Cysteamine (hydrochloride)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.235719
TGFBI transforming growth factor, beta-induced, 68kDa 0.185152
MYH9 myosin, heavy chain 9, non-muscle 0.0762266
NRXN3 neurexin 3 0.0716728
COL6A2 collagen, type VI, alpha 2 0.0686477
HMGA2 high mobility group AT-hook 2 0.063638
COL6A1 collagen, type VI, alpha 1 0.0634502
SMAD3 SMAD family member 3 0.0607021
AKAP12 A kinase (PRKA) anchor protein 12 0.0524147
ELL2 elongation factor, RNA polymerase II, 2 0.0516488
ECE1 endothelin converting enzyme 1 0.047874
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0475369
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0470241
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0449183
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0438919
NAV1 neuron navigator 1 0.0421306
COL7A1 collagen, type VII, alpha 1 0.0415424
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0407042
FLNA filamin A, alpha 0.0399611
PDLIM5 PDZ and LIM domain 5 0.0383875
FNDC3B fibronectin type III domain containing 3B 0.0383827
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0373244
SHB Src homology 2 domain containing adaptor protein B 0.0372745
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0364633
COL5A1 collagen, type V, alpha 1 0.0360053
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0355578
PLEC plectin 0.0343237
SEPTIN9 septin 9 0.0341833
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0334687
RTN4 reticulon 4 0.0324887
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0315761
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0309116
EGFR epidermal growth factor receptor 0.0305225
BBS9 Bardet-Biedl syndrome 9 0.029075
HIPK2 homeodomain interacting protein kinase 2 0.0285965
LIMS1 LIM and senescent cell antigen-like domains 1 0.0283887
AKAP13 A kinase (PRKA) anchor protein 13 0.0266038
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0263926
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0261629
MAPK8 mitogen-activated protein kinase 8 0.0259154
MYOF myoferlin 0.0257733
COL4A1 collagen, type IV, alpha 1 0.0255887
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0249905
SETD5 SET domain containing 5 0.0246176
CLIP2 CAP-GLY domain containing linker protein 2 0.0244472
CTBP2 C-terminal binding protein 2 0.0243585
DNAAF9 dynein axonemal assembly factor 9 0.0240654
HLA-B major histocompatibility complex, class I, B 0.0238554
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0237578
PTPRM protein tyrosine phosphatase, receptor type, M 0.0237018
ANKRD17 ankyrin repeat domain 17 0.0233624
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0233175
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0231245
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0230879
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0230413
PTK2 protein tyrosine kinase 2 0.0228845
SFPQ splicing factor proline/glutamine-rich 0.0225818
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0223513
N4BP2L2 NEDD4 binding protein 2-like 2 0.0221959
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0221593
MARCHF7 membrane associated ring-CH-type finger 7 0.0220061
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0218761
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0216714
PRSS23 protease, serine, 23 0.0216126
BCAR3 breast cancer anti-estrogen resistance 3 0.0215
PHF14 PHD finger protein 14 0.0214574
LOC112694756 uncharaterized LOC112694756 0.0214005
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0213287
JARID2 jumonji, AT rich interactive domain 2 0.0213203
CA12 carbonic anhydrase XII 0.0212516
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0212133
ATXN1 ataxin 1 0.0210312
C1D C1D nuclear receptor corepressor 0.021028
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0209823
ANKRD11 ankyrin repeat domain 11 0.0208764
CD59 CD59 molecule, complement regulatory protein 0.0207163
MACF1 microtubule-actin crosslinking factor 1 0.020563
LOXL2 lysyl oxidase-like 2 0.0205251
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0204697
BACE2 beta-site APP-cleaving enzyme 2 0.020238
GSK3B glycogen synthase kinase 3 beta 0.0201952
CUL3 cullin 3 0.0201791
SMYD3 SET and MYND domain containing 3 0.0200976
LGALS3 lectin, galactoside-binding, soluble, 3 0.0200782
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0200273
MEF2A myocyte enhancer factor 2A 0.0199168
KMT2C lysine (K)-specific methyltransferase 2C 0.0198736
FAM20C family with sequence similarity 20, member C 0.019868
CD44 CD44 molecule (Indian blood group) 0.0198547
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0198311
MYO9B myosin IXB 0.0195976
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0195895
ANKRD12 ankyrin repeat domain 12 0.0194229
MCL1 myeloid cell leukemia 1 0.0194029
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0193985
