Cystic Fibrosis_Intestinal Epithelium_GSE765 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE765
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Genes

600 genes differentially expressed during Cystic Fibrosis_Intestinal Epithelium_GSE765 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
MRPL4 mitochondrial ribosomal protein L4 5.40898
HAUS8 HAUS augmin-like complex, subunit 8 4.40161
TMED2 transmembrane emp24 domain trafficking protein 2 3.97905
HMGN1 high mobility group nucleosome binding domain 1 3.77735
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 3.59679
PRDX6 peroxiredoxin 6 3.58448
RAB7A RAB7A, member RAS oncogene family 3.37656
UNC50 unc-50 homolog (C. elegans) 3.21696
RAB20 RAB20, member RAS oncogene family 3.21115
DMBT1 deleted in malignant brain tumors 1 3.17831
TUBB tubulin, beta class I 3.08955
C5ORF15 chromosome 5 open reading frame 15 3.00672
ACPP acid phosphatase, prostate 2.86683
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 2.6525
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.60577
ACOT7 acyl-CoA thioesterase 7 2.59904
TMEM97 transmembrane protein 97 2.52491
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 2.51827
ANXA5 annexin A5 2.40076
FAM192A family with sequence similarity 192, member A 2.39529
ZNHIT1 zinc finger, HIT-type containing 1 2.38747
TEX30 testis expressed 30 2.35978
TSPAN9 tetraspanin 9 2.34338
MTIF2 mitochondrial translational initiation factor 2 2.33633
POMP proteasome maturation protein 2.3126
JAK3 Janus kinase 3 2.29802
RNF149 ring finger protein 149 2.26195
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.2438
ZNF207 zinc finger protein 207 2.23591
CCDC12 coiled-coil domain containing 12 2.22968
PTPN2 protein tyrosine phosphatase, non-receptor type 2 2.18745
TPI1 triosephosphate isomerase 1 2.18704
MRPL18 mitochondrial ribosomal protein L18 2.17614
NXT1 nuclear transport factor 2-like export factor 1 2.16369
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.15018
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 2.12545
JAGN1 jagunal homolog 1 (Drosophila) 2.12446
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.12
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.10103
ATF6B activating transcription factor 6 beta 2.07083
FN1 fibronectin 1 2.06217
MYEOV2 myeloma overexpressed 2 2.06058
NRD1 nardilysin (N-arginine dibasic convertase) 2.01762
CWC15 CWC15 spliceosome-associated protein 2.0087
KRAS Kirsten rat sarcoma viral oncogene homolog 1.99906
ZFAND5 zinc finger, AN1-type domain 5 1.99093
RPS24 ribosomal protein S24 1.96484
UQCRC1 ubiquinol-cytochrome c reductase core protein I 1.94213
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.93159
SLC25A39 solute carrier family 25, member 39 1.9281
MRPS28 mitochondrial ribosomal protein S28 1.90938
SMYD5 SMYD family member 5 1.9024
MTX2 metaxin 2 1.90049
SOD3 superoxide dismutase 3, extracellular 1.89012
POLD2 polymerase (DNA directed), delta 2, accessory subunit 1.87075
IFITM3 interferon induced transmembrane protein 3 1.86353
PXK PX domain containing serine/threonine kinase 1.86029
NEK2 NIMA-related kinase 2 1.82237
GARS glycyl-tRNA synthetase 1.78729
MRPL35 mitochondrial ribosomal protein L35 1.78522
SHISA5 shisa family member 5 1.7349
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.73052
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.69403
STK40 serine/threonine kinase 40 1.68671
RFC2 replication factor C (activator 1) 2, 40kDa 1.68153
C20ORF24 chromosome 20 open reading frame 24 1.66902
PQLC3 PQ loop repeat containing 3 1.66884
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.66451
PLRG1 pleiotropic regulator 1 1.66406
H19 H19, imprinted maternally expressed transcript (non-protein coding) 1.65199
MDP1 magnesium-dependent phosphatase 1 1.6478
LAT linker for activation of T cells 1.64445
LGALS8 lectin, galactoside-binding, soluble, 8 1.61987
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 1.5828
RPL3 ribosomal protein L3 1.55952
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 1.55024
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.54871
OXCT1 3-oxoacid CoA transferase 1 1.54852
ARL1 ADP-ribosylation factor-like 1 1.54509
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 1.53899
PRDX4 peroxiredoxin 4 1.53693
OCIAD1 OCIA domain containing 1 1.53621
