Cysteamine (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cysteamine (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cysteamine (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.1171
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.073388
H1-0 H1.0 linker histone 0.0700263
MKI67 marker of proliferation Ki-67 0.0628725
TPX2 TPX2, microtubule-associated 0.0620099
SNX9 sorting nexin 9 0.0608791
CENPF centromere protein F, 350/400kDa 0.058938
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0545844
ACTN4 actinin, alpha 4 0.0542593
ZNRF3 zinc and ring finger 3 0.0540921
NCEH1 neutral cholesterol ester hydrolase 1 0.0534523
BCL2L1 BCL2-like 1 0.0509045
PTK2 protein tyrosine kinase 2 0.0494148
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0484291
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0461054
NEBL nebulette 0.0457281
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0454392
MACC1 metastasis associated in colon cancer 1 0.0449946
MYOF myoferlin 0.0422607
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0414556
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0411789
SVIL supervillin 0.0410206
NAV2 neuron navigator 2 0.0409305
TBC1D5 TBC1 domain family, member 5 0.0406996
PKP4 plakophilin 4 0.0398073
UBE2H ubiquitin-conjugating enzyme E2H 0.039698
TXNIP thioredoxin interacting protein 0.0387121
EHBP1 EH domain binding protein 1 0.0370902
FRMD5 FERM domain containing 5 0.0370554
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0365039
ECT2 epithelial cell transforming 2 0.0362377
SMC4 structural maintenance of chromosomes 4 0.0352676
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0352667
PRELID2 PRELI domain containing 2 0.0345086
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.034446
OSBPL10 oxysterol binding protein-like 10 0.034235
CENPE centromere protein E, 312kDa 0.0328919
ITGA6 integrin, alpha 6 0.0324262
RAD21 RAD21 homolog (S. pombe) 0.032389
TGFA transforming growth factor, alpha 0.0319421
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0316754
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0299003
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0298499
EZR ezrin 0.0297725
NCKAP1 NCK-associated protein 1 0.0292277
CKAP5 cytoskeleton associated protein 5 0.0292188
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0279315
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0278899
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0278308
CLDN4 claudin 4 0.0277463
CCNL1 cyclin L1 0.0271934
FAM3C family with sequence similarity 3, member C 0.0270392
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0269114
GPSM2 G-protein signaling modulator 2 0.0268093
KIF4A kinesin family member 4A 0.0265649
ANKRD28 ankyrin repeat domain 28 0.0261064
PLAUR plasminogen activator, urokinase receptor 0.0257074
TRAPPC9 trafficking protein particle complex 9 0.0253416
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0253354
ANXA11 annexin A11 0.0252705
AOPEP aminopeptidase O (putative) 0.0246714
NRP1 neuropilin 1 0.0245455
NKD1 naked cuticle homolog 1 (Drosophila) 0.0245336
ANKRD12 ankyrin repeat domain 12 0.0245228
SMYD3 SET and MYND domain containing 3 0.0244693
KLF10 Kruppel-like factor 10 0.0241809
SRPK2 SRSF protein kinase 2 0.0240249
TXNRD1 thioredoxin reductase 1 0.0238564
KDM7A lysine (K)-specific demethylase 7A 0.0237257
KMT2C lysine (K)-specific methyltransferase 2C 0.0235649
SKAP2 src kinase associated phosphoprotein 2 0.02348
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0234006
EXOC6B exocyst complex component 6B 0.023333
MATR3 matrin 3 0.0229605
ARHGAP42 Rho GTPase activating protein 42 0.0229003
WWOX WW domain containing oxidoreductase 0.0225211
GSK3B glycogen synthase kinase 3 beta 0.0223579
CTNND1 catenin (cadherin-associated protein), delta 1 0.0222951
YAP1 Yes-associated protein 1 0.0222927
USP3 ubiquitin specific peptidase 3 0.0219722
TRIM44 tripartite motif containing 44 0.0219476
FLNA filamin A, alpha 0.0218466
DIAPH1 diaphanous-related formin 1 0.0218328
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0215433
CEP192 centrosomal protein 192kDa 0.0213585
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0212612
NAMPT nicotinamide phosphoribosyltransferase 0.0212014
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 0.021169
NF1 neurofibromin 1 0.0210503
RNF145 ring finger protein 145 0.0210308
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0208234
ETV6 ets variant 6 0.0205654
RPS21 ribosomal protein S21 0.0204926
TNRC18 trinucleotide repeat containing 18 0.0204604
BCLAF1 BCL2-associated transcription factor 1 0.020349
EXOC4 exocyst complex component 4 0.0203365
RNF43 ring finger protein 43 0.0202775
EPS8 epidermal growth factor receptor pathway substrate 8 0.0202473
NPEPPS aminopeptidase puromycin sensitive 0.0200749
B2M beta-2-microglobulin 0.0198303

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.103214
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0818364
