Cytarabine (hydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.084788
FBN1 fibrillin 1 0.043657
COL5A2 collagen, type V, alpha 2 0.0408577
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0389187
TRIO trio Rho guanine nucleotide exchange factor 0.0387125
ATP13A3 ATPase type 13A3 0.037778
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0374238
DST dystonin 0.0339364
POTEF POTE ankyrin domain family, member F 0.0274575
HDAC9 histone deacetylase 9 0.0267419
FNDC3B fibronectin type III domain containing 3B 0.0261455
SOD2 superoxide dismutase 2, mitochondrial 0.0255663
TNIP1 TNFAIP3 interacting protein 1 0.0245862
PICALM phosphatidylinositol binding clathrin assembly protein 0.0244575
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0231925
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0230344
OGA O-GlcNAcase 0.022923
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0224546
MYH9 myosin, heavy chain 9, non-muscle 0.0220946
ADAM17 ADAM metallopeptidase domain 17 0.0220196
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0219204
XPO1 exportin 1 0.021275
APP amyloid beta (A4) precursor protein 0.0210413
FCHSD2 FCH and double SH3 domains 2 0.0209038
RUNX1 runt-related transcription factor 1 0.0208423
CDH13 cadherin 13 0.0208404
WTAP Wilms tumor 1 associated protein 0.0204868
GLS2 glutaminase 2 (liver, mitochondrial) 0.0203511
MACF1 microtubule-actin crosslinking factor 1 0.0197524
MSI2 musashi RNA-binding protein 2 0.0197367
TRIM22 tripartite motif containing 22 0.0196623
CD109 CD109 molecule 0.019379
COL7A1 collagen, type VII, alpha 1 0.0193477
MSN moesin 0.0189334
TPM3 tropomyosin 3 0.0187268
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0183884
ADAM9 ADAM metallopeptidase domain 9 0.0182784
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.018196
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0180315
ZMAT3 zinc finger, matrin-type 3 0.0179308
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0177827
SDK1 sidekick cell adhesion molecule 1 0.0177592
ZNF292 zinc finger protein 292 0.0177565
ANKRD10 ankyrin repeat domain 10 0.0177413
KDM6A lysine (K)-specific demethylase 6A 0.0176344
PCBP2 poly(rC) binding protein 2 0.0172885
CYLD cylindromatosis (turban tumor syndrome) 0.0167344
HELZ helicase with zinc finger 0.0167342
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0166608
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0166506
DENND5A DENN/MADD domain containing 5A 0.016558
NCKAP1 NCK-associated protein 1 0.0164195
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0163304
FRMD4A FERM domain containing 4A 0.0159102
UBA6 ubiquitin-like modifier activating enzyme 6 0.0158103
NBAS neuroblastoma amplified sequence 0.0156192
SPAG9 sperm associated antigen 9 0.0155893
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0155188
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0153449
SLC39A11 solute carrier family 39, member 11 0.0153115
KIFAP3 kinesin-associated protein 3 0.0150816
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0150682
PUM2 pumilio RNA-binding family member 2 0.0149129
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0148766
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0148643
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0148466
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0148458
FAM168A family with sequence similarity 168, member A 0.014738
USP9X ubiquitin specific peptidase 9, X-linked 0.014737
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0145857
MYOF myoferlin 0.0143791
MARCHF6 membrane associated ring-CH-type finger 6 0.0143203
YEATS2 YEATS domain containing 2 0.0141757
MBNL2 muscleblind-like splicing regulator 2 0.014156
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0140535
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0138525
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0136589
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0136262
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0135693
ANKRD36 ankyrin repeat domain 36 0.0134875
SBF2 SET binding factor 2 0.0134793
CDC73 cell division cycle 73 0.0133167
RICTOR RPTOR independent companion of MTOR, complex 2 0.0133076
PTK2 protein tyrosine kinase 2 0.0132258
NUP58 nucleoporin 58 0.0131145
ADAM19 ADAM metallopeptidase domain 19 0.0129526
ITGAV integrin, alpha V 0.0129407
PDE4D phosphodiesterase 4D, cAMP-specific 0.0129053
FXR1 fragile X mental retardation, autosomal homolog 1 0.0129041
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0128688
WAC WW domain containing adaptor with coiled-coil 0.0128547
FNIP1 folliculin interacting protein 1 0.0128391
TLE4 transducin-like enhancer of split 4 0.0127421
CSNK1G1 casein kinase 1, gamma 1 0.0126688
OSBPL3 oxysterol binding protein-like 3 0.0126417
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0125578
