Cytarabine (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.122778
LMTK2 lemur tyrosine kinase 2 0.100388
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0950143
EPS8 epidermal growth factor receptor pathway substrate 8 0.0903968
FLNB filamin B, beta 0.0864156
SDC4 syndecan 4 0.0751529
SLMAP sarcolemma associated protein 0.0742892
PCBP2 poly(rC) binding protein 2 0.0715549
AHNAK AHNAK nucleoprotein 0.071532
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0691174
OGA O-GlcNAcase 0.0681089
PSD3 pleckstrin and Sec7 domain containing 3 0.0664757
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0648796
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0641403
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0632294
ADAM9 ADAM metallopeptidase domain 9 0.0625391
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0617624
UBA6 ubiquitin-like modifier activating enzyme 6 0.0615322
ZEB1 zinc finger E-box binding homeobox 1 0.0600724
GLS2 glutaminase 2 (liver, mitochondrial) 0.0588849
KRT8 keratin 8, type II 0.0580336
PLEC plectin 0.0577758
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0557884
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0546535
DSCAM Down syndrome cell adhesion molecule 0.0538596
SMAD3 SMAD family member 3 0.0537903
GRB10 growth factor receptor-bound protein 10 0.0531048
ITGA6 integrin, alpha 6 0.0522968
SPAG9 sperm associated antigen 9 0.0520287
TPM3 tropomyosin 3 0.0501808
ADAM17 ADAM metallopeptidase domain 17 0.0496989
NCOA3 nuclear receptor coactivator 3 0.0496122
PTK2 protein tyrosine kinase 2 0.0491528
CCNL1 cyclin L1 0.048994
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0482159
ACTG1 actin gamma 1 0.0479308
PUM2 pumilio RNA-binding family member 2 0.0473527
FGD4 FYVE, RhoGEF and PH domain containing 4 0.047053
CCNY cyclin Y 0.045829
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0451255
MYH9 myosin, heavy chain 9, non-muscle 0.0451199
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0450023
ARRDC3 arrestin domain containing 3 0.044827
FXR1 fragile X mental retardation, autosomal homolog 1 0.0443737
ZNF292 zinc finger protein 292 0.0437645
TSC22D2 TSC22 domain family, member 2 0.0434179
CAPRIN2 caprin family member 2 0.0430681
DPY19L1 dpy-19-like 1 (C. elegans) 0.0430534
NCKAP1 NCK-associated protein 1 0.0428016
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0421259
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0418931
AFDN afadin, adherens junction formation factor 0.0415686
SLK STE20-like kinase 0.040597
FAM107B family with sequence similarity 107, member B 0.0399544
BAIAP2L1 BAI1-associated protein 2-like 1 0.0397679
DSPP dentin sialophosphoprotein 0.0393362
RTN4 reticulon 4 0.0388581
TOP1 topoisomerase (DNA) I 0.038034
RICTOR RPTOR independent companion of MTOR, complex 2 0.0371227
NEK7 NIMA-related kinase 7 0.0371063
MED13L mediator complex subunit 13-like 0.0369995
FAM13A family with sequence similarity 13, member A 0.0365968
SERTAD2 SERTA domain containing 2 0.0356552
PICALM phosphatidylinositol binding clathrin assembly protein 0.0355112
ATP13A3 ATPase type 13A3 0.0352109
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0351614
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0350593
OSBPL3 oxysterol binding protein-like 3 0.0341349
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0337774
PARD3 par-3 family cell polarity regulator 0.0337288
YTHDC1 YTH domain containing 1 0.03369
APLP2 amyloid beta (A4) precursor-like protein 2 0.0336318
ARHGAP26 Rho GTPase activating protein 26 0.0334433
POTEF POTE ankyrin domain family, member F 0.033275
ESYT2 extended synaptotagmin-like protein 2 0.0322851
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0322517
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0321969
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0321015
MATR3 matrin 3 0.0321014
GOLGA4 golgin A4 0.0320909
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0320631
JMJD1C jumonji domain containing 1C 0.0318793
ITCH itchy E3 ubiquitin protein ligase 0.0316257
NAMPT nicotinamide phosphoribosyltransferase 0.031532
CORO1C coronin, actin binding protein, 1C 0.0314855
KCMF1 potassium channel modulatory factor 1 0.0313617
ACVR1 activin A receptor, type I 0.0313229
EIF4A2 eukaryotic translation initiation factor 4A2 0.0312497
CHD1 chromodomain helicase DNA binding protein 1 0.0309574
QKI QKI, KH domain containing, RNA binding 0.0309073
HSPA8 heat shock 70kDa protein 8 0.0306317
TUFT1 tuftelin 1 0.0304687
RALB v-ral simian leukemia viral oncogene homolog B 0.030449
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0303979
RCOR1 REST corepressor 1 0.0303793
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0301315
PGK1 phosphoglycerate kinase 1 0.0298851
TNIP1 TNFAIP3 interacting protein 1 0.0297506
TRA2A transformer 2 alpha homolog (Drosophila) 0.0294655