CD3D CD3d molecule, delta (CD3-TCR complex) 1.52851
AMMECR1L AMMECR1-like 1.52581
PHB2 prohibitin 2 1.51211
PPP6R3 protein phosphatase 6, regulatory subunit 3 1.50791
SAMM50 SAMM50 sorting and assembly machinery component 1.50627
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 1.5052
WDR82 WD repeat domain 82 1.50358
NPC2 Niemann-Pick disease, type C2 1.48751
SDCBP syndecan binding protein (syntenin) 1.4855
DAPK2 death-associated protein kinase 2 1.47635
EIF3A eukaryotic translation initiation factor 3, subunit A 1.47519
DDB1 damage-specific DNA binding protein 1, 127kDa 1.47499
CAPN5 calpain 5 1.47169
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 1.47001
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) 1.46941
CORO1C coronin, actin binding protein, 1C 1.45244
ZNF746 zinc finger protein 746 1.44605
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.44271
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 1.43876
FGF11 fibroblast growth factor 11 1.43873
SF3B5 splicing factor 3b, subunit 5, 10kDa 1.43613
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 1.432
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 1.42735
FRYL FRY-like 1.42353
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 1.41822
PREPL prolyl endopeptidase-like 1.40094
FOXD2 forkhead box D2 1.40066
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) 1.39523
ERCC4 excision repair cross-complementation group 4 1.39107
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 1.38673
PEX11B peroxisomal biogenesis factor 11 beta 1.38472
MRPL28 mitochondrial ribosomal protein L28 1.3843
TRAPPC1 trafficking protein particle complex 1 1.37759
ZDHHC3 zinc finger, DHHC-type containing 3 1.37367
HTT huntingtin 1.3723
TMEM55A transmembrane protein 55A 1.36841
ANKRD13A ankyrin repeat domain 13A 1.36088
ELP3 elongator acetyltransferase complex subunit 3 1.35677
NDE1 nudE neurodevelopment protein 1 1.35309
DAGLB diacylglycerol lipase, beta 1.35006
PQLC1 PQ loop repeat containing 1 1.33997
FAM96A family with sequence similarity 96, member A 1.32685
ARMC10 armadillo repeat containing 10 1.30966
SERTAD1 SERTA domain containing 1 1.3026
CHEK1 checkpoint kinase 1 1.29867
ALLC allantoicase 1.29605
DRD3 dopamine receptor D3 1.29567
OLA1 Obg-like ATPase 1 1.28571
SYNGR2 synaptogyrin 2 1.27474
EIF3C eukaryotic translation initiation factor 3, subunit C 1.27459
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 1.27306
ATP13A1 ATPase type 13A1 1.27192
DSCR3 Down syndrome critical region 3 1.26741
BPGM 2,3-bisphosphoglycerate mutase 1.26508
WDR61 WD repeat domain 61 1.25188
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 1.24988
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 1.24852
PID1 phosphotyrosine interaction domain containing 1 1.24015
CUL1 cullin 1 1.22946
PRDX3 peroxiredoxin 3 1.22264
KLK8 kallikrein-related peptidase 8 1.21748
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 1.21372
JCHAIN joining chain of multimeric IgA and IgM 1.21007
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 1.20447
SNAP47 synaptosomal-associated protein, 47kDa 1.18979
SEP15 15 kDa selenoprotein 1.18918
ROMO1 reactive oxygen species modulator 1 1.18891
CKS1B CDC28 protein kinase regulatory subunit 1B 1.18675
TFB2M transcription factor B2, mitochondrial 1.18005
RAD52 RAD52 homolog (S. cerevisiae) 1.17796
GPC3 glypican 3 1.1743
C9ORF16 chromosome 9 open reading frame 16 1.1674
CCNB2 cyclin B2 1.16581
TMEM179B transmembrane protein 179B 1.16491
TSPAN12 tetraspanin 12 1.16258
E2F5 E2F transcription factor 5, p130-binding 1.15893
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) 1.15688
H1F0 H1 histone family, member 0 1.15104
DSC2 desmocollin 2 1.14397
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 1.14046
KIAA1524 KIAA1524 1.13741
TMX2 thioredoxin-related transmembrane protein 2 1.13379
IMP3 IMP3, U3 small nucleolar ribonucleoprotein 1.13216
RBM3 RNA binding motif (RNP1, RRM) protein 3 1.12567
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 1.1172
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 1.11604
THOC3 THO complex 3 1.1152
KLHL9 kelch-like family member 9 1.11428
PLK1 polo-like kinase 1 1.11211
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.11009
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 1.10718
FCF1 FCF1 rRNA-processing protein 1.10687
