Cytarabine (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.207526
FRMD4A FERM domain containing 4A 0.058923
PAX8 paired box 8 0.0574752
PLK2 polo-like kinase 2 0.0534029
TPM3 tropomyosin 3 0.0530272
DIAPH3 diaphanous-related formin 3 0.0517337
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0513895
AKAP9 A kinase (PRKA) anchor protein 9 0.0488454
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0454052
OSBPL3 oxysterol binding protein-like 3 0.043493
CXCL8 chemokine (C-X-C motif) ligand 8 0.0432737
GDF15 growth differentiation factor 15 0.0419406
MSN moesin 0.0412443
MBD5 methyl-CpG binding domain protein 5 0.0398291
SAMD4A sterile alpha motif domain containing 4A 0.0393983
CMIP c-Maf inducing protein 0.0382183
PTBP3 polypyrimidine tract binding protein 3 0.0379563
STOM stomatin 0.0369831
DENND2B DENN domain containing 2B 0.0367395
PDE4D phosphodiesterase 4D, cAMP-specific 0.0357578
ATP13A3 ATPase type 13A3 0.0357231
MYH9 myosin, heavy chain 9, non-muscle 0.0353867
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0347811
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0345032
RAD51B RAD51 paralog B 0.0341815
DGKI diacylglycerol kinase, iota 0.033941
HDAC9 histone deacetylase 9 0.0337749
KDM6A lysine (K)-specific demethylase 6A 0.033774
TPST1 tyrosylprotein sulfotransferase 1 0.0334568
SPAG9 sperm associated antigen 9 0.0332011
CD46 CD46 molecule, complement regulatory protein 0.0331862
ARHGAP26 Rho GTPase activating protein 26 0.0331231
ZBTB20 zinc finger and BTB domain containing 20 0.0331084
SEPTIN9 septin 9 0.0328831
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0326705
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0323857
MACF1 microtubule-actin crosslinking factor 1 0.032339
P3H2 prolyl 3-hydroxylase 2 0.0320173
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0319449
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0314153
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 0.030783
KMT2C lysine (K)-specific methyltransferase 2C 0.0304268
SPIDR scaffolding protein involved in DNA repair 0.030073
RNF220 ring finger protein 220 0.0299793
NRIP1 nuclear receptor interacting protein 1 0.0298832
SDC4 syndecan 4 0.0297132
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0294653
ADAM9 ADAM metallopeptidase domain 9 0.0288614
ZCCHC7 zinc finger, CCHC domain containing 7 0.0283683
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0283431
EPS8 epidermal growth factor receptor pathway substrate 8 0.028053
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0269122
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0267196
NRG1 neuregulin 1 0.0266684
FNIP1 folliculin interacting protein 1 0.0264632
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0264205
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0264153
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0261181
MON2 MON2 homolog (S. cerevisiae) 0.0259533
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0258666
THSD1 thrombospondin, type I, domain containing 1 0.025798
UBE2H ubiquitin-conjugating enzyme E2H 0.0256992
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0255192
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0254764
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0254444
ANKRD33B ankyrin repeat domain 33B 0.02541
TNS1 tensin 1 0.0253219
AKAP13 A kinase (PRKA) anchor protein 13 0.0252831
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0252812
FDXR ferredoxin reductase 0.0252527
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0252324
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0251863
RUNX1 runt-related transcription factor 1 0.0249374
MSI2 musashi RNA-binding protein 2 0.0248864
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0248094
BCL2L1 BCL2-like 1 0.0247076
BIRC6 baculoviral IAP repeat containing 6 0.0247007
PTCHD4 patched domain containing 4 0.0246808
AGMO alkylglycerol monooxygenase 0.0246192
EXOC4 exocyst complex component 4 0.0244291
ESYT2 extended synaptotagmin-like protein 2 0.024245
CD109 CD109 molecule 0.0239151
COG6 component of oligomeric golgi complex 6 0.0237788
CSF1 colony stimulating factor 1 (macrophage) 0.0237767
SSH2 slingshot protein phosphatase 2 0.023694
ZMAT3 zinc finger, matrin-type 3 0.0236257
COL4A1 collagen, type IV, alpha 1 0.0234833
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0234093
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.0233706
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0233049
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0230998
ATXN10 ataxin 10 0.0230142
CCL2 chemokine (C-C motif) ligand 2 0.0229856
CENPP centromere protein P 0.0228529
CERS6 ceramide synthase 6 0.0225915
KIRREL3 kin of IRRE like 3 (Drosophila) 0.022485
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0222841
