Cysteamine (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 0.118196
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0956658
ZSWIM6 zinc finger, SWIM-type containing 6 0.0811645
ASPH aspartate beta-hydroxylase 0.069322
GRB10 growth factor receptor-bound protein 10 0.0673215
STC2 stanniocalcin 2 0.0604161
HMGA2 high mobility group AT-hook 2 0.0596739
MCL1 myeloid cell leukemia 1 0.0569216
LIMCH1 LIM and calponin homology domains 1 0.0538451
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0531545
INTS6 integrator complex subunit 6 0.0531006
VCL vinculin 0.0497821
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.049638
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0487782
EXT1 exostosin glycosyltransferase 1 0.0486113
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0463815
ACTG1 actin gamma 1 0.0461873
FTH1 ferritin, heavy polypeptide 1 0.0455469
SFTPA2 surfactant protein A2 0.0454013
ENO2 enolase 2 (gamma, neuronal) 0.0452835
MRPS6 mitochondrial ribosomal protein S6 0.045028
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0444725
PDLIM5 PDZ and LIM domain 5 0.0423923
APLP2 amyloid beta (A4) precursor-like protein 2 0.042209
AEBP2 AE binding protein 2 0.0417373
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0405697
VEGFA vascular endothelial growth factor A 0.0384193
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0381975
SEPTIN9 septin 9 0.0377949
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0374752
TCIM transcriptional and immune response regulator 0.0374336
PDE4D phosphodiesterase 4D, cAMP-specific 0.0374078
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0373024
EFNA5 ephrin-A5 0.037266
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0369374
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0363442
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0362648
LOC102724023 ES1 protein homolog, mitochondrial 0.0359493
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0356851
DUSP6 dual specificity phosphatase 6 0.0352105
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0345029
CUX1 cut-like homeobox 1 0.0344831
GPC6 glypican 6 0.0340382
BRD2 bromodomain containing 2 0.0339635
FN1 fibronectin 1 0.0338925
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0328655
LRRC23 leucine rich repeat containing 23 0.0321467
RPL37A ribosomal protein L37a 0.0315348
DSTN destrin (actin depolymerizing factor) 0.03129
SRRM2 serine/arginine repetitive matrix 2 0.0312052
TOP1 topoisomerase (DNA) I 0.0304653
PALLD palladin, cytoskeletal associated protein 0.0304499
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0296745
GLIS3 GLIS family zinc finger 3 0.0295988
EGR1 early growth response 1 0.0287948
SHB Src homology 2 domain containing adaptor protein B 0.0282454
RASAL2 RAS protein activator like 2 0.0280242
SLC38A2 solute carrier family 38, member 2 0.0274587
RPS12 ribosomal protein S12 0.0271498
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0267926
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0266453
RPL28 ribosomal protein L28 0.0263977
SVIL supervillin 0.0262531
MYO1E myosin IE 0.0256336
CTBP2 C-terminal binding protein 2 0.0254033
TUFT1 tuftelin 1 0.0253681
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0253136
FHL2 four and a half LIM domains 2 0.0252984
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0247332
BICD1 bicaudal D homolog 1 (Drosophila) 0.0244418
NCOR2 nuclear receptor corepressor 2 0.0244137
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0238926
POTEF POTE ankyrin domain family, member F 0.0238491
NPAS2 neuronal PAS domain protein 2 0.023712
IFI44L interferon-induced protein 44-like 0.02371
ZFYVE16 zinc finger, FYVE domain containing 16 0.0237037
LOXL2 lysyl oxidase-like 2 0.0236825
DOCK5 dedicator of cytokinesis 5 0.0236053
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0234532
ANKRD28 ankyrin repeat domain 28 0.0233394
TGFB1 transforming growth factor, beta 1 0.0232648
N4BP2L2 NEDD4 binding protein 2-like 2 0.0229852
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0229815
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0229103
CCSER1 coiled-coil serine-rich protein 1 0.022796
GPATCH2L G patch domain containing 2-like 0.0227801
RPL37 ribosomal protein L37 0.0226783
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0223231
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0223097
ZCCHC7 zinc finger, CCHC domain containing 7 0.022051
PRKCA protein kinase C, alpha 0.0220178
SPIRE1 spire-type actin nucleation factor 1 0.0219755
FRY furry homolog (Drosophila) 0.0217755
ABR active BCR-related 0.0215683
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0214441
CLIP2 CAP-GLY domain containing linker protein 2 0.0211009
EGFR epidermal growth factor receptor 0.021044
KDM6B lysine (K)-specific demethylase 6B 0.0209674
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0208317
POU2F2 POU class 2 homeobox 2 0.020686

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.265109
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.237564