RPL13A ribosomal protein L13a 1.10333
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 1.1005
COL1A2 collagen, type I, alpha 2 1.09765
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.0969
SRP19 signal recognition particle 19kDa 1.09448
UBA2 ubiquitin-like modifier activating enzyme 2 1.08859
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 1.08573
HNRNPR heterogeneous nuclear ribonucleoprotein R 1.08482
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 1.08221
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 1.081
MRPL30 mitochondrial ribosomal protein L30 1.07492
CDC37 cell division cycle 37 1.07362
MRPL51 mitochondrial ribosomal protein L51 1.07255
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 1.06523
MFSD5 major facilitator superfamily domain containing 5 1.06298
MTDH metadherin 1.06195
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 1.06185
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.05688
TSPO translocator protein (18kDa) 1.05398
BIRC5 baculoviral IAP repeat containing 5 1.05237
NPDC1 neural proliferation, differentiation and control, 1 1.05026
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 1.04893
RAD23B RAD23 homolog B (S. cerevisiae) 1.04783
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 1.04612
TAC1 tachykinin, precursor 1 1.04263
C4ORF27 chromosome 4 open reading frame 27 1.03951
CDCA8 cell division cycle associated 8 1.03903
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 1.03521
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1.0345
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 1.03253
PNO1 partner of NOB1 homolog (S. cerevisiae) 1.02536
PRC1 protein regulator of cytokinesis 1 1.01805
POU2F3 POU class 2 homeobox 3 1.01669
GSPT1 G1 to S phase transition 1 1.01631
CSTB cystatin B (stefin B) 1.01447
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 1.0094
TLR6 toll-like receptor 6 1.0082
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 1.00812
PCSK7 proprotein convertase subtilisin/kexin type 7 1.00546
MRPL48 mitochondrial ribosomal protein L48 1.00448
TMEM45A transmembrane protein 45A 0.996855
LY6G6D lymphocyte antigen 6 complex, locus G6D 0.99649
CCNG1 cyclin G1 0.996072
SMAD4 SMAD family member 4 0.992287
ACOT9 acyl-CoA thioesterase 9 0.991046
XRN2 5'-3' exoribonuclease 2 0.989898
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 0.989408
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 0.988987
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.986274
CKS2 CDC28 protein kinase regulatory subunit 2 0.984696
CUL2 cullin 2 0.983198
TRIM27 tripartite motif containing 27 0.982883
NUP50 nucleoporin 50kDa 0.981942
CORO1B coronin, actin binding protein, 1B 0.978273
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.978235
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.973319
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.971094
TLN1 talin 1 0.969442
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.968683
TNF tumor necrosis factor 0.965366
NUDCD3 NudC domain containing 3 0.964594
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.958198
CLP1 cleavage and polyadenylation factor I subunit 1 0.957973
GLOD4 glyoxalase domain containing 4 0.955919
CRYBB2 crystallin, beta B2 0.950834
REXO2 RNA exonuclease 2 0.947958
IPO5 importin 5 0.947675
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 0.942877
AMZ2 archaelysin family metallopeptidase 2 0.94153
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 0.940621
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 0.938291
CHUK conserved helix-loop-helix ubiquitous kinase 0.935963
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.933322
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.930804
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.929168
WDR81 WD repeat domain 81 0.927194
TP53 tumor protein p53 0.925799
GSTO1 glutathione S-transferase omega 1 0.924539
OPHN1 oligophrenin 1 0.924227
PGAM1 phosphoglycerate mutase 1 (brain) 0.924042
FAM3D family with sequence similarity 3, member D 0.916369
SLC39A7 solute carrier family 39 (zinc transporter), member 7 0.915127
DHCR24 24-dehydrocholesterol reductase 0.914671
SLMO2 slowmo homolog 2 (Drosophila) 0.908998
TRABD TraB domain containing 0.908831
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.908607
