Cysteine and methionine metabolism Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034]. (Kyoto Encyclopedia of Genes and Genomes, hsa00270)
External Link https://www.kegg.jp/entry/hsa00270
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Genes

51 proteins participating in the Cysteine and methionine metabolism pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADI1 acireductone dioxygenase 1
AGXT2 alanine--glyoxylate aminotransferase 2
AHCY adenosylhomocysteinase
AHCYL1 adenosylhomocysteinase-like 1
AHCYL2 adenosylhomocysteinase-like 2
APIP APAF1 interacting protein
ATAT1 alpha tubulin acetyltransferase 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BHMT betaine--homocysteine S-methyltransferase
BHMT2 betaine--homocysteine S-methyltransferase 2
CDO1 cysteine dioxygenase type 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ENOPH1 enolase-phosphatase 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GNMT glycine N-methyltransferase
GOLT1A golgi transport 1A
GOT1L1 glutamic-oxaloacetic transaminase 1-like 1
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
IL4I1 interleukin 4 induced 1
KYAT1 kynurenine aminotransferase 1
KYAT3 kynurenine aminotransferase 3
LACC1 laccase (multicopper oxidoreductase) domain containing 1
LDHA lactate dehydrogenase A
LDHAL6A lactate dehydrogenase A-like 6A
LDHAL6B lactate dehydrogenase A-like 6B
LDHB lactate dehydrogenase B
LDHC lactate dehydrogenase C
LOC102724560 cystathionine beta-synthase
MAT1A methionine adenosyltransferase I, alpha
MAT2A methionine adenosyltransferase II, alpha
MAT2B methionine adenosyltransferase II, beta
MDH1 malate dehydrogenase 1, NAD (soluble)
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MPST mercaptopyruvate sulfurtransferase
MRI1 methylthioribose-1-phosphate isomerase 1
MTAP methylthioadenosine phosphorylase
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NPR2 natriuretic peptide receptor 2
PHGDH phosphoglycerate dehydrogenase
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
RAI1 retinoic acid induced 1
SBDS Shwachman-Bodian-Diamond syndrome
SDSL serine dehydratase-like
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
VSIG2 V-set and immunoglobulin domain containing 2