil 2A 0.0237751
STAU2 staufen double-stranded RNA binding protein 2 0.0237459
PARD3B par-3 family cell polarity regulator beta 0.0232179
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0228441
RPS6 ribosomal protein S6 0.0227404
HSPA8 heat shock 70kDa protein 8 0.0224225
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0223106
RHOB ras homolog family member B 0.022043
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0218163
DOCK5 dedicator of cytokinesis 5 0.0215059
PRDX1 peroxiredoxin 1 0.0211611
SMAD6 SMAD family member 6 0.0211248
HDAC9 histone deacetylase 9 0.0209945
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0206366
ZNF438 zinc finger protein 438 0.0205229
FER1L6 fer-1-like family member 6 0.0205139
ANXA1 annexin A1 0.0204514
EIF3L eukaryotic translation initiation factor 3, subunit L 0.0204315
ATP5F1E ATP synthase F1 subunit epsilon 0.020314

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.217167
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122514
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.11341
RBM39 RNA binding motif protein 39 -0.0993967
NAMPT nicotinamide phosphoribosyltransferase -0.0939556
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0762437
EVI5 ecotropic viral integration site 5 -0.075347
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.073878
GOLGA4 golgin A4 -0.0733775
ZNF292 zinc finger protein 292 -0.0714117
KDM3A lysine (K)-specific demethylase 3A -0.0693547
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0689711
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0674079
KMT2E lysine (K)-specific methyltransferase 2E -0.0609859
ZFAND3 zinc finger, AN1-type domain 3 -0.0604033
SSBP2 single-stranded DNA binding protein 2 -0.0569417
TMSB4X thymosin beta 4, X-linked -0.05482
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0544684
BIRC6 baculoviral IAP repeat containing 6 -0.0523818
MATR3 matrin 3 -0.0523338
QKI QKI, KH domain containing, RNA binding -0.0520477
CAMTA1 calmodulin binding transcription activator 1 -0.0506255
DSCAM Down syndrome cell adhesion molecule -0.0504311
RPL31 ribosomal protein L31 -0.0493243
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0492885
ADAM10 ADAM metallopeptidase domain 10 -0.0478109
WAC WW domain containing adaptor with coiled-coil -0.0476792
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0476168
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0474572
NIPBL Nipped-B homolog (Drosophila) -0.0464812
EXT1 exostosin glycosyltransferase 1 -0.0462858
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0455139
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0449088
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0446708
SMNDC1 survival motor neuron domain containing 1 -0.0436949
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0434929
FNDC3B fibronectin type III domain containing 3B -0.042309
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0414536
PDIA3 protein disulfide isomerase family A, member 3 -0.0413337
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0412539
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0405671
CDC73 cell division cycle 73 -0.0402983
NUP58 nucleoporin 58 -0.0397967
USP34 ubiquitin specific peptidase 34 -0.0396457
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0395039
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0393611
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0388085
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0386308
RLF rearranged L-myc fusion -0.038362
CAMKMT calmodulin-lysine N-methyltransferase -0.03773
DENND4A DENN/MADD domain containing 4A -0.0373168
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0371295
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0369611
ITCH itchy E3 ubiquitin protein ligase -0.0364501
TOP2B topoisomerase (DNA) II beta 180kDa -0.0358112
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0358096
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0356126
XPO1 exportin 1 -0.0352739
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0350247
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0346956
DLG1 discs, large homolog 1 (Drosophila) -0.034236
RAB6A RAB6A, member RAS oncogene family -0.0340058
FUBP1 far upstream element (FUSE) binding protein 1 -0.0338597
NCKAP1 NCK-associated protein 1 -0.0337731
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0334829
FBXO11 F-box protein 11 -0.0334768
PRRC2C proline-rich coiled-coil 2C -0.0334725
MEF2A myocyte enhancer factor 2A -0.0333757
ANK2 ankyrin 2, neuronal -0.0333078
RYBP RING1 and YY1 binding protein -0.0332493
TFG TRK-fused gene -0.0331359
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0329371
PUM2 pumilio RNA-binding family member 2 -0.0329198
GLS2 glutaminase 2 (liver, mitochondrial) -0.0328673
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0324333
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0323175
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0323008
TRA2A transformer 2 alpha homolog (Drosophila) -0.0316574
STRN3 striatin, calmodulin binding protein 3 -0.0311559
COG5 component of oligomeric golgi complex 5 -0.0310418
GARS1 glycyl-tRNA synthetase 1 -0.030772
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0307557
ZMYM2 zinc finger, MYM-type 2 -0.0305276
CUL3 cullin 3 -0.030507
VIM vimentin -0.0303902
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0301528
MED13L mediator complex subunit 13-like -0.0300856
TCF12 transcription factor 12 -0.0299466
NF1 neurofibromin 1 -0.029704
PDS5B PDS5 cohesin associated factor B -0.0294454
NFIA nuclear factor I/A -0.0292346
RPS2 ribosomal protein S2 -0.0290093
LCORL ligand dependent nuclear receptor corepressor-like -0.0289972
ACBD3 acyl-CoA binding domain containing 3 -0.0289617
NAP1L1 nucleosome assembly protein 1-like 1 -0.0288242
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.028786
RAB1A RAB1A, member RAS oncogene family -0.0286999
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0280751
ECPAS Ecm29 proteasome adaptor and scaffold -0.0280215
SRSF11 serine/arginine-rich splicing factor 11 -0.0279706