GUSB glucuronidase, beta 0.90802
GHRHR growth hormone releasing hormone receptor 0.897984
MATK megakaryocyte-associated tyrosine kinase 0.897609
FAM195B family with sequence similarity 195, member B 0.894131
BCAP29 B-cell receptor-associated protein 29 0.892648
SKAP2 src kinase associated phosphoprotein 2 0.892553
E2F3 E2F transcription factor 3 0.892545
GDAP2 ganglioside induced differentiation associated protein 2 0.890816
CD27 CD27 molecule 0.888789
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 0.887651
BCL10 B-cell CLL/lymphoma 10 0.885703
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.882578
ASS1 argininosuccinate synthase 1 0.880421
CD53 CD53 molecule 0.879295
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 0.874358
MRPS14 mitochondrial ribosomal protein S14 0.873623
PLAUR plasminogen activator, urokinase receptor 0.871812
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.870853
CDCP1 CUB domain containing protein 1 0.869311
KIF22 kinesin family member 22 0.86728
ANLN anillin, actin binding protein 0.865028
GDF9 growth differentiation factor 9 0.861725
SSR1 signal sequence receptor, alpha 0.859391
CD14 CD14 molecule 0.858866
CYHR1 cysteine/histidine-rich 1 0.858373
UBXN1 UBX domain protein 1 0.855929
CTNND2 catenin (cadherin-associated protein), delta 2 0.853442
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.851467
ZCCHC7 zinc finger, CCHC domain containing 7 0.850494
RNF44 ring finger protein 44 0.850229
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.84985
COL5A2 collagen, type V, alpha 2 0.849533
PTCD2 pentatricopeptide repeat domain 2 0.848808
PGP phosphoglycolate phosphatase 0.844236
SIX2 SIX homeobox 2 0.841424
HIAT1 hippocampus abundant transcript 1 0.838853
MFAP5 microfibrillar associated protein 5 0.838469
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 0.837859
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.835304
POLRMT polymerase (RNA) mitochondrial (DNA directed) 0.834122

decreased expression

Symbol Name Standardized Value
TUBB2A tubulin, beta 2A class IIa -3.85449
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -3.79541
TMEM169 transmembrane protein 169 -3.75083
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.57018
COPA coatomer protein complex, subunit alpha -3.42212
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 -3.11919
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.94427
LONP2 lon peptidase 2, peroxisomal -2.76929
ACAA2 acetyl-CoA acyltransferase 2 -2.73347
H2AFV H2A histone family, member V -2.68979
C12ORF57 chromosome 12 open reading frame 57 -2.62395
GALT galactose-1-phosphate uridylyltransferase -2.61839
PGRMC2 progesterone receptor membrane component 2 -2.5002
CMC4 C-x(9)-C motif containing 4 -2.43747
SSBP2 single-stranded DNA binding protein 2 -2.3978
PRPF6 pre-mRNA processing factor 6 -2.39092
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) -2.36421
ADAMDEC1 ADAM-like, decysin 1 -2.31141
LTA4H leukotriene A4 hydrolase -2.25241
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -2.25221
SERBP1 SERPINE1 mRNA binding protein 1 -2.20451
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.18838
GTF2B general transcription factor IIB -2.17313
LMBR1L limb development membrane protein 1-like -2.13934
KRT86 keratin 86, type II -2.11434
SIDT2 SID1 transmembrane family, member 2 -2.07277
UBL3 ubiquitin-like 3 -2.02092
SIRT3 sirtuin 3 -2.01599
WDTC1 WD and tetratricopeptide repeats 1 -1.99307
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -1.99274
CCNG2 cyclin G2 -1.94465
GIPC2 GIPC PDZ domain containing family, member 2 -1.89409
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -1.89007
AIP aryl hydrocarbon receptor interacting protein -1.87293
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -1.83907
GUCA2B guanylate cyclase activator 2B (uroguanylin) -1.83788
MGEA5 meningioma expressed antigen 5 (hyaluronidase) -1.80279
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase -1.78544
TMEM229B transmembrane protein 229B -1.77479
IFI30 interferon, gamma-inducible protein 30 -1.74565
DUSP12 dual specificity phosphatase 12 -1.74481
SFXN1 sideroflexin 1 -1.73898
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -1.69517
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -1.68637
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 -1.68496