IFRD1 interferon-related developmental regulator 1 -0.0670913
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0669661
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0660854
HM13 histocompatibility (minor) 13 -0.0660105
NDRG1 N-myc downstream regulated 1 -0.0578356
TPT1 tumor protein, translationally-controlled 1 -0.0559911
GNAS GNAS complex locus -0.0558411
INTS6 integrator complex subunit 6 -0.0531224
PDIA3 protein disulfide isomerase family A, member 3 -0.0518877
FNDC3B fibronectin type III domain containing 3B -0.0511837
CANX calnexin -0.0483979
VCL vinculin -0.0481885
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0408313
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0393962
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0392146
MAML2 mastermind-like 2 (Drosophila) -0.038365
GMDS GDP-mannose 4,6-dehydratase -0.0383414
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0380597
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.036735
CLIP2 CAP-GLY domain containing linker protein 2 -0.0365152
RPS24 ribosomal protein S24 -0.0362832
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0357579
RPS6 ribosomal protein S6 -0.0356763
RPS25 ribosomal protein S25 -0.0356757
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0356102
RPLP1 ribosomal protein, large, P1 -0.0354595
RPL35A ribosomal protein L35a -0.0350009
TPM4 tropomyosin 4 -0.0342768
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0338052
P4HB prolyl 4-hydroxylase, beta polypeptide -0.032956
CEMIP cell migration inducing protein, hyaluronan binding -0.0319001
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0317183
RTN3 reticulon 3 -0.0314768
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0314555
CEMIP2 cell migration inducing hyaluronidase 2 -0.0314515
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0305757
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0304364
TAS2R14 taste receptor, type 2, member 14 -0.0303245
GOLGB1 golgin B1 -0.0302914
KLF5 Kruppel-like factor 5 (intestinal) -0.0297266
UBAP2 ubiquitin associated protein 2 -0.029708
ZSWIM6 zinc finger, SWIM-type containing 6 -0.029638
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0295414
RCOR1 REST corepressor 1 -0.0293538
HDLBP high density lipoprotein binding protein -0.0290882
FAM107B family with sequence similarity 107, member B -0.0285797
CDK13 cyclin-dependent kinase 13 -0.0278164
RPL31 ribosomal protein L31 -0.0275801
TUFT1 tuftelin 1 -0.0275113
EPCAM epithelial cell adhesion molecule -0.0274589
COTL1 coactosin-like F-actin binding protein 1 -0.0273404
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0273205
SDK1 sidekick cell adhesion molecule 1 -0.0269435
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0269236
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0268881
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0266456
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0266114
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0263984
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0263862
MORF4L2 mortality factor 4 like 2 -0.0260172
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0259908
ANXA2 annexin A2 -0.0257769
PKM pyruvate kinase, muscle -0.025083
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0248921
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0247159
TMSB10 thymosin beta 10 -0.0243595
PDIA5 protein disulfide isomerase family A, member 5 -0.0242547
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0238143
BZW2 basic leucine zipper and W2 domains 2 -0.0235024
LASP1 LIM and SH3 protein 1 -0.023498
STX5 syntaxin 5 -0.0233941
RAB10 RAB10, member RAS oncogene family -0.0233121
MYH14 myosin, heavy chain 14, non-muscle -0.0231966
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0231459
RPLP0 ribosomal protein, large, P0 -0.0230291
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0228193
SRP54 signal recognition particle 54kDa -0.0227741
RPS3 ribosomal protein S3 -0.0225797
KDM5B lysine (K)-specific demethylase 5B -0.0225521
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0224298
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0224178
RAB7A RAB7A, member RAS oncogene family -0.0219786
KCMF1 potassium channel modulatory factor 1 -0.0219466
ZMYND8 zinc finger, MYND-type containing 8 -0.0216021
LGALS3 lectin, galactoside-binding, soluble, 3 -0.021476
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0213792
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0211886
KAT6B K(lysine) acetyltransferase 6B -0.0211632
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0211424
MYO1E myosin IE -0.020894
SEC24D SEC24 family member D -0.0208156
PTGES2 prostaglandin E synthase 2 -0.0207732
RPL15 ribosomal protein L15 -0.0207662
LARP1B La ribonucleoprotein domain family, member 1B -0.0206512
CTSD cathepsin D -0.0206408
GLG1 golgi glycoprotein 1 -0.0203737
COPB1 coatomer protein complex, subunit beta 1 -0.0203633
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0202643