Cytarabine (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.291338
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0349698
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0317086
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0300897
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0241378
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0233225
FBXO22 F-box protein 22 0.0225813
MON2 MON2 homolog (S. cerevisiae) 0.0224882
GOLGA4 golgin A4 0.0216743
FDXR ferredoxin reductase 0.0208042
COL7A1 collagen, type VII, alpha 1 0.0204077
SEPTIN9 septin 9 0.0203664
BTBD10 BTB (POZ) domain containing 10 0.0202978
CEP95 centrosomal protein 95kDa 0.020229
CSNK1G1 casein kinase 1, gamma 1 0.0201154
ADAM17 ADAM metallopeptidase domain 17 0.0192191
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0186144
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0186
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0182864
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0179726
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0179444
XPC xeroderma pigmentosum, complementation group C 0.0172786
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0167613
PTBP3 polypyrimidine tract binding protein 3 0.0167488
WDR43 WD repeat domain 43 0.016521
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0164426
MAST4 microtubule associated serine/threonine kinase family member 4 0.016324
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 0.0162479
STOM stomatin 0.0161909
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0159952
TBK1 TANK-binding kinase 1 0.0159462
DGKD diacylglycerol kinase, delta 130kDa 0.0159078
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.015906
ESYT2 extended synaptotagmin-like protein 2 0.0153397
DERA deoxyribose-phosphate aldolase (putative) 0.014917
MORC4 MORC family CW-type zinc finger 4 0.0147211
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0146562
HELZ helicase with zinc finger 0.0145887
RB1CC1 RB1-inducible coiled-coil 1 0.0145349
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0144162
RNF213 ring finger protein 213 0.0143058
CCNL1 cyclin L1 0.0141413
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.014095
KIAA1217 KIAA1217 0.0140607
DRAM1 DNA-damage regulated autophagy modulator 1 0.0140386
NAMPT nicotinamide phosphoribosyltransferase 0.0139885
C3 complement component 3 0.0139125
ELOVL7 ELOVL fatty acid elongase 7 0.0139083
BCL2L1 BCL2-like 1 0.0138742
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0137487
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.0134779
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0133816
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0132602
ABTB3 ankyrin repeat and BTB domain containing 3 0.0132399
TM7SF3 transmembrane 7 superfamily member 3 0.0131324
UBA6 ubiquitin-like modifier activating enzyme 6 0.0129695
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0125401
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0124246
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0123561
PVR poliovirus receptor 0.0122942
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0122633
RARS1 arginyl-tRNA synthetase 1 0.0122473
NRIP1 nuclear receptor interacting protein 1 0.0121967
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0121352
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0121131
MYO6 myosin VI 0.0120767
ETNK1 ethanolamine kinase 1 0.0120601
THSD1 thrombospondin, type I, domain containing 1 0.0118982
SOD2 superoxide dismutase 2, mitochondrial 0.0117291
ITSN2 intersectin 2 0.011641
CEP85L centrosomal protein 85kDa-like 0.011613
ATP13A3 ATPase type 13A3 0.0116046
NRCAM neuronal cell adhesion molecule 0.0115463
BBC3 BCL2 binding component 3 0.0112789
TBC1D22A TBC1 domain family, member 22A 0.0112269
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0111871
YEATS2 YEATS domain containing 2 0.0111473
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0111306
SP3 Sp3 transcription factor 0.0110491
NBAS neuroblastoma amplified sequence 0.0109588
VEZT vezatin, adherens junctions transmembrane protein 0.0108713
CALD1 caldesmon 1 0.0108396
ARTN artemin 0.0107282
KDM6A lysine (K)-specific demethylase 6A 0.0106355
DENND4A DENN/MADD domain containing 4A 0.0106014
KDM7A lysine (K)-specific demethylase 7A 0.0105759
LRMDA leucine rich melanocyte differentiation associated 0.0104923
ADAR adenosine deaminase, RNA-specific 0.0104459
PLAU plasminogen activator, urokinase 0.0103772
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0103207
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0102103
OSBPL3 oxysterol binding protein-like 3 0.0101647
KIRREL1 kirre like nephrin family adhesion molecule 1 0.00991858
ARL5B ADP-ribosylation factor-like 5B 0.00990039
IRAK2 interleukin-1 receptor-associated kinase 2 0.00986206
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.00975998