ACAD9 acyl-CoA dehydrogenase family, member 9 -1.67061
EI24 etoposide induced 2.4 -1.65511
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase -1.63156
OSBP oxysterol binding protein -1.63139
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -1.62978
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -1.62145
SBF2 SET binding factor 2 -1.61614
RAB18 RAB18, member RAS oncogene family -1.60667
DAP death-associated protein -1.60511
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -1.6034
FRMD8 FERM domain containing 8 -1.59785
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -1.54544
CAPRIN2 caprin family member 2 -1.53758
ZNF706 zinc finger protein 706 -1.53561
TSC22D1 TSC22 domain family, member 1 -1.52956
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -1.5247
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -1.52213
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 -1.50759
SNX3 sorting nexin 3 -1.49479
GOLPH3L golgi phosphoprotein 3-like -1.4688
WIPF1 WAS/WASL interacting protein family, member 1 -1.46477
ECH1 enoyl CoA hydratase 1, peroxisomal -1.45125
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -1.44248
RTN3 reticulon 3 -1.43518
C16ORF13 chromosome 16 open reading frame 13 -1.41404
IGBP1 immunoglobulin (CD79A) binding protein 1 -1.41066
TSPAN13 tetraspanin 13 -1.39245
TNNI1 troponin I type 1 (skeletal, slow) -1.39114
C11ORF1 chromosome 11 open reading frame 1 -1.38913
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -1.38717
ECI2 enoyl-CoA delta isomerase 2 -1.38073
GDI1 GDP dissociation inhibitor 1 -1.36231
RTN1 reticulon 1 -1.34985
PUF60 poly-U binding splicing factor 60KDa -1.34399
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -1.3435
KANK3 KN motif and ankyrin repeat domains 3 -1.3395
CRYL1 crystallin, lambda 1 -1.30959
SPINT1 serine peptidase inhibitor, Kunitz type 1 -1.29152
PRDX5 peroxiredoxin 5 -1.29013
DUSP16 dual specificity phosphatase 16 -1.28991
ERGIC2 ERGIC and golgi 2 -1.27793
SAR1B secretion associated, Ras related GTPase 1B -1.2779
ETFB electron-transfer-flavoprotein, beta polypeptide -1.27674
PRUNE prune exopolyphosphatase -1.25315
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -1.24789
ZC3H11A zinc finger CCCH-type containing 11A -1.24325
KIAA1191 KIAA1191 -1.2391
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -1.23355
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -1.23236
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -1.23211
IL10RB interleukin 10 receptor, beta -1.23149
CIDEB cell death-inducing DFFA-like effector b -1.23088
STIM1 stromal interaction molecule 1 -1.23034
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -1.22849
USP9X ubiquitin specific peptidase 9, X-linked -1.21764
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -1.21743
AP1AR adaptor-related protein complex 1 associated regulatory protein -1.21305
PEX14 peroxisomal biogenesis factor 14 -1.20452
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -1.20077
ANGEL2 angel homolog 2 (Drosophila) -1.19725
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 -1.19335
SVIL supervillin -1.1832
CTSH cathepsin H -1.17681
ABHD14A abhydrolase domain containing 14A -1.16647
MARCH5 membrane-associated ring finger (C3HC4) 5 -1.16525
UBXN6 UBX domain protein 6 -1.15983
RARS2 arginyl-tRNA synthetase 2, mitochondrial -1.15825
ETFA electron-transfer-flavoprotein, alpha polypeptide -1.15654
RUNDC3A RUN domain containing 3A -1.15271
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) -1.13743
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -1.12662
CDC123 cell division cycle 123 -1.11228
SPTSSA serine palmitoyltransferase, small subunit A -1.11117
NNMT nicotinamide N-methyltransferase -1.10981
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 -1.10896
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -1.10804
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -1.10753
PTPN9 protein tyrosine phosphatase, non-receptor type 9 -1.10742
SEC11A SEC11 homolog A (S. cerevisiae) -1.10689
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -1.10581
PTPRF protein tyrosine phosphatase, receptor type, F -1.10499
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit -1.09707
TMEM160 transmembrane protein 160 -1.09366
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -1.09356