NAMPT nicotinamide phosphoribosyltransferase -0.166586
CXCL8 chemokine (C-X-C motif) ligand 8 -0.144964
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127634
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0993282
CANX calnexin -0.0851967
CENPF centromere protein F, 350/400kDa -0.0844111
PTMA prothymosin, alpha -0.0776817
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0728342
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0675016
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0646879
MKI67 marker of proliferation Ki-67 -0.0642645
TMSB10 thymosin beta 10 -0.0609283
MARCHF6 membrane associated ring-CH-type finger 6 -0.0566789
RAD21 RAD21 homolog (S. pombe) -0.056014
ITGA1 integrin, alpha 1 -0.0554772
KDM3A lysine (K)-specific demethylase 3A -0.0534975
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0513569
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0511726
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0496567
TMSB4X thymosin beta 4, X-linked -0.0489255
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0478553
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.047544
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0473887
NIPBL Nipped-B homolog (Drosophila) -0.0461966
ZNF292 zinc finger protein 292 -0.04594
RNF145 ring finger protein 145 -0.0445037
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0442871
ANLN anillin, actin binding protein -0.0442563
LCORL ligand dependent nuclear receptor corepressor-like -0.0436388
FTL ferritin, light polypeptide -0.0429528
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0423987
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0418838
OGA O-GlcNAcase -0.0416529
IER3 immediate early response 3 -0.0402679
SPAG9 sperm associated antigen 9 -0.0396703
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0396046
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0393882
PGK1 phosphoglycerate kinase 1 -0.0386767
NPEPPS aminopeptidase puromycin sensitive -0.0386416
TXNRD1 thioredoxin reductase 1 -0.0368263
NEK7 NIMA-related kinase 7 -0.0365569
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0363499
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0360618
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.035944
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0358817
ARF1 ADP-ribosylation factor 1 -0.0350633
MATR3 matrin 3 -0.0349935
SEPTIN7 septin 7 -0.0348948
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0347872
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0347093
MIS18BP1 MIS18 binding protein 1 -0.0344732
RPL35A ribosomal protein L35a -0.0344081
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0342837
AHR aryl hydrocarbon receptor -0.0337856
VIM vimentin -0.0336353
RBM39 RNA binding motif protein 39 -0.0332101
RPS24 ribosomal protein S24 -0.0331565
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0327938
ZNF217 zinc finger protein 217 -0.0327171
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0325136
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0325074
ETV1 ets variant 1 -0.0317832
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0308278
SOD2 superoxide dismutase 2, mitochondrial -0.0305106
NAP1L1 nucleosome assembly protein 1-like 1 -0.0303189
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0301316
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0296869
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.029466
CLINT1 clathrin interactor 1 -0.0291751
AFF4 AF4/FMR2 family, member 4 -0.0291283
TFPI2 tissue factor pathway inhibitor 2 -0.0289739
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0285889
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.028584
CLTC clathrin, heavy chain (Hc) -0.0285049
RLF rearranged L-myc fusion -0.0284958
MCTP2 multiple C2 domains, transmembrane 2 -0.028484
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0284556
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0282685
ZMYND8 zinc finger, MYND-type containing 8 -0.0281781
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0281587
ZFR zinc finger RNA binding protein -0.0280991
WAC WW domain containing adaptor with coiled-coil -0.0280986
ECT2 epithelial cell transforming 2 -0.0279172
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0278615
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0277967
TPX2 TPX2, microtubule-associated -0.0277804
TPR translocated promoter region, nuclear basket protein -0.0277039
CEP350 centrosomal protein 350kDa -0.0274811
FNBP1 formin binding protein 1 -0.0273492
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0273355
WDR45B WD repeat domain 45B -0.026498
USP3 ubiquitin specific peptidase 3 -0.0264954
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0264356
ZMYM2 zinc finger, MYM-type 2 -0.0263491
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0261288
NDRG1 N-myc downstream regulated 1 -0.02599
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0259318
INSIG2 insulin induced gene 2 -0.0259076