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0222044
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0222007
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0221568

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.188178
ASPH aspartate beta-hydroxylase -0.158388
FTL ferritin, light polypeptide -0.153704
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.152893
TMSB10 thymosin beta 10 -0.138811
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127442
NAMPT nicotinamide phosphoribosyltransferase -0.102168
TXNRD1 thioredoxin reductase 1 -0.09405
CD44 CD44 molecule (Indian blood group) -0.0855635
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0781833
IGFBP3 insulin-like growth factor binding protein 3 -0.0723535
RRBP1 ribosome binding protein 1 -0.0602085
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0589264
TPT1 tumor protein, translationally-controlled 1 -0.0557247
FTH1 ferritin, heavy polypeptide 1 -0.0532112
GLIS3 GLIS family zinc finger 3 -0.0530005
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0492265
ANXA2 annexin A2 -0.0463364
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0454494
RPS24 ribosomal protein S24 -0.0454409
MT2A metallothionein 2A -0.0453001
HSPB1 heat shock 27kDa protein 1 -0.0441504
NDRG1 N-myc downstream regulated 1 -0.0424359
PTMA prothymosin, alpha -0.0417053
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0412863
RPLP1 ribosomal protein, large, P1 -0.041163
PKM pyruvate kinase, muscle -0.0411316
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0403703
EIF1 eukaryotic translation initiation factor 1 -0.0401988
RAI14 retinoic acid induced 14 -0.0394417
CENPF centromere protein F, 350/400kDa -0.038822
RPS6 ribosomal protein S6 -0.0384299
RPS5 ribosomal protein S5 -0.0382968
UBC ubiquitin C -0.0380966
EXT1 exostosin glycosyltransferase 1 -0.0377396
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0374317
IRS2 insulin receptor substrate 2 -0.0369999
ICAM1 intercellular adhesion molecule 1 -0.0368585
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0354961
MAP1B microtubule-associated protein 1B -0.035312
GARS1 glycyl-tRNA synthetase 1 -0.0352047
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.034311
RPLP2 ribosomal protein, large, P2 -0.0340002
NRP1 neuropilin 1 -0.0337812
HMGB1 high mobility group box 1 -0.0335348
TPM1 tropomyosin 1 (alpha) -0.0334637
RPL28 ribosomal protein L28 -0.0331142
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0330506
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.032609
RPS27A ribosomal protein S27a -0.0319295
RPL34 ribosomal protein L34 -0.0318409
RPL8 ribosomal protein L8 -0.0312905
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0304028
TUBB tubulin, beta class I -0.0302606
TMEM263 transmembrane protein 263 -0.0295429
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0293975
UGDH UDP-glucose 6-dehydrogenase -0.0293434
S100A10 S100 calcium binding protein A10 -0.0292679
RTN4 reticulon 4 -0.028994
TKT transketolase -0.0288674
SQSTM1 sequestosome 1 -0.028679
CA12 carbonic anhydrase XII -0.028626
RPLP0 ribosomal protein, large, P0 -0.0285697
PFN1 profilin 1 -0.0284654
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0278534
NAP1L1 nucleosome assembly protein 1-like 1 -0.0277169
RPL31 ribosomal protein L31 -0.0276877
EEF2 eukaryotic translation elongation factor 2 -0.0276856
MX1 MX dynamin-like GTPase 1 -0.0276218
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.027212
FLNA filamin A, alpha -0.0271707
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0270523
RPL12 ribosomal protein L12 -0.0268442
ARF1 ADP-ribosylation factor 1 -0.0266409
RPL35A ribosomal protein L35a -0.0264847
RACK1 receptor for activated C kinase 1 -0.0264252
OSMR oncostatin M receptor -0.0264038
STK17A serine/threonine kinase 17a -0.026303
RPS8 ribosomal protein S8 -0.0259243
CDCP1 CUB domain containing protein 1 -0.0257558
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0257233
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.025539
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0253735
RHEB Ras homolog enriched in brain -0.0253646
RPL19 ribosomal protein L19 -0.0252359
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0250524
GNAS GNAS complex locus -0.0248071
RPL9 ribosomal protein L9 -0.0247271
MKI67 marker of proliferation Ki-67 -0.0244946
NFIB nuclear factor I/B -0.0243286
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0242444
CBX3 chromobox homolog 3 -0.0241158
RPL23 ribosomal protein L23 -0.0240438
LDHA lactate dehydrogenase A -0.0239677
TPM4 tropomyosin 4 -0.0239503
RPS4X ribosomal protein S4, X-linked -0.0232303
RPS23 ribosomal protein S23 -0.0230156
TSHZ2 teashirt zinc finger homeobox 2 -0.0229754
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0227354
LOXL2 lysyl oxidase-like 2 -0.0224013