CD59 CD59 molecule, complement regulatory protein -1.08998
FCGBP Fc fragment of IgG binding protein -1.08871
APLN apelin -1.07987
ABHD5 abhydrolase domain containing 5 -1.07893
NAGLU N-acetylglucosaminidase, alpha -1.07454
SCOC short coiled-coil protein -1.0726
TYSND1 trypsin domain containing 1 -1.06901
HIST1H2BI histone cluster 1, H2bi -1.06062
GPX3 glutathione peroxidase 3 -1.05704
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -1.04942
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -1.04682
STX5 syntaxin 5 -1.0456
CACHD1 cache domain containing 1 -1.04344
LIPE lipase, hormone-sensitive -1.0409
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -1.03906
GGT5 gamma-glutamyltransferase 5 -1.03426
COL15A1 collagen, type XV, alpha 1 -1.032
PPA1 pyrophosphatase (inorganic) 1 -1.02949
AHCY adenosylhomocysteinase -1.02915
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -1.02762
FNTA farnesyltransferase, CAAX box, alpha -1.02591
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -1.02405
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -1.01888
STX4 syntaxin 4 -1.01626
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -1.01435
SELENBP1 selenium binding protein 1 -1.01077
IRF2BP1 interferon regulatory factor 2 binding protein 1 -1.00785
NXN nucleoredoxin -1.00135
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha -1.00079
ALPI alkaline phosphatase, intestinal -0.992618
COL7A1 collagen, type VII, alpha 1 -0.987153
FGFR2 fibroblast growth factor receptor 2 -0.985073
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -0.982513
ITM2B integral membrane protein 2B -0.97712
LTC4S leukotriene C4 synthase -0.973352
SLC46A1 solute carrier family 46 (folate transporter), member 1 -0.969812
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.967024
ABLIM1 actin binding LIM protein 1 -0.960276
TRIM47 tripartite motif containing 47 -0.959244
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -0.95405
PLEKHO1 pleckstrin homology domain containing, family O member 1 -0.952914
TGDS TDP-glucose 4,6-dehydratase -0.950935
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 -0.942432
SPRED2 sprouty-related, EVH1 domain containing 2 -0.937462
OSMR oncostatin M receptor -0.936618
VMP1 vacuole membrane protein 1 -0.934567
MTMR14 myotubularin related protein 14 -0.933998
BMP1 bone morphogenetic protein 1 -0.933285
SNX17 sorting nexin 17 -0.933199
MCL1 myeloid cell leukemia 1 -0.932675
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.929642
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -0.923606
INADL InaD-like (Drosophila) -0.923359
TM4SF5 transmembrane 4 L six family member 5 -0.922555
TSKU tsukushi, small leucine rich proteoglycan -0.917773
UBTF upstream binding transcription factor, RNA polymerase I -0.910684
SYT3 synaptotagmin III -0.908187
PROSC proline synthetase co-transcribed homolog (bacterial) -0.907846
EPHX2 epoxide hydrolase 2, cytoplasmic -0.906529
HADH hydroxyacyl-CoA dehydrogenase -0.906471
MFGE8 milk fat globule-EGF factor 8 protein -0.905685
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -0.900972
ITPK1 inositol-tetrakisphosphate 1-kinase -0.900323
HSPG2 heparan sulfate proteoglycan 2 -0.900059
MSL1 male-specific lethal 1 homolog (Drosophila) -0.897827
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.894869
RAB8A RAB8A, member RAS oncogene family -0.886058
IPO8 importin 8 -0.885421
LATS2 large tumor suppressor kinase 2 -0.880004
CDHR5 cadherin-related family member 5 -0.874027
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 -0.871198
DAO D-amino-acid oxidase -0.870329
SCG2 secretogranin II -0.863555
OTC ornithine carbamoyltransferase -0.863253
WDR7 WD repeat domain 7 -0.862768
ZBTB45 zinc finger and BTB domain containing 45 -0.862205
BCL7C B-cell CLL/lymphoma 7C -0.861922
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -0.860505
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.860464
ENPEP glutamyl aminopeptidase (aminopeptidase A) -0.856741
DHRS4 dehydrogenase/reductase (SDR family) member 4 -0.856186
SERINC3 serine incorporator 3 -0.85067
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -0.843026
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 -0.842107
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.840988
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.833035