MEF2A myocyte enhancer factor 2A 0.0125122
ANO6 anoctamin 6 0.0124953
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0124738
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0124318

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.325261
TMSB10 thymosin beta 10 -0.258962
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.245352
MT2A metallothionein 2A -0.161057
AKAP12 A kinase (PRKA) anchor protein 12 -0.148568
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127061
NDRG1 N-myc downstream regulated 1 -0.0951692
S100A10 S100 calcium binding protein A10 -0.0915287
CSTB cystatin B (stefin B) -0.0880724
IGFBP3 insulin-like growth factor binding protein 3 -0.0720993
LOX lysyl oxidase -0.0693069
LMNA lamin A/C -0.0629593
PTMA prothymosin, alpha -0.0592037
PODXL podocalyxin-like -0.0589059
HLA-B major histocompatibility complex, class I, B -0.0567909
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0566714
S100A6 S100 calcium binding protein A6 -0.0557462
PLAT plasminogen activator, tissue -0.048914
IFITM3 interferon induced transmembrane protein 3 -0.0483028
FTL ferritin, light polypeptide -0.0454122
ANXA2 annexin A2 -0.0453685
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0435741
MYADM myeloid-associated differentiation marker -0.0432748
TPT1 tumor protein, translationally-controlled 1 -0.0426328
B2M beta-2-microglobulin -0.0401976
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0370484
EIF1 eukaryotic translation initiation factor 1 -0.0359304
DLG1 discs, large homolog 1 (Drosophila) -0.0358484
IFITM1 interferon induced transmembrane protein 1 -0.0348838
UBC ubiquitin C -0.0343114
LOC112694756 uncharaterized LOC112694756 -0.0336994
STC1 stanniocalcin 1 -0.0333052
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0326358
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0315915
SLC38A1 solute carrier family 38, member 1 -0.0314089
CAVIN1 caveolae associated protein 1 -0.0312696
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0309062
RRBP1 ribosome binding protein 1 -0.0296684
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0294386
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0294125
CD44 CD44 molecule (Indian blood group) -0.0279798
RPL28 ribosomal protein L28 -0.0276615
RPLP1 ribosomal protein, large, P1 -0.0275128
HLA-C major histocompatibility complex, class I, C -0.0274577
LOXL2 lysyl oxidase-like 2 -0.0272643
SQSTM1 sequestosome 1 -0.0272255
RPL35A ribosomal protein L35a -0.0265084
MT1X metallothionein 1X -0.0264834
RPS8 ribosomal protein S8 -0.026126
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0260728
GNAS GNAS complex locus -0.0256671
SEC61G Sec61 gamma subunit -0.0251435
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0250945
RPS24 ribosomal protein S24 -0.0246742
CENPF centromere protein F, 350/400kDa -0.0244205
PKM pyruvate kinase, muscle -0.0243932
RPLP2 ribosomal protein, large, P2 -0.0239669
CCND1 cyclin D1 -0.0237913
TUBB4B tubulin, beta 4B class IVb -0.0237623
IFI6 interferon, alpha-inducible protein 6 -0.0237483
TAGLN2 transgelin 2 -0.023613
RPL12 ribosomal protein L12 -0.023077
RPS6 ribosomal protein S6 -0.022927
BSG basigin (Ok blood group) -0.0226647
RPL34 ribosomal protein L34 -0.0225006
TPM4 tropomyosin 4 -0.0224961
RPS19 ribosomal protein S19 -0.0224656
CD99 CD99 molecule -0.0223639
CALR calreticulin -0.0221932
RPL23 ribosomal protein L23 -0.0216426
HSPB1 heat shock 27kDa protein 1 -0.0215861
RPL36 ribosomal protein L36 -0.0214921
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0212714
S100A11 S100 calcium binding protein A11 -0.0212355
PRSS23 protease, serine, 23 -0.0211269
TM4SF1 transmembrane 4 L six family member 1 -0.0210801
MAP1B microtubule-associated protein 1B -0.0207987
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0206557
FLNB filamin B, beta -0.0206478
RPL32 ribosomal protein L32 -0.0203445
RPS27A ribosomal protein S27a -0.0203085
TUBB tubulin, beta class I -0.0202175
S100A4 S100 calcium binding protein A4 -0.0200884
ARL4C ADP-ribosylation factor-like 4C -0.0199937
PFN1 profilin 1 -0.019713
KLF6 Kruppel-like factor 6 -0.0197029
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0194006
VDAC1 voltage-dependent anion channel 1 -0.0193525
RPL37A ribosomal protein L37a -0.0191649
S100A9 S100 calcium binding protein A9 -0.018904
PLAUR plasminogen activator, urokinase receptor -0.0188341
RPS3 ribosomal protein S3 -0.0187712
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0186376
RACK1 receptor for activated C kinase 1 -0.0185725
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0185654
SLC38A2 solute carrier family 38, member 2 -0.0185113
RPL31 ribosomal protein L31 -0.0183291
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0183167
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0181928
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0181256