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.00975777
TMEM131 transmembrane protein 131 0.00972975
DMXL2 Dmx-like 2 0.0096
SDC4 syndecan 4 0.00946726

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.206348
TMSB10 thymosin beta 10 -0.198356
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.186947
VIM vimentin -0.160352
MT2A metallothionein 2A -0.117374
UBC ubiquitin C -0.11724
ANXA2 annexin A2 -0.103422
FTL ferritin, light polypeptide -0.0906553
RPS27A ribosomal protein S27a -0.0851143
TM4SF1 transmembrane 4 L six family member 1 -0.0762079
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0704137
ASPH aspartate beta-hydroxylase -0.0703
NDRG1 N-myc downstream regulated 1 -0.0640273
MT1X metallothionein 1X -0.0616231
EFNA5 ephrin-A5 -0.0613866
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0580721
PDE10A phosphodiesterase 10A -0.0580407
PKM pyruvate kinase, muscle -0.057056
THSD4 thrombospondin, type I, domain containing 4 -0.0565073
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0556084
RPL23 ribosomal protein L23 -0.0543224
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0540377
PDE4D phosphodiesterase 4D, cAMP-specific -0.0528155
EIF1 eukaryotic translation initiation factor 1 -0.0522329
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.051882
RPLP1 ribosomal protein, large, P1 -0.0514678
PTMA prothymosin, alpha -0.0500845
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0491148
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0486614
RPS19 ribosomal protein S19 -0.0485939
IGFBP3 insulin-like growth factor binding protein 3 -0.0478525
MAML3 mastermind-like 3 (Drosophila) -0.0463145
SLC35F3 solute carrier family 35, member F3 -0.0457067
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0456859
LDHA lactate dehydrogenase A -0.045605
EEF2 eukaryotic translation elongation factor 2 -0.0444186
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0434563
STC1 stanniocalcin 1 -0.0431564
EHBP1 EH domain binding protein 1 -0.0415748
AHNAK AHNAK nucleoprotein -0.0415661
RPS6 ribosomal protein S6 -0.0413809
IGFBP4 insulin-like growth factor binding protein 4 -0.0411687
KYNU kynureninase -0.0404101
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0402993
FAM107B family with sequence similarity 107, member B -0.0398063
DOCK5 dedicator of cytokinesis 5 -0.0385965
RPS24 ribosomal protein S24 -0.0379043
RPS16 ribosomal protein S16 -0.0377444
FLNB filamin B, beta -0.036561
RPS3 ribosomal protein S3 -0.0365445
MKI67 marker of proliferation Ki-67 -0.0363418
ENO1 enolase 1, (alpha) -0.0361253
TPT1 tumor protein, translationally-controlled 1 -0.0359414
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0358858
KRT81 keratin 81, type II -0.0352242
SLC38A2 solute carrier family 38, member 2 -0.0344995
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0342638
MCL1 myeloid cell leukemia 1 -0.0337576
RPL26 ribosomal protein L26 -0.0336882
EGFR epidermal growth factor receptor -0.0330356
NAP1L1 nucleosome assembly protein 1-like 1 -0.032617
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.032549
GRB10 growth factor receptor-bound protein 10 -0.0319945
RPL28 ribosomal protein L28 -0.031838
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0314557
HMGA2 high mobility group AT-hook 2 -0.0312714
S100A6 S100 calcium binding protein A6 -0.0309667
CENPF centromere protein F, 350/400kDa -0.0303561
S100A10 S100 calcium binding protein A10 -0.0300773
RPL8 ribosomal protein L8 -0.0299675
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0298342
RPL12 ribosomal protein L12 -0.0297775
ACTN4 actinin, alpha 4 -0.0294683
TPM1 tropomyosin 1 (alpha) -0.0294452
RPL19 ribosomal protein L19 -0.0289827
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0289017
TXNRD1 thioredoxin reductase 1 -0.0287289
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0286806
RPL37A ribosomal protein L37a -0.0284246
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0278412
RPL31 ribosomal protein L31 -0.0277201
BASP1 brain abundant, membrane attached signal protein 1 -0.0277155
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0275212
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0275012
RPS8 ribosomal protein S8 -0.027135
VCL vinculin -0.0271257
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.027011
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0269813
RPS13 ribosomal protein S13 -0.0265165
RPLP2 ribosomal protein, large, P2 -0.0264834
OSMR oncostatin M receptor -0.0257882
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0257793
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0256113
BTG1 B-cell translocation gene 1, anti-proliferative -0.0255874
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0253919
PRKCA protein kinase C, alpha -0.0250804
CANX calnexin -0.0250508
RACK1 receptor for activated C kinase 1 -0.0248912
RPS23 ribosomal protein S23 -0.0248529
RPL32 ribosomal protein L32 -0.0248261