HS1BP3 HCLS1 binding protein 3 -0.831087
UBL4A ubiquitin-like 4A -0.830631
SUMO3 small ubiquitin-like modifier 3 -0.824185
PLCD1 phospholipase C, delta 1 -0.823943
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) -0.819924
FAAH fatty acid amide hydrolase -0.818672
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.816162
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -0.815634
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.813283
LRP1 low density lipoprotein receptor-related protein 1 -0.808103
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.80671
LMO1 LIM domain only 1 (rhombotin 1) -0.806601
SPARCL1 SPARC-like 1 (hevin) -0.806552
BTD biotinidase -0.806391
RBM6 RNA binding motif protein 6 -0.804092
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 -0.803353
ANGPTL2 angiopoietin-like 2 -0.801781
RBP2 retinol binding protein 2, cellular -0.796535
GAS1 growth arrest-specific 1 -0.796376
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.794776
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.79163
DOLPP1 dolichyldiphosphatase 1 -0.789744
PHYH phytanoyl-CoA 2-hydroxylase -0.787181
SUMO1 small ubiquitin-like modifier 1 -0.785345
KLC1 kinesin light chain 1 -0.77973
CD81 CD81 molecule -0.777399
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -0.775468
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 -0.771718
PTPN21 protein tyrosine phosphatase, non-receptor type 21 -0.766545
HINT1 histidine triad nucleotide binding protein 1 -0.766222
SCARB1 scavenger receptor class B, member 1 -0.765327
NR1H3 nuclear receptor subfamily 1, group H, member 3 -0.765217
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.764564
SNX14 sorting nexin 14 -0.76309
ACSF3 acyl-CoA synthetase family member 3 -0.762678
FAM3C family with sequence similarity 3, member C -0.76235
SUSD6 sushi domain containing 6 -0.759114
SKI SKI proto-oncogene -0.757204
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.75508
SCAF8 SR-related CTD-associated factor 8 -0.753457
SCP2 sterol carrier protein 2 -0.753125
THUMPD3 THUMP domain containing 3 -0.752643
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -0.75177
MTSS1L metastasis suppressor 1-like -0.749541
FAM126B family with sequence similarity 126, member B -0.747312
SAMHD1 SAM domain and HD domain 1 -0.744839
RXRB retinoid X receptor, beta -0.740717
TM7SF3 transmembrane 7 superfamily member 3 -0.740092
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -0.737615
PPARA peroxisome proliferator-activated receptor alpha -0.735921
JTB jumping translocation breakpoint -0.73527
BAAT bile acid CoA:amino acid N-acyltransferase -0.733674
PTPRE protein tyrosine phosphatase, receptor type, E -0.733358
TMCO1 transmembrane and coiled-coil domains 1 -0.722302
NDRG4 NDRG family member 4 -0.720357
ELMOD3 ELMO/CED-12 domain containing 3 -0.719085
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -0.718571
CAT catalase -0.716726
FAM127C family with sequence similarity 127, member C -0.714399
ECI1 enoyl-CoA delta isomerase 1 -0.71269
CDK9 cyclin-dependent kinase 9 -0.711909
OSBPL11 oxysterol binding protein-like 11 -0.711384
SC5D sterol-C5-desaturase -0.710753
HMHA1 histocompatibility (minor) HA-1 -0.710245
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -0.710221
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.708755
HDAC5 histone deacetylase 5 -0.707382
CAPN1 calpain 1, (mu/I) large subunit -0.70191
POR P450 (cytochrome) oxidoreductase -0.701203
TSC22D4 TSC22 domain family, member 4 -0.701151
RESP18 regulated endocrine-specific protein 18 -0.698224
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -0.69765
EXTL3 exostosin-like glycosyltransferase 3 -0.695034
GSTZ1 glutathione S-transferase zeta 1 -0.693231
DNM2 dynamin 2 -0.692789
RNF167 ring finger protein 167 -0.692515
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -0.6924
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) -0.691771
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) -0.688863
WDR13 WD repeat domain 13 -0.687502
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -0.685043
FABP1 fatty acid binding protein 1, liver -0.683219
NFXL1 nuclear transcription factor, X-box binding-like 1 -0.681775
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.681484
EIF4A2 eukaryotic translation initiation factor 4A2 -0.677508
Funding