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0294111

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.240629
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127698
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.120815
LAMB3 laminin, beta 3 -0.109558
S100A10 S100 calcium binding protein A10 -0.106556
VIM vimentin -0.0980035
TPT1 tumor protein, translationally-controlled 1 -0.0973224
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0892601
EGFR epidermal growth factor receptor -0.0882562
NDRG1 N-myc downstream regulated 1 -0.0838201
F3 coagulation factor III (thromboplastin, tissue factor) -0.0785215
HMGA1 high mobility group AT-hook 1 -0.0754159
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0737485
SACK1A scaffolding CK1 anchoring protein A -0.0736873
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.072479
LAMA4 laminin, alpha 4 -0.0718341
IGFBP3 insulin-like growth factor binding protein 3 -0.0693128
PTMA prothymosin, alpha -0.0629135
HMGA2 high mobility group AT-hook 2 -0.0577848
FTL ferritin, light polypeptide -0.0568059
TXNIP thioredoxin interacting protein -0.0553707
SLC38A2 solute carrier family 38, member 2 -0.0534942
ANXA2 annexin A2 -0.053465
FTH1 ferritin, heavy polypeptide 1 -0.0529206
S100A11 S100 calcium binding protein A11 -0.052728
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0517151
EGR1 early growth response 1 -0.0469332
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0456241
LAMC2 laminin, gamma 2 -0.0426366
RPL8 ribosomal protein L8 -0.0425781
KLF6 Kruppel-like factor 6 -0.0422489
NPSR1 neuropeptide S receptor 1 -0.0421536
LMO7 LIM domain 7 -0.0415919
ZBTB20 zinc finger and BTB domain containing 20 -0.0413224
DIAPH2 diaphanous-related formin 2 -0.0406534
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0400039
RPS24 ribosomal protein S24 -0.0397095
RPL12 ribosomal protein L12 -0.0395278
RPL37A ribosomal protein L37a -0.0393169
RRBP1 ribosome binding protein 1 -0.0392317
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0390271
RPL34 ribosomal protein L34 -0.0389509
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0379196
RPL35A ribosomal protein L35a -0.0371024
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0368698
KLK10 kallikrein-related peptidase 10 -0.0368501
RPLP1 ribosomal protein, large, P1 -0.0361494
VCAN versican -0.0350625
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0348663
LY6E lymphocyte antigen 6 complex, locus E -0.0346147
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0335532
TM4SF1 transmembrane 4 L six family member 1 -0.0331789
GREB1L growth regulation by estrogen in breast cancer-like -0.0316861
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0300309
FERMT1 fermitin family member 1 -0.0297207
AKAP12 A kinase (PRKA) anchor protein 12 -0.0295749
RPS23 ribosomal protein S23 -0.0295152
RPL31 ribosomal protein L31 -0.0294979
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0294835
FBXO11 F-box protein 11 -0.0293189
GNAS GNAS complex locus -0.0292732
EIF1 eukaryotic translation initiation factor 1 -0.0291639
MYO1E myosin IE -0.0289719
CSTB cystatin B (stefin B) -0.0288113
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0288075
RPS8 ribosomal protein S8 -0.0287767
SLC35F3 solute carrier family 35, member F3 -0.0283256
RPS13 ribosomal protein S13 -0.027944
INTS6 integrator complex subunit 6 -0.0275451
RPS21 ribosomal protein S21 -0.0273963
S100A6 S100 calcium binding protein A6 -0.0273776
RPLP2 ribosomal protein, large, P2 -0.0270971
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.02693
H1-0 H1.0 linker histone -0.02668
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.026512
PDE4D phosphodiesterase 4D, cAMP-specific -0.0264147
RPLP0 ribosomal protein, large, P0 -0.026134
CLMP CXADR-like membrane protein -0.0258488
RPL28 ribosomal protein L28 -0.025651
RPS6 ribosomal protein S6 -0.0255799
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0252302
BLZF1 basic leucine zipper nuclear factor 1 -0.025003
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0246986
RPL32 ribosomal protein L32 -0.0244451
S100A4 S100 calcium binding protein A4 -0.0242531
RPS25 ribosomal protein S25 -0.0240605
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0239349
PERP PERP, TP53 apoptosis effector -0.0237367
THSD4 thrombospondin, type I, domain containing 4 -0.0234227
MIDN midnolin -0.0232738
RASAL2 RAS protein activator like 2 -0.0231209
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0230967
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0230871
IER3 immediate early response 3 -0.0229526
RPL11 ribosomal protein L11 -0.0229078
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.022806
TBCA tubulin folding cofactor A -0.0227707
S100A9 S100 calcium binding protein A9 -0.0227491
RPS14 ribosomal protein S14 -0.0226501
RPS27A ribosomal protein S27a -0.022629