ATP13A3 ATPase type 13A3 0.0193856
FOXJ3 forkhead box J3 0.019339
GSE1 Gse1 coiled-coil protein 0.0192896
MBD5 methyl-CpG binding domain protein 5 0.0192137
CLMP CXADR-like membrane protein 0.0191766

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.328399
CXCL8 chemokine (C-X-C motif) ligand 8 -0.151869
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.130829
VIM vimentin -0.124849
TMSB10 thymosin beta 10 -0.115858
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0921291
PTMA prothymosin, alpha -0.0854204
FTL ferritin, light polypeptide -0.0632421
F3 coagulation factor III (thromboplastin, tissue factor) -0.0632242
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0515724
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0512348
RPLP1 ribosomal protein, large, P1 -0.0407212
FN1 fibronectin 1 -0.0372205
ZMYND8 zinc finger, MYND-type containing 8 -0.0368329
RAB1A RAB1A, member RAS oncogene family -0.0360635
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0359922
RBM39 RNA binding motif protein 39 -0.0350394
CANX calnexin -0.0349415
B2M beta-2-microglobulin -0.0342618
S100A6 S100 calcium binding protein A6 -0.0338385
UBC ubiquitin C -0.0336094
S100A9 S100 calcium binding protein A9 -0.0330067
CALR calreticulin -0.0328835
MORF4L2 mortality factor 4 like 2 -0.0309269
RPS24 ribosomal protein S24 -0.0308549
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0307768
H3-3B H3.3 histone B -0.029956
LMAN1 lectin, mannose-binding, 1 -0.02987
POTEF POTE ankyrin domain family, member F -0.029735
TUBA1B tubulin, alpha 1b -0.0286844
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0279834
TMSB4X thymosin beta 4, X-linked -0.0277518
ANLN anillin, actin binding protein -0.0276377
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0270827
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0269173
CCNI cyclin I -0.0267672
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0264567
HMGB2 high mobility group box 2 -0.0261555
RPL31 ribosomal protein L31 -0.0261018
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0260774
TUBB tubulin, beta class I -0.0258908
FAM13A family with sequence similarity 13, member A -0.0252289
BIRC6 baculoviral IAP repeat containing 6 -0.0250681
PGK1 phosphoglycerate kinase 1 -0.0245483
ZNF395 zinc finger protein 395 -0.0245321
RPL34 ribosomal protein L34 -0.0243356
RAB2A RAB2A, member RAS oncogene family -0.024302
RPL35A ribosomal protein L35a -0.024251
SEPTIN7 septin 7 -0.0242398
RPL5 ribosomal protein L5 -0.0238312
QKI QKI, KH domain containing, RNA binding -0.0237781
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0236037
SLC38A1 solute carrier family 38, member 1 -0.0234629
RPS5 ribosomal protein S5 -0.0233499
EIF1 eukaryotic translation initiation factor 1 -0.0231896
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0231815
RPLP2 ribosomal protein, large, P2 -0.0228051
VDAC1 voltage-dependent anion channel 1 -0.022773
HMGB1 high mobility group box 1 -0.0220277
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0220217
CENPE centromere protein E, 312kDa -0.0215747
TNS3 tensin 3 -0.0214841
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0214156
TPT1 tumor protein, translationally-controlled 1 -0.0213793
NAMPT nicotinamide phosphoribosyltransferase -0.0210731
RPL26 ribosomal protein L26 -0.0208252
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0207174
STC1 stanniocalcin 1 -0.0205209
MATR3 matrin 3 -0.0205192
CBX3 chromobox homolog 3 -0.0204341
PKM pyruvate kinase, muscle -0.0203689
IL6 interleukin 6 -0.0203688
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0201582
ADM adrenomedullin -0.0198573
SKIC3 SKI3 subunit of superkiller complex -0.019768
LDHA lactate dehydrogenase A -0.0196822
SCARB2 scavenger receptor class B, member 2 -0.019404
COL3A1 collagen, type III, alpha 1 -0.0192457
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0191453
RACK1 receptor for activated C kinase 1 -0.019141
RPS23 ribosomal protein S23 -0.0190439
YBX1 Y box binding protein 1 -0.0190187
NCOA7 nuclear receptor coactivator 7 -0.0189543
MT2A metallothionein 2A -0.0189234
NDUFA4 NDUFA4, mitochondrial complex associated -0.0188229
STAG2 stromal antigen 2 -0.0187659
GNAS GNAS complex locus -0.0184928
NOP58 NOP58 ribonucleoprotein -0.0182809
DDIT4 DNA-damage-inducible transcript 4 -0.0182301
CENPF centromere protein F, 350/400kDa -0.0181154
TMEM123 transmembrane protein 123 -0.0180864
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.017988
IGFBP7 insulin-like growth factor binding protein 7 -0.0179255
RRBP1 ribosome binding protein 1 -0.0178982
LAMB3 laminin, beta 3 -0.0178748
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.017792
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0177615
CFDP1 craniofacial development protein 1 -0.0176785
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0175336
RPS13 ribosomal protein S13 -0.0175099